Myelosis Subleukemic - okufana ingozi wegazi ezingelapheki

myelosis Subleukemic ingenye iqembu kancane wegazi ezingelapheki, lapho imbangela isifo siba ushintsho sokugembula eyandulela amaseli myelocyte. Kanyekanye nokuvuthwa kahle lamaseli hematopoietic kule nqubo isifo athuthukile esisheshayo izilonda fibro-sclerotic e amathambo asemzimbeni nge kokucindezelwa concomitant the umnkantsha amathambo izinguquko proliferative e ubende kanye esibindini. Yingakho myelosis subleukemic okukhulunywe wegazi njengoba myeloproliferative.

Izizathu myelofibrosis futhi ezahlukeneyo lesi sifo

Ezimweni eziningi, lesi sifo kwenzeka ezigulini iminyaka engu-50 nangaphezulu, ngakho inani elithile enamathiselwe ukungasebenzi kahle kwezakhi zofuzo of zenuzi stem impahla sikakhokho amaseli, iziyaluyalu sokuhlasela kwamasosha omzimba, izifo ezibangelwa amagciwane. substrate morphological iba mieloza ushintshe yonke ezintathu lwegciwane hematopoiesis - granulocytic, megakaryocytic futhi erythroid. Kukithi kobukhulu lezi zinkinga futhi kuncike lesi sifo futhi Izibikezelo.

Ezimweni eziningi subleukemic myelosis ukuqhutshwa kunalokho kungavamile ukuba ingozi, futhi kukhona ukuhlanganisa okuqondile phakathi ubudala nesineke ngesikhathi kuqala lesi sifo futhi Izibikezelo - Encane isiguli, kwakuya kuba nzima myelofibrosis kwenzeka. In esigabeni ukuphela kwalesi sifo, okungenza ukuthuthukisa ngemva 5-15, ngisho iminyaka engu-20 ngemva ukuthola izimpawu zokuqala, iziguli zingase Blast crisis. Khona-ke lesi sifo siba izici wegazi acute: inani elikhulu ukuqhuma avele igazi neuropathy. Izimpawu ukuthuthukiswa zesifo ezifana ziyimfiva, izimpawu zokudakwa, silwane siyagula futhi oluhambisana syndrome. Kuvame anda ubende kanye esibindini. Kwezinye iziguli, kungenzeka inchubekelembili okusheshayo sifo ngokubukeka ekuseni yalesi sifo ukopha futhi anemizatsiey lesiguli.

Lwasemtholampilo isithombe mieloza subleukemic

Ngokuvamile iziguli Sikhathazekile uzwakalise ubuthakathaka jikelele, ukusinda esiswini, okwandisa nge ukunyakaza futhi ikakhulukazi ngemva kokudla (kungenxa nokwanda okuphawulekayo ubende kanye kwesibindi). Kukhona izikhalazo ikhanda, ubuhlungu amathambo nomgogodla. Kakhulu akuvamile, esigabeni ukuphela kwalesi sifo, isiguli singase ukuthuthukisa thuthuva ezinzima sezinzwa. Udokotela kufanele ngempela ngakususi funicular myelosis - isimo sokugembula isimiso sezinzwa ukuthi kwenzeka uma othile anaemia megaloblastic. Lesi simo ngokuvamile kwenzeka kwegazi, okuyinto eyenzeka in iziguli engayitholi enganele vitamin B12 emzimbeni.

Ngaphezu kwalokho, thrombosis ngokuvamile zenzeka, okuyinto iba imbangela ngokukhuphuka kwenani zegazi igazi neuropathy bebonke, futhi krovi.Poslednee coagulation iziyaluyalu kungase kubangelwe yokungavuthwa morphological ngisho ngempela inqwaba platelet. Ngokuhamba kwesikhathi, thrombocytosis kuholela ukuthuthukiswa splenomegaly, kodwa ubende sebeqala sokudiliza platelet hhayi kuphela kodwa futhi abomvu egazi, elibangela ukuthuthukiswa igazi.

Uhlelo Ukuhlolwa kanye nokwelashwa okukhethwa kukho iziguli

Sifo "myelosis subleukemic" kufanele sibeke hhayi ngesisekelo ukuhlolwa kwegazi sokucindezeleka, imiphumela wokubhoboza sternal noma iliac trepanobiopsy. Izinguquko in ukuhlolwa igazi ngokuyinhloko non-ethize kanye kuphela ukuhlonza ukwanda noma ukwehla enanini kwamangqamuzana egazi futhi ushintshe amaphesenti azo e awukwazi ihlonzwe "myelosis subleukemic".

Ukwelashwa lesi sifo kubuye sincike isimo umnkantsha kanye etholakalayo amathambo aqatha kwezinso. Kwezinye izimo, observation ngokwanele ashukumisayo esiguli, kanti myelofibrosis ngokushesha ethuthuka kufanele kube ukuqokwa kwe-chemotherapy.

In esigabeni ukuphela kwalesi sifo kwezinye izimo, kudingeka ukuba avume ukwelashwa ngemisebe, aphoyintimenti omkhulu ngamakhemikhali acute myeloid uhlelo lokwelapha wegazi, ukususwa ubende - kodwa esimweni ngasinye ekwelapheni isifo isiguli kufanele ubeke eyisazi oqeqeshiwe.