Creatinine - kuyinsakavukela egazini kanye nomchamo. Ukubaluleka basemtholampilo isampula

Creatinine - omunye elithile igazi yokuthakwa kwamakhemikhali kanye urinalysis. Kwamakhemikhali emitholampilo kunqunywa ngokuyinhloko filtration uphenyo reabsorbtsionnoy nemisebenzi kwezinso. Ukuze udokotela, creatinine, izinga ukwanda sokugembula yakhe noma lukhulu. Kodwa ake siqale sihlaziye lokho yalolu ketshezi futhi itholakala kanjani ekhiqizwa emzimbeni.

We-biochemistry ebhukwinitifundvo kungatholakala ukuthi creatinine ingenye okuthiwa ekupheleni-imikhiqizo umzimba. Kumiswa It is kusuka creatine amaprotheni ukukhonza mthombo wamandla sokuba imisipha. Ngo imisipha creatine kuyinto ekhuthaza othiwa phosphocreatine. Nge zokunciphisa imisipha creatine unika amandla ayo, futhi uyawuphula phansi yokugcina umkhiqizo - creatinine, amanzi ne phosphorus ezilinganisweni. Ngakho emzimbeni livela creatinine. okuhlushwa kwakho kuncike nenani yemisipha. Ngenxa yalokhu, igazi creatinine amadoda, ngesilinganiso ke, uhlale kunakunoma abesifazane.

Imikhiqizo ekupheleni inqubo amaprotheni umzimba excreted ngokusebenzisa izinso umchamo. I creatinine glomerulus kusukela egazini elicwengekileyo wadlula phakathi tubules kwezinso. Phakathi operation evamile izinso lususwe lonke umzimba, okungukuthi, kususwa kusukela egazini. Kuleli kusekelwe izici zayo omunye izivivinyo ebaluleke kakhulu izinso - sampula Rehberg. Ukusebenzisa kunqunywa filtration glomerular. Futhi ngesisekelo the GFR eyaziwa ibalwa kwezinso ijabulise reabsorption. Kodwa ake sixoxe ngalokhu kamuva.

Creatinine kabani sivamile abantu 0,044-0,106 mmol / l, futhi abesifazane - 0.44-0,88 mmol / L inyuka ikakhulukazi izinso izifo. Inani laboratories imiphumela yocwaningo kuvetwa kwezinye amayunithi - e micromoles. Ukuze bafake micromoles mmol creatinine izibalo kufanele iphindwe 1000. Ngokwesibonelo, izinga amadoda - 44-106 mmol / l.

creatinine Okuqhubekayo - omunye izimpawu eyinhloko nokwehluleka ukusebenza kwezinso. Kuyinto ngenxa yokuthi filtration ku glomeruli kwezinso incipha kakhulu izilonda lapho kwezinso.

Nokho, zokugula kwezinso - akukuphela kwesizathu sokwanda lokhu inkomba. Zonke izifundazwe kanye nezifo lapho kukhona ukuwohloka okusheshayo phosphocreatine bemisipha, ungase futhi ukwandisa creatinine egazini izinombolo eliphezulu. Lokhu kungenziwa lwaqiniswa umsebenzi kwemisipha, i-hyperthyroidism, ukudla okunothe amaprotheni, ukuntuleka kwamanzi emzimbeni, acromegaly.

Uma izimo ezihilela kwemisipha izicubu izilonda, creatinine anda, futhi. Ngokwesibonelo, indawo ebanzi esivimba amanzi infarction ephelezelwa creatinine anda. isifo Kushisa bhé kule ndawo, ukusha, wathatheka syndrome futhi ukuqhubeka izithelo zalo.

Ukuthatha imithi ethile kwandisa creatinine. kuyinsakavukela kwalo kungabhekwa kudlulwe uma isiguli uthola sulfonamides, barbiturates, imithi elwa namagciwane of tetracycline futhi aminoglycoside chungechunge.

Ukwehla creatinine lingaphansi kunalokhu okujwayelekile akanayo ukubaluleka zokuxilonga, njengenhlangano ukwanda. Kungase kube ngenxa engayitholi ukungadli ukudla amaprotheni, indlala, ukukhathala. Kwehliswe creatinine ngowesithathu lokuqala sokukhulelwa, edema, ascites. Kuyasiza ukunciphisa creatinine nokunwetshiwe ukusetshenziswa corticosteroids.

Ukuze esolwa ukwehluleka kwezinso, njengoba kakade asho, ngokuvamile iqondiswa Reberga isampula.

Uma kunqunywa kokuqhuba creatinine, izinga zazo egazini ukwehluleka kwezinso kungenziwa kakhulu lidlule futhi umchamo creatinine. Umchamo isampula Rehberg bugcogcwe emini, inikeza imiphumela esinembile kuka uma eqoqwe ngesikhathi esincane. Kuyadingeka ukukala ngokunembile umthamo yayo. Ilabhorethri silethwa esincane nsuku zonke ivolumu umchamo, zonke ayinayo ukuthela. Lapho lokuqoqa umchamo kufanele ugweme ukuzivocavoca, angadli amaprotheni kakhulu. Igazi shall esiswini esingenalutho ekuseni. I nsuku zonke creatinine excretion umchamo evamile alinganayo 4,4-17,7 mmol / usuku.

Ngemva sokunquma egazi noma omchamo creatinine, ngokwazi inani umchamo nsuku zonke, isisindo lesiguli kanye ukuphakama (okokugcina osebenza ikakhulukazi izingane) e-laboratory ifomula ekhethekile sinquma filtration glomerular bese - reabsorption ijabulise. Amazinga abadala phakathi-abaneminyaka: filtration glomerular ngoba amadoda - 82-140 ml / imiz, abesifazane - 81-128 ml / imiz. Norma ijabulise reabsorption - 95-99%. Uma ukwephula umsebenzi so-renal, lezi zimiso ziyancipha.