Creatinine imvume

Kwezokwelapha zanamuhla, inkulumo ethi "imvume" elimelela a ambalwa inkomba isivinini zokuhlambuluka uketshezi oluthile begazi. Ukusebenzisa le nkomba sehle kakhulu ukuqonda kwethu le pharmacokinetics futhi pharmacodynamics lezi kanye nezinye izinto.

Ngakho, ngokwesibonelo, creatinine imvume kunqunywa usebenzisa ukuhlola ukuthi kungakanani abakwaziyo Reberga-Toreeva. Kuyaphawuleka ukuthi kuleli cala kungenzeka ukuthola izinga filtration nomongo endogenously kwemiqondo abakudingayo kusukela ngaphandle (emithi kanye nezinye izindlela). Ukulinganisa wenziwa kubalwa zokuhlunga umfutho (glomeruli) plasma Ukukhululwa izinga kusukela into ethile. I-akhawunti esiqhutshwa yesikhathi esinqunyiwe (ikakhulukazi - usuku).

Ekhuluma creatinine, kufanele sinake yokuthi balikhipha nasezinguqulweni umzimba ngokuyinhloko ngenxa yomsebenzi filtration we nezinso. Ngokusekelwe lokhu, ezifana creatinine imvume izinga kwakuyoba semqoka kokuhlaziywa kwezinso glomerular filtration ukusebenza. Kumele kuqashelwe ukuthi le sibalo libhekene hhayi kuphela umthamo ukusebenza ohlelweni lemifanekiso, kodwa futhi ezinye ukuphazamiseka kwezitho zomzimba kanye nezinhlelo. Kushintshwe phansi, creatinine imvume futhi zingase zibe Indlela singenele igazi ligeleze izinso (isifo sokuqina kwemithambo yegazi, futhi ehlome acute nokuthuthukiswa - thromboembolism).

Izinga yokwehla womsebenzi kwezinso kwenzeka ngemva kweminyaka engamashumi amane. Ukunciphisa glomerular filtration isilinganiso 1% ngonyaka. Ngemva kweminyaka engamashumi ayisithupha, ezingeni lokuzivivinya yehliswe kancane ngokushesha (lezi zinguquko ngokuyinhloko lihlobene ukuguga umzimba). Nokho, kufanele kuphawulwe ukuthi iyiphi kuwukubonakaliswa izinguquko is hhayi waphawula ngenxa yokuthi abantu asebekhulile kuyehla zonke izinqubo umzimba, kuhlanganise synthesis creatinine endogenous.

Lapho silungiselela isampula Rehberg kuyadingeka ukukhipha ukusetshenziswa kwezidakamizwa ezithile ezingaba nomthelela Yiqiniso cwaningo (izidakamizwa "cortisol" "Furosemide", "Corticotropin", "Methylprednisolone," "thyroxine" kanye nabanye).

Ukuze ufake isampula umchamo amasampuli wenziwa, kanye ukuhlolwa igazi ezingeni isilinganiso plasma creatinine.

Phakathi izimpawu ngenjongo cwaningo: zokugula endocrine, ukuhlolwa umsebenzi kwezinso ukusebenza, kanye nokuhlolwa komthelela lokuzivivinya.

Kuye ezingeni lokwehliswa imvume ukuchaza lezi noma nokunye ukwephulwa.

• 30 ml / iminithi / m2 kanye 1.7 - ukwehla umsebenzi kwezinso e ngokulinganisela;
• 30-15 ml / iminithi / m2 1.7 - khona ukwehluleka kwezinso (noma ihlawulelwa degree subcompensated);
• <15 ml / iminithi / m2 1.7 - ukwehluleka kwezinso decompensation isigaba.

Kubalulekile ukuqonda ukuthi ikhono ukusebenza ohlelweni filtration inquma imvume kwezinso of creatinine, izinga zazo phakathi isampula Reberga kubonisa izinso evamile.

Nokho, ezinye izifo akuvezi izinguquko inkomba (isib pyelonephritis zezifo ezingelapheki).

creatinine ezingeni egazini lincike umsebenzi zamagama alo endogenous futhi izinga yayo excretion urinary. Kubalulekile ukuqonda ukuthi lesi sibalo akuxhomekile nje kuphela esimweni umsebenzi ohlelweni zokuhlunga, kodwa futhi ijubane futhi ivolumu reabsorption izidakamizwa kwetinhlavu umchamo eyinhloko.

Ngakho, okwamanje Reberga isampula (sokunquma imvume creatinine) ngokwanele ukuthola ukusetshenziswa kabanzi kwezokwelapha zokuxilonga. Ukuba nobuhlobo okuqondile phakathi imvume nezinso umsebenzi inikeza okusezingeni eliphezulu zokuxilonga inqubo ukubaluleka.