Invisible iso evamile Blashko umugqa emzimbeni womuntu

Imperceptible kuya nqunu amaphethini iso emzimbeni womuntu zenzeka ngaphansi kwethonya izici endogenous futhi exogenous ezimbi. Kunqunywa zokugula njengoba imigqa Blashko. Melanogenesis wabonakaliswa hypopigmentation, siphathelene neqembu izifo dermatoses. Kubonakala isithakazelo ingozi isayensi. Qonda isimiso ukubukeka kwe-isimila, kungenzeka ukuvimbela ukubukeka melanoma.

Umlando ekuhloleni izifo zesikhumba

umcwaningi German izinkinga dermatological wathola Blashko umugqa ngo-1901. Zimelela isibonelo lesikhumba, ezifanayo isakhiwo zonke iziguli. Lesi sifo yethiwa igama usosayensi, egama layo linguJehova Alfred.

Udokotela Wesikhumba ebuhlotsheni obase bukhona kakade nge okuvela zokugula X-chromosome. On isikhumba izinguquko enempilo imperceptible emakamu sabo esivamile sokuphila. Ngenxa ukuthuthelwa kunezinxushunxushu malanoblastov ukwakheka ebonakalayo esifundeni iphethini. Isimo amaseli soguquko lwegciwane singalawuleka luncike iloli omzimba sezinzwa. Nokho, izinkinga dermatological ingatholakala ifa azalwa naso lesi sifo.

Isizathu esiyinhloko salokhu ngeziphambeko isikhumba womuntu

Thola lezi zinto ezilandelayo Ezemfundo Blashko umugqa emzimbeni:

• Chimerism - uvame ukubizwa ngokuthi isimo lapho umuntu amawashi amabili izinhlobo DNA. Iqoqo elihlukile zezakhi zofuzo icuphe kumiswa lesikhumba emzimbeni. Le miphumela yembula ukulalana kwezihlobo nge ezinhlanga ezimbili ezihlukene. Izimbangela isikhumba zokugula iba Fusion iqanda eselivundisiwe ngendlela efanele usaqala yokukhulelwa.
• akha iphetheni kunezinxushunxushu is - Human ukucindezeleka ukungalingani.
• Ufuzo - izinguquko kuyi-DNA yomuntu. Isizathu sokuba ukubonakala zokugula azalwa naso kuba nevi: depigmented, esikhunjeni, sebaceous, komugqa verrucous ukuvuvukala.
• Bofuzo kuhlangana DNA phakathi embryogenesis - ososayensi ukukhwezwa isakhiwo kwezicubu womuntu: kwelinye yezinyoni iqoqo izakhi zofuzo siyenzeka. Nakuba umsuka yokugcina lisuselwe zygote olulodwa.

Ubunjalo ukubukeka dermatosis

Kuyangikhathaza ukuba akazi ukuthi igama elithi "Blashko umugqa" - kunjani ukuthi umugqa? Izinkinga ezinjalo ngokuvamile atholakala izinsana, akukho kuka 2% zazo beyizidlova ukubukeka pathologies. Isakhiwo DNA ekuqaleni iqukethe isifo ulwazi. kuphakama izimpawu kwangaphandle ngenxa ngeziphambeko Endocrinology umzimba.

Blashko umugqa libhekene amaseli ezintathu emzimbeni, ungumthombo sifo:

• keratinocytes Epidermal - zokugula atholwe ngokuvamile baphawula ngenxa chimerism.
• Pigment - ise izingqimba engezansi epidermis.
• Ukuphrofayela umngcele sombala amaseli - kuholela ushintsho ibala lesikhumba, edabula ulwelwesi engaphansi ku ungqimba phezulu dermis. Lesi simo siyenzeka at nature isegazini kwetinhlavu melanoma.

izimpawu zangaphandle

I izincwadi zezokwelapha ezisekelwe ekwazisweni inikeza ulwazi mayelana emigqeni Blashko: ukuthi iyisifo kwezicubu womuntu, esizibonakalisa uma ukwehluleka emzimbeni impilo. Ukwakheka iphethini ongabonakali ngemuva ingxenye sifana umbala izilwane: idube noma ngwe yaseBengal. Singasho kwaphawula emisebeni ultraviolet.

Umbala kwesikhumba womuntu kuncike lwalezozinto sombala i-melanin. Kumiswa It is in the epidermis kwezicubu, ungqimba basal yakhiwa melanocytes. Ngeziphambeko inqubo melanogenesis kuholela ushintsho umbala zibukeke lizwakale:

• Hyperpigmentation - iphethini kunezinxushunxushu of amnyama esikhumbeni, zihlukaniswa ngokucacile kusukela eziyisisekelo umthunzi izembozo.
• Hypopigmentation - ukulahlekelwa umbala kunamaqoqo amangqamuzana esikhumba, okuholela izindawo olumhlophe. zokugula ezingavamile waphawula ayibi ngaphezu kuka-1% ezisanda kuzalwa.

Kuwukubonakaliswa sangaphandle iphethini isifo siba V emise, ngesimo curls noma imigqa mihlobiso. Ngokuvamile kwakhiwa lezi zitho zomzimba:

• emuva;
• ezinhlangothini;
• emahlombe;
• ikhanda.

ekuxilongeni inkinga

Line umdwebo Blashko zile uma umuntu zishiswe ngemisebe ultraviolet, kodwa ngenxa yokuphila akuvamile sihamba ukuhlola okunjalo. Ukuze ukufunda isimo yomzimba eqala kakade ngezigaba okuqhubekayo isifo. Ngo ezisanda kuzalwa, amabala eliqhakazile hypopigmentation emzimbeni kunzima ukubona. Ingane ethola izinguquko eziphawulekayo isikhumba eminyakeni embalwa.

On isimo amaseli ehlaselwe iqoqo chromosome. Uma-ke ihlukile kakhulu ezigabeni eduze kwesikhumba, lokuchezuka ebonwe Umbala izindwangu. Ngakho hypopigmentation zingavela kwale mibandela elandelayo:

• izindawo kunezinxushunxushu - nesithakazelo kuyisayensi ngenxa izakhiwo engalingani. Isithombe siveza waphawula bobunjwa eziyinkimbinkimbi ngesimo bands, chess amaseli.
• Kuhunyushelwe - manifest endaweni eyodwa endaweni ethile.
• Generalized - kungase kuhambisane izifo yezitho zangaphakathi.

Kungani kudingeka sitadishe imidwebo esikhumbeni?

Odokotela aye ayisebenzisa kaningi ukuthungwa ukuhlaziywa kwezicubu at yezinkinga ebonakalayo isikhumba. Lapha, le nkomba eyinhloko umugqa Blashko, lesi sifo uyaphenywa uphethwe yini. Lokhu kuba ebalulekile lapho elandelayo izinkinga dermatological:

• chimerism;
• mosaicism;
• zoster;
• nevus;
• melanoma.

ukwakheka Inxanxathela ibalulekile kuphela ohlangothini ucwaningo, ngokuba ongelutho, azihlole ongakabi kuholele eziphethweni eziqinisekile ngalesi sifo. Ososayensi ukuhlela ukumambula injongo amaphethini emzimbeni womuntu. Mhlawumbe ukutholakala kuzosiza ukuqeda imiphumela ezingavamile esehlaselwa isifo sesikhumba esenyanyekayo.