Umuthi 'Prosulpin ": imfundo manual, ukubuyekezwa kanye analogue

Imithi ye-"Prosulfin" yokusetshenziswa isekwe njenge-agent antipsychotic enamandla, esetshenziselwa ukwelashwa kwezimo ezihlukahlukene zesimiso sezinzwa nezinye izifo. Imininingwane eminingi mayelana nomuthi ongenhla ufundwe.

Incazelo emfushane yokulungiselela

Lo muthi ungokwamaqembu e-benzamine asetshenzisiwe. Ngenye indlela, kungashiwo ukuthi izidakamizwa "i-Prosulfin" yi-neuroleptic ejwayelekile. Impendulo yabahloli ibonisa ukuthi isenzo sayo sihlose ukuvimbela ama-receptors e-dopamine (D2 no-D3). Ngenxa yalokhu, umuthi ongenhla uveza umphumela wokwelapha we-antipsychotic.

50 noma 200 mg ye-sulpiride iqukethe i-tablet eyodwa yokulungiselela "i-Prosulfin".

Yiqiniso, kwezinye izimo, imiphumela emibi uma uthatha le mithi ibonakala. Ngakho-ke, isiguli ngesikhathi sokulashwa ne-antipsychotic ngenhla kufanele sibe ngaphansi kokuqondisa okuqinile kodokotela.

Lo muthi unamafomu amaningi. Itholakala kwifomu yethebhulethi, kanye namafomu, isisombululo somjovo we-intramuscular kanye nomswakama wokuphatha ngomlomo.

Isidakamizwa kufanele sigcinwe ekamelweni lokushisa elivamile, kodwa hhayi ngaphezu kwama-degree angu-25 Celsius. Indawo kufanele ivikelwe kahle kusuka ekukhanyeni nasemswakeni. Cishe iminyaka emibili yisikhathi sokuphelelwa isikhathi sokulungiselela "i-Prosulfin". Ama-analog to find it akulula. Imakethe yezidakamizwa inikeza izinhlobo ezahlukene zezikhundla zomuthi ongenhla.

Umphumela wezamakhemikhali we-agent engenhla yokwelapha

Isidakamizwa esithi "Prosulfin", isithombe esinikezwa ngezansi, yisifo sokulwa nesifo sokulwa nesifo sofuba, okungukuthi, i-neuroleptic. Isidakamizwa sulpiride, ngenxa yokuvimbela ama-receptor e-dopamine esifundeni se-tuberoinfibdibular, sandisa kakhulu izinga leprolactin. Kumele kuqashelwe ukuthi ebangeni lama-60-80%, izinga lokuvimbela i-dopamine receptors lihluka.

Lezi zinsuku zibhekene nokufana okuphezulu ne-benzamide, enesici esiyingxenye, njengomphumela ohlangene ohlelweni lwe-neurotransmitter dopamine. Ngaphezu kwalokho, bavimbela ukwanda kokuhlanganiswa kwe-dopamine esifundeni se-synaptic, okungukuthi, abaphikisi be-auto-receptors ze-presynaptic D2 D3.

Kumele kuqashelwe ukuthi umuthi ongenhla ubhekwa umsebenzi olinganiselayo we-neuroleptic. Lesi sigaba sihlangene nesenzo se-timoanaleptic nesishukumisayo salesi sidakamizwa.

Isidakamizwa esingenhla sinesenzo esilandelayo sezemithi:

• I-antiemétique (i-dopamine receptors ivimbela indawo yokuqhafaza isikhungo sokuhlanza);
• I-Antidepressant;
• Antipsychotic.

I-Sulpiride ibonisa umphumela wokuvimbela ukucindezeleka emithini efika ku-600 mg. Ngaphezulu kwalesi sizinga, umphumela we-antipsychotic walesi sidakamizwa emzimbeni usuvele ukhona.

Ngaphezu kwalokho, ukulungiselela "i-Prosulfin", imfundo ibonisa lokhu, ikhiqiza umphumela wokukhetha i-hypothalamus enezimpawu zesilonda se-peptic nesigastroduodenitis. Ngesikhathi esifanayo, ukukhathazeka okukhulu kwezikhungo zentuthuko yesimiso sezinzwa kukhishwa, ukuhlinzeka kwegazi esiswini kuthuthukisiwe, ukwanda kwamathishu okugranulation, izinqubo zokucwiliswa kwe-mucus esiswini, ukuvuselelwa kwe-epithelium kwakha, ukwanda kwama-capillary ezinhlobonhlobo kuthuthukisiwe.

Ubani okufanele athathe lo muthi?

Iyini imithi "ye-Prosulfin" yezinkomba? Ngezinhloso zokwelapha imithi engenhla isetshenziselwa lezi zifo:

• Izifo ze-Psychosomatic;
• Ukucindezeleka izilonda zendlela yokugaya ukudla;
• Izilonda zesifo;
• I-Gastroduodenitis;
• Isilonda sesisu;
• I-syndrome ye-british irritable (obukhulu);
• Izilonda zezidakamizwa;
• I-neonicecific kolitis ulcerative;
• Ukucindezeleka kwe-etymologies ehlukene;
• Neuroses;
• Ukucindezeleka okusebenzayo;
• Izifo zesifo sofuba;
• Schizophrenia;
• Ukuphazamiseka kwengqondo okungapheli;
• I-Migraine;
• Ukuphazamiseka okukhulu kwengqondo;
• Ukuzivocavoca kwe-etymologies ehlukahlukene (neuritis vestibular, insufficiency vertebrobasilar, isifo Meniere, otitis media).

Umuthi othi "i-Prosulfin" yokusetshenziswa kuphakamisa ukusetshenziswa kokuphatha ukwephula ukuziphatha nokuziphatha kwengqondo ezigulini ezincane, okungukuthi, ezinganeni. Lezi yizifo ezinjengokuzulazula, ukukhathazeka, ukugxeka. Futhi, imishanguzo ye "Prosulfin" inconywa kakhulu ukuba isetshenziswe njengengxenye yendlela yokwelashwa kwe-autism ebuntwaneni. Leli thuluzi lisetshenziselwa ukuphatha iziguli ezincane ezineminyaka engama-6.

Ukungafani kokusetshenziswa komuthi ongenhla

Ukulungiswa "i-Prosulfin" akukhuthazwa ukuthi kusetshenziswe uma isiguli sinempawu ezilandelayo:

• Ukuziphendulela komzimba kuya ezingxenyeni zomuthi;
• Hyperprolactinemia;
• Izicubu ezisekelwe ku-prolactin (umdlavuza webele, i-prolactinoma ye-pituitary gland);
• Izifo ezibuhlungu;
• Uketshezi oludakayo olunobuthi oluqukethe utshwala;
• Ukuziphatha okunesihluku;
• Pheochromocytoma;
• Ukushisa okunamandla nezidakamizwa noma amaphilisi okulala okwelapha;
• I-psychoic psychosis.

Yonke le mibandela yizinqinamba eziqinile. Futhi, ukusebenzisa imithi ye-"Prosulfin" kuvunyelwe abesifazane abancancisayo abantwana babo, izingane ezingaphansi kweminyaka engu-18 (amaphilisi 200 mg), iziguli ezincane ezingaphansi kweminyaka engu-6 (amaphilisi 50 mg).

Ngaphezu kwalokho, kufanele kukhunjulwe ukuthi ngokulahlekelwa kwesifo se-lactose, i-malabsorption ye-glucose-galactose, ukubekezelelana kwe-lactose, futhi akuyona into efiselekayo yokusebenzisa ukulungiselela "i-Prosulfin". Ukungafani nokusetshenziswa komkhiqizo ongenhla kusebenza nakwabesifazane abakhulelwe. Ukusebenzisa iziguli ezinjalo kuvunyelwe kuphela uma inzuzo ekulindeleke kule mithi iyoba ngaphezulu kakhulu kunengozi engaba khona kusukela ebusweni.

Imiphumela emibi

Uma uthatha lesi sidakamizwa "i-Prosulfin" (imfundo ibonisa lokhu), kungase kube neminye imiphumela emibi:

• Ezingxenyeni zesimiso se-endocrine - i-galactorrhea, i-dysmenorrhea, i-amenorrhea, ubulukhuni, ukungabi namandla;
• Kusukela komphumela wezinzwa, ukuzamazama, isizungu, i-dyskinesia yokuqala, i-extrapyramidal syndrome, ukulala, i-akinesia ene-muscle hypertonia, i-akathisia, injabulo yemoto;
• Ukwandisa umsebenzi we-enzyme (kusukela ohlangothini lokugaya);
• I-héemolytic anemia, i-leukocytosis, i-anemia ye-anemia, i-granulocytosis, i-thrombocytopenic purpura eyenzeka ngokulinganisa okwenyuka kokulungiselela "i-Prosulfin" (isenzo se-lymph kanye nesistimu yegazi);
• I-Tachycardia, i-orthostatic hypotension, ukwehla noma ukwanda kokucindezela komzimba, ukwandiswa kwesikhathi se-QT, kwezinye izimo ukuthuthukiswa kwesifo esinobungozi njengoba kuqhuma amaphuzu (kusuka enhliziyweni nasesimisweni sakhe).

Eminye imiphumela emibi nayo ibangela le mithi. Ukulungiselelwa "i-Prosulfin" (imfundo, ukubuyekezwa kodokotela nezimpendulo zesiguli kufakazela ngalokhu) kungabangela izimo ezinjenge-tardive dyskinesia, ebonakala ngokunyakaza okungazibandakanyi komzimba noma ulimi (ngekhambo lokwelapha okuqhubekayo ngama-neuroleptics azo zonke amaqembu), i-hyperthermia. Ochwepheshe baxwayisa ukuthi kule ndaba yokugcina kubaluleke kakhulu ukukhansela lesi siluleko esingenhla ngesikhathi, njengoba ukukhuphuka kwezinga lokushisa kungaba isibonakaliso sokuthuthukiswa kwesifo esinjalo esiyingozi njenge- neuroleptic syndrome eyingozi.

Ukwanda kwesisindo somzimba, ukujuluka okukhulu, isikhumba sokukhukhumeza nokukhwabanisa - yonke lemiphumela emibi nayo ingabangela isidakamizwa "i-Prosulfin". Ukufundiswa, ukubuyekezwa kochwepheshe kuncoma ezimweni ezinjalo ukuthi ziyeke ukuthatha imithi engenhla bese uthintana nodokotela ngokushesha ukuze uthole usizo lwezokwelapha nezeluleko.

Sebenzisa ngesikhathi sokukhulelwa komkhiqizo ongenhla

Umphumela we-teratogenic wezidakamizwa awutholakalanga ngenxa yokuhlolwa kwezilwane. Abanye besifazane abasebenzisa le mithi ngenkathi bekhulelwe nabo abazange babone umphumela ongenhla. Kodwa lezi ziguli zithatha kakhulu izilinganiso ze-"Prosulfin". Imiyalo yokusetshenziswa, ukubuyekezwa kochwepheshe abanalo ulwazi oluqondile mayelana nokusetshenziswa kwesamba esiphezulu sezinto ezifana ne-sulpiride. Ayikho futhi ubufakazi bokuthi umuthi ongenhla uphumelela kanjani ekuthuthukiseni ubuchopho be-fetal.

Njengendlela yokuqapha, ochwepheshe abacebisi ukusebenzisa le mithi yabesifazane besimo. Nakuba kwezinye izimo, ukwelashwa okunezidakamizwa okukhulunywe ngenhla kusamukelekile ezigulini, okulindeleke ukuthi ingane ilandelwe, kodwa ngokulinganiselwe kwamanani amancane.

Ochwepheshe bathi uma umama ethatha ukwelashwa ngama-neuroleptics isikhathi eside, izinhlanzi ze-neonatal ziye zaba nezinkinga nokusebenza kwendlela yokugaya (isibonelo, ukubhuqa).

Uma owesifazane esebenzisa umuthi esikhathini ngaphambi kokubeletha, ke ukulawula umzimba wakhe nokuthuthukiswa komntwana ngokudokotela kuyadingeka.

Futhi, khumbula ukuthi isidakamizwa esithi "Prosulfin" singene ebisi lwebele. Imiyalo yokusetshenziswa, ukubuyekezwa kochwepheshe akuphakamisi ukuyithatha ngesikhathi sokulahlwa.

Ungathatha kanjani umuthi "u-Prosulfin"?

Imfundo iyala iziguli ukuthi zisebenzise i-antipsychotic ngenhla njalo ngamahora angu-8 kumphilisi owodwa. Akunconywa ukuthatha imithi emva kwe-4: 00, njengoba umsebenzi wayo ngalesi sikhathi uphezulu kakhulu. Kumele kuqashelwe ukuthi isetshenziswe kungakhathaliseki ukudla kokudla futhi yageza ngamanzi okwanele okulungiselelwa "Prosulfin".

Amathebulethi aqukethe ama-200 mg we-sulpiride athathwa ngezimpawu zesifo schizophrenia, i-psychosis enhle nokucindezeleka. Isidakamizwa singathathwa ngezindlela eziningana. I-dose yansuku zonke esiphezulu i-100 mg, okungukuthi, cishe amaphilisi ama-5.

Amathebulethi, afaka 50 mg we-sulpiride, imfundo ikhombisa ukuthatha uma isiguli sibonisa izimpawu ze-neurosis, ukukhathazeka. Kungakapheli amasonto amane, iziguli ezinjalo kufanele zidle okungenani eyodwa namaphilisi amathathu ngosuku.

Futhi, amaphilisi anjalo angathathwa ezinganeni ezinenkinga enkulu yokuziphatha. Ubudala beziguli ezinjalo kufanele kube ngaphezu kweminyaka engama-6. I-dose yansuku zonke esiphezulu yeziguli kulesi sigaba ivela ku-5 kuya ku-10 mg nge-10 kg yesisindo somzimba wengane.

Overdose

Imfundo ibonisa ukuthi imininingwane ngokudlula ngokweqile kwe-sulpiride inqunyelwe. Izimpawu ezilandelayo zingabonakala kule nkinga kwisiguli:

• Ukuvikelwa kolimi;
• I-Dyskinesia ene-spasmodic torticollis;
• Umbono ophundlekile;
• Umlomo omile;
• Kungenzeka ukuthuthukiswa kwe-NSA;
• Izimpawu ze-Extrapyramidal;
• Ukujuluka okukhulu;
• I-nausea;
• Umphumela wokuzonda;
• I-Gynecomastia;
• I-Parkinsonism;
• Ukucindezela komzimba okwandayo.

Ukwelashwa kwesimo esingenhla sesiguli kwenziwa kanje:

• Isisu sesiguli sageza;
• Iphethwe i-carbon activated;
• Ukwelapha okusetshenziselwayo kusetshenzisiwe.

Uma kunesidingo, ezimweni ezimbi kakhulu, udokotela angase anikeze ezinye izindlela zokuphatha, njenge-diuresis ephoqelelwe nge-infusion ye-alkaline izixazululo noma ukuqapha imisebenzi ebalulekile yomzimba.

Kumele kuqashelwe ukuthi lesi sidakamizwa sikhishwe kancane ngesikhathi se-hemodialysis.

Ezinye izigaba zeziguli kufanele zithathe izinyathelo ezikhethekile zokusebenzisa izidakamizwa "Prosulfin". Lokhu kusebenza ngokuyinhloko kwabesifazane abanenkinga yokungavamile, iziguli ezine-hypotension enkulu kanye nomfutho wegazi ophezulu.

Kubuye kubalulekile ukuqhuba ukuhlolwa kokuqala kwe-electrophysiological kanye nokwelashwa ezigulini ezinesithuthwane. Kumele kukhunjulwe ukuthi ukulungiselela "i-Prosulfin" kunciphisa umgogodla wokusebenza okuxubile.

Ngaphezu kwalokho, lapho ukushayela izimoto kufanele uqaphele kakhulu ngesikhathi ukwelashwa nemithi engenhla. Kubalulekile nokunciphisa imisebenzi edinga ukusabela okusheshayo kwengqondo nokukhushulwa kokunakwa.

Ukusebenzisana neminye imikhiqizo yokwelapha

Imfundo ayihambisani nokufakwa komuthi ongenhla ekwelashweni okuyinkimbinkimbi nge-levodopa. Izinto ezimbili ezisebenzayo ziphikisana. Uma isiguli esibhekene nesifo sika-Parkinson sithatha i-levodopa, udokotela kufanele akhethe ikhambi elinomphumela omncane we-extrapyramidal.

I-Arrhythmia efana ne-torsades de amaphuzu ingabangela inhlanganisela yokulungiselela "i-Prosulfin" nge:

• Izidakamizwa ezithathelwanayo eziseklasini Ia (izidakamizwa "Dizopiramid", "Quinidine");
• Amalungiselelo Pimozid, Haloperidol, Thioridazine, Cisapride, i-Pentamidine, i-imipramine yokucindezeleka;
• Izidakamizwa ezithintekayo ezibandakanya ekilasini lesithathu (iSotalol, Kakamiodaron);
• Izidakamizwa ezenza izimpawu zesifo ezifana ne-bradycardia (amabha-blockers of calcium iziteshi);
• Izidakamizwa ezithinta ukubonakala kwezibonakaliso ze-hypokalemia (i-laxatives evuselela, i-hypokalemic diuretics, i-tetracosactides, i-glucocorticoids);
• Abaphikisi base-Antiparkinsonian: apomorphine, amantadine, lisurid, ropinirole, entacapone, bromocriptine, selegiline, pramipexole, piribedil);
• I-neuroleptics, enekhono lokubangela izimpawu ze-pirouette tachycardia (i-Chlorpromazine, i-Amisulpride, i-Tsiammamizin, iPimozid, i-Droperidol, i-Levomepromazin, i-Tiaprid, i-Sertindol, i-Veralipride, i-Sulpiride). ;
• Izidakamizwa eziqukethe i-lithium (lokhu kukhulisa kakhulu ingozi ye-extrapyramidal disorders).

Futhi, akunjalo uma ukulungiswa "i-Prosulfin" kusetshenziswe utshwala. Lezi zinsuku zingase zibe nomphumela wokudambisa ama-neuroleptics.

Ngaphezu kwalokho, uma uthatha imithi engenhla ngokubambisana nezidakamizwa ezisemaphakathi (izidakamizwa ze-antiasthmatic, i-anorectics), khona-ke isiguli singase sibe nezimpawu zokucindezeleka okukhulu, ukwesaba, ukukhathazeka, ukukhathazeka.

Kumele kukhunjulwe ukuthi lesi sidakamizwa sokulwa nesifo sofuba sinciphisa izinga lokuphumelela kwe-ropinirole.

Ama-substitutes of the agent yokwelapha "i-Prosulfin"

Izidakamizwa zesidakamizwa esingenhla kwesifo se-antipsychotic:

• "Betamak T100";
• "Vero-Sulpirid";
• "Betamax T50";
• "Thumela";
• "Betamax";
• "Dogmatist";
• "I-Betamaks T200";
• "Sulpiride";
• "Egonil";
• "Sulpiril";
• "Eglek".

Kodwa ukufaka esikhundleni ngaphandle kokubonisana ngaphambili nodokotela akuphakamisi "imiyalo ye-Prosulfin" yokusetshenziswa. Ama-analogs akhe anemiphumela emibi yabo siqu. Kungabangela ukulimala okukhulu empilweni yesiguli.

Izimpendulo kudivayisi yezokwelapha "Prosulfin"

Ukubuyekezwa mayelana nesiluleko esingenhla kuningi kakhulu. Iziguli eziningi zithatha uma zicindezelekile. Bathi leli khambi lisiza ukuqeda izimpawu zalesi sifo ngo-100%.

Ngaphezu kwalokho, iziguli eziningi izimpendulo okwanele, okuyinto yezifo ezifana lokusangana, enterocolitis, nesifo, sengqondo, enteritis, isifo emathunjini, ukuhluthuka wamathumbu syndrome, wathatha lesi sidakamizwa "Prosulpin". Uphenyo ibonisa ukuthi kuzo zonke izimo, ithuluzi ukhiqiza an amazing ukuphulukisa umphumela. Ngaphezu kwalokho, iziguli ukubika ukuthi side effects zenzeka kakhulu akuvamile.

Umuthi ngenhla has nemiphumela emibi, ngakho ukuyisebenzisa ngaphandle kokubonisana ngaphambi udokotela akuvunyelwe nakancane.