Nicotinic acid: izinkomba ukusetshenziswa, imiphumela emibi, intengo

Niacin ungaba ku umzimba womuntu owenziwe kahle imiphumela ezihlukahlukene. Lokhu kuvumela ukusetshenziswa kwalo for ekwelapheni izifo eziningi isimiso sokujikeleza kwegazi, esiswini namathumbu, kanye izifo eziningi ukuthuthukisa ku isizinda isifo sokuqina kwemithambo yegazi kanye pellagra.

Bamba iqhaza umzimba izidakamizwa

Niacin kuyinto ngokuzimisela zonke izinqubo umzimba - futhi amaprotheni namafutha, futhi ama-carbohydrate. Lokhu kwenzeka ngenxa yokuthi iyingxenye ye-enzyme ukuthi ukusheshisa namachibi nokwehlisa ukusabela.

Ikakhulukazi izidakamizwa esebenzayo kuthinta umzimba kwamafutha. Ithanda ukuzihlalela yodwa zokunciphisa egazi cholesterol (ikakhulukazi "okubi") lapho Akhuthaza ukwakheka kwe-plaque e imithambo yegazi. Inombolo ewusizo kwakwakhe organic okuyinto uhlanganyela ngentshiseko izinqubo umzimba, futhi kungandisa nicotinic acid. Izinkomba ngoba ukusetshenziswa kwezidakamizwa yalezi zizathu, lokhu okulandelayo: iningi izifo eziningi ukuthuthukisa ku isizinda isifo sokuqina kwemithambo yegazi, izifo, njengesifo i lwemithambo occlusive (neuropathy lwemithambo occlusion), isifo ischemic zobuchopho futhi inhliziyo.

ukusheshisa ukugeleza kwegazi

Ngaphezu kwalokho, nicotinic acid izenzo ekwandiseni ngendlela ku-capillary (imithambo yegazi elincane). Ukhuthaza nje hawu igazi ngcono ukuphakelwa kwezitho zawo ezahlukene. Ngakho-ke, ungakwazi ukusheshisa izicubu kokuzalwa nilimaza ephulukisa izilonda futhi nicotinic acid. Izinkomba ukusetshenziswa zomuthi kulokhu: izifo eziningi amathumbu nasesiswini e ukuthethelelwa (phakathi exacerbations).

enquma

Umuthi wokuqala usiza ekwelapheni pellagra. Lesi sifo eba ngenxa ukuntula kuyinto nicotinic acid. Lokhu kuphakamisa yokuphazamiseka umzimba okuholela lesion kwesikhumba, lapho-ke siyenzeka ukulunywa, ukuvuvukala, ububomvu. Futhi, umsebenzi emathunjini ekhathazwa lapho pellagra, isisu (kuhlanganise nendlela enza ngayo kanye nolimi), ubuchopho (umphumela - komqondo). Endabeni ukuthuthukiswa ezincane lesi sifo kanye nokuntuleka nemiphumela engathi sína isimiso sezinzwa esiyinhloko nicotinic yokwelapha acid siyasebenza ngempela.

izifo ze-isisu namathumbu Ukwelashwa

Ukuze ekwelapheni pathologies okuyinto usasebenzisa nicotinic acid? Izinkomba ukusetshenziswa zomuthi kungenzeka okulandelayo - ezihlukahlukene izifo emathunjini nasesiswini. okungukuthi:

1. Kolwelwesi nge uketshezi esincishisiwe.
2. isilonda duodenal nasesiswini.
3. Nesifo.
4. Enteritis.
5. Pancreatitis efomini ezingamahlalakhona.

Kuzo zonke lezi zimo, ukusebenzisa nicotinic acid kwamukelekile kuphela ukuthethelelwa (ongekho izikhathi exacerbation). ukunakekelwa ngokukhethekile kuyadingeka ukusebenzisa lolu izidakamizwa ekwelapheni isilonda peptic, njengoba kungenzeka ingasebenzi ukusheshisa esiswini acid uketshezi phakathi exacerbation. Ngenxa yalokhu vasodilation kungenzeka ukuthi kuholela yezinkinga izifo ukopha.

malabsorption syndrome

Kukhona futhi izifo ze-isisu kanye emathunjini, okuyinto kakhulu sinciphise izinga lokutholakala kwengculazi ukumuncwa izingxenye ukudla emathunjini amancane futhi nicotinic acid. Lokhu zokugula ibizwa ngokuthi "malabsorption syndrome." Uhamba izifo eziningi ukuthuthukisa e pheshana emathunjini. Nge yilesi sifo esasikhipha a nicotinic acid ekhiqizwa ngemithambo yegazi noma intramuscularly.

Ukungabi acid

It is ukuthi of nicotinic acid ukuntula siyenzeka emzimbeni uma kwenzeka ukungondleki. imenyu njalo esekelwe ezihlukahlukene imikhiqizo, ngokungabi bikho isilwane wezokudla amaprotheni, izithelo nemifino akavumeli ukuba bazogcwalisa uhlelo kanye nezinhlaka umzimba ngokwanele ngakho. Esimweni esinjalo, nomuthi iqondiswa ngomlomo noma ngomjovo.

Futhi, nicotinic acid ukuntula kwenzeka ngenxa ezinzima izifo ezithathelwanayo imvelo ephelezelwa nokwanda okuphawulekayo lokushisa komzimba ngenxa ukuvuvukala isikhathi eside. Uma lokhu izidakamizwa kunikezwa kuphela ngaphandle inkathi exacerbation. Endabeni kwesibindi esingamahlalakhona noma isibindi sibe sesomile nicotinic acid alisetshenziswa.

Ezinye izifo

Yiziphi ezinye izimo, nicotinic acid? Izinkomba phakathi okulandelayo:

1. Isifo sokuqina kwemithambo yegazi kanye nezifo ezihlobene nayo - endarteritis obliterans, ischemic isifo senhliziyo. Ukusetshenziswa acid ngesivinini cholesterol umzimba, dilates imithambo yegazi, kuthuthukisa kwegazi ezicutshini futhi izitho.
2. izilonda trophic kanye amanxeba. Niacin kunomthelela ekuseni izicubu ukuvuselelwa nokwelashwa.
3. Ukubuyiselwa ukusebenza evamile izitho eziningi. I nomuthi, kulesi simo uba Vitamin.

Nicotinic acid: Side Effects

Yamukela nomuthi eyamukelekayo yini engaphezu kuka-6 amagremu emini. Ukuze bezibona kangcono nicotinic acid umzimba kufanele kudliwe kuphela ngemva kokudla futhi baphuze isiphuzo efudumele. Ngo esigabeni sokuqala ukwelashwa nale isidingo sokulawula ezingeni glucose egazini. Futhi ukuhlonza imiphumela engemihle acid kufanele ukuqapha umsebenzi kwezinso.

Kwesinye isikhathi izidakamizwa ayiqondakali Bangibheka iziguli, ngezinye izikhathi ububomvu kwesikhumba, kanye komzimba. Isizathu salokhu iyona zamagama anda prostaglandins, ukuphazamiseka pheshana emathunjini, hyperuricemia futhi yehlise glucose impendulo. Ngenxa yalesi sizathu, ngempumelelo, kodwa amazinga okukhishwa esikhulu nicotinic acid (3 kuya 5 amagremu ngosuku) ayikwazi niqonda umzimba ngamunye.

Imiphumela anobuthi zomuthi

Lokhu edepho izidakamizwa ngezinye izikhathi kubangela imiphumela ezinzima anobuthi kwesibindi. Ngakho-ke, ukusetshenziswa kwesikhathi eside nicotinic acid angenela control walo mzimba. imiphumela enjalo zomuthi kwesibindi ngenxa methylation yayo. Ngaphambi kokuba uqale ukuba baveze ukuthi imiphumela hepatotoxic ka nicotinic acid kakhulu sehlise izinga lipids egazini.

hypovitaminosis

Eside ukusetshenziswa nicotinic acid in inqwaba kuholela displacement we umzimba ascorbic acid. Lesi senzakalo ngokuthi hypovitaminosis. Ukuvimbela ke, ekuphathweni ezengeziwe kubhekwa amalungiselelo afanele ascorbic acid.

Okunye ngeziphambeko

Ngesikhathi ukusetshenziswa nicotinic acid njengoba kungenzeka ukwahluka elandelayo waphawula:

1. Ukwandisa asidi of juice esiswini (okubi kakhulu of isilonda).
2. Hyperglycemia.
3. Ukwenyuka ukuvama arrhythmias atrial in iziguli yenhliziyo Umthambo isifo (ezingavamile, kodwa kungenzeka).
4. Ukubukeka izindawo ensundu kokuba ikhava Velvety isikhumba (acanthosis).
5. Ukuvuvukala retina amehlo (a ezingavamile side effect).

Zonke zalezi zimpawu abasakwazi engazinzile futhi zinyamalale emva ukumisa nicotinic acid.

I inani lentengo lomuthi

Yeka ukuthi kuyinto niacin? Inani Pharmacy Russian zazisuka ruble 10,90. amaphilisi 50 at umthamo we 0.05 amagremu. Inani esiphezulu - mayelana 81 ruble 10 izitsha eziyisikhombisa izidakamizwa umthamo 10 mg / ml.