Isifo Myeloproliferative: izimbangela, izimpawu, uphethwe

Myeloproliferative isifo izimbangela, izimpawu, uphethwe ka iluphi okuzoxoxwa ngalo kamuva, bakha iqembu uthi, ngokumelene okuyinto kuyofika emnkantsheni wethambo, kukhulile ukukhiqizwa thrombocytes, erythrocyte noma leukocyte. Sekukonke kukhona eziyisithupha izinhlobo pathologies.

Uhlolojikelele

Omnkantsha ngokuvamile yenza isizukulwane stem (beya) amaseli. Ngemva kwesikhathi evuthwa, zigcwele. A lwama-stem cell kungenzeka yekucala kumiswa ezimbili izinhlobo izinto: eziningi ze-lymph kanye myeloid amaseli. amaseli beya izithombe for kumiswa leukocyte. Phakathi kwezakhi yochungechunge myeloid akhiqizwa:

• Erythrocyte. Bona athwala umoya-mpilo kanye nezinye izakhi uxhumo kwezitho nezicubu.
• Leukocyte. Lezi zici banesibopho ukuphikiswa nezinye pathologies ezithathelwanayo.
• Ama-platelet I. La mangqamuzana ukuvimbela ukopha, ifomu amahlule.

Ngaphambi ukuguqulwa ku igazi amangqamuzana abomvu, amangqamuzana amhlophe egazi noma izinhlayiya zegazi, ekunqandeni amaseli kuzomele udlule izigaba eziningana. Uma ekhona, isifo myeloproliferative, kwakheka semali indaba kokuqala is by eyodwa noma ngaphezulu izinhlobo amaseli kwakhiwa. Ngokuvamile zokugula sanda kancane kancane ngokwanele nge okwandisa izakhi igazi ngokweqile.

ngezigaba

Uhlobo okungenzeka isifo myeloproliferative incike inani erythrocyte, izinhlayiya zegazi noma leukocyte. Kwezinye izimo, umzimba okweqile wawubona izakhi ezingaphezu kweyodwa zilwane. Pathology uhlukaniswe:

• Okungalapheki wegazi neutrophilic.
• Polycythemia.
• Okungalapheki wegazi myelogenous.
• thrombocytopenia Essential.
• Idiopathic (ezingamahlalakhona) myelofibrosis.
• wegazi Eosinophilic.

isigaba sokugembula

Isifo myeloproliferative kungenziwa siguqulelwa wegazi oyingozi. Lesi simo libhekene ngokweqile amangqamuzana amhlophe egazi. Isifo myeloproliferative ayinakho zesiteji uhlelo oluthile. izinyathelo zokwelapha kuxhomeke ohlotsheni zokugula. Ngokuphathelene ezindleleni, lesi sifo myeloproliferative kungavuka ngeyodwa yalezi zindlela ezintathu:

• Ukuhluma kwamanye amathishu. Kulokhu, umdlavuza usabalala ezungezile izingxenye enempilo, ngibashaye.
• indlela Lymphogenous. isifo Myeloproliferative ukungena ohlelweni lymph kanye ezitsheni zawo basakaza nezinye izicubu kanye izitho.
• umzila Hematogenous. Amaseli umdlavuza ukungena kuma-capillary kanye emithanjeni abazondla ezicutshini futhi izitho.

Lapho ukusabalala isimila cells, cishe ukwakha entsha (zesibili) izimila. Le nqubo ibizwa ngokuthi Ukudlulela. Secondary ukuze izimila eyinhloko, kukhona uhlobo olufanayo lomdlavuza. Ngokwesibonelo, kukhona ukusabalala amaseli leukemic ebuchosheni. Ucwaningo luthole izakhi lwesimila. Babhekisela wegazi, hhayi umdlavuza ubuchopho.

izimpawu zokugula

Kanjani isifo myeloproliferative? Izimpawu ze-zifo ezilandelayo:

• kwesisindo, nokuzincisha ukudla.
• Ukukhathala.
• Isisu kabi umuzwa ukudla okusheshayo ukugcwaliswa. Kugcine sokucasuka ubende lakhulisiwe (splentomegaliey).
• Nezici ezithile ukuze ukopha, nokulimala, noma izimpawu zesifo ze thrombosis.
• ukwazi kahle.
• ubuhlungu bamalunga, ukuvuvukala, sokucasuka sokuqaqamba kwamalunga gouty.
• Iyakhala ezindlebeni.
• Soreness ngakwesokungxele quadrant engenhla esiswini kanye kwesokunxele ehlombe, okuyinto is phetho yisihlungu noma awe infarction we ubende.

inhlolovo

Myeloproliferative igazi disorder itholwa ngesisekelo nemiphumela laboratory. Ucwaningo kuhlanganisa imisebenzi elandelayo:

• Ukuhlola nesineke. Kulokhu, uchwepheshe inquma isimo jikelele ikhombisa izimpawu zokugula (ukuvuvukala, isibonelo), kanye display, kwakungekho muntu enempilo. Udokotela ubuye abuze mayelana yokuphila lesiguli, izifo kanye imikhuba emibi, linqume.
• Enwetshiwe Kla. Igazi amasampuli Kwenziwa ukunquma:
  
  - inani zegazi kanye amangqamuzana abomvu egazi;
  - ratio futhi isibalo leukocyte;
  - lizinga elithwala umoya-mpilo;
  - ngevolumu okuyinto elalihlala amangqamuzana abomvu egazi.

• Nenshisekelo kanye umnkantsha biopsy. Ngesikhathi inqubo, inaliti obukhulu eziyize is busuka sternum noma iliac ithambo. Lokhu zokukhwabanisa ikuvumela ukuba athathe isampula umnkantsha futhi yakhe izicubu kanye igazi. Indaba kuhlolwa ngesibonakhulu ngokuba khona amaseli angavamile kuwo.
• ukuhlaziywa Cytogenetic. Le nqubo ikuvumela ukubona izinguquko kuma-chromosome.

Isifo myeloproliferative: Ukwelashwa

Kuze kube manje, kukhona zokwelapha isifo eziningana. Omunye noma enye inketho ikhethwa kuncike ngezimo zesiguli futhi ukubonakaliswa ezihambisana nesifo myeloproliferative. Ukwelapha ingasatshenziswa ejwayelekile - efakazelwe umkhuba, noma zokuhlola. Indlela yesibili ukufunda ukusetshenziswa izindlela ezintsha ezihlukahlukene.

phlebotomy

Le nqubo kuthatha igazi emthanjeni. Indaba ke wathumela ukuba ukuhlaziya ezivamile kwamakhemikhali. Kwezinye izimo, phlebotomy ebekiwe iziguli uxilongwe isifo myeloproliferative. Ukwelashwa kulokhu ziqondiswe ukunciphisa isibalo erythrocyte.

platelet apheresis

Le ndlela efanayo kulowo eyedlule. Umehluko wukuthi kukhona Kwenziwa kokususwa platelet esengeziwe usebenzisa imishini ekhethekile. Isiguli uthatha igazi badabula isihlukanisi. Ubeke platelet. "Purified" igazi emuva esigulini.

ukumpontshelwa

Le nqubo kuyinto igazi. Kulesi simo esikhundleni ezinye izakhi. Ikakhulukazi, isiguli esikhundleni amaseli wabo ubhujiswe futhi ezilimele uthola ukumpontshelwa igazi amangqamuzana amhlophe, amangqamuzana egazi abomvu nama-platelet.

ngelashwa nangemithi

Le ndlela kuhilela ukusetshenziswa kwezidakamizwa cytotoxic. Isenzo sabo kuhloswe ukubhujiswa isimila cells noma okwehlisa ukukhula izimila. Ukuze isicelo ngomlomo, emthanjeni noma esicutshini izidakamizwa, izithako zabo asebenzayo ukungena kwegazi, ekuqedeni izakhi sokugembula. Lokhu kubizwa ngokuthi yi nokwelashwa ngamakhemikhali letindzala. amasu Regional kuyinto isingeniso kusho ku umsele umgogodla, zithinteka isitho noma umzimba ingaphakathi ngqo.

ukwelashwa ngemisebe

Ukwelashwa Kwenziwa usebenzisa imvamisa eliphezulu x-ray noma ezinye ngemisebe. ukwelashwa ngemisebe ingafinyelela ukuqedwa ngokuphelele isimila cells bese wehlisa ukukhula izimila. Ekusebenteni, ezimbili izinhlobo zokwelapha. Kwangaphandle ukwelashwa ngemisebe iyona ukuchayeka unit, etholakala eduze isiguli. Lapho i ukugcwaliswa inqubo yangaphakathi Kwenziwa izinto radioactive izinaliti, catheters, amashubhu, abese injected ngqo isimila noma ezicutshini elise eduze nayo. Iyiphi indlela uzobe onguchwepheshe isicelo, kuye ngezinga of umdlavuza yenqubo. Iziguli uxilongwe myeloproliferative igazi sifo zishiswe, njengoba umthetho, endaweni ubende.

Ukwelashwa ngamakhemikhali nokushiswa nge kwezitho kwamaseli

Le ndlela yokwelashwa ukusetshenziswa kwezidakamizwa ebulilini futhi esikhundleni abathintekayo antitumor isinyathelo amangqamuzana amasha. izakhi beya kukhona esibuya noma isiguli kanye eqandisiwe. Emva kokuphothula nokwelashwa ngamakhemikhali, is busuka impahla umzimba egcinwe. Innovations amaseli ziqala ukuvuthwa futhi sikhuthaze ukwakheka kwamaseli amasha igazi.

isikhathi ekululameni

Ngemva ukwelashwa, isiguli kufanele ubone udokotela wakho njalo. Ukuze ukuhlola kungenzeka ukusebenza yokwelapha kudingeke aqhube uchungechunge izinqubo esetshenziswa ngaphambilini ngaphambi kokuba aye kudokotela. Ngokuhambisana Imiphumela, isinqumo ukuqhubeka, ekupheleni noma ushintsho yokwelashwa lwemithi. Okunye ukuhlola kufanele liphindwe njalo, ngisho nangemva beqeda imfundo ethatha zokwelapha. Bavumela wena ukuhlola umthelela imicimbi kanye ukubona kokushelela.