"Disulfiram": ukubuyekezwa. "Disulfiram": incazelo, intengo

Kulesi sihloko, sanquma ukuba ngikutshele ukuthi lena izidakamizwa ngokuthi "Disulfiram". Yokusetshenziswa, impendulo izinkomba Izimali ziyophinda kuchaziwe ngezansi. Ngaphezu kwalokho, uyofunda ukuthi yini izindleko wathi imithi, ukuthi likhiqizwa kunoma yiluphi uhlobo ukuthi lifakwa ngezithako zawo, njalo njalo. D.

Ifomu kanye nokwakheka emaphaketheni

I nomuthi "Disulfiram", yokusetshenziswa okuyinto ebiyelwe ebhokisini elenziwe amakhadibhodi, is imakethwa ngesimo isixazululo oily kanye amaphilisi kwezokuphatha temlomo na yenzeka.

Ifomu yokuqala ikhiqizwa izitsha eziyisikhombisa 20 ml, futhi eyesibili neyesithathu - e ingilazi izimbiza at amayunithi 10 no-20 ngokulandelana.

Isithako asebenzayo we nomuthi kuyinto disulfiram. Ngaphandle-ke, umuthi iqukethe futhi izingxenye ezengeziwe (kuncike amafomu wokukhishwa): chloride sodium, mannitol, isitashi, sodium stearate, PEG-6000, i-MCC, i-calcium diphosphate, cellulose hydroxypropyl, stearic acid kanye polyoxyl 40.

izakhiwo kwemithi

Kuyini phambi kwethu imithi? Abakushoyo ngaye Izibuyekezo wezokwelapha? "Disulfiram" has a emelene utshwala umphumela.

Uma uthola leli thuluzi liphawuleka umphumela wawo obonakalayo utshwala umzimba. Ngenxa yalokho, metabolites ephephile akhiwa, okuyinto ukwandisa lokuhlushwa ezinobuthi ezifana acetaldehyde. Nguye inquma kusebenta izidakamizwa.

Nge ekuphathweni emthanjeni of a nomuthi, kanye neziguli yayo temlomo cishe ngokushesha baqala ukuzizwa ukufikelwa ukushisa, dyspepsia acute, tachycardia, asthenia eqinile ngisho hypotension liguqubele. Ngaphezu kwalokho, ukubukeka lokudakwa ngu acetaldehyde kunomthelela ukuya utshwala ukuqedwa kwayo nesineke yotshwala.

amapharamitha pharmacokinetic

Iyiphi indima has izidakamizwa imingcele kinetic? Kuthiwani umbiko ukumuncwa yayo Izibuyekezo? "Disulfiram" ugxile ngempela ngokushesha futhi cishe ngokuphelele kusukela esiswini.

Lapho uyisebenzisa, kukhona umzimba eliphezulu ingxenye esebenzayo, futhi phakathi naleso metabolites eziningana kwakhiwa. Bheke komkhiqizo Kwenziwa ngokusebenzisa emaphashini kanye nezinso.

izinkomba

Izidakamizwa "Disulfiram", intengo oboniswe ngezansi, kuvezwa ngoba:

• ekwelapheni ukuluthwa utshwala ezingamahlalakhona;
• nokuvinjelwa lokubuya kwesifo ekwelapheni ukuluthwa utshwala ezingamahlalakhona.

Thatha le imithi ngokubona kwayo engathandeki. Kumele ukhethe udokotela.

Izimo

Izidakamizwa "Disulfiram" ngemithambo yegazi futhi ngomlomo akunconyelwe lezi zifo ezilandelayo:

• izifo neuropsychiatric;
• isithuthwane;
• sikashukela.

Futhi, lolu izidakamizwa aluboniswa ngesikhathi sokukhulelwa, nokuzwela ingxenye esebenzayo futhi ingxenye eyengeziwe, ibele.

Kufanele futhi wazi ukuthi ngokucophelela okukhulu lokhu izidakamizwa Kunconywa ukuthatha in iziguli kahle isibindi umsebenzi, umgudu wokuphefumula nezinso.

Izidakamizwa "Disulfiram": yokusetshenziswa

Ukusetshenziswa noma yiluphi uhlobo izimali Kuvumeleke kuphela kuma-oda kadokotela. Udokotela ubophekile ukuba aqhube luhlolo egcwele isiguli, bese ukhetha umuntu ukwelashwa lwemithi futhi ulapha ngoba kuye.

Ngokusho imiyalelo, umthamo avareji nsuku zonke zomuthi kwezokuphatha temlomo imayelana 125-500 mg.

Njengoba umjovo kanye yenzeka zomuthi ke lezi zindlela kufanele kwenziwe i uchwepheshe abanolwazi. Kulokhu umthamo Kunconywa zomuthi incike izici nesineke nokugasela ngamandla isifo ekhona.

side effects

imiphumela emibi izidakamizwa okukhulunywa engingayenza ukumshayela? Kuthiwani ngalo bathi izibuyekezo? "Disulfiram" azivamile imbangela esiyingozi ohlangothini ukusabela. Lapho udle kungenzeka ezinye ukuphambuka e ipheshana wokugaya ukudla bese khona angiyithandi metallic kanye nokuthuthukiswa zokusha kwesibindi.

Ngaphezu kwalokho, ukwephula kungavuka kwemizwa uhlelo imisebenzi. Izimo ezinjalo engathandeki zihlanganisa polyneuritis nemilenze ephansi, nokugula ngengqondo, ukukhohlwa, disorientation kanye bekhanda.

Futhi, ningawenzi ngakususi ukuthuthukiswa ukusabela okuhlukahlukene iguliswa, eyayibonakala senziwa amponjwana (isib nciphisa, ukufa uhlangothi, arrhythmias inhliziyo, edema palsy futhi isilethikusebenza).

Izimpawu ukweqisa izidakamizwa

Ukulungiselela "Disulfiram" ngesikhathi ebulilini kungabangela imiphumela enjengokuwa, ikhoma nezimpendulo zezinzwa yingozi.

Ukuqeda lezi zimpawu kumele achithe yokwelapha lingaze esibhedlela, okumele ngempela zihlanganisa imisebenzi ngokukhishwa kobuthi egazini.

sinqobe nomuthi

Ochwepheshe baye bafakazela ukuthi neutralization ephelele izidakamizwa ayikwazi kubhekwe.

Uma kudingekile, okukhiphayo "Disulfiram" nomzimba womuntu (umthamo isb, ukusabela kabi komzimba ukuze esanda yokutholwa utshwala) Kwenziwa izinqubo ezithile.

Kuyindlela yokuvimbela lokhu ukusetshenziswa kwezidakamizwa ascorbic acid. Iqondiswa ngemithambo yegazi. Lo msuka ayivumeli utshwala ukuze siguqulwe sibe acetaldehyde, okuyilokho, eqinisweni, kubangela kabi.

Zingase esetshenziswa ephedrine futhi H1-blocker.

izidakamizwa ekuhlanganyeleni

Ingabe kuyamukeleka ukusebenzisa ezinye izidakamizwa phambi kwethu imithi? Kuthiwani izidakamizwa ekuhlanganyeleni Izibuyekezo uthi? "Disulfiram" lihambisana anticoagulants kwandisa isinyathelo sabo, futhi kwandisa ingozi ebangela ukopha.

ukwelashwa kanye kanye nemithi kadokotela izidakamizwa okuyinto akheka esibindini, kungaba ngokuphawulekayo zilulaza ngesikhathi senqubo.

Ukuhlanganisa mao inhibitor, tricyclic antidepressant futhi phenothiazine nemikhiqizo nge "Disulfiram" kungase kube nomthelela ukuvela eziyinkimbinkimbi ohlangothini ukusabela.

Inhlanganisela lokhu kusho nge "buspirone" kubangela ukuthuthukiswa okuyize. imithi Njengokuthi "Amitriptyline", ngokuvamile sithuthukisa umphumela "Disulfiram" futhi uvusa imiphumela yayo anobuthi nesimiso sezinzwa.

Okubukwe nomuthi uyakwazi okwandisa lokuhlushwa chlordiazepoxide futhi diazepam egazini, ukunciphisa ukushuba ukusabela ezinobuthi futhi okubangela isiyezi.

Nge inhlanganisela "Disulfiram" nge "isoniazid" kungase okucindezeleka nesiyezi, "metronidazole" - ukudideka kanye sengqondo acute, a "Omeprazole" - kahle ukwazi, ne-caffeine - encishisiwe excretion yayo emzimbeni.

"Chlorzoxazone" kwandisa lokuhlushwa anti-utshwala izidakamizwa egazini, futhi "Chlorpromazine" icacisa hypotension.

Izidakamizwa "Disulfiram": ukubuyekezwa, intengo kanye analogue

imiphumela efanayo kufanele izidakamizwa ezifana "Ekzorran", "Radotera", "Aspen", "Krotenal", "Tetlong", "Refuzal", "Stoptil", "Antietil", "Kontrapot", "Tetradin", "Antietan" "Dizetil", "Alkofobin", "Aversan", "Anticoli", "Antabuse", "Esperal", "Lidevin", "Abstinil".

Kungakanani buyisidakamizwa "Disulfiram"? Intengo yaleli izidakamizwa amaphilisi ububanzi ruble 200-1000 (kuye ngokuthi umenzi). Ngokuphathelene ukuma nolwelwesi, kanye isixazululo oily, bona angathengwa ruble 600-2400.

Izibuyekezo Iningi ekwakhiweni samanje akhayo. Kuyaphawuleka ukuthi ngokuvamile leli izidakamizwa isetshenziselwa ukwelashwa imfihlo zabantu umlutha wotshwala. Ochwepheshe batusa akunika lesi sakhiwo ngaphandle kolwazi lesiguli.

Ngokwe impendulo labo wasebenzisa izidakamizwa ecabange ngakho kakhulu ngempumelelo elwisana nesifiso sokufuna athathe umthamo omusha utshwala. Ngokuvamile, ngemva kokwamukela izidakamizwa isiguli kuphakama ukungezwani yotshwala. Uma utshwala waphasiswa ngemva kokusebenzisa izidakamizwa, kudala dyspepsia acute, ngamanzi, asthenia ezinzima, tachycardia, ngisho hypotension liguqubele.