Medicine "primidone": yokusetshenziswa futhi impendulo

izinkampani yesilungu yanamuhla ukukhiqiza inani elikhulu izidakamizwa antiepileptic. Kanjani ukuqonda ezihlukahlukene izidakamizwa? Ukuze wenze lokhu, vula ochwepheshe abanolwazi. Uyokwazi ukukhetha ngawe umuthi kwaphumelela kakhulu, okuzokwenza neqhaza isipho esibalulekile nesineke.

Ethandwa kakhulu izidakamizwa antiepileptic iziguli nodokotela kuyinto imithi "primidone". Iziyalezo ukusetshenziswa kwezidakamizwa wathi, ifomu ukukhululwa kanye izakhiwo zalo izokwethulwa ngemva kwesikhashana.

Ukwakheka, ukuma emaphaketheni

Thenga imithi "primidone" kungaba amafomu ezimbili ezihlukene. Itholakala njengendlela impuphu ethathwa ezipakishiwe kucwazi ezimbili-ungqimba kanye ebhokisini amakhadibhodi, ngokulandelana. Futhi kusho ukuthi ungathenga ngesimo amaphilisi ibhamuza amaphakethe kanye amabhokisi.

Isithako asebenzayo kule izidakamizwa izenzo primidone. Futhi-ke yakhiwa nezinsizasenzo (kuncike amafomu wokukhishwa).

Isenzo zomuthi

Uyini ikhambi "primidone"? Yokusetshenziswa ibonisa ukuthi lokhu izidakamizwa antiepileptic. Lokho kwenza umphumela omnene okuyiluthayo, kodwa futhi kunciphisa excitability we izinzwa ukuthi zitholakala focus sokuwa.

Yini izakhiwo nezinye esivela nomuthi "primidone"? eliqhaqhazelayo Essential uma eqeda igazi lokuhlushwa 12 .mu.g / ml.

izakhiwo kinetic

Izidakamizwa "primidone" (amaphilisi kanye powder) angabacwasi ngokushesha futhi cishe sokugxila ngokuphelele kusukela pheshana emathunjini. Ubuningi esiphezulu izidakamizwa izuzwe ngemuva kwamahora amathathu. I bioavailability lokhu umuthi 90-100%. Esikhathini igazi ke sibopha ukuthi amaprotheni kancane (cishe 20%).

Isigamu-ukuphila kwalesi ejenti kuyinto amahora 7-15.

Ngo isibindi, nomuthi ingxenye eguquliwe ukuba phenobarbital (u-20%) kanye feniletilmalonamid. Lezi metabolites ifa umsebenzi antiepileptic. Bona excreted ngu nezinso.

umthamo wegazi lesiguli kuyadingeka ukuze balondoloze umuthi lokuhlushwa oqabulayo 12 UG / ml. Kuyinto lezi yizinkomba neqhaza cishe okwehlisa. Lapho nezinye izinhlobo isithuthwane (isib amafomu non-convulsive ka nokuquleka polymorphous nezinye), umphumela yokwelapha is hhayi njalo ufinyelelwe. Kulokhu, ukuphathwa eziyinkimbinkimbi.

Izinkomba ukusetshenziswa zomuthi

Kwezinye izimo, isiguli ezinqunyiwe imithi efana "primidone"? Izibuyekezo babike ukuthi leli thuluzi ngempumelelo ephatha isithuthwane zasezindaweni ezihlukahlukene, kanye nokuquleka ngokwengxenye futhi generalized. With ukuthuthukiswa nokuquleka ebalulekile, myoclonic futhi akinetic lo muthi ayisasebenzi.

Izimo imithi

Kwezinye izimo, musa akunikeze imithi "primidone"? Yokusetshenziswa imibiko ukuthi asivunyelwe ukusebenzisa izindlela e khona hypersensitivity (kuhlanganise barbiturates), kanye kwegazi, isibindi kanye nokwehluleka ukusebenza kwezinso, ukukhulelwa, ngemisebe ibele.

Medicine "primidone": yokusetshenziswa

Ngayiphi umthamo is ekunike umuthi sisuke sicabanga? Uphuzwe ngomlomo emva ukusetshenziswa ukudla olulodwa-isikhathi umthamo owodwa we-125 mg. Ngemva kwalokho, njalo ngemva kwezinsuku ezintathu, kusho inani izidakamizwa kukhuphuke ngo-250 mg for iziguli omdala futhi 125 mg izingane eziye zaphetha engu-9.

Lokhu ukwelashwa iyaqhubeka kuze elamukelekile.

esiphezulu I umthamo wansuku zonke izingane 1 g (ngezigaba ezimbili) kanye nabantu abadala - 1.5 g

side effects

Ngeshwa, phambi kwethu izidakamizwa antiepileptic ngokuvamile kubangela imiphumela engathandeki. Lezi zihlanganisa ukozela ngokweqile, ikhanda, isiyezi, ukukhathazeka, ukucobeka, isicanucanu, ukuntuleka kwegazi emzimbeni, ukuhlanza, leukopenia, komzimba nezinto, futhi lymphocytosis.

Kakhulu akuvamile nomuthi asebenzayo kungabangela nystagmus, ataxia, "i-lupus" syndrome, ukusabela zengqondo, arthralgia, anaemia megaloblastic, kanye nokusetshenziswa isikhathi eside - sezidakamizwa.

amacala ukweqisa izidakamizwa

Ukuthatha amaphilisi amaningi zomuthi kungabangela izimpawu njengokuba nesiyezi, ataxia, isicanucanu futhi ngikhishwe ukucindezeleka we sezinzwa umsebenzi ohlelweni. Ukuze ekwelapheni izimo esinjalo isiguli is wageza esiswini, namalahle ocushiwe futhi ukwelashwa lingaze.

Ukuhambelana nezinye izidakamizwa

Ukulungiselela "primidone" esuselwe potentiates umphumela cyclophosphamide, methotrexate futhi sulfonylureas kanye hypnotics. Iphinde ngesivinini umzimba, kwandisa umsebenzi enzyme isibindi microsomal, kunciphisa umphumela corticosteroids, acetaminophen, ISS, tricyclic antidepressant, anticoagulants, "Chloramphenicol", "DTIC", "Cyclosporin" glycosides inhliziyo "disopyramide", "Levothyroxine", "Doxycycline "" theophylline "," metronidazole "," Quinidine "," mexiletine "vitamin D,« fenoprofen, "caffeine" Aminophylline "futhi" oxtriphylline. "

nomuthi Okubukwe ithuthukisa CNS ukucindezeleka lihambisana izindlela emaphakathi depremiruyuschim isenzo kanye notshwala.

Izidakamizwa "amphetamine" kubambezela ukumuncwa phenobarbital.

Lihambisana carbonic anhydrase inhibitor iyakhula osteopenia.

Lokhu kunciphisa ukumuncwa griseofulvin ejenti ukuthi kunciphisa umsebenzi wayo antifungal. Iphinde sithuthukisa imiphumela anobuthi "enflurane", "methoxyflurane" futhi "halothane".

"Methylphenidate" ikhuthaza okusithiyayo lokugayeka kokudla futhi primidone ukwandisa lokuhlushwa yayo egazini.

"Leucovorin" ukuphuza amaphilisi amaningi kunciphisa umphumela primidone anticonvulsant. Kuyefana nasendleleni lesi sidakamizwa "Phenylbutazone".

izincomo ezithile

Izidakamizwa "primidone" ingasetshenziswa ukwelashwa eziyinkimbinkimbi anticonvulsant. Ukukhansela futhi esikhundleni zomuthi kwaba kancane kancane.

Ngokunakekela okukhulu, wamisa u abantu abadala kanye immunocompromised. With ukuthuthukiswa megaloblastic anaemia nomuthi khansela futhi linqume ukwelashwa nge vitamin B12 noma i-folic acid.

I-ejenti kuncike kunciphisa womuntu lengqondo ukusabela. Ngakho-ke, lokho akusho libeke nabashayeli izimoto nabantu omsebenzi wakhe ehlangene imishini kuyingozi.

Ngokunakekela lokhu izidakamizwa isetshenziswa izingane.

izindlela ezifanayo

Umuthi kungenziwa indawo "primidone"? Analogue kwaleli thuluzi angathengwa ngasiphi ekhemisi noma umyalo World Wide Web.

Ochwepheshe bezifo, babe izakhiwo efanayo nemithi ezifana "hexamidine", "Benzonal" futhi "Phenobarbital".

nobufakazi

Abathengi abathatha izidakamizwa antiepileptic ezifana "primidone" umshiya okubuyayo kuphela. Ngokusho Embikweni wazo, lezi izidakamizwa ubhekana kahle umsebenzi walo. It kuvimbela nesenzakalo ukuquleka ngokwengxenye futhi generalized. Futhi, lokhu imithi esiza ekunciphiseni izimpawu isithuthwane.

Ngokuqondene Izibuyekezo ezingezinhle, cishe bonke of them Baphawula iqiniso ukuthi leli thuluzi kunomthelela ukuvela inqwaba engemihle. Ngakho-ke, ukusebenzisa ikhambi elinjalo kufanele kuphela ukuqokwa udokotela.