Izidakamizwa zeVasodilator.

Izidakamizwa ze-Vasodilator yimithi enesisindo esiphumuzayo emasongweni ezitsha, ngenxa yalokho isibani semikhumbi sanda. Leli qembu lezidakamizwa lisetshenziswe ikakhulukazi njengendlela yokwelapheka emithini yokulwa ne-antihypertensive and analgesic.

Izidakamizwa ze-Vasodilator zingahlukaniswa ngokomzimba zibe yi-beta-adrenoblockers, nitrate nama-inhibitors we-ACE receptors.

Indlela yokusebenza ye-B-adrenoblockers incishisiwe kuze kufike ukuvalwa kwamapipi omzimba we-muscle we-cardiac kusukela kwesenzo sama-catecholamines. Futhi banomthelela wehlisa inani lezinhliziyo ngomzuzu, okuholela ekunciphiseni komkhiqizo wenhliziyo. Ukuvinjelwa kwamakhemikhali we-peripheral receptors kuholela ekunciphiseni kwe-myocardial oxygen ukusetshenziswa kanye nokuncipha kwengcindezi yegazi.

I-Beta-adrenoblockers inomphumela wokuvimbela, kanye nokucindezela umsebenzi we-renin e-plasma yegazi. Leli qembu lezidakamizwa linomphumela we-cardioprotective, isb. Isiza ukubuyisela i-myocardiocytes. I-Beta-adrenoblockers ihlukaniswe ibe yinto ekhethiwe futhi engakhethi (nangaphandle kokusebenza kwangaphakathi kwe-sympathomimetic).

Abamele ukhiye:

1. I-Propranolol ne-Nadolol (ngaphandle komsebenzi wangaphakathi we-sympathomimetic).
2. U-Pindolol no-Oxprenolol (ngokukhona komsebenzi wangaphakathi).
3. I-Bisoprolol, i-Betoxolo, i-Atenolol (ikhetha).

Kunezinhlobo zezifo lapho ukusetshenziswa kwe-beta-blockers kuboniswa khona:

- IHD, i-angina pectoris;

- Ukucindezeleka komzimba, isifo;

- ukuphazamiseka kwesigqi (tachycardia);

- ukwehluleka kwenhliziyo;

- I-infarction ye-Myocardial emlandweni;

- Migraine.

Kunezinhlayiyana ezithile ekuqokweni kwe-beta-adrenoblockers ekukhulelweni, isifo sikashukela kanye ne-lactation, kodwa lokhu akusho ukuthi bayaphikisana nalezi zimo. Ukungafani okuphelele kokuqokwa kwezidakamizwa yilokhu:

- isifo se-pulmonary chronic obstructive;

- isifo se-vascular peripheral;

- ukuvinjelwa kwenhliziyo 2-3 degrees.

Imiphumela emibi uma ukhetha abavimba:

- Izifo ezinjenge-Vascular ngesimo sezinyopho noma ezibandayo, isiphithiphithi esikhulu se-bronchi.

- ukwephulwa kwefomu legazi (ukwanda kwegazi glucose, ukubukeka kwe-urea).

Amalungiselelo e-vasodilator eqenjini le-nitrate ingenye yemithi yokuqala yokusebenzisa umfutho wegazi ophezulu, i-myocardial ischemia, kanye nezinkinga. Indlela yokwenza kwabo ukunciphisa ukumunwa kwe-oksijeni ku-myocardium, ngenxa yalokho umvuthwandaba wendawo owandisa futhi ukubuyiswa kwegazi okubuhlungu kunciphisa. Lezi zidakamizwa zenza ukwanda kwegazi kwegazi ngenxa ye-vasodilation, futhi ngenxa yalokho, kunciphisa ukuphazamiseka kwemithambo ye-coronary.

Amalungiselelo e-Vasodilator yochungechunge lwe-nitroglycerin ayinakusetshenziswa lapho kunezinkinga zokuphefumula kwe- cerebral nokunyuka kwengcindezi engavamile, Kulesi simo baqinisa kuphela ubuhlungu besifo.

Izidakamizwa ze-Vasodilator zekhanda zisetshenziselwa imithi ye-migraines ne- spasms yemithwalo yegazi. Ezimweni ezinjalo, kungcono ukusebenzisa iqembu le-beta-adrenoblockers, banomphumela owenziwe myorelaxing ezindongeni zemithambo yegazi

Iqembu lokugcina lezidakamizwa - izidakamizwa ze-vasodilator, ezitholakala ekilasini lama-ACE inhibitors. Lezi zinto zisetshenziswe ikakhulukazi ngomlando we-infarction ye-myocardial, umfutho wegazi ophezulu, ukungasebenzi kwe-ventricular yenhliziyo. Ukuqhathaniswa nokuqokwa kwabo kuwukukhulelwa, i-hyperkalemia, isifo se-artificial renal.

Indlela yokusebenza yalezi zidakamizwa ukubonakaliswa kwemiphumela ye-neurohumoral (uhlelo olwandisiwe lwe-kallikrein-kinin, izinga elinyusayo le-endothelium-okuphumuzayo isici) kanye nomphumela we-metabolic (umonakalo we-antioxidant, izinga le-potassium elandayo, ukuzwela okukhulu kwezicubu zomzimba).

Isidakamizwa se-vasodilatation sivame ukusetshenziswa emisebenzini yezokwelapha yanamuhla futhi sinomthelela omuhle wokwelashwa ezifweni zezimpahla zekhanda nenhliziyo, kanye nokuba khona kwenqubo ye-ischemic ezinxenyeni zenhliziyo.