Izidakamizwa "IJardines": incwadi yomsebenzisi, izibuyekezo, ama-analogs, isithombe, umkhiqizi

Isifo sikashukela sinesifo esibi esingasinaki nganoma yisiphi isimo. Naphezu kweqiniso lokuthi ayikho imithi engaphulukisa isikhathi eside esihlokweni, ngosizo lokuphathwa kahle kwezidakamizwa ezithile, kungenzeka ukunciphisa ukubonakaliswa kwalesi sifo okungenani futhi unikeze isiguli isilinganiso esiphakeme sokuphila.

Esinye sezidakamizwa ezinqunyelwe uhlobo lwesifo sikashukela 2 yilona ikhambi elibizwa ngokuthi iJardins. Imiyalo yokusebenzisa lesi sidakamizwa ilula, futhi umphumela welashwa uyabonakala. Yingakho emithi yesimanje le mithi isetshenziswa kaningi. Futhi ulwazi mayelana nokulungiswa luyaqhubeka luvame kakhulu. Isibonelo, luyiphi indlela ekhishwa ngayo futhi kuthinta kanjani umzimba? Kungenzeka yini ukuthi ube nesisindo esibi kakhulu? Ingabe kukhona ukuphikiswa kokungeniswa? Kungakanani umuthi futhi ngingawufaka esikhundleni sento? Iziguli eziningi zifuna izimpendulo zale mibuzo.

Incazelo yendlela yokukhululwa nokubunjwa

Isidakamizwa esithi "iJardins" (isithombe sephakheji sibona ngenhla) sitholakala ngesimo samaphilisi e-biconvex azungeze, agcwele i-membrane yefilimu. Zidwezwe umbala ophuzi ophuzi. Ingxenye enkulu esebenzayo yomuthi yi-empaglyflosin. Emakethe yesimanje samakhemikhali, umuthi onesilinganiso esithile ukhiqizwa - i-tablet eyodwa ingaqukatha u-10 noma 30 mg wezinto ezisebenzayo.

Ngokwemvelo, lo muthi uqukethe ezinye, izingxenye ezisizayo. Ikakhulukazi, i-lactose, i-magnesium stearate, i-croscarmellose i-sodium, i-microcrystalline cellulose, i-anhydrous colloidal silicon dioxide, i- hydroxypropylcellulose. Igobolondo lefilimu liqukethe i-macrogol 400, i-hypromellose, i-yellow iron oxide, i-titanium dioxide ne-talc.

Izakhiwo eziyinhloko zemithi zesidakamizwa

Ngokuvamile emithi yesimanje isidakamizwa "iJardins" sisetshenziswa. Ochwepheshe bathi izidakamizwa zikuvumela ukuba ufinyelele imiphumela emihle ngempela. Kodwa lo muthi usebenza kanjani emzimbeni womuntu?

I-Empagliflozin yi-inhibitor yokukhetha ukuncintisana, evuselelayo, ekhuthele kakhulu ye-sodium-dependent glucose transporter yehlobo lwesibili. Njengoba izifundo zibonisile, le nto ithuthukisa ukulawulwa kwe-glycemic kulabo abaphethwe uhlobo lwesifo sikashukela. I-Empagliflozin inciphisa izinga le-glucose lokuphindaphinda kabusha ngezinso. Njengoba wazi, inani le-glucose elidonswa yizinso lixhomeke ekugxilweni kwalo egazini, kanye nesilinganiso sokuhlunga kwe-glomerular. Ezigulini ezithatha lezi amaphilisi, inani le-glucose ekhishwe nge-urine landa. Ngakho-ke, lesi sidakamizwa sinciphisa ngokushesha ushukela wegazi eziguli ezine-type 1 yesifo sikashukela.

Izindlela zokwenza izidakamizwa azitholakali nhlobo umphumela we-insulini noma ukusebenza kwamaseli e-beta we-pancreas, ngakho-ke ingozi yokuthuthukisa i-hypoglycemia incane. Kuye kwaphawula ukuthi lesi sidakamizwa sithuthukisa umsebenzi wamaseli e-beta, kodwa futhi sinegalelo ekucubunguleni amafutha, okuholela ekunciphiseni kwesisindo somzimba, okubhekwa njengokuwusizo uma isiguli sibhekene nesisindo esiningi.

Pharmacokinetics nolwazi olwengeziwe

Kukhona idatha enkulu kwi-pharmacokinetics yalesi sidakamizwa, etholakalayo ngokusebenzisa izivivinyo ze-laboratory (iziguli ezinezinhlobo zesibini zesifo sikashukela zithinteka kuzo).

Ngemuva kokuthatha into esemqoka yalesi sidakamizwa iminywe ngokushesha, ingena ngaphakathi ezindongeni zegciwane lokugaya. Ukuhlushwa okuphezulu egazini lesiguli kubonakala ngemva kwamahora angu-1-1,5 emva kokuphathwa. Emva kwalokho, inani le-empagliflozin eplasma liyancipha - okokuqala kukhona isigaba esisheshayo sokusabalalisa izidakamizwa, bese kuthi isikhathi esincane sokugcina sokusetshenziswa kwesisetshenziswa somzimba.

Ngesikhathi sokucwaninga, kwaqaphela ukuthi ukuqina komphumela wesistimu we-empaglyflosin kwanda ngezinga elikhulayo lomuthi. Futhi, izivivinyo zibonise ukuthi uma uthatha umuthi nge-high-calorie, ukudla okunamafutha, ukuphumelela kwawo kwehle kancane. Noma kunjalo, lokhu kuguqulwa akubalulekile ngokomtholampilo, ngakho-ke amaphilisi angadliwa kungakhathaliseki ukudla ukudla.

Into esebenzayo yalesi sidakamizwa ibophezela ku-86% we-plasma ye-plasma amaprotheni. Phakathi nokucwaninga kwegazi lomuntu, ama-metabolite amathathu ase-glucuronide atholakala, kodwa inani lawo lamasistimu alingekho kuka-10% wezinga eliphelele le-empaglyflosin.

Ukuphela kokuphela kokuphela kokuphila kwalesi sidakamizwa kungamahora angu 12-12.5. Uma iziguli zithatha amathebulethi kanye ngosuku, izinga elizinzile lempahla esebenzayo egazini ligcinwe ngemuva kwesilinganiso sesihlanu. Njengoba sekushiwo kakade, lesi sidakamizwa asikwazi ukwenza ama-metabolites. Iningi lalo lidutshulwa emzimbeni kanye namazinyo, ezinye - izinso kanye nomchamo, nangendlela engashintshi.

Futhi phakathi nocwaningo kwakunqunywa ukuthi noma isisindo noma ubulili besiguli asithinte kanjani umphumela wesidakamizwa. Ukuhlolwa eqenjini leziguli ezineminyaka engaphezu kuka-85, kanye nezingane nezingane ezincane akuzange kwenziwe, ngakho-ke akukho idatha ekuphepha kwalolu mithi yalezi zigaba zeziguli.

Naphezu kokusetshenziswa kwezidakamizwa, ukuphumelela kokwelapha kuxhomeke kakhulu ekusebenzeni kwezinso. Yingakho ngaphambi kokuba uqale ukuthatha amaphilisi, kubalulekile ukuhlola ngokugcwele uhlelo lwe-excretory, nokudlulisa izivivinyo zomchamo. Ukuhlolwa okunje kufanele kuphindwe njalo ngesikhathi sokwelashwa (okungenani kanye ngonyaka). Ngaphezu kwalokho, ukuhlolwa kufanele kuthathwe futhi kulawo macala uma izidakamizwa ezintsha zihanjisiwe emgomweni wokwelapha. Kumele kuthiwa ezigulini ezithatha le mithi, ukuhlolwa kwe-glucose kuyoba nomphumela omuhle we-laboratory urinalysis - lokhu kuvamile ngokuphelele, ngoba kuhlobene nokuziqhenya komphumela we-empaglyflosin emzimbeni.

Kuze kube manje, alukho ulwazi mayelana nokuthi isidakamizwa sithinta kanjani umama okhulelwe kanye nesisu, nokuthi ngabe izinto ezisebenzayo zingene ebisi lwebele.

Izinkomba eziyinhloko zokuthatha imithi

Ngabe izidakamizwa zeJardins zifanele nini? Imiyalo yokusetshenziswa ibonisa ukuthi emithi yesimanje imithi isetshenziselwa amacala alandelayo:

• Uhlobo lwesifo sikashukela uhlobo 2;
• Ukuthuthukisa nokulawula iglycemia kweziguli ezikhulile.

I-Monotherapy yenzeke lapho kungenakwenzeka ukulawula i-glycemia ezigulini ngisho nokudla okulungile kanye nephethini elihambelanayo lokuzikhandla ngokomzimba, futhi ngenxa yezizathu ezithile noma enye ukusetshenziswa kwe-metformin akunakwenzeka (isibonelo, ngenxa yokungezwani komuntu ngamunye).

Njengengxenye yokwelashwa okuyinkimbinkimbi, lesi sidakamizwa sisetshenziswa kanye ne-insulin nezinye izidakamizwa ze-hypoglycemic, uma imithi yokwelashwa eyisisekelo, ukudla okufanele kanye nokusebenza komzimba akukwazi ukugcizelela isimo sesiguli.

Kunoma yikuphi, kufaneleka ukukhumbula ukuthi udokotela kuphela ongangena kulezi zidakamizwa ezifundweni. Ukungenisa izidakamizwa ezingalungile kungenza ngcono isimo, futhi ngesifo esinesifo sikashukela, lokhu kungabangela imiphumela embi.

Izidakamizwa "IJardins": imiyalelo yokusetshenziswa

Ngokuvamile, inkinga ebalulekile yiluhlelo lokuthatha lezi amaphilisi. Udokotela kuphela ongakhetha isilingo esifanele semithi "IJardins". Imiyalo yokusetshenziswa iqukethe izincomo ezijwayelekile kuphela.

Njengomthetho, iziguli zinconywa ukuthatha u-10 mg we-empaglyflosin kanye ngosuku - lokhu kusebenza kokubili okuhlangene nokukhonjiswa kwe-monotherapy. Kulezo zimo lapho umzimba wesiguli ubekezelela khona kahle izidakamizwa, kodwa umthamo ojwayelekile awunikeli imiphumela oyifunayo, umthamo wansuku zonke unganyuka ube ngu-25 mg. Usuku luvunyelwe ukuthatha ngaphezu kweyodwa tablet.

Ngokwemvelo, umthamo ulungiswa udokotela kuye ngokuthi isimo sesiguli, ubudala sakhe futhi, nakanjani, umphumela wokwelashwa. Futhi cabanga ngesethi yeminye imithi umuntu ayithatha.

Ungaphuza amathebulethi ekuseni ngesisu esingenalutho, futhi kamuva, ngesikhathi noma emva kokudla, ngoba izinqubo zokugaya azithinti kakhulu ukumuncwa nokusabalalisa izingxenye ezisebenzayo zalesi sidakamizwa.

Isikhathi somuthi sincike esimweni sesiguli, izinga le-glucose egazini. Ngezinye izikhathi udokotela angakwazi ukukhansela imithi ngemuva kokuba i-hyperglycemia ithathwe ngaphansi kokulawula. Kwezinye izimo, amaphilisi athathwa isikhathi eside, futhi ngezinye izikhathi ukwamukela kuqhutshwa izifundo. Lokhu kungathathwa kuphela ngudokotela oya khona ngokusekelwe emthonjeni wezokwelapha, kanye nemiphumela yokuhlolwa kwesimiso.

Ingabe kukhona imingcele yokungeniswa? Ukuphikisana okuyisisekelo

Akuzona zonke iziguli ezivunyelwe ukwelashwa ngosizo lwamathebulethi "e-Jardins". Imfundo ifakazela ukuthi umuthi owanikeziwe unezinombolo eziningi zokuphikisana. Ngolwazi lwabo kuyadingeka ukufunda ngaphambi kokuqala kokwelashwa, njengoba kungenjalo kunezinkinga eziningi ezingase zithuthuke. Ngakho, lesi sidakamizwa asikwazi ukusetshenziselwa amacala alandelayo:

• Uhlobo lwesifo sikashukela uhlobo 1;
• Ubukhona be-ketoacidosis yesifo sikashukela;
• Isidakamizwa esithi "iJardins" ayinqunyelwe phambi kwe-hypersensitivity kunoma yiziphi izingxenye ezikhona (qiniseka ukuthi ufunda ukubunjwa ngaphambi kokuthatha imithi);
• Ezinye izifo ezingavamile ezizalwa njengezifo, ngokwesibonelo, ukungabekezeki kwe-lactose, i-glucose-galactose malabsorption, ukungabi khona kwe-lactase (i-enzyme ephula ama-molecule lactose), njll, nayo iphikisana;
• Kwezinye izinhlobo zokuhluleka ukuqeda izinsola, lawa maphilisi ayasetshenzisiwe, ngoba amane nje akanalo umphumela;
• Isidakamizwa sinemikhawulo ethile yobudala, ikakhulukazi, ayinqunyelwe iziguli ezingaphansi kweminyaka engu-18, ngoba izifundo zaleli qembu azikwenziwe; Futhi imithi iphikisana nabadala (iminyaka engaphezu kwengu-85);
• Isidakamizwa singaholela ekunciphiseni kokunciphisa kwengcindezi yegazi, ngakho-ke ukuphikisana nokufaka izinsolo kubandakanya ezinye izifo zenhliziyo;
• Ngesikhathi sokukhulelwa nokuncelisa izidakamizwa akuvunyelwe, ngoba ukuphepha kwamathebulethi phakathi nalezi zinsuku zokuphila komfazi akuqinisekisiwe.

Umuthi "IJardins" ubizwa ngokuthi ukuphikisana kwezihlobo. Lokhu kusho ukuthi ukuthatha izidakamizwa kungenzeka, kodwa kuphela ngaphansi kokuqapha okucophelela kukadokotela, ngoba kukhona ingozi yezinkinga. Ngengozini, iziguli ezisengozini yokuthuthukisa i-hypovolemia. Futhi, amaphilisi asetshenzisiswa kahle nge-synthetic insulin.

Ukuphikisana okuhlobeneyo kufaka phakathi izifo zendlela yokugaya, ezihambisana nokulahlekelwa uketshezi (isifo sohudo, ukuhlanza). Amathebulethi aqaphele amisiwe phambi kwezilonda ezithathelwanayo zesistimu ye-genitourinary. Ukwelashwa kweziguli ezineminyaka engaphezu kuka-75 kufanele kuhlolwe futhi. Kunoma yikuphi, kufanele nakanjani utshele udokotela ukuthi kukhona izifo ezithile - ngakho-ke ochwepheshe bazokwazi ukunikeza ukwelashwa okuphephile.

Ukusabela okunzima okungenzeka

Akuyona imfihlo kunoma ubani ukuthi imithi eminingi ingabangela ukusabela okuhlangene kwezinye izimo ezithile. Ngakho ingabe kukhona ingozi yezinkinga uma uthatha amaJardins? Imfundo ibonisa ukuthi ezinye izinkinga kungenzeka. Nalu uhlu lwemiphumela emibi kakhulu:

• Ukusabela okuvame ukwedlulela yi-hypoglycemia, nakuba kubonakala sengathi, njengomthetho, ngokumelene nokwamukelwa ngesikhathi esisodwa kwe-empaglyflosin nge-synthetic insulin noma okutholakala kwe-sulfonylurea.
• Ngesinye isikhathi ngemuva kwesizinda semithi, iziguli zathola izifo ezithathelwanayo nezifo ezithathelwanayo, ikakhulukazi i-vulvovaginitis, i-balanitis, i-candidiasis yangasese, kanye nezinye izifo ezithathelwanayo.
• Kusukela ohlangothini lwe-metabolism lungathuthukisa u-hypoglycemia kuphela, kodwa futhi ne-hypovolemia.
• Ezinye iziguli nazo zikhononda ngokugcoba njalo.
• Phakathi kweziguli asebekhulile, ukuphelelwa amanzi kwamanzi kwakuvame kakhulu ngemuva kwesiqondiso.

Lezi yizinkinga ezinkulu ezikhona, lapho amaphilisi "IJardins" angahola khona. Kodwa-ke, ukubuyekezwa, kusikisela ukuthi imiphumela emibi kakhulu engavamile kakhulu. Kodwa-ke, uma ubona noma yikuphi okubuhlungu ngemuva kwemithi yokwelashwa, kufanele uxoxe nodokotela ngokushesha. Mhlawumbe ushintsho olulula emithini luyoba ngokwanele ukuqeda ukusabela okubi. Ngakolunye uhlangothi, kwezinye izimo kunconywa ukuba ukhansele ngokuphelele le mithi, ubeke esikhundleni sakho ngomunye umuthi.

Ulwazi mayelana nokuxhumana neminye imikhiqizo yokwelapha

Isidakamizwa se-Jardins sixhumana kanjani nezinye izidakamizwa? Ubufakazi bodokotela bubonisa ukuthi ngesifo sohlelo oluhlelwe kahle, ingozi yezempilo yesiguli ayiyinto encane. Noma kunjalo, izingxenye ezisebenzayo zomuthi ngokuhambisana nezinye izinto zingathinta umzimba womuntu ngezindlela ezahlukene:

• Lesi sidakamizwa ngezinye izikhathi sithuthukisa umphumela we-diuretic we okuthiwa "loop" kanye ne-thiazide diuretics. Ngakho-ke, kukhona ingozi yokuphelelwa amandla kwamanzi futhi, ngenxa yalokho, ukuthuthukiswa kwesimo sengqondo esiphezulu.
• Ngenxa yokuthi iziguli zinganciphisa ukucindezelwa kwegazi, akuyona into engathandeki ukuhlanganisa izidakamizwa ukwandisa umfutho wegazi kanye namathebulethi "iJardins". Ukuphawula kodokotela kunalokho kubonisa ukuthi umthamo ofanele wezo zombili izidakamizwa kunciphisa ingozi ibe yincane.
• Njengoba sekushiwo kakade, ukuphathwa ngesikhathi esisodwa kwalesi sidakamizwa nge-synthetic insulin kanye nezidakamizwa ezenza ukuvinjwa kwe-hormone yemvelo emzimbeni womuntu, kungaholela ekuthuthukiseni kwe-hypoglycemia. Ezimweni ezinjalo, ukulungiswa okucophelela nokulungiswa kwesilinganiso nakho kuyadingeka.

Izidakamizwa "IJardins": ama-analogues kanye nalabo abathintekayo

Akuzona zonke iziguli ezifanelekile kulo muthi. Ngenxa yezizathu ezithile, abantu bangenqaba ukusebenzisa izidakamizwa zeJardins. Imifishane yale mithi, yebo, ikhona. Ngaphezu kwalokho, imakethe yesimanje yezokwelapha inikeza izidakamizwa eziningi ezithinta umzimba ngale ndlela.

Isibonelo, ngokuvamile iziguli zibekwe izigulane ngezixazululo zemithi enjengale "Baeta" no "Victoria". Ngendlela, lawa ma-substitutes avela eqenjini elidumile laseJalimane. Ngesinye isikhathi iziguli zibekwa umuthi "Guarem" ezinqolobaneni. Kunezinye izidakamizwa ezingashintsha "i-Jardines". Ama-analogues akhe amaphilisi e-Invocana, i-Novonorm neRepodiab.

Naphezu kwenani elikhulu labafaka endaweni, akukho cala lingakwazi ukuzisiza. Udokotela kuphela owazi umlando wakho wezokwelapha angakhetha i-analogi enhle kakhulu, ephumelelayo nephephile. Kuphinde kubalulekile ukuphinda uphinde uphinde uthi isifo sikashukela siyisifo esibi, kanti ukusetshenziswa okungenakusetshenziswa kwezidakamizwa kulokhu kungaholela ekubambeni kwezinkinga, kuze kufike umphumela obulalayo.

Isidakamizwa sinani?

Akuyona imfihlo kunoma ubani ukuthi iziguli eziningi izindleko zemithi zibaluleke kakhulu. Kuyafaneleka ukuqonda ukuthi izibalo kulokhu zizoxhomeka ezinkambweni eziningi. Isibonelo, ekucatshangweni kubalulekile ukuthi uthathe isilinganiso kanye nenani lamathebulethi ephaketheni, idolobha elihlala kulo isiguli, inqubomgomo yezezimali ye-ekhemisi nomphakeli, njalonjalo.

I nomuthi "Dzhardins" (umakhi - "Boehringer Ingelheim Pharma") ngesikhathi umthamo 10 mg isithako esisebenzayo abiza ruble 2000-2200 amaphilisi 30. Uma sikhuluma izidakamizwa umthamo 25 mg ke izindleko zizoba ethe xaxa, okungukuthi kusuka 2100 kuya ruble 2600. Bekungaba iphakethe eshibhile amaphilisi 10, izindleko zazo zokhahlamba kusuka 800 ruble 1000. Manje unethuba ukuba amphuzise ibhajethi anolaka ngoba ngemithi "Dzhardins". izidakamizwa obambele, ngasendleleni, kungamenza alahlekelwe ngaphezulu. Ngakolunye uhlangothi, intengo ezinye izidakamizwa ezifanayo kancane. Kunoma ikuphi, kufanele siqondiswe hhayi kuphela izindleko kodwa futhi ngomphumela ezingaba yokwelashwa, ngoba impilo liyakufanelekela noma ikuphi imali.

Uphenyo kodokotela neziguli ngemithi

Ngiqinisekile abantu abaningi bazi ukuthi ngokubuza ngokubona ezigulini eziye kwadingeka kakade ukuze ukwelashwa, ungathola ulwazi oluningi oluwusizo. Ngakho ukukhuluma mayelana nomkhiqizo zokwelapha "Dzhardins"? Uphenyo odokotela isikhathi esiningi akhayo. Ngempela, amaphilisi ukusiza kulesetayelekile umzimba, isimo iziguli. Ngokusho ukuhlola izibalo, imiphumela emibi yokwelapha azisenzeki ngokuvamile kakhulu, nahlukane nabo kungaba ukulungiswa okulula nokushintsha kokudla nokufakwa.

Iziguli ngokwabo uthanda imithi "Dzhardins". Izibuyekezo akhayo, njengoba uthola wesifunda ulula, futhi imiphumela emihle zenzeka kunalokho ngokushesha. Tablets ngempela ukuhlangabezana nezindinganiso eziphakeme izinga German. I yokuntula zomuthi akunakubangelwa mhlawumbe ukuthi izindleko kuqhathaniswa high, njengoba abanye nozakwabo ishibhile. Ngakolunye uhlangothi, izidakamizwa ezifanayo kusukela abakhiqizi European nazo ngezinye izikhathi ezimbili, futhi ashibhile ngezinye izikhathi kathathu.

Kunoma ikuphi kubalulekile ukuqonda ukuthi "Dzhardins" - amaphilisi akusiza kujwayeleke ukusebenza emzimbeni ngesikhathi sikashukela uhlobo lwesibili, kodwa abakwazi ukuqeda lesi sifo esiyingozi. Ukuzelapha kulokhu okungalungile, kodwa ngenxa ungakhohlwa ukuthi kubalulekile ukulandela yonke izincomo kanye tinkhombandlela udokotela. Ukuzisebenzisa kahle imithi esiza ukulawula amazinga igazi glucose, futhi ngenxa yalokho, ukuthuthukisa izinga lempilo isiguli sikashukela.