"Glyurenorm": yokusetshenziswa, nozakwabo yangempela

Insulin sikashukela engaphansi mellitus noma isifo sikashukela uhlobo lwesibili ibizwa ngokuthi isifo umzimba. It libhekene Hyperglycemia okungamahlalakhona, okuyinto eba ngenxa iziyaluyalu e-insulin nokuxhumana izicubu amaseli.

Izimpawu zalesi sifo iyona ukoma futhi ukoma emlonyeni, ukuchama ngokweqile, ukuba buthakathaka kwezicubu, isikhumba ukulunywa, izilonda ezimbi zazhivlyaemost kanye nokukhuluphala ngokweqile. Ukuze ekwelapheni sikashukela sohlobo 2 usebenzisa izidakamizwa "Glyurenorm". Yokusetshenziswa, analogs, properties kanye ukuma izidakamizwa wathi ethulwa ngezansi.

Ukwakheka izidakamizwa, incazelo yalo, emabhokisini ukuma

Ngayiphi ifomu isidakamizwa "Glyurenorm"? Yokusetshenziswa ibika ukuthi lesi sakhiwo iyatholakala ngesimo amaphilisi mhlophe futhi abushelelezi round ukuma, nge Valium futhi imiphetho beveled, futhi libhalwe "57C" nelogo yenkampani.

Isakhi esiyinhloko zomuthi kubhekwa gliquidone. Futhi-ke lakhiwe omisiwe corn isitashi, monohydrate lactose, corn isitashi kanye encibilikayo magnesium stearate (compounds ezengeziwe).

Ngo ukudayiswa izidakamizwa "Glyurenorm" (amaphilisi) ihlinzekwa e ibhamuza amaphakethe of izingcezu 10, iziphi zahlanganiswa ngo amaphakethe amakhadibhodi.

izidakamizwa

Uyini izidakamizwa "Glyurenorm"? Yokusetshenziswa ibika ukuthi lokhu ejenti hypoglycemic, sulfonylurea (isizukulwane sesibili). Kuhloswe kuphela abaphathi ngomlomo.

Kubhekwe umuthi kunemiphumela vnepankreaticheskim futhi pancreatic. It kuvusa uketshezi insulin kanye potentiates indlela glucose aqashwe we lasungulwa.

Ukuhlolwa ku izilwane zokucwaninga luye lwabonisa ukuthi lesi sidakamizwa "Glyurenorm" imfundo okuyinto equkethwe ebhokisini elenziwe amakhadibhodi, uyakwazi ukunciphisa insulin kwezicubu adipose futhi isibindi lesiguli. Lokhu kwenzeka ngokusebenzisa ukushukuma postreceptor indlela ukuthi ayengumlamuleli waso-insulin, kanye lenyuka yokwamukela nalokho.

umphumela hypoglycemic ngemva kokudla nokufakwa eba emva kwemizuzu 65-95. Ngokuphathelene umphumela esiphezulu zomuthi, kwenzeka emva amahola angu 2-3 ukufunda futhi kuthathe amahora mayelana 8-10.

izakhiwo kinetic

Ukusetshenziswa "Glyurenorma" imfundo inikeza ukuthi ukusetshenziswa isilinganiso esisodwa somuthi we izidakamizwa (15-30 mg) kunomthelela ukumuncwa yayo okusheshayo nokuphelele kusukela ipheshana emathunjini (mayelana 80-95%). Peak lokuhlushwa yayo ngemuva kokuthi ifinyelela ihora 2.

isithako we nomuthi has ziyezwana okusezingeni eliphezulu ukuze plasma amaprotheni.

Ayikho idatha ku ematfuba odlulayo gliquidone zawo noma izithako zawo ngokusebenzisa placenta noma gazi ebuchosheni lapho. Futhi, akukho ulwazi mayelana gliquidone Ukungena ku ubisi lukamama.

Lapho umzimba "Glyurenorm" izidakamizwa? Yokusetshenziswa uthi onganakanga inxusa akheka esibindini ngu demethylation futhi hydroxylation.

The main ingxenye gliquidone nemikhiqizo etholakala ngokusebenzisa emathunjini. Isikhathi isigamu-ukuphila umuthi 1-2 amahora.

Ngo nasebekhulile oseqinile iziguli imingcele kinetic "Glyurenorma" efanayo.

Ngokusho ochwepheshe, lokhu kusho umzimba engashintshwa in iziguli esingamahlalakhona hepatic. Kufanele kuphawulwe ukuthi iziguli ezine-kahle izinso umsebenzi izidakamizwa akusho buthelela.

ubufakazi

Kungaphansi kwaziphi izimo izidakamizwa ephumelela kunazo iziphatha "Glyurenorm"? Yokusetshenziswa, ukubuyekezwa bathi inkomba ukusetshenziswa salo sikashukela sikashukela uhlobo lwesibili kwasebekhulile futhi oseqinile (nge ukwehluleka Ukudla).

Enqabelo ukuze bathole imishanguzo engabasiza

Kukuyiphi amacala is contraindicated linqume amaphilisi "Glyurenorm"? Yokusetshenziswa ukhombise Izimo elandelayo zomuthi:

• ngakanye porphyria acute;
• ngifundise ngesifo sikashukela Uhlobo lokuqala;
• ukuhluleka hepatic, ezinzima;
• sikashukela lactic, precoma, ketoacidosis futhi equlekile;
• isikhathi ngemva resection lomdlavuza pancreatic;
• Ezinjalo imvelo ezingavamile lezinceku isifo njengoba galactosemia, ukungezwani ne-lactose, ukuntuleka lactase nezinhlayiyana zikashukela-galactose malabsorption;
• isimo sibi isiguli (isib izinqubo sina kuhlinzwa, nezifo ezithelelwanayo angase azithole);
• ngesikhathi sokukhulelwa;
• ezincane yobudala (ngenxa yokuntuleka idatha ukuphepha nokusebenza ngempumelelo zomuthi kuleli qoqo leminyaka batholakale);
• ibele;
• hypersensitivity kuya sulfonamides.

Qaphela ukulungiselela reception

Nge kokucabangisisa nomuthi engabelwe kona:

• syndrome okunomkhuhlane;
• yokuntuleka zikashukela-6-phosphate dehydrogenase;
• yezifo indlala yegilo (ayephuli imisebenzi yayo);
• etshwaleni.

Izidakamizwa "Glyurenorm": yokusetshenziswa

"Glyurenorm" namaphilisi ngaphakathi kuphela. Ngezinye reception yabo kubalulekile ukuhambisana nayo yonke izincomo udokotela mayelana umthamo kanye imithi yokudla. Akuvunyelwe ukuyeka ukuphuza umuthi ngaphandle kokubheka nge onguchwepheshe.

Kokuqala umthamo yokubika izindlela kuyinto amaphilisi 0.5 (ngamanye amazwi, 15 mg) ngesikhathi sasekuseni kuqala. Umuthi kumele kuthathwe ekuqaleni ekudleni. Ngemva ukusetshenziswa kwalo kungavunyelwe Ukweqa ukudla.

Uma usebenzisa 1/2 iphilisi akakubangeli ngcono, ngemuva kokuxoxisana udokotela ukwandisa umthamo kancane kancane. Ngezinye umthamo zonke izinsuku we "Glyurenorma" Ningabizi lutho ngaphezu 2 amaphilisi, lingase lithathwe kanye ngesikhathi sasekuseni.

Uma udokotela utjho Isikali ephakeme zomuthi, wabe esekhonza iminyaka umphumela engcono kufanele ihlukaniswe 2 noma 3 ngemithamo.

Ukweqiwa Ephakeme kuze 4 amaphilisi ngelanga ngokuvamile hhayi ukwandisa ukusebenza kahle yabo. Ngakho-ke, ingabe kufanele ngithathe imithi "Glyurenorm" olukhulu kunalolu lemali is hhayi Kunconywa.

Ngo abantu izinso kahle umsebenzi umthamo udinga ukulungiswa.

Ukuthatha izidakamizwa mg ezingaphezu kuka-75 in iziguli kahle isibindi umsebenzi kudinga ukuqapha njalo odokotela.

kanye "Glyurenormom" nesineke kungenzeka ngaphezu kwalokho esabelwe 'metformin "Nge umphumela enganele zokwelapha.

amacala ukweqisa izidakamizwa

Reception ebulilini sulfonylurea nemikhiqizo ngokuvamile kuholela kahle kungakhuphula izinga likashukela. Ngaphezu kwalokho, ukweqisa izidakamizwa kwaleli thuluzi kungabangela lezi zimpawu ezilandelayo: ukujuluka, tachycardia, ukucasuka, indlala, ikhanda, palpitations, liqhaqhazela, ukuqwasha, ukungahlaliseki, angaboni kahle futhi inkulumo, nokulahlekelwa ukwazi.

Uma izimpawu kahle kungakhuphula izinga likashukela kufanele uthathe glucose noma ukudla okunothe carbohydrate.

side effects

Manje, niyazi, kulokho ekunike umuthi ezifana "Glyurenorm". Yokusetshenziswa zomuthi Futhi liye okuxoxwe ngawo ngenhla.

Ngokusho kwemibiko iziguli, edilini izimali kungaba:

• thrombocytopenia, angina, agranulocytosis;
• paresthesia, kahle kungakhuphula izinga likashukela, isiyezi;
• leukopenia, ikhanda elibuhlungu, amabhithi, ukozela;
• yokuhlala thuthuva, ukukhathala, hypotension;
• ukuhluleka zenhliziyo, nomlomo owomile, Stevens-Johnson syndrome;
• kwehle esesuthi, photosensitivity ukuphendula, isicanucanu, ukuqubuka,
• isifuba, ukuhlanza, ubuhlungu besifuba, cholestasis;
• ukuqunjelwa, ukulunywa, uhudo, ukungakhululeki lapho esiswini.

izidakamizwa ekuhlanganyeleni

Lapho concomitantly nge gliquidone "Allopurinol", ACE inhibitor, antifungals, analgesics, coumarin okunye, ama-NSAID nezinye umphumela hypoglycemic kungenziwa iyakhula kuqala.

"Rifampicin" barbiturates futhi "Phenytoin" umphumela hypoglycemic aphansi "Glyurenorma".

izincomo ezithile

ejenti hypoglycemic kwezokuphatha temlomo akufanele ithathe Ukudla wezokwelapha.

Abantu abanesifo sikashukela zonke izincomo udokotela kufanele ngokuqinile waphawula.

Uma izimpawu kahle kungakhuphula izinga likashukela kufanele ngokushesha ukuthatha ukudla equkethe ushukela.

Ukuvivinya umzimba kungase kwandise umphumela hypoglycemic zomuthi.

Njengoba sazi ukuthi kwezinso excretion gliquidone by kancane, nomuthi Okubukwe ingasetshenziswa yini ngokuphepha in iziguli ukungakhuli so-renal kanye nephropathy of sikashukela.

Phakathi izifundo zokwelapha kwatholakala ukuthi ukusetshenziswa kwezidakamizwa olucutshungulwayo is akhenge arhelebhe ukwandisa esisindo lesiguli izinyanga ezingu-30. Ngaphezu kwalokho, amacala beziphawuleka isisindo ukwehla emzimbeni by 1-2 kg.

Analogs kanye nokubuyekeza

Ngu analogue zomuthi "Glyurenorm" zihlanganisa indlela esilandelayo: "Gliklada", "Amiks", "Glianov", "Glayri", "Glibetik".

Izibuyekezo of the imithi samanje esingasinika ukuhlangabezana ezahlukene kakhulu. Ngokusho imibiko abathengi, lokhu izidakamizwa iphumelela kakhulu futhi kufinyeleleke kuwo wonke umuntu. Nokho, kufanele kuphawulwe ukuthi iziguli eziningi azisho exinwe uhlu side effects lokhu ejenti. Nakuba odokotela bathi kwenzeka kakhulu kuyaqabukela kuphela ezimweni ezithile.