"Valacyclovir": yokusetshenziswa, ukubuyekezwa. Analogs "valaciclovir"

izifo ezibangelwa amagciwane ulinda indoda ngaso sonke isikhathi sokuphila kwayo ngokushesha. Nabanye babo, amasosha omzimba umuntu enempilo ungaphatha bebodwa. Futhi ukubhekana umuntu qobo okudingeka ukuba antivirals ekhethekile. umkhakha Modern has ukuthuthukiswa kanye ukukhiqizwa nemithi - abekho embonini yokwenziwa kwemithi - isungule futhi silungele angayinikeza iziguli zayo bezempilo uhlu le mithi. Omunye wabo umuthi "Valacyclovir."

Umgomo we operation ye nomuthi

The main asebenzayo izidakamizwa "valaciclovir" - hydrochloride valaciclovir (556 mg iphilisi ngalinye). valacyclovir Pure - 500 mg. Le ngxenye kuvimbela synthesis amagciwane DNA okubangela herpes kuvimbela ukufanisana izinqubo (retards noma ngokuphelele kuvimbela wokubuyelela kabili molecule e-DNA).

Ngemva nomuthi engena emzimbeni, inqamuka ku acyclovir futhi L-valine. Khona-ke, ngokusebenzisa phosphorylation ka acyclovir triphosphate kwakhiwa okuyilokho, eqinisweni, kuvimbela herpes igciwane DNA zamagama, akukuniki kubo (DNA) double. Mhlawumbe lokhu kungenxa yokuthi acyclovir ezifakwe isakhiwo se-viral DNA. Singasho ukuthi "Valacyclovir" iyashesha abakhethayo ngokuphathelene kwezicubu ehlaselwe igciwane.

Ihogela ithonya "valaciclovir"

Ngokuvamile, "Valacyclovir" ukufundiswa ukusetshenziswa ngokomthetho (bezempilo - lokuqoka ukuthola) kubantu abaphethwe izifo ezithathelwanayo of nolwelwesi lwamafinyila kanye isikhumba, cuphuluza igciwane Herpeszoster. Ake ukwamukela izidakamizwa ngenhloso yokuvimbela. Futhi, ochwepheshe angaqoka "Valacyclovir" ukuze kuvikelwe of cytomegalovirus ukutheleleka, okungase kwenzeke phakathi kwesikhathi nasezinkingeni ezilandela ngemva kokuhlinzwa mayelana isitho ukufakelwa. Ngempumelelo izidakamizwa intando ezimise okwama-tile prolechivanii.

Izimo kanye nemikhawulo ukuthola

"Valacyclovir" is contraindicated kubantu nge sensitivity high kuya Isakhi esiyinhloko esebenzayo zomuthi. izidakamizwa isicelo Ingamukeleki phakathi kwezitho e izinso Ukufakelwa kanye umnkantsha. Futhi hhayi uqoke "Valaciclovir" iziguli ezinegciwane lesandulela-ngculaza (uma ezingeni CD ₄ lymphocyte ungadluli umugqa 100 mg / l). Kukhona Izimo zokuthola imithi ezinganeni kanye intsha ngaphansi kweminyaka eyi-18. Ngaphandle kulokhu kungase kube abanezingane ezake zaba Ukufakelwa izitho zezinzwa. Iziguli ezinjalo zivunyelwe ukwelapha "valaciclovir" nge engu-12 ubudala.

Ngokuphathelene imikhawulo, kusukela "Valacyclovir" - imithi uvuka indlobane, kukhona imingcele yokusebenzisa yayo abesifazane abakhulelwe nabancelisayo. Noma yimuphi zocwaningo laboratory ekhethekile ngale ndaba wenziwa.

Uma owesifazane uhlela ayakhulelwa, nomntwana, futhi emzimbeni amanga ithule herpes igciwane, kufanele ukwazi udokotela. Abangakazalwa ingane exacerbation of herpes ukutheleleka kungaba yingozi. Phakathi lokuzalwa kukhona okungenzeka ukutheleleka kwengane kusuka kumama. Ilungelo lokuba kule Ngaphakathi mo of khulelwa kuhlelwe ahlolwe zokukwazi khona emzimbeni lohlobo herpes yesibili. Futhi, Udokotela angase anikeze isiguli amanye amasheke ojwayelekile ukuhlonza kungenzeka igciwane herpes.

Kunoma ikuphi, ngaphambi kokuba aye kudokotela zomuthi kulesi sigaba iziguli umsebenzi wezempilo ukuqhathanisa umphumela olulindelekile yokwelapha i izingozi impilo kamama umntwana esikhathini esizayo noma kakade ozalwa. Kukhona ulwazi acyclovir ligqame ubisi lwebele e lokuhlala ukuthi kukhona izikhathi eziningana ephakeme kunaleyo lokuhlushwa yayo yi-plasma (kusukela ezikhathini 0.6 kuya 4.1).

Imiphumela engemihle

On the ukulungiselela "Valacyclovir" yokusetshenziswa njengoba izimangalo nomuthi ukuthi kungabangela uhlu olude izigigaba ezingezinhle. Kusukela izidakamizwa isidlulile zonke zokwelapha kanye izifundo elibukelayo (iqembu kweziguli herpes zoster, herpes nenye kuye, kodwa ephelezelwa immunodeficiency), manje atholakala cishe yonke imiphumela engemihle.

Human Git angaphendula isicelo ekunciphiseni nomuthi ku epigastrium. Can ukuthuthukisa izimo njengesifo sokuzincisha, isicanucanu, ukuhlanza, uhudo, isifo sokusha kwesibindi, enzyme isibindi ephakeme.

On the ingxenye isimiso sezinzwa esiyinhloko kungaba yokusabela kuya "Valacyclovir" (kobufakazi nesineke - ubufakazi) ngesimo isiyezi nekhanda, ukudangala, ukuhhema, ukwazi kahle (ngempela ezingavamile). Uma iziguli kwezinso e nokusebenza kwezinso noma ezinye izici ungalokothi uphuze - mhlawumbe ukuqala ikhoma. Ngezikhathi ezithile kungaba asizwe ukusabela esimiso senhliziyo nemithambo yegazi njengoba tachycardia (kwenhliziyo), noma ukunyuka komfutho wegazi.

Kaningi kukhona komzimba bemvelo: ukulunywa, ukuqubuka, urticaria, anaphylaxis, angioedema futhi angioedema. Phakathi kwezinye izenzakalo ezimbi ukuthola nomuthi "Valaciclovir" (analogs ntombazane ngokuyisisekelo ukusabela okufanayo noma ezithi azifane) angagcina dyspnea, photosensitivity, amanzi emzimbeni (amanzi emzimbeni), thrombocytopenia (kwehle nezinamba zegazi, okuyinto kuhambisana nobunzima ukuze kunqandwe ukopha, ukopha sithuthukiswe). Futhi, odokotela bathi mayelana ukubonakaliswa okungenzeka nasopharyngitis, anaemia aplastic, vasculitis.

Indlela yokuthola futhi imodi tekukhipha

"Valaciclovir" (amaphilisi) kuthathwe ngomlomo nakudla. reception imodi umthamo ziyahlukahluka kuye ngokuthi isifo nokugasela ngamandla isimo lesiguli.

Ngokuvamile, lokhu imithi engabelwe ekwelapheni herpes igciwane. Kulezi zimo umthamo nsuku zonke 1000 mg (2 amaphilisi). Kunconywa ukuthatha ngemithamo ezimbili, esinye isibhebhe sibonisa ekuseni nakusihlwa. ukwelashwa izidakamizwa kungaba isukela 5 kuya ku-10 izinsuku (Yiqiniso ezinzima zalesi sifo). Kule modi, futhi umthamo ofanayo zomuthi esithathwayo njengoba isilinganiso izifo.

Amashingili "Valacyclovir" imfundo manual incoma ukuthatha ngendlela ehlukile. Lapha umthamo 1000 mg - umsebenzi. Thola Mode - kathathu ngosuku (ie 6 amaphilisi ngelanga, kathathu nge 2 izingcezu ...). Inkambo yokwelashwa kuvame ukuthatha izinsuku ezingu-7. Ukushesha emva kuqala izimpawu zesifo isiguli befuna usizo lwezokwelapha, umphumela omuhle kuyofezwa ngokushesha.

Ukuze iziguli kwezinso e nokusebenza kwezinso zidinga Isikali ukulungiswa.

Ezinye izici isicelo "valaciclovir"

Kubantu abanalesi nokwehluleka ukusebenza kwezinso ekusebenziseni izidakamizwa kwandisa amathuba yokuba nezinkinga zokungasebenzi kahle kwemizwa kulandele noma ifomu okunzima isifo. Iziguli yokuguga kufanele kube phakathi Inkambo yokwelashwa ukwandisa baphuza uketshezi. Kumelwe siqaphele ukuthi abantu abaphethwe i-isifo sesibindi.

Uma imithi aqokwa ngesincomo ekwelapheni izifo ezifana, njengesifo samabhamuza ezithweni zangasese, "Valacyclovir" ngeke bakwazi ukuvimbela ukutheleleka ngegciwane umlingani. Ngakho-ke, phakathi ukwelashwa kufanele bengahlanganyeli ubulili.

Uma isiguli kudingeke ukuthi ukufakelwa izinso noma umnkantsha, ke uzwakalise isithombe emtholampilo yokutheleleka nge-HIV, kukhona isimo immunodeficiency ezinzima, ukusetshenziswa "valaciclovir" kungaholela engelapheki, kuholele ekufeni. Mhlawumbe ukuthuthukiswa purpura thrombocytopenic: izinguquko sokugembula esicini esisodwa noma ngaphezulu yezingxenye hemostasis oluboniswa melkopyatnistyh nokopha capillary esikhumbeni, ngaphansi kwesikhumba noma nolwelwesi lwamafinyila. Kukhona amathuba uremic syndrome (ukumisa umsebenzi izinso, umchamo ukuyeka umsebenzi). Zombili lezi zimo (purpura futhi uremia) nge awokuthi kungaholela ekufeni.

Musa ukhombe "Valacyclovir" ukuba izingane ezingaphansi kweminyaka engu-18 ubudala, njengoba akukho isipiliyoni emitholampilo neziguli ezinjalo.

Uma esikhathini Inkambo yokwelashwa isiguli eba sokuwa ukuyaluza, ukuhhema, delirium, ukudideka - kusukela ukusetshenziswa kwezidakamizwa kufanele kunqanyulwe futhi uthintane onguchwepheshe.

Ukuxhumana nezinye izidakamizwa

Noma yimuphi isifo abalulekile ukubonakaliswa ukuxhumana "valaciclovir" nezinye izidakamizwa hhayi kusungulwa. Nokho, i-main esebenzayo ingxenye ekwakhiweni kuyinto okukhipha nge izinso by uketshezi ijabulise. Ngakho-ke, iyiphi imithi kuleyo ndlela excretion, kuthathwe parallel, ngeke izinkinga inqubo kanye anda emakamu plasma valacyclovir. Okokuqala abasebenzi bezempilo kufanele sinake cimetidine futhi efanayo izidakamizwa ukuthi uvimbele ijabulise uketshezi indlela.

I lokuhlushwa acyclovir e -plasma luyanda futhi ngenkathi ethola "valaciclovir" futhi "Mycophenolate". Parallel ethola Pharmaceuticals, sibe nzima noma okuphazamisa ukuzihlanganisa nabanye izinso ( "Tacrolimus", "Cyclosporin" futhi m. P.), Ingabe ukuthuthukisa umthwalo kulezi zitho.

izidakamizwa ezifanayo

Uhlu izidakamizwa elwa namagciwane namuhla ubanzi ngokwanele. Kwaziqondanela nje ukuthi ikhodi ATC 4th Izinga izidakamizwa eziningi, kodwa nomuthi abaseduze "Valacyclovir" "Valtrex", "Vayora", "Valogard", "Valtsikon", "Valavir", "Valvira", "Vatsireks". Lolu hlu akayena ngempela ephelele, kungenzeka ukuze uqhubeke.

I yasakazwa zabathengi isidingo kuzo zonke analogue uyawuthanda namuhla "Valtrex". Lokhu analog amazwe, ngempahla asebenzayo efanayo. Ukusebenza kahle ekulungisweni kanye ukuvama izimpawu ezingathandeki, ohlangothini ukusabela ezifanayo "valaciclovir". Umehluko ukhona kuphela intengo, "Valtrex" ezibizayo nokunye okuningi. Ngakho-ke, iziguli eziningi unesithakazelo umbuzo "Valacyclovir" noma "Valtrex" - okuyinto engcono. Impendulo - kokubili mithi ngempumelelo ngokwanele.

Umbono iziguli kanye kwezempilo abaqeqeshiwe yomuthi

Iziguli eziningi aphendule nomuthi ngendlela enhle. Ebonisa ngezinga eliphezulu kahle "Valacyclovir" (izibuyekezo kwabasebenzi bezempilo kanye neziguli ngendlela efanayo) ekwelapheni herpes igciwane. Ukuvuvukala buphela ngokushesha futhi isikhathi ngokwanele eside ingekho futhi. Kaningi, kanye namaphilisi abantu basebenzisa eliqukethe wamafutha izidakamizwa valaciclovir (olunye uhlobo izidakamizwa ukukhululwa). Ezimweni ezinjalo, nekusebenta ukwelashwa kuyathuthuka, yalokho omuhle kufinyelelwa esikhathini esifushane yesikhathi. Nokho, iziguli kufanele kukhunjulwe ukuthi okwamanje ayikho imithi ezingaba ukuhlukana emzimbeni igciwane herpes, it is hhayi okwamanje athuthukile. Kunemithi kuphela ukwelashwa lingaze.

Nokho, kusukela iqembu ahlukene iziguli ungezwa ukubonakaliswa ukusabela ezingezinhle. Ngokuvamile kuba ukuphambuka e pheshana emathunjini: isicanucanu, ukuhlanza, dyspepsia. abathengi abaningi aneliseke izindleko elincane iphilisi noma wamafutha ngayinye "Valacyclovir." analogue yayo, njengoba umthetho, ibiza kakhulu, futhi ukuphumelela ukusabela okufanayo enqabayo nazo ezifanayo.

Abasebenzi bezempilo futhi uqinisekise ukuphumelela kwalesi izidakamizwa elwa namagciwane ukwelapha izifo eziningi walolu hlobo.

"Valacyclovir" - inombolo izidakamizwa 1?

"Valaciclovir" imfundo manual ukuma njengoba izidakamizwa kuyaphumelela namagciwane. Izifo Lokudabuka viral kungaba kahle futhi zichithe unomphela ukuphila komuntu. Nokho panacea, ake sithi ngu-herpes ukutheleleka ingakamiswa yasungulwa. Yebo, futhi yisiphi isifo yegciwane angase abuyele ngemva kwenkathi ethile yesikhathi. Isiphetho kuyinto self-injongo nokusebenzisa "valaciclovir" ngaphandle kokubonisana udokotela igcwele izinkinga ezingathi sína. I okungenani ukuthi kungalindeleka - kungcono nje ukungabi khona kwemiphumela omuhle. Uma kukhona izinkinga ezingathi sína umzimba okuhlobene isebenze izinso ukufakelwa efanayo izinso kanye umnkantsha self "valaciclovir" ungakwazi futhi ingabe ziholele ekufeni. Futhi imiphumela emibi eminingi.

Uma izidakamizwa kumele aqokwe udokotela ukuya, ngubani futhi wazakhela wesifunda eyamukelayo futhi ekhethiwe Isikali kahle "valaciclovir" ekwelapheni isifo kuyoba esiphezulu ngesikhathi esincane amathuba izigameko ezingezinhle ezavela kanye nezinkinga kusukela ekutholeni nomuthi.