Protamine sulfate: Incazelo kanye Umsebenzisi

Kuyini into izidakamizwa njengoba protamine sulfate? imiyalelo ukusetshenziswa kwaso, kanye ukuma nangenxa yobufakazi izimali uzobe ezibalwe ngezansi.

Ukwakheka, incazelo, ifomu

Kuyini protamine sulfate? Le isixazululo uphumile njengoba uketshezi aphuzi noma kungenambala esobala senzelwe abaphathi emthanjeni. Ukulungiswa ezisuselwa kulesi izidakamizwa inegama elifanayo, futhi eminye yakhiwa amanzi umjovo.

Ngo ukuthengiswa "Protamine sulfate" ihlinzekwa in vials ukuthi ezibekwe kule uhlaka ingqamuzana polyvinyl chloride ifilimu, okuyinto Agcwele amakhadibhodi amabhokisi. Futhi esikhathini iphakethe ibekwe yokusetshenziswa futhi ngikwazi ukuqala ampoule.

isenzo izidakamizwa

Kuyini protamine sulfate? Umhlahlandlela ibika ukuthi lokhu omelene heparin (ethize). 1 mg ketshezi uyakwazi zokuyithena umthamo wegazi lesiguli ka mayelana 80-115 IU of heparin.

Isenzo yokubika kusho emva umjovo emthanjeni iqala ngokushesha futhi ihlala cishe amahora amabili. Complexation zomuthi ngenxa yobuningi amaqembu cationic ukuthi abophele anionic izikhungo heparin.

Ngokusho imiyalelo protamine sulfate kubantu is complexed heparin-protamine, okuyinto ephula ukukhulula yokugcina.

Ngo ukweqisa izidakamizwa lokhu kusho isiguli ingancishiswa kakhulu igazi ekunqandeni, kusukela kubhekwe ejenti asebenzayo ekwakhiweni liveza umsebenzi okusezingeni eliphezulu anticoagulant.

Pharmacokinetics izindlela

Yini anezakhi kinetic we sulfate heparin protamine? Ngokusho ochwepheshe, it has izakhiwo pharmacokinetic zomuthi ezingazange wafunda. Ngakho-ke, basuke singamelwe mathupha.

Izinkomba isixazululo

Kwezinye izimo, isiguli emthanjeni isixazululo "Protamine sulfate" angabelwa? Isicelo sale izindlela kuboniswa:

• ngaphambi kokuba sihlinzwe kubantu ukuthatha heparin ngenhloso ezelaphayo;
• ngesikhathi hyperheparinemia;
• ukopha okwenzeka ngenxa heparin ukweqisa izidakamizwa;
• emva kokuhlinzwa ku imithambo yegazi kanye inhliziyo kwegazi extracorporeal.

Enqabelo isisombululo uya khona

Izidakamizwa "Protamine sulfate" (ikhambi uyithenga kumele linqume udokotela) is contraindicated kulezi zimo ezilandelayo:

• nge thrombocytopenia;
• sensitivity high izakhi zomuthi;
• hypotension ezinzima;
• hyperheparinemia azalwa naso noma idiopathic (kule isimo imithi ingaphumeleli, futhi ungakwazi futhi kakhulu ukuthuthukisa ukopha);
• Ukuphatha insulin nezinye izidakamizwa oqukethe sulfate protamine;
• komzimba nezinto imikhiqizo inhlanzi, kuhlanganise umlando;
• esingamahlalakhona adrenal.

Asinakusho ukuthi isipiliyoni ukusetshenziswa kwezokwelapha kwaleli thuluzi ezinganeni lilinganiselwe.

Phakathi nokukhulelwa kanye lactation "Protamine sulfate" ingasetshenziswa. Nokho, lokhu kufanele kwenziwe kuphela uma, uma umphumela ukwelashwa siphezulu kunamanye ingozi kungenzeka ezingenzeka embungwini noma ingane.

Ukulungiselela "Protamine sulfate": yokusetshenziswa

isixazululo Okubukwe kufanele kuphethwe kancane IV ukuvuza noma bolus. Ngakho izinga zokuphatha kumele singeqi 5 mg ngomzuzu. isingeniso Ngokushesha zomuthi angabangela isiguli ukuphendula anaphylactoid.

Isikali se-nomuthi incike indlela yokuphathwa. Umthamo ibalwa kumele ziyoncibilika 300-500 ml 0.9% amandla i-sodium chloride solution. It is nhlobo ukungena kuka-150 mg izidakamizwa imizuzu 60.

• Nge bolus umjovo umthamo protamine sulfate kuyehla kuncike Isikhathi esidlulile kusukela nokuphathwa heparin. Lokhu kungenxa yokuthi mithandazo ngokuqhubekayo asuswe umzimba womuntu.
• Uma heparin iqondiswa ukuvuza emthanjeni, kubalulekile ukumisa ukumnika bese usebenzisa mayelana 20-30 mg protamine sulfate.
• Lapho umjovo ongama ka heparin umthamo protamine sulfate 1-1.5 mg 100 IU heparin. Kanjalo 25-50 mg lokuqala kufanele kancane iqondiswa ngemithambo yegazi, futhi ubukhulu ezisele - ukuvuza emthanjeni amahora 8-17. Kungenzeka futhi ukuphatha ngakanye, kodwa kuyodingeka ukuqapha okuqinile APTT.
• Lapho kokungenela ngokushesha uma extracorporeal isixazululo kwegazi Isikali kubhekwe 1.5 mg-100 ME heparin.

Isikhathi esiphezulu yokwelapha izimali kuyinto 3 izinsuku.

Action ngu-uhlamvu

Ingabe sulfate protamine ukubangela ukusabela ezingezinhle? Manual ithi ngokuvamile lokhu izidakamizwa kahle ikubekezelele iziguli. Nokho, kwezinye izimo, kungase namanje kubangele nemiphumela emibi kuyingxenye omzimba, senhliziyo wokugaya ukudla, kanye isikhumba:

• bradycardia, ukuncipha komfutho wegazi;
• ukuhlanza nesicanucanu;
• ukulunywa, ukuqubuka kwesikhumba, ukuthuthukiswa ukusabela anaphylactoid;
• uzizwa ashisayo, uzizwa esifushane umoya, futhi ngamanzi kwesikhumba.

Nokwenza kanye nokuxhumana nezinye izidakamizwa

isixazululo Okubukwe senzelwe abaphathi emthanjeni aluhambelani penicillins futhi cephalosporins. Sikhishwe ukuthi isitha, ongaphakeme yamangqamuzana isisindo heparins, izidakamizwa esebenzayo kungase kwandise isikhathi futhi ukushuba isinyathelo non-depolarizing imisipha relaxants.

Ukweqisa izidakamizwa zomuthi lingaphathelaniswa ne ukopha. Lokhu kungenxa yokuthi ketshezi okukhulunywa has a umsebenzi okusezingeni eliphezulu anticoagulant. Kulokhu, enifeza ukwelashwa lingaze liyadingeka.

ulwazi oluthile

Okufanele ukwazi ngaphambi kokuthi ungene ku isixazululo ezifana protamine sulfate? Ochwepheshe bathi ukusetshenziswa kwalesi izidakamizwa kufanele ziqashwe udokotela onikeza kufanele iqaphe njalo isiguli igazi ekunqandeni.

Ngaphambi ukwethulwa izidakamizwa kudingekile ukuqinisekisa igazi ivolumu nesineke ezanele sika. Lokhu kungenxa yokuthi hypovolemia kakhulu kwandisa ingozi wokugoqa.

izimo Isitoreji ukunikezela Pharmacy, impilo eshalofini

Kungakhathaliseki ithengiswe ngokukhululekile Pharmacy izidakamizwa "Protamine sulfate '? Recipe ngolimi Latin noma isiRashiya, qiniseka ukukhombisa wemithi, kungenjalo izidakamizwa ikhishwe.

Ukugcina izindlela kubhekwe kunesidingo e kude nezingane futhi avikelwe elangeni lapho izinga lokushisa emoyeni ku 4 ne 10 degrees. Kufanele kuqashelwe ukuthi le emthanjeni isixazululo "Protamine sulfate" Kunoma yikuphi akumele simisiwe.

Shelf yokuphila yalo umuthi iminyaka 4 kusukela usuku ukwakhiwa. Ungayisebenzisi ke ngale kokuphela kwalesi sikhathi.

analogue kwezidakamizwa kanye nokubuyekeza ngakho

Analogue ku amathuluzi okubika ababaningi kakhulu. Isixazululo emthanjeni ungayithola enye by izidakamizwa ezifana "Protamine" futhi "Protamine-Verein".

Ngokuphathelene umthengi ukubuyekezwa, cishe bonke of them akhayo. "Sulfate Protamine" - lokhu esebenza kahle kakhulu futhi ngempumelelo izindlela singatholwa yinoma ubani. It is lokhu umbono olwabiwa iningi iziguli. Zithi lokhu imithi akukuniki heparin ekuvimbeleni inqubo igazi ekunqandeni, ekuthuthukiseni isimo lesiguli ngesikhathi ukopha esindayo.

Ngokuqondene kokufaneleka yalesi izidakamizwa ahlanganisa umphumela wawo ngokushesha futhi isikhathi eside. Ngaphezu kwalokho, ukuze sifinyelele nomphumela kwelapha isiguli liyadingeka lokufeza ukwelashwa eside. Isikhathi esiphezulu ukusetshenziswa kwalesi izidakamizwa izinsuku ezintathu.