Phospholipid syndrome: Izimbangela Nezingozi Sifo

Phospholipid syndrome - a zokugula ezijwayelekile Lokudabuka sokuhlasela kwamasosha omzimba. Against isizinda isifo ngokuvamile kuyagcinwa semithambo, izinso, amathambo kanye nezinye izitho. In the ukungabikho yokwelapha isifo kungaholela yezinkinga eziyingozi kwaze kwaba sekufeni isiguli. Ngaphezu kwalokho, lesi sifo ngokuvamile ezitholakele abesifazane ngesikhathi sokukhulelwa, engozini impilo kamama nengane.

Yiqiniso, abantu abaningi ufuna ulwazi olwengeziwe, abute imibuto ngezimbangela zokuziphendukela isifo. Yiziphi izimpawu kufanele Ngibheka? Ingabe ikhona phospholipid syndrome ukuhlaziywa? Ingabe imithi ukunikeza izindlela eziphumelelayo ukwelashwa?

syndrome Phospholipid: kuyini?

Ngokokuqala ngqá sifo iye yachazwa muva. Ulwazi olusemthethweni ngaye yashicilelwa 1980. Njengoba abasebenza ekutadisheni wamathambo IsiZulu Grem Hyuz, lesi sifo uvame ukubizwa ngokuthi 'uHughes syndrome. Kukhona futhi amanye amagama - syndrome antiphospholipid, antiphospholipid omzimba syndrome.

Syndrome Phospholipid - isifo sokuhlasela kwamasosha omzimba lapho izivikeli mzimba iqala kokukhiqiza amasosha omzimba okuyinto ukuhlasela phospholipids somzimba siqu. Njengoba yalolu ketshezi kufakwe ulwelwesi kwabaningi iseli izindonga, kanye lesion ngaphansi ukugula enjalo ephawulekayo:

• Amasosha omzimba ukuhlasela amaseli enempilo endothelial, ukunciphisa izinto ukukhula kanye synthesis prostacyclin, okuyinto unomthwalo ukunwetshwa izindonga isitsha. Against isizinda isifo khona kungukuphula platelet wokuhlanganisa.
• Phospholipids atholakala ezindongeni platelet ngokwabo, okuholela wokuhlanganisa anda futhi ukubhujiswa okusheshayo.
• Phambi omzimba kuba waphawula ukwanda igazi ekunqandeni kanye buthakathaka umsebenzi heparin.
• Inqubo nolokubhujiswa akuyona indiva futhi ezinzwa.

Igazi uqala clot e imithambo yegazi, ukwakha amahlule ukuthi ukuphazamisa ukugeleza kwegazi, futhi kungakho umsebenzi kwezitho ahlukahlukene - ngakho ukwakha syndrome phospholipid. Izimbangela Nezingozi izimpawu zesifo nesithakazelo kubantu abaningi. Phela, ngokushesha lesi sifo lutholwa, ngenxa yezinkinga ngaphansi ozokhula esigulini.

Ziyini izimbangela eziyinhloko zalokhu lokugula

Kungani abantu ukuthuthukisa phospholipid syndrome? ingase ibe khona ehlukile Izizathu. Kuyaziwa ukuthi ngokuvamile kakhulu isiguli yofuzo. Ukugula eba uma ukungasebenzi kungenza isimiso somzimba sokuzivikela, okuyinto ngasizathu simbe iqala ukukhiqiza amasosha amangqamuzana omzimba siqu. Kunoma yikuphi, lesi sifo kufanele okuthile isiqalile. Kuze kube manje, ososayensi bakwazi ukubona izici eziningana ingozi:

• Phospholipid syndrome ngokuvamile eba khona microangiopathy, ikakhulukazi trobotsitopenii, hemolytic-uremic syndrome.
• Izinto eziyingozi ezingabangela i zihlanganisa ezinye izifo sokuhlasela kwamasosha omzimba ezifana lupus erythematosus, vasculitis, scleroderma.
• Ukugula ngokuvamile eba khona ngenxa yomdlavuza ngo-isiguli.
• Izinto eziyingozi ezingabangela i zihlanganisa izifo ezithathelwanayo. A engozini oluthile mononucleosis ezithathelwanayo ne-AIDS.
• Amasosha Omzimba zingavela ngesikhathi DIC.
• It is D. kwaziwe ukuthi isifo okungase kwakheke ngokuhamba seziguli ezithola imithi ethile, kuhlanganise izinto zokuvimbela inzalo hormone, psychotropics, "novokainamid" futhi t.

Ngokwemvelo, kubalulekile ukuze sithole ukuthi kungani isiguli uye wazakhela syndrome phospholipid. Ukuxilongwa kanye nokwelashwa kufanele bavezwe futhi uma kunokwenzeka imbangela impande lesi sifo.

Ukunqotshwa kwe-uhlelo senhliziyo nemithambo yegazi lapho phospholipid syndrome

Ukuphalala kwegazi izitsha - lezi "uphawu" yokuqala kuthinta syndrome phospholipid. Izimpawu ze-ke kuncike nesigaba lesi sifo. Amahlule ngokuvamile akha ekulesi lokuqala emincane. Besephula ukusakaza igazi, okuyinto kuhambisana izicubu ischemia. Esitho ethintekile uhlale cool touch, isikhumba uphendulela eliphaphathekile futhi imisipha kancane kancane yoma. Isikhathi eside ukungondleki izicubu kuholela necrosis nezilonda ezingapholi omlandelayo.

Ithuba futhi deep vein thrombosis esitho, okuyinto kuhambisana ukuvuvukala, ubuhlungu, ukuhamba kahle. Lesi sifo phospholipid kungenziwa nzima thrombophlebitis (ukuvuvukala udonga semithambo), ukuthi kuhambisana imfiva, Ukugodola, isikhumba ububomvu ku lesion futhi abukhali, ubuhlungu obuhlabayo.

kumiswa amahlule ezitsheni ezinkulu igazi kungaholela ekuthuthukisweni kwe-pathologies ezilandelayo:

• yomthambo i-aorta syndrome (ephelezelwa waba ukwanda okukhulu kwezincwadi ingcindezi izitsha emzimbeni elingaphezulu);
• ngalesi sifo, aphakeme vena cava (ngoba isimo inikezwe libhekene edema, cyanosis kwesikhumba, ngopha emakhaleni, kuqhoqhoqho kanye kuqhoqhoqho);
• syndrome ka bakhiphe elezinga eliphansi vena cava (ephelezelwa ukuphazamiseka kwegazi engxenyeni engezansi yomzimba, isitho somzimba ukuvuvukala, ubuhlungu emilenzeni, izibunu, emzimbeni imbilapho).

Thrombosis kuthinta ukusebenza inhliziyo. Ngokuvamile lesi sifo kuhambisana ukuthuthukiswa angina, umfutho ophakeme wegazi ophikelelayo, isilethikusebenza.

ukulimala nezinso izimpawu eziyinhloko

Thrombus kumiswa kuholela kahle kwegazi, hhayi kuphela ezingalweni nasemilenzeni - futhi ahlupheke izitho zangaphakathi, ikakhulukazi izinso. Nge ukuthuthukiswa kwesikhathi eside phospholipid syndrome kungenzeka lo okuthiwa infarction kwezinso. Lesi simo sihambisana ubuhlungu emuva aphansi, kuncishiswe inani umchamo futhi khona igazi kulo amanyela.

I ihlule kungenzeka ukuvimba Umthambo kwezinso, okuyinto kuhambisana izinhlungu abukhali, isicanucanu nokuhlanza. Lesi isimo esiyingozi - uma iyekwa ingelashwa, angagcina inqubo necrotic. imiphumela eziyingozi phospholipid syndrome zihlanganisa izinso microangiopathy lapho amahlule encane yegazi akhiwa ngokuqondile glomeruli kwezinso. isimo esinjalo sivame ukuholela ukuthuthukiswa ezingamahlalakhona ukwehluleka kwezinso.

Ngezinye izikhathi kukhona kahle kwegazi e nezindlala adrenal, okuholela ukuphazamiseka amazinga ama-hormone.

Yini nezinye izitho okungenzeka bahlukunyezwe?

Phospholipid syndrome - isifo esithinta izitho eziningi. Njengoba kushiwo, amasosha omzimba kuthinte neuronal cell ulwelwesi, okuyinto ngeke akwenze ngaphandle nemiphumela. Iziguli eziningi esekhala bekhanda njalo eqinile ukuthi zivame ukuhambisana isiyezi, isicanucanu nokuhlanza. Kukhona kungenzeka ukuthuthukiswa kwempilo yengqondo.

Ezinye iziguli amahlule e yegazi ukunikeza igazi ligeleze analyzer optic. yokuntuleka isikhathi eside umoya-mpilo nezakhi kuholela yoma we emsipheni optic. thrombosis olungenzeka izitsha ngwengwzi ne ukopha okwalandela. Ezinye pathologies ocular, ngeshwa, engelapheki: ezibukwayo ukungakhuli ahlale nesiguli ukuphila.

Ngo inqubo sokugembula kungenzeka bazibandakanye namathambo. Abantu ngokuvamile kutholakala ukuthi uphethwe yini kwamathambo esethola, okuyinto kuhambisana ukusonteka amathambo kanye waphuka njalo. Okuningi esiyingozi iyona necrosis aseptic ithambo.

Ukuze ukugula futhi esibonakala ngokuqina Izilonda. Ngokuvamile isikhumba wemikhawulo yasenhla nemithombo yasenzansi akhiwa spider emithanjeni. Ngezinye izikhathi uzophawula ukuqubuka isici kakhulu, okuyinto ufana encane, nokopha ukukhomba. Ezinye iziguli ziba erythema phezu amathe ezinyawo nezintende zezandla. Kukhona njalo ongama hematoma kumiswa (nasizathu sobala) kanye ukopha ngaphansi ipuleti nail. ukuphazamiseka engapheli eyayiqhutshwa ijwabu trophic akuhileli ezilondeni eside ukuphola futhi kunzima ukuyelapha.

Sithole ukuthi kuyinto syndrome phospholipid. Izimbangela Nezingozi izimpawu zesifo - ezindabeni ezibucayi. Phela lezi zici kuzoncika abakhethiwe ukwelashwa udokotela lwemithi.

syndrome Phospholipid: Ihlahlubo

Yiqiniso, kulesi simo isikhathi kubaluleke kakhulu ukuthola khona isifo. Umsolwa syndrome phospholipid, udokotela wakho kungase ngisho ngesikhathi anamnesis. Push lo mbono uma isiguli uyakwazi thrombosis futhi emithambo yegazi izilonda, yisisu njalo, izimpawu igazi. Yiqiniso, ukuhlolwa okwengeziwe ezengeziwe.

Ukuhlaziywa kwe-syndrome phospholipid siqukethe ekunqumeni ezingeni amasosha phospholipids egazini iziguli. Ngokuvamile, ukuhlaziya negazi akunakulidla uqaphela nokuncipha platelet count, kukhuphuke erythrocyte sedimentation isilinganiso, kwenani labafana leukocyte. Ngokuvamile lesi sifo ephelezelwa anaemia hemolytic, okuyinto kungabonakala nakulokho ku izifundo laboratory.

Ngaphezu kwalokho kwenziwe ngegazi kwamakhemikhali. Isiguli sinelungelo isamba anda gamma globulin. Uma zokugula isizinda bekulimele isibindi, kwandisa umthamo bilirubin egazini, futhi ane-alikhali phosphatase. Ephambi kwezinduna isifo so-renal kungabonakala nasemkhakheni ukwanda serum creatinine kanye urea.

Ezinye iziguli futhi bancome ethize ukuhlolwa kwegazi immunological. Ngokwesibonelo, izifundo laboratory ungentiwa ukunquma isici samathambo futhi lupus coagulant. Lapho phospholipid syndrome igazi angathola khona amasosha abomvu egazi, kukhuphuke lymphocyte. Uma kukhona izinsolo umonakalo omkhulu isibindi, izinso, amathambo, kuzakuba khona izivivinyo wezinsimbi, kuhlanganise-X-ray, ultrasound.

Yini yezinkinga sifo lihlotshaniswa?

Uma ungatholi ukwelashwa, syndrome phospholipid kungaholela yezinkinga eziyingozi kakhulu. Against ngemuva lesi sifo imithambo yegazi kwakhiwa amahlule, zona ngokwazo kuyingozi. Amahlule vimbela imithambo yegazi, zikhala evamile ukuzungeza igazi - izicubu kanye izitho ungatholi izakhamzimba ezanele nomoya-mpilo.

Ngokuvamile ngokumelene isizinda isifo, iziguli ziba unhlangothi isilethikusebenza. esitho embolism kungaholela esibhibhayo. Njengoba kushiwo ngenhla, iziguli kuyagcinwa ukuze ukungasebenzi nezinso nezindlala adrenal. Umphumela esiyingozi amaningi embolism yamaphaphu - lokhu zokugula eba babazi, hhayi kuzo zonke izimo, isiguli ehluleka ukuletha ngesikhathi esibhedlela.

Ukukhulelwa in iziguli phospholipid syndrome

Njengoba sekushiwo, lesi sifo phospholipid sitholakale ngesikhathi sokukhulelwa. Yeka indlela okuyingozi ukugula nokuthi yini okufanele uyenze esimweni esinjalo?

Ngenxa syndrome phospholipid ezitsheni kwakhiwa amahlule ukuthi clog imithambo ethwala igazi ukuze umzanyana. Embryo ongawamukeli-mpilo ngokwanele nezakhi ezondla umzimba, e-95% izimo lokhu kuholela yisisu. Ngisho noma kungaba ukuthi ukukhulelwa kuphazamisa akuyona kuphazamisekile, kukhona ingozi abruption esinomhlapho ekuseni nokuthuthukiswa sekwedlule preeclampsia, okuyinto iyingozi kakhulu kokubili umama nengane.

Okungcono kakhulu, owesifazane kufanele bahlolelwe ezingeni lokuhlela. Noma kunjalo phospholipid sifo ngokuvamile kutholakala ukuthi uphethwe yini ngesikhathi ukhulelwe. Ezimweni ezinjalo, kubaluleke kakhulu ukuqaphela khona lesi sifo futhi sithathe izinyathelo ezidingekile. Ngokuba nokuvimbela umama ikusasa thrombosis singasetshenziswa eyabelwe anticoagulation ngemithamo emincane. Ngaphezu kwalokho, abesifazane kufanele njalo elibukhali ukuze udokotela ungase uqale ukuqaphela abruption esinomhlapho. Njalo ezinyangeni ezimbalwa, omama abakhulelwe iphathwa eqinisa yokwelapha, ukuthatha amalungiselelo equkethe amavithamini, amaminerali kanye Antioxidants. Nge efanele, ukukhulelwa ngokuvamile kuyaphela ngokuphepha.

Uyini ukwelashwa?

Kuthiwani uma umuntu kutholakala phospholipid syndrome? Ukwelashwa kuleli cala eziyinkimbinkimbi, futhi kuncike khona e isiguli izinkinga ezithile. Njengoba isizinda isifo ifomu amahlule, yokwelapha ngokuyinhloko okuhloswe ngaso ehlambulula igazi. Isimiso ukwelashwa ngokuvamile kuhilela ukusetshenziswa amaqembu amaningana izidakamizwa:

• anticoagulants Okokuqala ezimisiwe isinyathelo ngokungaqondile, namanxusa antiplatelet ( "aspirin", "Warfarin").
• Ukwelashwa ngokuvamile kuhlanganisa izidakamizwa abakhethayo non-steroidal anti-inflammatory lendabuko, ngokukhethekile "Nimesulide" noma "Celecoxib".
• Uma lesi sifo lihlotshaniswa omzimba izicubu erythematosus namanye izifo sokuhlasela kwamasosha omzimba, lo Udokotela angase anikeze isiguli imithi yokwelashwa steroid (izidakamizwa hormone eqeda ukuvuvukala). Njengoba sihambisana nale lingasetshenziswa, izidakamizwa immunosuppressive ezicindezela umsebenzi namasosha omzimba futhi ukunciphisa ukukhiqizwa kwamasosha omzimba enobungozi.
• Abesifazane abakhulelwe ngezinye izikhathi ngemithambo yegazi iqondiswa immunoglobulin.
• Iziguli ngezikhathi ukuthatha amalungiselelo equkethe amavithamini yeqembu B.
• Ukuze impilo jikelele, ukuvikela ulwelwesi yeselula nezitsha esetshenziswa izidakamizwa, Antioxidants, futhi amalungiselelo aqukethe a eyinkimbinkimbi polyunsaturated okunamafutha acid ( "Omacor", "Mexicor").

Lokhu kuyasiza isimo lesiguli kuthinta inqubo electrophoresis. Uma kuziwa yesibili phospholipid syndrome, kubalulekile ukulawula isifo eyinhloko. Ngokwesibonelo, iziguli ezinemishini vasculitis futhi lupus kufanele zithole ukwelashwa okufanele lezi pathologies. Libuye isikhathi kubalulekile ukuthola izifo ezithathelwanayo futhi afeze yokwelapha ezifanele kuze ukululama ephelele (uma kungenzeka).

Onalesi sifo ngoba iziguli

Uma phospholipid syndrome kwatholakala ngesikhathi isiguli wathola ukunakekelwa, onalesi sifo sisihle kakhulu. Ukuqeda lesi sifo ngeshwa ngeke kwenzeke, kodwa imithi ungalawula okubi kakhulu yayo kanye nokwelashwa yokuvimbela ka thrombosis. Kubhekwe isimo esiyingozi lapho lesi sifo lihlotshaniswa thrombocytopenia nomfutho wegazi ophakeme.

Kunoma yikuphi, ngaphansi kokuqondisa udokotela wamathambo kufanele ibe zonke iziguli kwathiwa unesifo "phospholipid syndrome." Ngokusebenzisa ukuhlaziywa okubuyelelako njengokwenza kangaki kudingeka kudlule Luhlolo ngezinye odokotela ukuthi imithi kufanele kuthathwe njengendawo ukuqapha isimo umzimba wayo siqu - konke lokhu uzokutshela udokotela ukuba khona.