MMF (mycophenolate mofetil): incazelo, analogs

Mycophenolate mofetil (INN Mycophenolic acid) likhona iqembu immunosuppressants. Ake sihlole kabanzi amacala lapho kubalulekile ukusebenzisa izidakamizwa, yiziphi contraindications ukusebenzisa kwayo kanye neminye imiphumela emibi.

Ngaphezu kwalokho, sithola ukuthi kukhona in zanamuhla kwemithi izindlela ezifanayo.

Okufingqiwe

mycophenolate mofetil itholakala ngendlela kanzima gelatin amaphilisi e ngezinyo lendlovu nge powder emhlophe ngaphakathi.

Thenga izidakamizwa Pharmacy kuphela uma une kadokotela lukadokotela.

Shelf ukuphila iminyaka emibili kusho. Gcina kufanele kube ezingeni lokushisa kuze kube degrees 25.

Ukuze ube ukuqonda okubonakalayo ukuthi sisuke sicabanga ukubukeka izidakamizwa (mycophenolate mofetil), isithombe ngenhla ukukhonza Ngokwesibonelo engokomfanekiso.

isidakamizwa

Omunye capsule izindlela iqukethe 250 mg kwakwakhe esebenzayo (mycophenolate mofetil). Ngaphezu kwalokho, izingxenye samanje nasizayo, ezifana sodium croscarmellose, microcrystalline cellulose, povidone kanye magnesium stearate.

Pharmacokinetics

Ngemva umuthi ukumuncwa wako nokuphelele umzimba presystemic. Kulokhu, lo lokuhlushwa izidakamizwa esebenzayo e-plasma siyenzeka ngenxa ushintsho yayo okusheshayo ku metabolites asebenzayo.

Kusho excreted nge umchamo futhi indle.

izinkomba

Kwezinye izimo, sebenzisa ka mycophenolate mofetil? Yokusetshenziswa siphendule lo mbuzo ngokushesha.

Odokotela linqume ngokuthatha izidakamizwa ukuze prophylaxis of acute ukufakelwa ukubandlululwa iziguli emva izinso ukufakelwa, isibindi noma inhliziyo.

Izimo

Azisekho izimo eziningi lapho ukusetshenziswa kwezidakamizwa akuvunyelwe nakancane "Mycophenolate mofetil". Lezi zihlanganisa khona hypersensitivity lesiguli ketshezi esebenzayo eyinhloko noma ezinye izingxenye ze-ejenti, kanye phakathi nokukhulelwa kanye lactation.

Kusebenta nokuphepha zomuthi ekwelapheni izingane ungazange sezihlonziwe, ngakho musa ukuyisebenzisa Pediatrics.

side effects

Mycophenolate mofetil ukwazi avuse abanye imiphumela emibi. Ukusetshenziswa Its lihambisana cyclosporine futhi corticosteroids kungabangela sohudo, ukuhlanza, leukopenia futhi sepsis. Kwezinye izimo, kwakukhona ukuthuthukiswa lymphoma nezinye komdlavuza, ikakhulukazi kwesikhumba.

Ngaphezu kwalokho, zonke iziguli ukufakelwa basengozini ukubhebhetheka kwezifo ezithathelwanayo, eyayibonakala cuphuluza Amagciwane ezingosomathuba. Okuvame kakhulu phakathi kwabo kukhona i-herpes, candidiasis futhi cytomegalovirus.

Okunye ukusabela ezingezinhle engaveza ngokwabo ngesimo ezimise okwama-tile, pheshana urinary nezifo, rhinopharyngitis, komzimba, ukuqothuka kwezinwele okungavamile kuphelile kokusebenza kwesibindi, esophagitis, ukopha emathunjini, izifo elingenhla ipheshana zokuphefumula, ukukhwehlela, ikhanda, Gastroenteritis, ukukhathala, sinusitis, candidiasis ngomlomo , pancreatitis, pancytopenia, neutropenia, nokunye.

Kukhona usongo okukhulu futhi kwezinye izimo imihlola nayingozi njengesifo sofuba, endocarditis webhaktheriya, izifo atypical mycobacterial.

Umthamo nokuPhatha

Indlela yokusebenzisa lesi sidakamizwa "Mycophenolate mofetil"? Imiyalelo elikulo, inikeza ulwazi olulandelayo.

Ngokuba nokuvimbela izinso ukwenqatshwa. Umthamo lokuqala ejenti ukuba busuka umzimba emahoreni angama-72 emva ukufakelwa olwenziwa. Ngemva kwalokho, isiguli uzodinga ukuthatha 1 g kabili izindlela suku.

Ngakho mycophenolate mofetil ngokuvamile iqondiswa lihambisana corticosteroids futhi cyclosporin.

Ngokuba nokuvimbela inhliziyo ukwenqatshwa. Umthamo yokuqala kufanele kusekelwe zingakapheli izinsuku eziyi 5 emva kokuhlinzwa olwenziwa. Ngemva kwalokho imali edingekayo mkhiqizo 1.5 g kabili ngosuku

ukweqisa izidakamizwa

Idatha izidakamizwa ukweqisa izidakamizwa, "mycophenolate mofetil," ayitholakali.

Kusho akunakwenzeka ngokuthini emzimbeni by hemodialysis. Izidakamizwa okubophela acid Bile (cholestyramine) angase lula ukususwa umzimba IFC, okwandisa excretion yayo.

Izici isicelo

Phezu ukuthola we neutropenia nesineke kumele kungancipha umthamo futhi eduze ukuqapha isimo sezempilo lesiguli noma ukuphazamisa ukwelashwa mycophenolate mofetil.

Ephambi kwezinduna ezinzima ezingamahlalakhona ukwehluleka kwezinso okufanele eduze ukuqapha isimo sempilo kanye ingeqi a esiphezulu umthamo izindlela, lokukhulunywa ngako kulendzaba kufana 2 g ngosuku.

ezigulini esezikhulile (iminyaka 65) Kunconywa ukusetshenziswa 1 g zomuthi, izikhathi 2 ngosuku.

Ulwazi mayelana nokusebenza kwama-ejenti e-nokwelashwa kweziguli ukwehluleka kwezinso ngubani kwavele ukufakelwa isibindi noma inhliziyo, ulahlekile. Futhi, akukho ulwazi mayelana nokuthi umuthi ngempumelelo iziguli izilonda isibindi ngubani kwavele inhliziyo ukufakelwa senziwa.

izinyathelo zokuqapha

Kunoma ikuphi ayikwazi ukuvula capsule belungiselela. Kufanele ugweme ukuxhumana ngqo powder:-ke lapho ephefumula, contact nge isikhumba noma nolwelwesi lwamafinyila. Nokho, kwenzeka, Uma, kufanele ngokushesha ugeza indawo ethintekile ngensipho namanzi.

analogue kwezimali

Zikhona imithi Ungashintshanisa umkhiqizo "Mycophenolate mofetil"? Analogs Yiqiniso, kukhona. Sinenkosi INN efanayo (International Nonproprietary Igama), noma ikhodi ATC. Ingabe kuphela spectrum athe ukuhluka kancane umsebenzi futhi imali yezindleko.

Isenzakalo esidume kunazo zonke kukhona izidakamizwa ezilandelayo:

• "Baksmun". Sisetshenziswa ndawonye cyclosporine futhi corticosteroids nokuvimbela ukwenqaba inhliziyo, isibindi noma izinso emva ukufakelwa.
• "Zenapax." Isetshenziselwa ukuvimbela ukwenqaba ukufakelwa izinso lihambisana cyclosporine GCS.
• "Imusporin". Isetshenziselwa nokwelashwa kwezitho utshalwe futhi umnkantsha kanye rheumatoid arthritis, uveitis endogenous, isifo Behcet sika, omzimba izicubu erythematosus, kanye nezinye izifo.
• "Imufet". Kanye izidakamizwa main, i-ejenti iqondiswa lihambisana corticosteroids futhi cyclosporin yokuvimbela ukwenqaba inso utshalwe noma isibindi.
• "Layfmun". Ithuluzi has a spectrum ebanzi senzo. Ingasetshenziselwa ukuze kuvinjelwe futhi kwelashwe ukungamukeleki kwezitho utshalwe umzimba futhi umnkantsha, kanye arthritis, nephrotic syndrome, amafomu asebenzayo we omzimba izicubu erythematosus, isifo Behcet sika, uveitis endogenous kanye nezinye izifo.
• "Mifenaks". Izinkomba ukusetshenziswa ziyefana ukuthi we iyindlela eyinhloko.
• "Mifortik". Njengoba iklanyelwe ukuvimbela ukwenqaba izinso utshalwe.
• "Mofilet". Izinkomba nokusetshenziswa zifana ne mycophenolate mofetil.
• "Panimun". Asetshenziswe ukufakelwa kwamaphaphu, inhliziyo, izinso, umnkantsha, amanyikwe, kanye nezifo ezithile.
• "CellCept." It angabelwa lapho ukufakelwa izinso.
• "Sertikan". It is kuboniswe for izinso ukufakelwa noma iziguli inhliziyo ngokulinganisela noma ongaphakeme ingozi immunological.
• "Tsikloral". Isetshenziswa ngesikhathi esifanayo ne nezinye izidakamizwa e isitho Ukufakelwa.
• "Ekvoral". Isetshenziselwa ku kwezitho we parenchymal izitho, kanye nokuvimbela kwenqatshwa emva ukufakelwa.

Naphezu kweqiniso lokuthi zonke zibe uhlobo olufanayo isinyathelo, ngaphambi esikhundleni izidakamizwa main kunoma iyiphi enye, kufanele uqale ubheke, futhi bonana nodokotela wakho kuqala.