Mikoflyukan: yokusetshenziswa

ifomu Isikali

Ukulungiselela "Mikoflyukan" ukufundiswa oboniswe ngezansi zingaba ngesimo amaphilisi ne lokuhlala ehlukene efana esebenzayo noma ngesimo isixazululo ukumnika. Izibhebhe asemhlophe, ukuma round futhi emaphethelweni kancane bevelled.

Ngo amaphilisi equkethe 50 mg lomcebo asebenzayo nhlangothi zombili umbono «F», futhi ngakolunye - "50". Ifomu ithebhulethi "Mikoflyukan" 150 mg isithako esisebenzayo - «F150» kanye umugqa kuhlukane, ngokulandelana.

Ukulungiswa isixazululo Ayinambala, okusobala, ngaphandle izinhlayiya.

Ukwakheka: Tablets

izidakamizwa Active: i-fluconazole - 50/150 mg (1 ithebhu.).

Excipients:

- Silicon dioxide ,

- i-lactose,

- povidone,

- magnesium stearate

- Valium,

- talc,

- cellulose mikrokristallicheskayae

isixazululo

izidakamizwa Active: i-fluconazole - 2/200 mg (1 ml isitsha futhi 1, ngokulandelana).

Excipients:

- Amanzi Injection,

- i-sodium chloride.

Isenzo kwemithi zomuthi "Mikoflyukan"

Umhlahlandlela uthi ukulungiswa iphathelene ejenti antifungal we esuselwe triazole. Fluconazole zivimbela ergosterol zamagama kanje: inikeza lesi permeability ka odongeni cell. Umuthi uyasebenza ngokumelene Microsporum, Candida, Trichophyton, Cryptococcus neoformans.

Isici esivelele sesimiso isenzo kwemithi zomuthi ukuthi kokubili inhibitor ukukhetha cytochrome P450 e isikhunta, kodwa ngesikhathi esifanayo, alibonisi yimuphi umsebenzi emelene nalesi simiso enzyme abantu.

Pharmacokinetics

Umuthi kahle amuncwa ngemva kokuphathwa, futhi ukudla ngokuhlanganyela ngokuthatha izidakamizwa akuphazamisi ukumuncwa yayo. Bioavailability - 90%. Umuthi zisakazwa bonke kwezitho nezicubu zomzimba. Ngakho lokuhlushwa yayo emakamu plasma ilingane izitho elandelayo nezicubu: uketshezi ngokuhlanganyela, ubisi lwebele, ngamathe, uketshezi lwesitho sangasese sowesifazane, isikhwehlela namanzi perinatal, futhi cerebrospinal uketshezi bioavailability kungaba isukela 50 ku-90%.

Ngaphezu kwalokho, e izitho ezithile nezicubu of emakamu izidakamizwa lingadlula emakamu-plasma. Phakathi kwabo, lo epidermis, dermis, le corneum stratum, ujuluke ketshezi. Ingxenye-ukuphila - amahora angaba ngu-30.

Izinkomba ukusetshenziswa zomuthi "Mikoflyukan"

Ukufundiswa uthi isidakamizwa has a umsebenzi omkhulu ngokumelene nezilwanyana ezincane sezifo ezilandelayo, yiziphi okwakumenza angenwe izifo kalula fungal:

• candidiasis letindzala,

• cryptococcosis,

• candidiasis mucosal,

• candidiasis sangasese somuntu wesifazane,

• nokuvimbela izifo fungal

• isikhumba mycoses,

• onychomycosis,

• pityriasis versicolor,

• parakoktsidiovikoz,

• coccidioidomycosis,

• pistoplazmyuoz,

• sporotrichosis.

imiphumela emibi izidakamizwa "Mikoflyukan"

Izibuyekezo leqembu test emva uchungechunge izifundo zomuthi, kuhlanganise i-placebo-test kanye nezinye izindlela zocwaningo zikhombisile ukuthi isidakamizwa kungenzeka imiphumela elandelayo uhlangothi:

- maqondana ipheshana wokugaya ukudla:

• Ubuhlungu obukhulu besisu,

• isicanucanu,

• ukubuyisa,

• isifo sohudo,

- maqondana sezinzwa uhlelo izitho:

• isiyezi,

• ikhanda;

- ngokuphathelene komzimba:

• ukusabela anaphylactic umzimba,

• ukuqubuka kwesikhumba.

Izimo lesi sidakamizwa "Mikoflyukan"

Imiyalelo emuthini lithi contraindications reception yayo incane ngokwanele, phakathi kwabo:

• enyakeni 1,

• sokukhulelwa,

• luvelo kwakwakhe triazole futhi i-fluconazole.

izidakamizwa ekuhlanganyeleni

Prothrombin isikhathi akhula ukusetshenziswa kwezidakamizwa anticoagulant coumarin hlobo.

Izisetshenziswa ezilethwayo ka sulfonylurea temlomo ejenti hypoglycemic ukwandisa ingxenye-ukuphila kwabo nabo i-fluconazole.

Fluconazole isikhathi isigamu-ukuphila kuyehla lapho baxhumane nge rifampicin.