"Zaldiar": yokusetshenziswa. Ukubuyekeza, intengo, incazelo umkhiqizo

Ubuhlungu ingenye izenzakalo ezingemnandi kakhulu ukuphila komuntu. Iningi izidakamizwa ekhona bayakwazi ukususa ababuthakathaka noma naphakathi umfutho nobuhlungu. analgesics opioid, ezihlanganisa izindlela "Zaldiar" ezichazwe kulesi sihloko, ngisho kusiza ukubabulala ubuhlungu obukhulu kubangelwa izifo ezingathi sína kwababhemayo.

Naphezu kweqiniso lokuthi izidakamizwa akuyona kwezidakamizwa, akhululwe kuphela Pharmacy ngu kadokotela (ifomu 148). Lokhu kungenxa yokuthi izingxenye ezithile kufakwe ngezithako zawo, ukufaka ochwepheshe izinto ezinamandla. Amanani entengo emithi kuleli qembu asikwazi kubhekwe atholakale inqwaba abathengi, okuyilona elisebenzayo futhi isithiyo eziqondile izidakamizwa kwandile. Kodwa sizobe ukukhuluma kancane kamuva, kodwa ekuqaleni siyowuqonda ingxenye amaphilisi, izakhiwo eyinhloko izithako zako asebenzayo nokunye okuningi.

Ukwakheka "Zaldiar" Tablets

Uyini isici "Zaldiar" izidakamizwa? Ukwakheka - yilokho inendima enkulu e ukusebenza kwanoma yimuphi umuthi. Ngaphezu paracetamol aziwayo futhi asetshenziswa kabanzi elikhona izibhebhe isamba 325 mg, "Zaldiar" yakhiwa into eyaziwa ngokuthi tramadol hydrochloride (37.5 mg). Uma abathengi bayawazi paracetamol cishe kusukela ebuntwaneni, ukuthi tramadol incane eyaziwayo emibuthanweni ebanzi. Ngaphezu kwalokho, ngezinye izikhathi kubhekwa izidakamizwa, lapho empeleni akusiyo. Njengazo zonke analgesics opioid zokwenziwa imvelaphi, tramadol unekhono ukwenza ngezindlela ezimbili, ingasetshenziswa ukuqeda ubuhlungu okujula okusezingeni eliphezulu naphakathi. Imininingwane engeziwe mayelana nalokhu kuzoxoxwa ngakho engxenyeni ezindaweni kwemithi.

Ngaphezu eselaphayo, ukulungiselela "Zaldiar" yakhiwa iqoqo izingxenye asizayo: i-cellulose, nesitashi, magnesium stearate, udayi, kanye nabanye abaningi.

Incazelo lokulungisela ifomu ukukhululwa

nomuthi Ikhishwa ngesimo amaphilisi, enteric-camera ulwelwesi igobolondo. Ukuma thebhulethi oblong, nxazonke, biconvex, camera ngakolunye uhlangothi eliqoshwe umbhalo othi "T5", futhi ngakolunye - logo yomenzi "Gryunental". Emgodleni umbala - ukukhanya yellow. Ekuqaleni kwawo-ngaso leso sikhathi izibhebhe kuyabonakala izingqimba ezimbili: yangaphandle futhi kwangaphakathi ophuzi - omhlophe noma cishe emhlophe.

"Zaldiar" Tablets zihlanganiswe amabhamuza yizicucu 10, okuyinto ezibekwe amabhokisi 1, 2, 3 noma 5 izingcezu kanye yokusetshenziswa.

Pharmacokinetics futhi pharmacodynamics ka "Zaldiar" izidakamizwa

Ukulungiswa kuhlanganisa ezimbili nje izinto asebenzayo nge analgesic umphumela. Yingakho iphilisi "Zaldiar" yokusetshenziswa libhekisela ukulungiswa elihlangene. Umthelela ukukhululeka ubuhlungu kulokhu ubabonisa ndlela eziningana. ekuqedeni Ngakho ubuhlungu ngisho ezinzima.

Pharmacodynamics paracetamol iyona ukungaqaliswa kokusebenza cyclooxygenase e ubuhlungu kanye lokushisa izikhungo ingqondo. Kulokhu, ketshezi akuphazamisi kwezicubu neuropathy, okungukuthi prostaglandinsinteticheskie zabo umsebenzi. Ngaphezu kwalokho, paracetamol akuphazamisi amanzi electrolyte ukulingana umzimba.

Tramadol izenzo ku ubuhlungu izikhungo kancane ehlukile: ketshezi futhi metabolites yayo unekhono kusebenze okuthiwa ama-receptor m-opioid. Iphinde oyenza la mangqamuzana non-opioid by ulwelwesi hyperpolarization ku synapse ka emgogodleni futhi izinzwa emgogodleni. Naphezu ukufana isenzo ka tramadol nge into, umphumela walo incane izikhathi 6000, ezifana morphine.

Absorption we-paracetamol no tramadol e ipheshana yesisu kwenzeka ngokushesha ngokwanele. Ukunciphisa ephelele paracetamol kuyinto ngokushesha okuningi kunalokho tramadol. Cleavage idatha ye izithako ezisebenzayo senzeka ikakhulu esibindini. Basuke etholakala ikakhulukazi ngohlelo urinary (30% azizange zishintshe, okungenani ngo-60% njengoba metabolites).

izinkomba

I nomuthi "Zaldiar" yokusetshenziswa incoma ukuthi esimweni umfutho ophansi futhi enamandla ubuhlungu zasezindaweni ezihlukahlukene (isifo, ukulimala, ukuvuvukala, nokunye. D.). Ngaphezu kwalokho, kuzuzisa ukusebenzisa lolu ukulungiselela izinqubo zokwelapha ngaphambi (zokuxilonga nokwelapha) angabangela ubuhlungu. Thenga izidakamizwa "Zaldiar" ngaphandle kadokotela, njengoba kushiwo ngenhla, akunakwenzeka. Yingakho ukusebenzisa kwayo itholakala kuphela ezimweni lapho idingeka khona ngempela.

Izimo

Mayelana nokusetshenziswa Zaldiar "imiyalelo amaphilisi 'ukusetshenziswa libhekisela Izimo ukuthini lokho ukungabi nakwenzeka kwento ethola izidakamizwa, kanye nozakwabo yakhe izithako ezisebenzayo. I contraindication sokuqala nesibaluleke kakhulu kubhekwa isici esiyingqayizivele bathole ezinye zezici zalo ephambili, kuhlanganise adjuvants. Enye contraindication iminyaka lesiguli engu-14. Ngaphezu kwalokho, kukhona uhlu sasivumela olubanzi izifo kanye nezimo lapho ngokuthatha izidakamizwa akunakwenzeka ngenxa ingozi yezinkinga ezihlukahlukene.

Ngakho, sicabangela izimo lapho amaphilisi contraindicated "Zaldiar" (analogs zezinto asebenzayo futhi akufanele isetshenziswe ezimweni ezibalwe ngezansi):

• zesifo sokuwa kungukuthi elawulwa edonsa izidakamizwa ethize;
• izifo ezibucayi nezinso isibindi, e hepatic ethile futhi ukwehluleka kwezinso;
• isimo ngemuva kokuhoxiswa kokuhlelwa izidakamizwa, noma okuthiwa ukuhoxiswa syndrome;
• utshwala noma izidakamizwa ukudakwa (kuhlanganise imithi, sezinzwa uhlelo depressants, hypnotics, analgesics nezinye izidakamizwa).

Lithi ngaphezulu ayadingeka ukuze ihambisane. Here'sa uhlu izimo ngaphansi kwazo "Zaldiar" ukusetshenziswa kwezidakamizwa kudinga aqashelwe ngokucophelela futhi njalo isiguli:

• ukwethusa, okuholela ekulimaleni noma kwezinye izimo;
• ukuhlukumezeka craniocerebral of kobukhulu obuhlukahlukene;
• waqinisa intracranial wegazi (hypertension);
• isithuthwane, engayitholi elawulwa kwemithi;
• ukungakhuli umsebenzi zokuphefumula;
• ukudideka noma Ukwehluleka ukucacisa ukuqaphela of imvelaphi ezahlukene;
• izifo ezibangelwa amagciwane isibindi (i-hepatitis);
• izifo yaleli pheshana biliary;
• Ukuphuza ngokweqile kanye isifo sesibindi noma cha;
• ukuncika izidakamizwa kwelashwa;
• hyperbilirubinemia (ingozi);
• ubuhlungu epigastric odabuka ongaziwa.

Ngaphezu kwalokho, lesi sidakamizwa "Zaldiar" imfundo manual uncoma ethatha ngokuqapha ukuze abantu abaneminyaka engama-75, kanye labo, ngaphezu izidakamizwa, psychotropic ebekiwe namanye amanxusa analgesic ne okuthiwa isinyathelo central (kuhlanganise izinzwa wendawo ).

Ukuze ugweme ingozi ngokungadingekile isiguli, udokotela kufanele ngaphambi enquma izidakamizwa ukuba nizifeze zonke uphenyo oludingekayo, ngawo ungakwazi ukuhlonza isifo eshiwo ngenhla.

Indlela ukuthatha lesi sidakamizwa "Zaldiar": isitatimende

Izidakamizwa "Zaldiar" samukelwa kuphela ngaphansi kweso lwezokwelapha. Umthamo kanye imodi reception Uchwepheshe inquma, esekelwe ngezimo zesiguli, degree of kobukhulu ubuhlungu. Ngokwe-izincomo odokotela, kumele uthathe amaphilisi wonke ngaphandle ichoboza futhi ngaphandle ukuhlafuna. Inani lamanzi okuyinto beyihlanza ngemithi yokwelapha, kumele kwanele ukuba isifundazwe ukuqinisekisa ukuthi wangena esiswini, ngaphandle kwesithiyo.

Umthamo kokuqala abadala (engaphezu kwengu-14) kuyinto 1-2 amaphilisi, kuncike iseluleko isazi. Usuku is hhayi Kunconywa ukuba asebenzise ngaphezulu kuka 8 amaphilisi "Zaldiar". Phakathi amathekhiniki kumele nasemkhakheni isikhawu amahora 6. Uma omunye reception ngasizathu simbe ukuthi awukho, asikho isidingo ukusebenzisa samanje futhi odlule izidakamizwa imithamo.

Ukuze ezigulini esezikhulile (engaphezu kuka-75), ungasebenzisa umthamo evamile zomuthi, kodwa kuyafaneleka ukucabangela iqiniso lokuthi ukususwa izingxenye umuthi namaphesenti metabolites zabantu ezinjalo ubelokhu kancane kuka kwezinye amaqembu eminyaka. Kule ndaba, kutuswa ukwandisa isikhawu phakathi nedili amaphilisi ukuze amahora 10-12.

Sezinso futhi isibindi ukwehluleka nayo idinga imodi ukulungiswa reception bese metering "Zaldiar" izidakamizwa. Kufanele kuqashelwe ukuthi cishe aphume emzimbeni ngesikhathi hemodialysis tramadol amaphilisi isithako esebenzayo. Ngakho, iziguli ezinemishini kahle izinso umsebenzi akufanele thatha okuphindaphindiwe imithi umthamo ngemva kwalokhu nqubo, njengoba kungase kuholele ukweqisa izidakamizwa. Labo izincomo zingalungiswa iziguli ezinzima kahle umsebenzi hepatic. Kulokhu, ingozi yezinkinga awusiwo tramadol futhi paracetamol kusuka. Ubungozi yezinkinga kwandisa kakhulu kubantu kabani isibindi uye washintsha ngenxa imithelela yotshwala.

Ukuxhumana zomuthi nezinye izidakamizwa

Ukulungiselela "izilinganiso Zaldiar 'zazo uzobe kuchazwe lapha, uyakwazi basebenzisane izidakamizwa eziningi. Hhayi ngaso sonke isikhathi inhlanganisela enjalo kunomphumela omuhle umzimba wesiguli. Yingakho ochwepheshe batusa ukuthi abantu abathatha lezi amaphilisi, umbiko ngokuthatha izidakamizwa lapho abelwa nezinye izidakamizwa.

Kubalulekile ukukhumbula ukuthi i-reception izidakamizwa ngokuhlanganyela "Zaldiar", uzobe umemezele intengo zazo ku, nezinye izidakamizwa opioid kufaka engozini okwesula ukubanga izinto asebenzayo maqondana receptor ubuhlungu. Uma kudingeka, lokhu Ihora izidakamizwa nezinye izidakamizwa ne izakhiwo ezifanayo kufanele uyekwa.

Imithi ukucindezela umsebenzi we CNS, okuhlanganisa zinhlungu futhi imithi elele ukwandisa side effects isici "Zaldiar" amaphilisi. Kuyefana nasendleleni imikhiqizo utshwala ezisekelwe.

Inani izidakamizwa, isici esiyinhloko okuyinto lokungeniswa ka microsomal namachibi, kanye tricyclic antidepressant, barbiturates futhi ethanol, banciphise umthelela asebenzayo izingxenye amaphilisi "Zaldiar" phakathi nendawo ubuhlungu, lapho ithonya lazo analgesic sinciphile. Inciphisa nobude isenzo izidakamizwa.

Ukusetshenziswa ahlangene we barbiturates ne izidakamizwa kunciphisa ukusebenza we-paracetamol kanye notshwala kanye kungabangela ukuthuthukiswa pancreatitis acute efomini. izidakamizwa Nonsteroidal eqeda ukuvuvukala akunconywa ukuthatha ngokuhlanganyela amaphilisi "Zaldiar" ngenxa yokusebenza kwabo oluthile paracetamol. Iqiniso lokuthi leli kakhulu kwandisa ingozi ukwehluleka kwezinso futhi kwezinso papillary necrosis izakhiwo. Ezimweni ezimbi kakhulu, isiguli angagcina umdlavuza izinso noma esinyeni.

Ngekusetjentiswa eside lesi sidakamizwa "Zaldiar" okwandisa ukusebenza emzimbeni ngisho encane anticoagulants DOX, okuholela kwengozi ukopha.

ukusabela ezingezinhle

Ngo amaphilisi "Zaldiar" kukhona eminingi engemihle ethinta cishe zonke izinhlaka futhi izinhlelo. Ngokuvamile, iziguli ezinemishini ngosuku lokuqala ethola izimali uqale ukuphazamisa isiyezi, ngokwengxenye ukukhohlwa, Ukudlikizela noma ukuzamazama. Futhi phakathi ukusabela ezingezinhle umzimba ukuze inqubo ukulungiselela okukhulunywa ezinjengokungcoliswa ukozela noma ukuqwasha, isicanucanu, ukubuyisa, iziyaluyalu wokugaya ukudla, nokushaya kwenhliziyo. Ngaphezu okungenhla, iziguli zingase zibhekane kokuya esikhathini semfene, ukubambezeleka noma ukungabi khona ukuchama, dyspnea, anaemia aplastichnaya.

Isikhathi eside ukwelashwa "Zaldiar" izidakamizwa angagcina sezidakamizwa noma izimpawu zokuqaleka emva ukwehluleka ngokuzumayo ekuthatheni amaphilisi. Ukuze ugweme lokhu, akufanele uthathe lo muthi isikhathi eside ukwedlula imiyalelo Kunconywa ukuba isetshenziswe, futhi ukuqedwa zomuthi edingekile ukuze baveze umntwana ukunciphisa kancane kancane umthamo.

Izixwayiso

Long ongalawuleki reception amalungiselelo equkethe tramadol kungabangela sezidakamizwa, obonakaliswe ukwethuka, umsebenzi lengqondo zokwesaba. Kule ndaba, isikhathi sokwelashwa "Zaldiar", ogama intengo kuqhathaniswa eliphezulu, kubalulekile ukuba ngokuqinile ukugcina isikhathi watusa nabaphathi bawo. Iziguli ngaphambili babenobuhlobo, kufanele imithi ngaphansi kweso lwezokwelapha.

Ukushayela izimoto kanye nokuphathwa izakhi eziyinkimbinkimbi esikhathini ukwelashwa izidakamizwa stop kangcono.

analogue izidakamizwa "Zaldiar": amanani kanye nokubuyekezwa

Ngakho, kusukela phezulu, singaphetha ngokuthi ebaluleke kakhulu, yini okufanele iqondise yokwamukela "Zaldiar" izidakamizwa - imfundo. amaphilisi Inani liqhathaniswa neminye imithi enamandla akubonakali eliphezulu kakhulu, futhi cishe ngo-800 ruble iphakethe ngalinye. Analogs babe ukulungiselela kancane: okuqukethwe yezingxenye ezimbili asebenzayo bungabonakala ngaphandle ithebhulethi "Forsodol", ogama value iphezulu kakhulu. Ngokungangabazeki, amanani entengo emithi kusukela iqembu analgesics opioid akukwazi ongaphakeme, njengendlela yokuthola "Zaldiar" kuyinto ezingabizi kakhulu phakathi imikhiqizo efanayo.

Ochwepheshe bezifo, lokhu sidakamizwa sisiza ukuba ubhekane nezingcindezi ubuhlungu, ngisho ezimweni ezinzima kakhulu. Noma kunjalo, zibonisa ukuthi isikhathi eside noma engalawuliwe ukwelashwa izidakamizwa kungaholela nemiphumela engalindelekile, futhi okungekuhle. Iziguli uye wawusebenzisa lo izidakamizwa futhi basutha nokusebenza kwakhe. Kodwa kuqashelwe ukuthi kususwe kufanele kube kancane kancane. Njengoba ezingaphezu kuka-70% amacala unezimpawu ukuhoxiswa okuthiwa.