"Indomethacin" (amaphilisi): yokusetshenziswa, ngempela

Omunye abamele iqembu nonsteroidal izidakamizwa eqeda ukuvuvukala buyisidakamizwa "Indomethacin" (amaphilisi). Ngenxa eqeda ukuvuvukala yayo, analgesic nemiphumela antipyretic yokusetshenziswa kwawo for ekwelapheni izifo ukuvuvukala, okudambisa ubuhlungu, ukunciphisa ukuvuvukala kanye ukubuyisela ukuhamba ngokuhlanganyela.

Incazelo ukulungiselela

The main isithako zomuthi kuyinto indomethacin, ezihlobene indole acetic acid nemikhiqizo. Ngaphakathi emaphaketheni nomuthi "Indomethacin" lichaza njengoba izakhi amaphilisi Umhlahlandlela nge zokuzivikela enamathela enteric elivumela ejenti asebenzayo adedelwe emathunjini, ngokudlula esiswini. Ukuma amaphilisi round, biconvex, phezulu embozwe igobolondo ukukhanya ansundu.

Tablets kukhona imithamo amaningi: 25 mg, 50 mg kanye 100 mg indomethacin. Kutholakala abangu-10 noma 40 izingcezu iphakethe ngalinye.

Zonke izinhlobo Isikali

Ngaphezu kwalokho amaphilisi, zikhona nezinye izinhlobo "Indomethacin" ukulungiselela ukusetshenziswa sib a okuqhubekayo ukukhululwa capsule umthamo 75 mg. Ukuze abaphathi rectal, suppositories asetshenziswa nge umthamo mg 50. Ukuthola izinhlelo zokusebenza ongaphandle wadala wamafutha 5% no-10% no-3% ijeli.

mshini wezenzo

I nomuthi kuyinto nonsteroidal antiinflammatory ejenti isinyathelo letindzala, esesikhundleni antiinflammatory, decongestant, analgesic nemiphumela antipyretic. Njengoba unamathele izidakamizwa "Indomethacin" (amaphilisi) Umhlahlandlela indlela yakhiwa incazelo ukusebenza kwawo isithako esebenzayo ehambisana ne-ukwehla cyclooxygenase umsebenzi uhlobo 1 no-2. Ngebanga lalokho, lokhu enzyme kunomphumela zokukhekheleza on arachidonic acid esehlisa ukuguqulwa prostaglandin. Lezi izinto ezibangela ukuvuvukala ubuhlungu.

ziphephile Indomethacin antiplatelet umphumela, ekunciphiseni platelet clumping kwamangqamuzana egazi. Into attenuates ubuhlungu ngesikhathi ubuhlungu bamalunga esimweni ezolile futhi ephathekayo, kunciphisa ekuseni ukuqina nokuvuvukala, kwandisa ibanga motion. Isenzo indomethacin okuhloswe ngazo ukunciphisa ukuvuvukala. Umthelela luniketwe linanikhulu lesikhatsi ngosuku lwesikhombisa yokwelashwa, izibhebhe izidakamizwa.

ukuthi awukudla

Kususelwa lo mshini wezenzo, "Indomethacin" tablet imfundo manual uncoma ukusebenzisa for ukwelashwa letindzala ka:

• syndrome articular;
• Izifo ukuvuvukala of the system zemisipha kubangelwa samathambo psoriatic, samathambo sokuqaqamba kwamalunga juvenile ehlombe eqandisiwe, ankylosing spondylitis, isifo ngokuhlanganyela deforming osteitis futhi uretrookulosinovialnom syndrome;
• izifo esiwohlozayo of the system zemisipha kubangelwa osteochondrosis nge radicular syndrome, osteoarthrosis amalunga omzimba, ngaphandle inyonga arthrosis intervertebral;
• ekubhebhetselisa isifo, esehlanganise ezicutshini;
• rheumatism;
• izilonda suppurative sokuvuvukala izikhwama periarticular futhi imisipha;
• acute izimpawu ubuhlungu beqolo kanye nezinye izingxenye yomgogodla lapho neuralgia sciatic nezinye izinzwa, nokuvuvukala kwemisipha;
• ukuvuvukala esicindezelayo kwezicubu ezithambile noma amalunga omzimba.

Kungasiza kanjani ukuba ubhekane ikhanda, kokuya esikhathini, amazinyo, isifo sofuba.

Njengoba i-ejenti asizayo zezifo ezithathelwanayo namakhambi ukuvuvukala ezifana pharyngitis, namathansela, otitis isebenzisa nomuthi "Indomethacin" (amaphilisi). Izinkomba zihlanganisa ekwelapheni cystitis, adnexitis, prostatitis.

Umuthi siyasebenza ngoba ukususwa syndrome febrile ezihlobene nesifo Hodgkin sika, lymphoma, izimila metastatic, lapho akenzi-paracetamol kanye acetyl salicylic acid.

Indlela

"Indomethacin" imithi amaphilisi iqondiswa isiguli ngezilinganiso ethile esekelwe degree of isifo. Ngokuvamile, abantu abadala baqale nokuthola umthamo 25 mg kathathu ngosuku ngemva kokudla.

Uma umphumela ukwelashwa alwanele evelele umthamo double ku-50 mg 3 izikhathi ngosuku. Ubuningi umthamo ovumelekile kumele singeqi 200 mg indomethacin. Ngemva ukuba ngcono okukhulu okubangelwa ukwelashwa, ukwelashwa kufanele simiswe amasonto kuphela ngemva 4 usebenzisa inkathi eyedlule noma umthamo encishisiwe. Uma iziguli ukuthatha amaphilisi okuhlela umndeni isikhathi eside "Indomethacin" imfundo manual uncoma umthamo 75 mg isithako esisebenzayo ngosuku.

ukwelapha ezinganeni

Ukuze ingane umthamo wansuku zonke ebalwe siphindaphindeka 2.5 noma 3 mg ku yakhe mass umzimba, uphuzwe 3-4 izikhathi. Iqembu ngalinye ubudala enikeziwe ukusetshenziswa i umthamo kokuqala nsuku zonke:

• izingane 3 kuya eminyakeni 7 iqondiswa kusukela mg 50 kuya ku-75 mg, okuhambelana amaphilisi 2 noma 3;
• izingane 7 iminyaka engu-12: kusuka 75 mg-100 mg, okuhambelana amaphilisi 3 noma 4;
• Izingane engu-12 ebekiwe kusukela mg 100 kuya 125 mg, okuhambelana 4 noma 5 amaphilisi.

Ezinsukwini zokuqala ezimbalwa, kufanele uthole ukuthi isidakamizwa umzimba wengane, ngakho sebenzisa umthamo elincane imithi. Isikhathi yokwelapha nomyalo "Indomethacin" (amaphilisi) njengenhloko kwesikhathi 6 kuya 7 days.

Izici reception

Kule ndaba, kukhona kungenzeka nemiphumela emibi eyamukelayo kusho "Indomethacin" amaphilisi, akukuhle ukusebenzisa for ekwelapheni acute imfiva rheumatism ebuntwaneni. Kokuqhubeka ku ubisi lwebele, isithako esebenzayo lingena egazini womntwana, kwandisa jaundice bokuphila kuleli kwezinsana kokunqotshwa amaseli isibindi. Ukuze ugweme lokhu, khansela ibele.

Asebekhulile, iziguli ezinemishini isibindi onesifo, izinso, ipheshana wokugaya ukudla, izimpawu dyspeptic, umfutho wegazi ophakeme, congestive senhliziyo emva kokuhlinzwa, isifo i-Parkinson, isifo sokuwa, abakhulelwe I neyesi-II senyanga nawabela ukwelashwa Indomethacin liyadingeka ukuqapha isimo umzimba. Kuyadingeka ukulawula umsebenzi kwezitho eziyinkinga, kanye ngemva kwezinsuku 7 ukuba bahlole igazi neuropathy.

Uma esikhathini esidlule iguliswa non-steroidal izidakamizwa eqeda ukuvuvukala, lesi sidakamizwa "Indomethacin" (amaphilisi) uqokwa ezimweni ezibucayi.

Asincomi umsebenzi enobungozi ekwelapheni, njengoba zabagula ukunakwa lengqondo umsebenzi.

Uma ungakwazi ukuthatha

Kukhona izifo lapho imithi contraindicated "Indomethacin" (amaphilisi). Ukusetshenziswa Its akunakwenzeka:

• hypersensitivity kuya indomethacin;
• ebukhoneni erosive kanye izilonda emathunjini wokugaya ukudla esigabeni acute;
• lapho "aspirin triad", libhekene ukungabekezelelani ukuba acetylsalicylic acid, ama-polyp acinene kanye somoya bronchial;
• ngesikhathi hemodyscrasia;
• lapho ushintsho evelele kwesibindi nezinso;
• ngesikhathi ukubambezeleka nosawoti kanye uketshezi nge kungenzeka edema neuropathy;
• e ezinzima ukwehluleka ezingamahlalakhona uhlamvu we myocardium;
• ngesikhathi ingcindezi ephakeme;
• isifuba somoya bronchial;
• e ukuvuvukala kwamanyikwe;
• ku III senyanga esesibelethweni wengane;
• ibele;
• kubantfwana labancane kunalabo engu-3.

ukusabela ezingezinhle

Imithi "Indomethacin" (amaphilisi) kungenzeka ukuthi umataniswe nge izigameko ezingezinhle ezavela omubi ezithinta isimo zomzimba womuntu. Ukuze ukusabela ezivamile enqabayo ibandakanya ukucanuzela kwenhliziyo, sokuzincisha ukudla, ubuhlungu esiswini, ukuvuvukala, ukuqunjelwa, ukuqunjelwa.

Ezimweni ezingavamile, side effects singenzeka erosive kanye izilonda emathunjini, ukopha futhi perforation isisu kanye izindonga emathunjini; applasticheskoy noma anaemia hemolytic, leukopenia, thrombocytopenia, agranulocytosis, amawala, nezinwele, isikhumba ukulunywa, ukuquleka, angioedema, bronchospasm.

Izimpawu enobuthi epidermal necrolysis, kakhulu kuyaqabukela waphawula ukushaqeka anaphylactic, erythema nodosum.

Phakathi ukwelashwa kungakusiza konakalise ukusebenza kwe-kwezinso excretory kanye kwesibindi, kwandisa umthamo bilirubin, transaminases hepatic.

ukusetshenziswa kwesikhathi eside lesi sidakamizwa "Indomethacin" (amaphilisi) akusho ukubeka eceleni ukusabela ezingezinhle elihlobene ne ubuthongo thuthuva, isiyezi, peripheral neuropathy, ikhanda elibuhlungu, ukuyaluza, ukucasuka, ukukhathala. Basuke izimpawu ingaphazamisi we-cornea, conjunctivitis, ukuzwa ukungakhuli, tinnitus, umfutho wegazi ophakeme, edema.

Izibuyekezo

Kubalulekile ukulandela yonke imithetho izidakamizwa, ngakususi konke Izimo.

Axutshwa ku ukwamukelwa "Indomethacin" Izibuyekezo izidakamizwa. Tablets babe kahle emzimbeni okungatheni kuka umthamo amafomu ukusetshenziswa yangaphandle. Ngaphezu kwalokho, izidakamizwa esebenzayo iphathelene inhibitor ka Cyclo-oxygenase 1 no-2, okuyinto abhekwa kangako futhi kubangele eziningi ukusabela engathandeki yaleli pheshana gastro-emathunjini.

Rheumatologists neziguli zabo, odokotela abahlinzayo ngokuvamile linqume izidakamizwa entsha ye kusukela iqembu oxicams. Bona zivimbela uhlobo cyclooxygenase 2 kuphela, ngaphandle kokuphazamisa uhlobo enzyme 1, iqinisekisa ukukhiqizwa prostaglandins ukuthi ukuvikela isimiso sokugaya ukudla bungene. Yingakho oxicams likulimaze kancane esiswini kunokwelapha "Indomethacin" (amaphilisi). impendulo Imiyalelo negative ihlanganisa incazelo emibi, kodwa lokhu akusho ukuthi noma yikuphi ukwelashwa kufanele kuboniswe. Konke kuncike izici umzimba.

Iziguli eziningi, lokhu kusho kulondolozwa iqolo, myalgia, neuralgia intercostal, lapho eminye imithi musa asize. A imiphumela emibi cishe musa kuphakama kusukela ekwelapheni "Indomethacin" izidakamizwa. Izibuyekezo amaphilisi walulama iziguli ekhiqizwa omuhle. Nakuba ingozi lubonakala ngaso sonke isikhathi, futhi kuphela udokotela angakunika umuthi yokwamukela umuthi okungathi sína njengalokho.

analogs

Tablets ngempahla asebenzayo Indomethacin akhiqizwa izinkampani abaningi bezinye izizwe kanye ezifuywayo, ezifana inkampani "Sopharma", "Ludwig Mekle" "Nycomed", "Farmahim", "Berlin Chemie Menarini," "Altfarm". ngamunye kuphela izidakamizwa igama layo ukuhweba, ukubunjwa yayo izingxenye asizayo. Zonke osinga izimpawu ezifanayo ukusetshenziswa, imiphumela emibi, Izimo.

Umuthi ethandwa kakhulu "Indomethacin Sofarma" (amaphilisi). Akhiqizwa umthamo 50 no-100 mg ngu "Sofarma" (Bulgaria). Libhekisela non-steroidal izidakamizwa eqeda ukuvuvukala.

Enye pair of hhayi esingaphansi analogue eyaziwa - imithi "Indomethacin 50 mg Berlin-Chemie" futhi "Indomethacin 100 mg Berlin-Chemie". Akhiqizwa imithamo amabili (50 no-100 mg) yinkampani Italian "Berlin-Chemie Menarini".

Lapho belungela ukuya khona "Indomethacin" (amaphilisi) kufanele analogue nama ukukhiqizwa Russian. Zitholakala e umthamo amafomu ahlukene. kukhona nozakwabo main:

• "Indomethacin-Acre" Chemical-Pharmaceutical Plant JSC "Akrikhin";
• "Indomethacin-Altfarm", LLC "Altfarm";
• "Indomethacin-Biosynthesis", JSC "Biosynthesis";
• "Vero Indomethacin", OJSC "Veropharm".