"Izoket" Amathe: imfundo manual, ukubuyekezwa, izincazelo, analogue, intengo

Namuhla, izazi eziningi linqume iziguli vasodilator fafaza "Izoket" prophylactically noma, uma kudingeka, cupping le imivimbo. Umuthi has uhla lwezindawo izinkomba ezahlukene. Isetshenziselwa ngempumelelo ekwelapheni pathologies zenhliziyo, kuhlanganise ukuba ulwe izimo sibi.

kwemithi

ejenti asebenzayo zomuthi kusukela pectoris angina libhekene evelele vasodilating futhi vasodilator izakhiwo. Isosorbide dinitrate kuvusa kumiswa nitrogen oxide e umzimba futhi kunciphisa nezidingo imisipha yenhliziyo oksijini amandla, ngaleyo ndlela kuncishiswe umthwalo myocardium. It ngempumelelo kunciphisa ingcindezi kule yokujikeleza kwegazi eliya emaphashini, incipha igazi ligeleze ATRIUM kwesokudla, kunciphisa inhliziyo ventricular odongeni ukungezwani kanye nokunciphisa ingcindezi diastolic futhi umsebenzi systolic ekuthuthukiseni kubo. Umuthi akunamthelela ukuvama Kufinyeta ezisekujuleni kwenhliziyo futhi ubabonisa izitsha cerebral kahle. Ingase futhi kwandisa yegazi yezingalo Mater Dura zobuchopho futhi kanjalo abuhlungu ekhanda. Esebenzisa ithonya phezu ukuhanjiswa yenhliziyo ukugeleza kwegazi endaweni lapho ukugeleza kwegazi sinciphile. Ngo CHD (isifo senhliziyo) futhi angina ngenxa isenzo zomuthi in iziguli ithuba ukwandisa umsebenzi kuvunyelwe.

Futha "Izoket" matasa ngokushesha yonkana mucosa kwendawo umlomo, ngakho umphumela isicelo yawo iyaqala ukonakala ngemuva kwemizuzwana 30 futhi ihlala kufika 120 amaminithi. Ngenxa ijubane ngokuvamile elibekelwe iziguli ekhahlamezekile kwezimiso oyingozi.

ukukhululwa Ifomu

Umuthi yisisombululo ecacile, okuyinto Ayinambala futhi ine iphunga oludakayo. Iza izinhlobo ezimbili:

1. Futha "Izoket" umthamo sublingual. With okukodwa phezu dispenser ikhishwe ngendlela amathonsi encane omunye umthamo yayo lapho yakhiwa 1.25 mg isithako esisebenzayo - isosorbide dinitrate elementi asizayo: ethanol futhi Macrogol 400. Ukwakheka aerosol unephutha freon, Nokho sihlobana izidakamizwa ayinangozi imvelo. Akhiqizwa amabhodlela esobala 15 ml, phama ebhokisini nge dispenser kanye nemiyalelo. Glass ibhodlela lika 300 ukuchofoza (ngemithamo), ikuvumela ukuba iqaphe inani izidakamizwa futhi ukuthola indawo ngendlela esifike ngesikhathi.
2. Isixazululo ngefomu CONCENTRATE senzelwe infusions. 1 ml le ukulungiselela equkethwe 1 mg element esebenzayo ye isosorbide dinitrate futhi izinto asizayo: i-sodium chloride, i-sodium hydroxide, amanzi. Omunye isitsha - 10 ml isixazululo ukumnika. Itholakala amakhadibhodi amaphakethe of izingcezu 10 ngamunye.

izinkomba

Futha "Izoket" ochwepheshe baqokwa stenokardicheskie ukuhlaselwa zonke izinhlobo futhi njengoba isilinganiso izifo ukuba sizigweme. It is ibuye Kunconywa for post-infarction uthi, isilethikusebenza esigabeni oyingozi, okwandisa ukubekezelelana kanye IMS kanye therapy ye yenhliziyo Umthambo spasm. Aerosol "Izoket" asetshenziswa ngempumelelo njengoba izidakamizwa ngokwehluleka inhliziyo e-ventricle engakwesobunxele. Ngokusho imiyalelo, ukugxilisa ingqondo ukumnika ezinqunyiwe ukuze iziguli pathologies ezinjalo yisimiso senhliziyo nemithambo yegazi:

• angina engazinzile okwenzeka isimo preinfarction noma infarction odlule esivimba amanzi;
• angina vasospastic;
• isilethikusebenza efomini acute, kubangelwa ukwehluleka i-ventricle engakwesobunxele wenhliziyo;
• vasospasm yenhliziyo ngesikhathi ukungenelela kuhlinzwa;
• ukuhluleka inhliziyo zonke izinhlobo;
• acute ventricular kwesokunxele ukuhluleka kwenhliziyo;
• edema yamaphaphu.

Izindlela ukusetshenziswa aerosol

A ukulungiselela ngesimo isifutho wafutha phakathi ngalo ingaphakathi ngomlomo esiguli, ngenxa yalokhu-ke ngokushesha ingena ukusakaza igazi. umjovo ngamunye inikeza ukungenisa umthamo owodwa. Yokusetshenziswa libhekisela izindlela ezihlukahlukene usebenzisa izidakamizwa, kuye ngezimpawu.

Ukuze cupping stenokardicheskie kuhlasela phambi ukucindezeleka oluzayo izingane ngokomzimba noma ngokomzwelo kungabangela acute, imisiwe emishinini yokuphefumula, kanti isiguli uthola kusuka ku 1 kuya ku-3 ngemithamo ngezikhawu amasekhondi angu-30 phakathi imijovo. Khulisa Isikali ngaphandle kwesiqondiso Uchwepheshe akuvumelekile.

Endabeni exacerbation esolwa ukuhluleka kwenhliziyo noma isilethikusebenza, acute phezu nesineke uthola kusuka ku 1 kuya ku-3 ngemithamo ngaphansi kolawulo esiqinile kokubili ukushaya kwenhliziyo nomfutho wegazi. Uma intuthuko ke inqubo kamuva esiphindwe imizuzu emihlanu yisinqumo se kudokotela. Esikhathini esilandelayo ngemva kwemizuzu eyishumi, isimo kufanele izinze. Kungenjalo, ungaphinda zokukhwabanisa waphinda ngaphansi kokuqondisa kukadokotela.

Ngaphambi inqubo yokwelapha cupping spasm yenhliziyo (i catheterization zokuxilonga noma zokwelapha) zaphathwa isiguli ngomjovo 1-2. Lapho kuphakama isidingo umthamo kungaba liphindwe, kodwa kuphela uma nemingcele ukulawula kwegazi.

izincomo Specific ukusetshenziswa isifutho

Ezimweni lapho isifutho entsha sisetshenziswa okokuqala, noma emva komthamo sokugcina kube ngaphezulu kwamahora angu-24, kungcono uqondise cindezela lokuqala emoyeni, ngoba ingaqukatha umthamo edingekayo. Ukuze Ukweqiwa ngokuhambisana nebulizer imfundo njalo sicindezelwe kuze kube sekupheleni, base bededelwa. Phakathi ukusetshenziswa nge dispenser spray ibhodlela kumele kube upwardly futhi zibheka. Qaphela futhi ugweme wachela ku emehlweni. Phakathi naso sonke isikhathi ukuphathwa kudinga ukuzithiba njalo wegazi (BP), kanye ECG eliyifa. Inani wegazi akufanele ibe ngaphansi kuka-100 mm HG. Art. zokuqaleka ngokushesha umyalelo izidakamizwa zwe, pho umthamo esimisiwe kancane kancane. utshwala kawavunyelwa uma uthatha aerosol "Izoket".

Izibuyekezo ochwepheshe abonisa ukuthi umthamo ephakeme imithi, ngokuvamile i-aphoyintimenti noma ukusetshenziswa ehlelekile kungaholela ukuthuthukiswa ukubekezelelana esigulini. isici okunjalo luthuthukiselwa ukusetshenziswa nezinye izidakamizwa ukuthi yakhiwa nitrate. Ezimweni ezinjalo, odokotela batusa ukukhansela ukusetshenziswa kwezidakamizwa izinsuku 2-3, futhi emva Inkambo yokwelashwa njalo, eyathatha amasonto 3-6, thatha ikhefu izinsuku 3-5, futhi esikhundleni salo okwesikhashana ngamanye izidakamizwa kanye nemiphumela efanayo. Ezimweni eziningi, ngemva kokuphazamiseka noma ukuqedwa ukuzwela isiguli abuyiselwe esikhundleni ngokushesha. kusho izingxenye etholakala metabolites njengoba iziso sesizogcwala.

Isikali futhi isicelo isixazululo

Ngokusho izidingo ekulungiseleleni imfundo 'Izoket "(isixazululo ukumnika) sisetshenziswa ngemithambo yegazi. I umthamo we vrechom ekwelapheni ngamunye yakhelwe hemodynamic kanye nemingcele basemtholampilo isiguli. Ukwelashwa kufanele uqale nge umthamo ongaphakeme nokukhuphula kancane imenze lemali edingekayo. Imiyalelo Isikali Isincomo 2-7 mg / ihora, ngokulandelana, umthamo isilinganiso imayelana 7.5 mg / ihora. Ezimweni ezimbi kakhulu isidingo ivolumu zingandiswa-10 mg / ihora.

Ezimweni eziningi, abantu senhliziyo zidinga ngemithamo ephakeme zomuthi. Ukwethulwa kwe izidakamizwa kufanele ukwelashwa inpatient ngaphansi kokuqondisa onguchwepheshe futhi ukusetshenziswa izinhlelo ezizenzakalelayo ukumnika. Yonke inqubo kuhambisana wukulawula izinkomba kwegazi (blood pressure kanye kwenhliziyo).

Isixazululo kwezokuphatha emthanjeni yahunyushwa ngo izimo oyinyumba ngokushesha ngaphambi inqubo. Umuthi is hhayi egcinwe kwamahora angu-24. izindlela nokulungiselela:

• ukuze lokuhlushwa 0.01% (micrograms 100 / ml) - 50 ml 0.1% izidakamizwa angenza 500 ml ukulungiswa ilungele ukuphatha;
• ukuze lokuhlushwa 0.02% (200 micrograms / ml) - 100 ml 0.1% isixazululo zomuthi angakhiqiza 500 ml we nomuthi ilungele ukuphatha.

Izimo futhi izindlela

Umuthi aluboniswa for iziguli hypersensitive ukuba compounds nitrate, kanye nezinye izakhi aerosol "Izoket". Isicelo nqatshelwe uma isiguli izifo ezifana:

• hypotonia, lapho ingcindezi systolic ingaphansi 90 mm HG.
• esingamahlalakhona semithambo esigabeni oyingozi, isib, ngesikhathi ukushaqeka noma phula semithambo;
• pericarditis futhi tamponade pericardial;
• usashaqekile cardiogenic ezimweni lapho kungekho kungenzeka ukulungisa ezinye indlela kwengcindezi i-ventricle engakwesobunxele wenhliziyo;
• zenhliziyo hypertrophic;
• Ukuvalwa glaucoma.

Ngaphezu kwalokho, izidakamizwa aluboniswa abantu ngaphansi iminyaka eyishumi nesishiyagalombili ubudala. Yokusetshenziswa uncoma ukusetshenziswa kwezidakamizwa ngokucophelela okukhulu ngaphansi kweso njalo ezimweni ezinjalo:

• isilethikusebenza nge flow-acute lapho isiguli unephutha ingcindezi encishisiwe kwesokunxele inhliziyo ventricle ukugcwaliswa;
• waqinisa intracranial;
• mitral kanye / noma stenosis yomthambo i-aorta;
• uzingela ematfuba nesenzakalo isiguli iziyaluyalu orthostatic e ukulawulwa kwegazi;
• kwezinso noma isibindi ukwehluleka.

Nokukhulelwa kanye lactation

Ososayensi e-ukuthuthukiswa izifundo izidakamizwa isilwane sezenziwe. Ukuhlolwa phezu vivinyo lwabonisa ukuthi uNkulunkulu ukuthi umphumela olimazayo embungwini is hhayi lwenziwa. Nokho, phakathi nokukhulelwa kanye lactation isikhathi ukuqokwa aerosol Kunconywa kuphela labo izimo lapho izinzuzo okuhlose abesifazane kuyoba kakhulu okukhulu naphezu kwengozi engase ivele ezingenzeka embungwini noma ukuncelisa ingane. Ukwelashwa kulezi zimo okufanele kwenziwe ngaphansi kokuqondisa esiqinile ochwepheshe, ukulawula kwegazi ngezimiso (blood pressure kanye inhliziyo beat rate), kanye isimo jikelele isiguli.

Ukuxhumana nezinye izidakamizwa

Akuvunyelwe ukwabelana vasodilators futhi "Izoket" ukulungiselela (spray). Ukusebenzisa kwabo ekuhlanganisweni kungabangela kukhuphuke umphumela hypotensive. Umphumela ofanayo akuhileli reception kanyekanye "Izoket" futhi ezifana imithi aerosol: antihypertensives, blocker-calcium channel, "Quinidine" noma "novokainamid" neuroleptics, 5-phosphodiesterase inhibitor.

Kucinisa umphumela antianginal lapho isetshenziswa ngesikhathi esifanayo ne izidakamizwa ezifana "Amiodarone", "propranolol", "Nifedipine", "Verapamil," futhi nabanye blocker we-calcium channel kancane.

Ukwandiswa ingcindezi intracranial e isiguli singenakukwazi ezenzeka phakathi ukwelashwa nge atropine nezinye m-holinoblokatorami.

ukwehla ngokweqile wegazi, okuholela perfusion yenhliziyo, kubonakala ngaphansi kwethonya-alpha-blocker futhi sympathomimetic.

Imiphumela emibi kanye nokubuyekeza

Iziqondiso ezichazwe eziningi side effects ukuthi kungahle kubangelwe izidakamizwa "Izoket" (spray). Uphenyo ezinye iziguli ziphathwe lokhu izidakamizwa, ukhombise ukubonakala ikhanda, okuyinto kwezokwelapha ibizwa ngokuthi "ama-nitrate nama". Njengomthetho, ngemva kwezinsuku ezingu-2-3 inkinga ubalekela ngokwa futhi ayidingi ukulungiswa. Kunalokho thukela nomuthi kungadala ezinjengokungcoliswa isicanucanu, ububomvu kwesikhumba, ukuhlanza, nomlomo owomile. Ezinye iziguli abathola umuthi okokuqala ngqa, okhalazayo lobuthakathaka jikelele, isiyezi, kunciphisa umfutho wegazi futhi umuzwa ukucobeka. Loku kubangelwa thuthuva elincane ukusebenza uhlelo senhliziyo nemithambo yegazi. Bona ziphakame uma usebenzisa eyinhloko noma Udlule umthamo Kunconywa.

Nokho, ngokuvumelana ukubuyekezwa, iziguli uqaphela nokusebenza ngempumelelo. Futhi lapho ithola ngokuhambisana nezidingo professional amathuba okuba nemiphumela engemihle azisenzeki ngakho njalo. Ukukhethwa iyona ikhanda ezinsukwini zokuqala ukusetshenziswa, okuhambisana iningi amacala, kodwa ngokuvamile sihamba ngemva kwezinsuku ezimbalwa.

Okwedlulele ivolumu esiphezulu

Ukweqisa izidakamizwa zomuthi kungabangela eziningi ngeziphambeko sina: nakwisyncope, nciphisa, ophezulu intracranial, komzimba, ukuquleka, ezibukwayo umsebenzi neziyaluyalu, ukujuluka kakhudlwana, methemoglobinemia, bradycardia, ukukhubazeka, kanye ikhoma. Yingakho kubalulekile ukuzithiba inhliziyo, futhi athathe izidakamizwa ngokuqinile ngokuvumelana nezidingo onguchwepheshe!

Uma izimpawu ezichazwa kudinga ukususwa zomuthi nokuqhuba izifundo ukwelashwa okuhloswe ngaso ezibangela ukuzinza isimo lesiguli.

analogs

Nomuthi "Kardiket» (CHWARZ Pharma, Germany) - one of the imithi ejwayelekile ezivamile (analogs) zomuthi "Izoket" (spray). Intengo yale esikhundleni luncike lokuhlushwa izidakamizwa iyasebenza, futhi nenombolo amaphilisi e iphakheji.

Ngokwesibonelo, i-ejenti e izibhebhe 20 mg "Kardiket kuthiye ukukhula" (20 nama-PC. On iphakethe) kuyinto ruble 62 kuya 72, kuyilapho ukulungiselela esifanayo, ngalesi umthamo amaphilisi 40 mg lokunyathelisa nenani izingcezu 50, inenani ruble 210-220.

Iqembu nemithi "Nitrosorbid" ekhiqizwa yizinkampani ezimbalwa isiRashiya, nokuba amafomu ahlukahlukene woyekelo, futhi, uba nezidakamizwa esikhundleni "Izoket". Analogue yaleli qembu banegama "Nitrosorbide-Rusfar", "Nitrosorbide", "Nitrosorbide NS", "Nitrosorbide-UWI."

izindleko

Pharmacy Russian kuyodingeka bakhokhe ruble ngayinye umthamo ekwakhiweni "Izoket" (spray) 365 470. Kumiswa intengo kuye indawo lapho uphuma khona okudayisa kanye isimo salo. Kumawebhusayithi ezithengisa imithi angathengwa ngemali ephansi kuka ekhemisi ezivamile eduze ekhaya lakho. Kodwa lapho iyala phezu Internet kuyodingeka bakhokhe ruble 200 for kwezidingo noma wamukele enenkululeko endimeni ex, okungasekelwe njalo eseduze ngokwendawo.

Futhi, noma ngasiphi ekhemisi ungakwazi ukuthenga iphakethe (10 izitsha eziyisikhombisa) isixazululo kanzulu ukuze ukumnika "Izoket". wentengo kuhluka ruble 906-980.

Uhlolojikelele

Umuthi ekhiqizwa yinkampani German "YUSB Pharma GmbH". Impilo eshalofini iminyaka emihlanu. Imigomo ukudayiswa - khona udokotela. Ngemva isikhathi eside ukusetshenziswa kunconywa ukuhlola ukusebenza sprayer. Ilebuli we aerosol kukhiwa umcibisholo phansi. Lapho ketshezi ifinyelela izinga kufanele kube ukuze uthole umuthi omusha, njengoba ukusetshenziswa i ibhodlela ekhona kuphela kungenzeka nge kancane esitshekile, lapho tube oncelayo egxilile ketshezi.