Imiyalo yokusetshenziswa "i-Ursocho". I-Analogs yezidakamizwa nokubuyekezwa ngakho

Lesi sihloko sizonikeza imiyalelo eningiliziwe yokusetshenziswa kwe-Ursohol. Sizokutshela ngalokho okushiwo lesi sidakamizwa, yimiphi imiphumela emibi kanye nokuphikisana okukhona. Ngaphezu kwalokho, kusukela kulesi sihloko uzofunda mayelana nezindleko zemithi ebhekene nayo, izilinganiso zayo kanye nezakhiwo zemithi.

Ukwakhiwa kwemithi, ifomu yokwenza kanye nokupakisha

Imiyalo yokusetshenziswa kwe-"Ursohola" ithi lesi sidakamizwa sithengiswa kuphela ngefomu lamakholomu. I-ursodeoxycholic acid isebenza njengento esebenzayo yale agent . Ngokuqondene nezinto ezingeziwe, lezi zinto ezilandelayo zisetshenziswa njengezikhemisi: isitashi sezambane, i- magnesium stearate, i-methylcellulose ne-anhydrous silicon colloidal dioxide.

Ekhemisini, umuthi "i-Ursohol" ungathengwa ezinkathini zemizila, ubeke ebhodini lekhadibhodi (10, 50 noma 100 izingcezu ngamunye).

Izakhiwo zomzimba zalesi sidakamizwa

Imiyalo yokusetshenziswa kwe-"Ursohola" iqukethe ulwazi ukuthi lesi sidakamizwa sinesifo sofuba, isimiso somzimba esibambileyo, isisindo sokuzivikela, ukuchithwa kwegazi, isenzo se-cholelithic ne-choleretic.

I-element esebenzayo ihlanganiswa kalula kwi-membrane ye-hepatocyte, igxilise isakhiwo sayo futhi ivikele amangqamuzana e-isibindi kusukela ezintweni ezilimazayo.

Lesi sidakamizwa sivimbela ukumuncwa kwe-bile lipophilic acid emathunjini, okwandisa inzuzo yabo "ye-fractional" ngesikhathi sokusakaza kwe-enterohepatic. Kulesi simo, kudala ukubunjwa kwe-bile, ecebile kuma-bicarbonates. Ngenxa yalokho, kwandisa ukuhamba kwayo, futhi kushukumisa ukuhoxiswa kwe-bile ene-acids e-acids emathunjini.

Ngokufaka esikhundleni se-bile non-polar acids, isidakamizwa esithi "i-Ursohol" sikwazi ukwakha ama-micelle angenayo into enobuthi. Futhi, lesi sidakamizwa sinciphisa ukuqala kwe-cholesterol esithombeni esinjengesibindi.

Into esebenzayo ikwazi ukwenza ama- crystals (oketshezi) ngamakhemikhali e-cholesterol , nokuvimbela ukungena kwayo emathunjini, ukunciphisa i-lithogenicity ye-bile, ukunciphisa inkomba ye-cholatecholesterol, ukuchitha amatshe e-cholesterol nokuvimbela ukubukeka kwawo.

Nge-cholestasis, lesi sidakamizwa senza i-proteinase esekelwe yi-calcium, sinciphisa ukuhlushwa kwe-bile acids (i-lithocholic, i-cholic, i-deoxycholic, njll) futhi ivuselela i-exocytosis.

Umsebenzi we-immunological wezidakamizwa ungenxa yokunciphisa "ukuhlaselwa" kwama-immunoglobulin angenawo amandla.

Pharmacokinetics yomuthi

Iyini imfundo mayelana ne-pharmacokinetics yomuthi? "I-Ursohol" imithi esheshayo ingene emncane nakwe-ileum ngemva kokungenisa. Ukwamukela kahle emathunjini kubangelwa ukusabalalisa okuncane nokuthutha okusebenzayo, ngokulandelana.

Ukuhlushwa okukhulu kwesidakamizwa eplasma kubonakala emaminithini angu-30-60 emva kokuphathwa.

Ngokusetshenziswa njalo, i-substance esebenzayo iba i-acidi e-bile enkulu egazini. Ngesikhathi esifanayo, cishe ngo-97-99% kokuqukethwe okuphelele.

Isidakamizwa sifinyelela kahle ngokusebenzisa umkhawulo we-placental. Cishe amaphesenti angu-50 kuya ku-75% womuthi adutshulwe ndawonye ne-bile, kanye namazinyo (kancane).

Izimpawu zokusetshenziswa komkhiqizo wokwelapha

Ngabe iziphi odokotela abanika imithi "i-Ursohol" ezigulini? Imfundo, izimpendulo zongcweti zithi le remedy iyakuboniswa ngokuphelele ngokuphathelene nokuphambene okunjengokuthi:

• Umonakalo wesibindi (kubandakanya ukulimala kwesibindi sokuphuza utshwala).
• I-hepatitis enamandla, i-hepatitis engapheli ene-sylrome ye-cholestatic;
• I-cirrhosis ye-biliary yesibindi (eyinhloko), i-atresia ye-intrahepatic tract tract, i- sclerosing cholangitis (eyinhloko), i-cholestasis ene-parenteral nutrition;
• I-Dyskinesia ye-bile ducts;
• I-cystic fibrosis yesibindi (i-cystic fibrosis);
• I-Reflux-gastritis (i-biliary) ne-reflux-esophagitis;
• Ukutholakala kwama-gallstones (cholesterol) ku-gallbladder (uma kungenakwenzeka ukuthi basuswe ngendlela endoscopic noma yokuhlinzwa).

Phakathi kwezinye izinto, izidakamizwa esizicubungulayo zisetshenziselwa ukuvimbela ukulimala kwesibindi ngenkathi kusetshenziswa izidakamizwa ze-cytotoxic hormonal kanye nezinzalo zokubeletha.

Ukungahambisani nokusetshenziswa komkhiqizo wokwelapha

Kuziphi izimo akunconywa ukusebenzisa imithi esiyicabangayo? Impendulo mayelana nesicelo "i-Ursohola" ithi lesi sidakamizwa sinombhalo omkhulu kakhulu wezingqinamba. Ake sicabangele uhlu lwabo okwamanje:

• I-cirrhosis yesibindi, ikakhulukazi esiteji sokukhokha;
• Ukwethembeka kwesiguli kwezidakamizwa;
• Izifo ezinzima ze-gallbladder, amathumbu nama-bile ducts, okuvuthayo;
• I-colcer ulcerative ayikho emthethweni;
• Ukuba khona kwama-gallstones ahlanganisiwe, ukwephulwa komsebenzi wokusebenza we-gallbladder, ukuvinjelwa okuphelele kwepheshana le-biliary, i-colic hepatic;
• Ukukhubazeka okukhulu kwe-pancreas noma izinso;
• Isifo sikaCrohn;
• Ukukhulelwa.

Kungenzeka ukuthatha i- "Ursohol" ngenkathi ibeletha? Odokotela bathi uma kunesidingo sokumisa imithi ngesikhathi sokulahlwa, kubalulekile ukuxazulula inkinga yokuyeka ukuncelisa. Uma kungenjalo, impilo yengane esanda kuzalwa ingakwazi ukuwohloka kakhulu.

Isidakamizwa "I-Ursohol": imiyalelo yokusetshenziswa

Amazwana kulo muthi, sizohambisa kancane kancane. Manje ngifuna ukukutshela ukuthi lesi sidakamizwa kufanele sithathwe kahle kanjani.

Sebenzisa imithi esiyicabangayo kufanele ithathwe ngomlomo kuphela. Kulokhu, ama-capsules akufanele ahlaziywe. Badinga kuphela ukuphuza inani elanele lamanzi ahlanzekile.

Izinga lansuku zonke zalesi sidakamizwa kuthathwa ngesikhathi. Yenza lokhu ngokushesha ngaphambi kokulala.

Ukuze ukwelashwa izifo zesibindi ezingapheli futhi ezinzima, kanye nokuqedwa kwama-gallstones, imithi inqunywe umthamo we-10 mg / kg kanye ngosuku. Ukwelashwa ngezidakamizwa kwenziwa ngokuqhubekayo isikhathi eside.

Uma kukhona ukuphonswa kwe-bile endaweni yesisu noma isisu, isiguli simiswe i-capsule engu-1 ngosuku. Isikhathi sokwelapha sisuka ezinyangeni eziyisithupha kuya ngonyaka.

Ukuze kuvikelwe odokotela be-cholelithiasis (okuphindaphindiwe) batusa ukuba bathathe imithi izinyanga ezimbalwa ngemuva kokuthi wonke amatshe aqedwe.

Uma ukwelapha izifo ezingapheli zesibindi, ubude besikhathi sokwelashwa bungaba phakathi kwezinyanga ezimbalwa kuya eminyakeni emibili.

Nge-reflux esophagitis (i-biliary) ne-reflux gastritis, imithi kufanele ithathwe 250 mg kanye ngosuku ngaphambi kokulala. Inkambo yokwelashwa okunjalo ivame izinsuku ezingu-10-14.

Nge-cirrhosis ye-biliary (eyisisekelo), lesi sidakamizwa sinqunywe kumthamo we-10 mg / kg.

Imithi esiyicabangayo ingahle ibekwe ngisho nangenxa yezingane ezincane. Kodwa kufanele uhlale ucabangela isisindo somntwana.

Izingane ezinesisindo somzimba wama-25-50 kg zinikezwa i-capsule 1 ngosuku. Uma ingane isisindo esingaphezu kuka-50 kg, inqunywe ama-capsules amabili.

Ukudlula ngokweqile komuthi

Imfundo yokusetshenziswa kwe-Ursohol ayiqukethe ulwazi oluthe xaxa mayelana nokudlula ngokweqile kwalesi sidakamizwa. Nokho, leli qiniso alisho ukuthi lingathathwa ngaphandle kokulawula futhi ngaphandle kokuqokwa kukadokotela.

Kwezinye izimo, ngemuva kokusebenzisa kabi izidakamizwa ezibuzwayo, iziguli zingathola izibonakaliso zokudlula ngokweqile ezifana nesifo sohudo. Ukuqeda lesi sigqila, kufanele uke ukuphuza imithi. Njengokwelashwa okuphawulekayo, odokotela batusa ukugcina ibhalansi ye-electrolyte nomswakama emzimbeni.

Imiphumela emibi

Ingabe umuthi "i-Ursohol" ingathinta umzimba womuntu ngendlela engafanele? Ukusetshenziswa kwalesi sidakamizwa kwamanye amacala kubangela ezinye imiphumela emibi. Ake sicabangele uhlu lwabo okwamanje:

• Isifo sohudo;
• Ukuphendula kwe-allergen;
• Ukwandisa umthamo we-transaminases egazini;
• I-nausea;
• Ukubamba;
• Ubuhlungu esifundeni se-epigastric.

Ukuxhumana namanye amadivayisi wezokwelapha

Ngiyakwazi yini ukuthatha imithi esiyicabangela neminye imithi? Imithetho ekhonjiwe ithi ngani ngalokhu? "I-Ursohol" ayikhuthazwa ngesikhathi esifanayo ne-cholestyramine, i-colestipol ne-antacids, equkethe i-aluminium hydroxide. Lokhu kungenxa yokuthi le mithi inciphisa kakhulu inqubo yokumuncwa kanye nemiphumela yomuthi. Ngakho-ke, ukwamukela kwabo ngesikhathi esisodwa akusizi ngalutho.

Umuntu akanakusiza ukusho ukuthi ukusebenza komuthi okucatshangelwayo kuncishiswe ngezindlela ezinjengokuthi "Bezafibrate", "Vala", "I-Probuson". Leli qiniso liwukuthi ngesikhathi sokwamukela kwakwandisa ukwedlula uketshezi lwe-cholesterol.

Phakathi kwezinye izinto, izidakamizwa "i-Ursohol" zandisa ukusebenza kwezidakamizwa zokulwa nezidakamizwa ezithathwe ngaphakathi.

Izici zokusetshenziswa komkhiqizo wokwelapha

Yini okudingeka ukwazi ngaphambi kokuba uqale ukuthatha imithi yama-Ursohol? Ukubuyekezwa kwalesi sidakamizwa kusho ukuthi kufanele isetshenziswe kuphela ukuqothula amatshe we-bile cholesterol (okungukuthi, ama-ray angama-ray), ubukhulu bawo abudluli ku-15-20 millimeters. Ngaphezu kwalokho, ukwenza ukwelashwa nalo muthi kuvunyelwe kuphela nge-gallbladder esebenzayo, futhi nangendlela yokulondoloza i-bile evamile ne-cystic duct.

Ukuqapha ukusebenza kahle kokwelashwa, ochwepheshe batusa ukuthi njalo izinyanga eziyisithupha ukuqhuba i-X-ray nokuhlolwa kwe-ultrasound ye-bile ducts. Uma kwenzeka ukuthi ngemva kokuphela kwezinyanga eziyisithupha (ngemuva kokuqala kokuthatha lesi sidakamizwa), ukwehla kwama-gallstones akuzange kwenzeke, ngakho-ke akukho ndawo yokuqhubeka nokwelapha.

Abamele besifazane ababuthakathaka bokubeletha ngenkathi belashwa nalesi sidakamizwa kumele basebenzise kuphela ukuvimbela izisu ezingekho-hormonal noma zokuvimbela ukuvimbela izisu zomlomo ezinomqondo onciphise we-estrogen.

Ngemithi yesikhathi eside (isikhathi esingaphezu kwenyanga eyodwa), kufanele njalo (okungenani kanye ngenyanga) uthathe ukuhlola igazi kwegazi. Lokhu kuyadingeka ukuze kunqume umsebenzi we-transaminase ye-hepatic (ezinyangeni ezintathu zokuqala zokwelashwa).

Uma kwenzeka isiguli singenalutho emfanekisweni wegazi, odokotela kudingeka ukuba banciphise umthamo wesidakamizwa. Uma imingcele ingavamile ngaphakathi kwenyanga eyodwa, imithi kufanele imiswe.

Izindleko zezidakamizwa nezifanekiselo zayo

Intengo yesidakamizwa "i-Ursohol" ihluka phakathi kwama-ruble angu-180-250 aseRussia (ama-capsules ayishumi). Ngenxa yokuthi le mithi kufanele ithathwe isikhathi eside, ukwelashwa kungadala isiguli kakhulu.

Ngisiphi isidakamizwa okufanele ngiyisebenzise uma ungawutholi umuthi u-Ursohol? Ama-analogues alo muthi angatholakala kunoma iyiphi ikhemisi. Lezi zihlanganisa izidakamizwa ezilandelayo: i-Ursofalk, i-Ursosan, i-Cheludexan, i-Livedoksa, i-Ukrliv, i-Urdoksa, i-Ursodex ne-Ursolizin.

Ukubuyekeza mayelana nomuthi

Ngokwezibuyekezo zeziguli, isidakamizwa esithi "i-Ursohol" sichitha ngokuphumelelayo amatshe e-cholesterol ku-gallbladder, futhi ivimbela ukubunjwa kwabo okuphindaphindiwe. Ngaphezu kwalokho, lesi sidakamizwa sibheka izifo ezihlukahlukene zesibindi, kufaka phakathi izilonda zayo ezinobuthi, isifo sofuba esiphundu nesiguli, isifo se-cirrhosis njalonjalo.

Ngokuqondene nezibuyekezo ezingalungile, ngokuvamile zihlobene nemiphumela emibi, kanye nezindleko eziphakeme zesidakamizwa. Nakuba ochwepheshe bathi inkokhelo yale mithi ihambisana ngokugcwele nekhwalithi yayo nokusebenza kwayo.