Umuthi "Metrogil" (ngaphakathi). Imiyalo

Isidakamizwa esithi "Metrogil" (nge-intravenously) sibhekisela kwizidakamizwa ezilwa namagciwane kanye nama-antiprotozoal. Into esebenzayo yalesi sidakamizwa i-metronidazole. Isidakamizwa sikhombisa umsebenzi wayo ngokuhambisana nezinambuzane ezinama-gram-positive, okuphoqeleka ama-anaerobes. Kuhlangene ne-amoxicillin Helicobacter pylori izenzo. Ukuphikisana nezidakamizwa ezibonisa ama-anaerobes, i-aerobic microorganisms. Isidakamizwa sandisa ukuzwela ukuxiliswa kwezicubu, sibhekisa ukubonakaliswa okufana ne-disulfiram, kushukumisa izinqubo zokulungisa.

Umuthi "Metrogil" (ukuphathwa ngokubambisana). Pharmacokinetics

Nge-infusion ye-500 mg imizuzu engu-20, okuqukethwe okungaphezulu kwesidakamizwa egazini kubonakala ngehora. I-metabolism inamaphesenti ama-30-60% omuthi. I-metabolite esemqoka ine-antimicrobial and antiprotozoal effects. Cishe ama-60-80% amaqabunga omchamo, kanti udoti ludluliselwa ku-15% wemithi.

Ukuqokwa

Isidakamizwa siboniswa ukwelashwa nokuvimbela izilonda ezithathelwanayo ezibangelwa ama-microbes ezibucayi. Ngokuyinhloko, lesi sidakamizwa sinconywa ngokungenelela kokuhlinzwa emgodini we-urinary nezitho zangasese. Izinkomba kufanele zibandakanye i-sepsis, i-hepatic ne-intestinal amebiasis ngesimo esibi, i-osteomyelitis, ama-abscesses obuchopho, isikhumba esincane. Imithi "Metrogil" (intravenously) inqunywe izilonda zezicubu ezithambile, isikhumba, amathambo, izifo ezithathelwanayo, izifo zokwelapha. Isidakamizwa sinconywa ukuba i- radiotherapy yezifo (njenge-radiosensitizer ezimweni zokuphikiswa kwe-neoplasm okubangelwa yi-hypoxia kumaseli awo).

Isu Lokusebenza

Isilinganiso sokuqala kubaguli abavela eminyakeni engu-12 - kusuka kwesigamu kuya kwesigamu esisodwa se-drip. Ubude bokumnika imaminithi engamashumi amathathu kuya kwangu-40. Ngamahora angu-8 alandelayo, lesi sidakamizwa sinikezwa 500 mg ngamunye. I-infusion rate isu-5 ml / min. Ngokubekezelelana okugculisayo, emva kokungenwa kwe-2-3 kokuqala, kusetshenziselwa injection yejet. Isikhathi sokwelashwa yisonto. Usuku lungavunyelwe ngaphezu kuka-4 g. Iziguli ezingaphansi kweminyaka engu-12 ubudala, imishanguzo ye- "Metrogil" (nge-intravenously) inqunywe ngokuvumelana nalesi simiso ngesilinganiso esisodwa sama-milligram ayisikhombisa nengxenye kilogram. Ukuze kuvikelwe ukucindezeleka ngesikhathi sokungenelela kokuhlinzwa, iziguli ezineminyaka engu-12 zinqunywe ngaphambi kokuhlinzwa kusuka ku-0.5 kuya ku-1 g ngosuku nosuku olulandelayo ngo-1.5 g / ngosuku. (0.5 mg njalo ngamahora angu-8). Uma lisetshenziswe njenge-agent ye-radiosensitizing, ukuphathwa kwenziwa nge-dropwise ku-160 mg / kg noma ku-4 kuya ku-6 g / m ² emzimbeni womzimba. Ukumnika okwenziwe kungakapheli isigamu sehora ngaphambi kwe-irradiation.

Umphumela wesiphelo sesidakamizwa esithi "Metrogil" (ngaphakathi). Ukubuyekeza

Njengomkhuba wokubonisa, ngenkathi kuqaphela izinga lokungeniswa kanye nomgomo wokulinda, imiphumela engathandeki ikhula ngokungavamile. Ngokusho kwezingcweti, iziguli zibekezelela ukwelapha ngokweqile. Ngokuvamile kungenzeka kube nokuphulwa komsebenzi we-GASTROINTESTINAL TRACT, isimiso sezinzwa. Ngesisekelo se-hypersensitivity, ukuthuthukiswa kwe-reactionergic kungenzeka. Ezinye iziguli zazinxushunxushu, zihloswe, zifisa ukudla, i-mouthfeel yensimbi.