"Azathioprine": imfundo manual, ukubuyekezwa, izincazelo, analogs

Okubizela lesi sidakamizwa "Azathioprine"? Imiyalelo isicelo oluthunyelwe ejenti uzobe achazwe kulo magazini. Siphinde bakutshele ukuthi kukhona contraindications analogue babe lokhu izidakamizwa, yini kubiza, kuzokwenzekani uma ukweqisa izidakamizwa, nokunye. D.

Ukwakheka, emaphaketheni, ijamo, incazelo nomuthi

Ngayiphi Lelifomu liyatholakala ekhelini izidakamizwa "Azathioprine"? Yokusetshenziswa busikisela ukuthi leli imithi itholakala ifomu tablet. isithako wabo asebenzayo uba azathioprine. Futhi kule izidakamizwa futhi zihlanganisa izithako engeziwe ngesimo amazambane isitashi, gelatin, i-lactose, ne-calcium stearate.

Ngo iphakheji ithengiswe lesi sidakamizwa "Azathioprine"? Yokusetshenziswa zomuthi is ebiyelwe ebhokisini amakhadibhodi, okuyinto ibekwe ugodo ephuzi Valium amaphilisi e ibhamuza amaphakethe of izingcezu 50.

izici kwemithi ye nomuthi

Kuyini lokhu imithi ngokuthi "Azathioprine"? Yokusetshenziswa, ochwepheshe zangempela abanolwazi sisho futhi ukuthi izidakamizwa okukhulunywa kuyinto analog "hypoxanthine", "i-adenine" futhi "guanine", kufakwe isakhiwo acid nucleic futhi babonakalise nomphumela Ukuvinjwa maqondana ekwandeni kwezicubu cell division.

"Azathioprine" - ejenti immunosuppressive. isenzo sayo kuhloswe cytotoxicity yeselula.

Kubhekwe umuthi ukwazi zivimbela ukuphendula kwezicubu ukungavumelani futhi kuthinte ukufanisana omzimba, kodwa kuphela ngezinga elincane. Kuqhathaniswa "mercaptopurine" izidakamizwa esebenzayo liveza evelele.

izidakamizwa Pharmacokinetic

Ngemva izidakamizwa temlomo is kahle ugxile kusukela pheshana emathunjini. It has a isibopho ongaphakeme ne-plasma amaprotheni (cishe 30%).

I biotransformation wokukhulula izidakamizwa kwenzeka nge tioinozinovoy acid mercaptopurine (ngamanye amazwi, metabolite esebenzayo). Ingcosana imithi ku nezicubu. Kulokhu, lokuhlushwa encane izidakamizwa ezitholakele ebuchosheni.

Ingxenye-ukuphila azathioprine, futhi metabolites yayo asebenzayo imayelana 6 amahora. I lokuhlushwa eliphezulu kakhulu izidakamizwa egazini waphawula emva kwemizuzu 70-110.

Umuthi kukhishelwa cishe ngokuphelele kanye Bile, futhi% 1-2 kuphela - by nezinso.

amaphilisi izinkomba

Yini prescribers "Azathioprine" (imiyalelo for ukusetshenziswa kwezidakamizwa, analogs, ukubuyekezwa izokwethulwa kamuva)? Lokhu ukulungiselela kuzibonakalisa ngempumelelo lapho kwezinso ezilandelayo:

• psoriasis;
• rheumatoid arthritis;
• obomvu omzimba izicubu erythematosus ;
• izilonda emathunjini;
• dermatomyositis;
• myasthenia gravis;
• inhlamba Pemphigus;
• periarteritis nodosa;
• isifo Crohn ;
• glomerulonephritis, sokuhlasela kwamasosha omzimba;
• ukusha kwesibindi kohlobo ezingamahlalakhona esebenzayo;
• Reiter Syndrome ;
• purpura thrombocytopenic idiopathic.

Kufanele kuphawulwe ukuthi ngokuvamile leli khambi ezinqunyiwe nokuvimbela ukufakelwa ukwenqatshwa. Kodwa kulokhu uphuzwe lihambisana namanye nemithi.

Izimo ukusetshenziswa kwezidakamizwa

Yokusetshenziswa zomuthi "Azathioprine" ulwazi iziguli mayelana Izimo ezilandelayo:

• ukuhluleka hepatic ;
• hypersensitivity kuya izingxenye esebenzayo noma asizayo imithi;
• ngesikhathi sokukhulelwa;
• isimo hematopoiesis abacindezelwe;
• ubudala zezingane;
• ibele.

Nomuthi "Azathioprine": Isikali kanye nokuphathwa

Thatha "azathioprine" amaphilisi kumele iqondiswa ngomlomo. Esimweni ngasinye, umthamo we izidakamizwa kunqunywa kumuntu ngamunye, kuya ebufakazini obutholakalayo, kanye kobukhulu isifo futhi ukwelashwa concomitant.

Ngokuba nokuvimbela imithi xhumelela kwenqatshwa ebekiwe lihambisana "cyclosporin" futhi corticosteroids. Ekuqaleni ukuthatha yokwelapha imithi in umthamo ukulayisha okungukuthi 5 mg ngayinye kg (phezu izinyanga ezimbili). Ngemva kwalokho imithi yesondlo umthamo (1-4 mg ngayinye kg 3 ngemithamo). Ngokuvamile, ukwelashwa okunjalo baqhubeka isikhathi eside. Uma ukhansela umthamo ukwelashwa imithi lehliselwa kancane kancane.

Ngezinye okuvela izimpawu zokuqala ukwenqaba isitho utshalwe liyadingeka ukwandisa umthamo wansuku zonke nomuthi futhi 4 mg ngayinye kg.

Ukuze ekwelapheni ezinye izifo nomuthi ngokuvamile yaphathwa umthamo zonke izinsuku we 1.5-2 mg ngayinye kg 4 ngemithamo ahlukaniswe. Uma kudingeka, lemali ebekiwe zomuthi zingandiswa ukuba 200-250 mg (ihlukaniswe 4 ngemithamo). Isikhathi ukwelashwa nge leli thuluzi isethwe ngamunye, uchwepheshe abanolwazi.

Indlela yokusebenzisa "Azathioprine" (amaphilisi) rheumatoid arthritis? Yokusetshenziswa, izilinganiso (ukulungiselela echazwe yethulwa ngenhla) uthi for ekwelapheni izifo ezifana ebekiwe 1-2.5 ngayinye kg ngosuku mg (ihlukaniswe 2 imithamo). Isikhathi yokwelapha kumele kube okungenani izinyanga 3. Njengoba isekela isiguli unikezwa isilinganiso 0.5 mg ngayinye kg (umthamo owodwa).

Ukuze ekwelapheni kwesibindi kohlobo B okungamahlalakhona (umsebenzi) linqume umthamo zonke izinsuku we 1-1.5 mg ngayinye kg.

Amacala izidakamizwa ukweqisa izidakamizwa

Yiziphi izimpawu ukweqisa izidakamizwa zenzeka edilini lomshado okungalungile "Azathioprine" izidakamizwa? Yokusetshenziswa, odokotela real abanolwazi asho ukuthi umthamo ephakeme zomuthi kungadala isimo ahlukahlukene dyspeptic, pancytopenia, iziyaluyalu imisebenzi kwesibindi kanye nokwenza ngcono nezinye side effects zomuthi.

Njengoba ukwelashwa imihlola efana imithi lingaze. Uma kudingekile, hemodialysis. Nokho, qaphela ukuthi le nqubo akuqinisekisi nokuqedwa ephelele ketshezi asebenzayo kusuka emzimbeni.

izidakamizwa ekuhlanganyeleni

Njengezinye izidakamizwa kuthinta izidakamizwa "Azathioprine"? Yokusetshenziswa lithi babambisane nokuphathwa ejenti nge "Allopurinol" kungaba ngcono imiphumela anobuthi wokuqala, futhi ngokuhlanganyela "-co-trimoxazole" ngokuvamile kuholela nemiphumela myelotoxic.

ukwelashwa kanye kanye nge-ACE inhibitor kwandisa ingozi leukopenia ezinzima.

Lihambisana namanye immunosuppressants (isb, "Cyclosporins", glucocorticoids, anti-CD3 amasosha omzimba) ngokuvamile kakhulu ube nezinguqulo ezihlukahlukene neoplasms kanye nezifo.

ukulungiselela Okubukwe ubukisa umphumela abasiphikisayo ukuze nedepolyarizuyushim imisipha relaxants.

Kufanele kuqashelwe ukuthi ukugoma ngesikhatsi ukwelashwa "azathioprine" ungakwazi ngempela kalula kuholele nokucindezela ukukhiqizwa kwamasosha omzimba (uma yokugoma inactivated), kanye ukwandisa ukufanisana viral (nge nokwethulwa kwemigomo bukhoma).

izincomo ezithile

Izinto ukwazi ngaphambi akunikeze imithi "Azathioprine"? Yokusetshenziswa, yangempela (analogue imithi ezibalwe ngezansi) sibeke ukuthi ezinyangeni zokuqala ezimbili yokwelapha edingekayo isonto ngalinye ukuze bagcine iphethini wegazi neuropathy. Emva kwalesi sikhathi, isifundo ikhombisa izingxenye nge imvamisa 1 ezinsukwini ezingama-30.

Kuyadingeka ukuqapha ezingeni bilirubin, phosphatase ane-alikhali kanye enzyme isibindi.

Ephambi kwezinduna kwezinso of izinso, isibindi, kanye reception ezikanye "Allopurinol" Isikali nomuthi ngaphansi ukucatshangelwa kumele ibe ngu- 1/4 ingxenye.

"Azathioprine" ngokucophelela okukhulu babelwe kulezo ziguli okukuyo herpes zoster, upokisi, xanthine oxidase ukuntuleka kwamavithamini, ukungezwani futhi ngesikhathi emisebeni noma ukwelashwa cytotoxic.

Analogue futhi intengo izidakamizwa

Yini esikhundleni "Azathioprine"? Yokusetshenziswa (intengo nemithi ezibalwe ngezansi) ithi sebeyicwaningisisile izidakamizwa has ontanga ambalwa. I efanayo kakhulu umthelela zihlanganisa imithi ezilandelayo:

• "Alpha-fetoprotein."
• "Alfetin".
• "Stemokin".
• "Profetal".
• "Revlimid".

Njengoba ngentengo ke lo mkhiqizo awukho eliphezulu kakhulu. amaphilisi 50 "azathioprine" ngokwesilinganiso kukhona ruble Russian mayelana 230.

Uphenyo nomuthi

A ukubuyekezwa ambalwa zomuthi "Azathioprine" kusho okuxubile. Abanye abantu ukuthatha imithi ngenxa yesifo sokuhlasela kwamasosha omzimba, weneliseka ukuchayeka yayo ngempumelelo kanye nokuntuleka okukhulu engemihle. Nokho, abanye iziguli kungukuthi obuzwiwa yimuphi umphumela, futhi ngenxa yalokho banquma abakukhethayo kwezinye izindlela.

Kufanele kuqashelwe ukuthi zonke izinkomba ukusetshenziswa zomuthi "Azathioprine" ibhekisele izifo kunalokho sina okuyiwona yokwelapha ngalokulingene anga kuphela kube abanolwazi lochwepheshe. Kule ndaba, esimweni izinsolo khona yisiphi isifo ohlwini ngenhla, kufanele ahlolwe yezokwelapha esibanzi, hhayi ukuzithiba medicate.