"Azathioprine": analogue, intengo, umhlahlandlela kanye nokubuyekeza

isifo sokuhlasela kwamasosha omzimba - iqembu izimo zokucabanga okubangelwa isifo lapho luyanda umsebenzi wamasosha omzimba owakhe umzimba. Ukuze kuncishiswe ukuzivikela komzimba, ebekiwe izidakamizwa ukuthi nesimiso somzimba sokuzivikela. Leli qembu izidakamizwa lubaluleke ku kwezitho ukuvimbela xhumelela ukwenqatshwa. Ake sibheke umuthi onjalo, njengoba "Azathioprine" analogs zomuthi, futhi yokusetshenziswa zezici zalo.

kwebalingisi kwemithi

Ngokwengxenye yakhe izidakamizwa "Azathioprine" iqukethe isithako esebenzayo of the gama elifanayo. Le ngxube yamakhemikhali kuyinto esuselwe izinto ezidingekayo ukuze zamagama of DNA ne-RNA. Emzimbeni, azathioprine unika DNA zamagama, futhi ngenxa yalokho, kuvimbela cell division izinqubo ezicutshini. Ukwehlisa umsebenzi wamasosha omzimba kubangelwa ithonya izidakamizwa "Azathioprine" ku lymphoid.

Ngakho kukhona okusithiyayo of cell division izinqubo kanye neselula amasosha omzimba. Ngemva ukwethulwa "Azathioprine 'ukulungiselela umzimba ukuncishiswa okungavamile inani phagocytes futhi yehlise immunoglobulin zamagama. Ake eminye sihlaziye ulwazi: iziphi izici "Azathioprine" izidakamizwa analogue, intengo, yokusetshenziswa.

Pharmacokinetics

Umuthi is kahle kakhulu angena kwegazi, kanye okuhlushwa wobuningi waphawula ngemva kwamahora angu-2 kuphela ngemva kokuphathwa ngomlomo. Umuthi akuyona ikakhulukazi emizileni ukuze plasma amaprotheni: ngibopha yayo kubo kuze kube u-30%. Ukuze azathioprine isici ukusebenza umzimba eyinhloko noma pass lokuqala ngokusebenzisa isibindi.

Edabula hepatocytes, umuthi is akheka kuya kwakwakhe esebenzayo - mercaptopurine, futhi lapho kuba nemiphumela pharmacodynamic. Ekwakhiweni excreted cishe ngokuphelele Bile. I umchamo excreted ngezinga elingekho ngaphezu kuka-2% wezindleko nomuthi.

izinkomba

Ukulungiselela "Azathioprine" analogue ngalolu ketshezi esebenzayo efanayo akhonjiswa ukuze isetshenziswe ukufakelwa ukuvimbela xhumelela kwenqatshwa ukuphendula.

Futhi, isidakamizwa wayisebenzisa practice rheumatological ukwelapha isifo samathambo onaso sibe nezifo sokuhlasela kwamasosha omzimba ezifana isifo sokusha kwesibindi, omzimba izicubu erythematosus, psoriasis, purpura thrombocytopenic, pemphigus, nabanye abaningi.

Izimo

Izidakamizwa "Azathioprine" is contraindicated in iziguli hypersensitivity kuya ingxenye izidakamizwa. Ngenxa yokuthi lo muthi kuvimbela wonke amagciwane wegazi, "Azathioprine" is contraindicated ku yezifo igazi (anaemia leykotsito- futhi lymphopenia, thrombocytopenia), kanye abakhulelwe nabancelisayo.

Sebenzisa ngesikhathi sokukhulelwa futhi ibele

Ingqikithi asebenzayo ludlulele ngaphakathi ubisi lwebele futhi ngokusebenzisa isithiyo gematoplatsentarny. Kule ndaba, ukusetshenziswa is hhayi Kunconywa e abakhulelwe kanye nokuncelisa ibele. Uma kudingekile, ukuqokwa izidakamizwa noma analogue yayo kulesi sigaba sabantu kuyadingeka ukuhlola ubungozi ukusetshenziswa ukusetshenziswa kwezidakamizwa kanye nobungozi unina nele-fetus. Lapho ukwabela ejenti phakathi ibele muva ukukhansela.

Izici isicelo

Umuthi futhi analogs yayo kufanele lisetshenziswe ngokuqapha e iziguli upokisi, futhi kwezinye iziguli kanye nokuntuleka xanthine oxidase.

side effects

Iqembu esemqoka ye emibi ehambisana okusithiyayo of umnkantsha umsebenzi, obangela ukukhiqizwa kwamangqamuzana egazi abomvu. Ekusebenziseni analogs equkethe azathioprine, ukwanda ubukhulu lamaseli igazi, ukuncishiswa leucocyte ukubala, ukubala platelet, ukuntuleka kwegazi emzimbeni.

Ukuze ingxenye ipheshana wokugaya ukudla ezivame kakhulu emibi ibandakanya: kwehle esesuthi, sezinyawo neziyaluyalu, kahle umsebenzi hepatic, izilonda emathunjini yokusetshenziswa pheshana emathunjini. ukulahlekelwa olungenzeka hepatocytes, kulandele ukwanda bilirubin noma ezinye izivivinyo kokusebenza kwesibindi. In iziguli othola uhlinzwe ukuze isitho Ukufakelwa nezicubu angagcina pancreatitis, izilonda emathunjini of ingaphakathi lesisu, amathumbu, ukuthuthukiswa kwesibindi anobuthi.

komzimba kwenzeka kakhulu kuyaqabukela lapho zaphathwa izidakamizwa "Azathioprine" analogs kwezindlu kusekelwe kuyo (isb, "Azathioprine"). Izenzo neze, ikakhulu ngenxa ukuqubuka kwesikhumba noma uthi okunomkhuhlane.

Phakathi kwezinye imiphumela emibi kufanele kuphawulwe ukuthuthukiswa izinqubo yesibili ezithathelwanayo emzimbeni, ukubukeka ubuhlungu kwemisipha ne ngokuhlanganyela, acute kwezinso esingamahlalakhona sokusebenza. Kwezinye izimo ezinzima, lesi sidakamizwa "Azathioprine" analogue ngalolu ketshezi esebenzayo esifanayo kungabangela isifo sokulahlekelwa igazi hemolytic, enika izimpawu kusukela isimiso sezinzwa esiyinhloko. Azathioprine njengoba pharmaceutically izidakamizwa esebenzayo, ingxenye igama elifanayo izidakamizwa futhi analogue yayo, unomthelela evelele embungwini (imiphumela teratogenic futhi mutagenic) nonekhono ingqondo ukubonakala isimila izinqubo kanye umdlavuza wabo okwalandela. Ngakho, kubalulekile ukuba uhlole ukuqokwa izidakamizwa "Azathioprine" (amaphilisi) ukubuyekezwa, izincazelo, analogue izidakamizwa bese ukhetha amacebo kwesokudla. Lapho ubheka ikusasa, siphawula ukuthi njengoba esebenzayo isithako azathioprine uzabalaza nemiphumela ezuzisayo phezu inkambo isifo, ngokuvumelana izinkomba. Lokhu kuboniswa odokotela nje kuphela kodwa futhi iziguli ngokwabo.

"Azathioprine" - omqondofana, analogs

Azathioprine - esiyingqayizivele ngendlela yalo into kokuba isenzo immunosuppressive. Uma sicabangela emakethe ezithaka imithi akuyona kakhulu amalungiselelo emelelwa kahle equkethe azathioprine. Analogs "azathioprine" kungenziwa linikezwa izidakamizwa ezinjalo, njengoba "Azathioprine".

Umuthi itholakala ifomu ithebhulethi nge efanayo okuqukethwe azathioprine. I ehilelekile kuphela izindleko "Azathioprine" zomuthi, okungakwazi ezikhathini 4-5 izindleko "azathioprine" ukukhiqizwa Russian.

Ubuthi kanye ukweqisa izidakamizwa

Izidakamizwa ukweqisa izidakamizwa "Azathioprine" futhi okuphikisana nalo "Azathioprine" wabonakaliswa iziyaluyalu pheshana emathunjini, ukucindezelwa of umnkantsha umsebenzi, kanye lenyuka isibindi umsebenzi ukuhlolwa. ukwelashwa ubuthi njengoba izidakamizwa uqobo kanye analogue yayo siyefana, okuhloswe ngaso nokuqedwa okusheshayo zomuthi emzimbeni. Ayikho yokuvimbela ethize. izindlela Dialysis ngokukhishwa kobuthi egazini aphumelela ngokwengxenye ngoba imfuyo kusebenza kuze kube kubo excreted hhayi ngokuphelele.

Izixwayiso

Umuthi futhi analogs yayo kungukuthi Kunconywa ukuba isetshenziswe eside. Ekuqaleni ekwelapheni kudinga nokuqapha njalo amaseli wegazi neuropathy, kanye nokuqapha enzyme isibindi.

Esikhathini esizayo, ukulawula nsuku zonke sokuthatha ikhefu, ziqhuba izifundo ukuqapha kanye noma kabili ngenyanga.

isiphetho

Umuthi futhi analogs yayo angaqoka kuphela uchwepheshe abanolwazi. Ngaphambi kokuqala ukuthatha inkambo zoku- ahlolwe ngokugcwele futhi mhlawumbe ukuqhuba yokwelapha yesondlo. Ukuze uthole olunye ulwazi, kwenza ukuqokwa kwe "Azathioprine" imiyalelo ukulungiselela ukusetshenziswa. Inani, analogue kwaleli thuluzi njengengxenye negagasi iziguli. Ngakho, izindleko ubuncane amaphilisi 50 kuyinto endaweni ruble 250-300, futhi mayelana analogue eshiwo ngenhla. Ngaphambi kokuqala ukuthatha inkambo wena kumelwe acabangele "kochwepheshe" futhi "nebubi 'futhi baqale ukwelashwa.