Antidepressant "Velaksin": kobufakazi nesineke, yokusetshenziswa, analogs

Ngingaba ukuthenga antidepressant ngaphandle kadokotela? Uhlu imikhiqizo efana ingenkulu. Lokhu kungenxa yokuthi ingase idle isikhathi esiningi, futhi zaziziningi engemihle. Ngakho-ke, ngaphambi kokuthatha zindlela, qiniseka ukuthi uvakashela onguchwepheshe.

ulwazi olujwayelekile

Ukucindezeleka hhayi ziphathwe izidakamizwa. Kodwa ncono kusebenta isimiso sezinzwa, odokotela abaningi namanje linqume ukuba iziguli zabo antidepressant ahlukahlukene. Omunye wabo lesi sidakamizwa "Velaksin". Nobufakazi ngalokhu ithuluzi kanye nezici zayo futhi yokusetshenziswa izokwethulwa ngezansi.

Ukwakheka izidakamizwa, injalo zokukhiqiza

Ngayiphi ifomu ke ukhiqiza i antidepressant ngokuthi "Velaksin"? Amaphilisi kanye amaphilisi - kukhona kuphela izinhlobo zomuthi.

Tablets "Velaksin" asemhlophe, kuqoshiwe uhlangothi olulodwa "E741", futhi isiyingi ukuma flat futhi chamfer. isithako yabo esebenzayo venlafaxine, okumelelwe ngesimo a hydrochloride. Bahlanganiswa nalesi imithi zihlanganisa izingxenye asizayo ezifana colloidal Silica anhydrous, monohydrate lactose, sodium isitashi glycolate, magnesium stearate futhi MCC.

amaphilisi Phama ibhamuza amaphakethe kanye amabhokisi ngokulandelana.

Izidakamizwa "Velaksin" - amaphilisi, yokusetshenziswa zazo ebiyelwe isembozo, iphepha, gelatin futhi eliqinile. Sinenkosi orange ansundu cap futhi substrate kungekho nto enemibala emihle. Uphiko asebenzayo yaleli fomu ubuye venlafaxine kwakwakhe. Ngaphezu ingoma yakhe lokhu imithi zihlanganisa izithako engeziwe.

Njengoba imisebenzi izidakamizwa?

"Velaksin" - isizukulwane esisha elwa nokudangala. Ngokusho isakhiwo chemical izidakamizwa zalo asebenzayo ingeyona isiphi isigaba eyaziwayo antidepressant (isib tricyclic, tetracyclic, noma ezinye). Ochwepheshe bathi izidakamizwa iyasebenza enantiomer 2 racemate.

Umgomo we isinyathelo yalesi izidakamizwa ihlobene ikhono layo potentiate le CNS emsipheni ngiyibona yokudlulisela.

Ngokusho imiyalelo, venlafaxine futhi metabolite yayo enkulu (EFA noma O-desmetilvenlafaksin) ukumela inhibitor anamandla we reuptake ka norepinephrine futhi serotonin futhi inhibitor ezibuthakathaka Dopamine reuptake. Asinakusho ukuthi lezi izinto bekwazi ukunciphisa umsebenzi beta-adrenergic emva imithi olulodwa futhi njalo. EFA futhi venlafaxine aphumelela ngokulinganayo ngokumelene reuptake ka neurotransmitters.

Yini enye engingabuye izidakamizwa emangalisayo "Velaksin"? Umhlahlandlela ibika ukuthi isithako esebenzayo zomuthi ine wahlangana ngobuhlobo la mangqamuzana n- m-cholinergic, ubuchopho α1-adrenoceptors futhi histamine H1-receptor. Ngaphezu kwalokho, kuvimbela isenzo mao futhi ayinaso ukufana ne fentsiklidinovymi, opioid, benzodiazepine futhi NMDA-receptor.

I kinetics zomuthi

ngabe izidakamizwa amuncwa umzimba, "Velaksin" (amaphilisi)? Iziyalezo yokusetshenziswa uthi ingxenye esebenzayo yalesi izidakamizwa kahle ugxile kusukela esiswini. Ngemva umthamo owodwa we-nomuthi ngezilinganiso ka 25-150 mg lokuhlushwa yayo eliphakeme egazini kufinyelelwe ngemuva kwamahora 2.4. Ngakho venlafaxine lisasetshenziswa akheka phakathi pass lokuqala ngokusebenzisa isibindi. Uma umuthi nokudla, ngenkathi isiqongo sayo lokuhlushwa inyuka ngo imizuzu 27-30 e-plasma.

I metabolite main kubhekwa indlela O-desmetilvenlafaksin. isigamu-ukuphila nokuqeda yayo uhhafu-ukuphila venlafaxine kuyinto 11 no-5 amahora, ngokulandelana (okukhipha ngefomu ingashintshiwe nge izinso).

I kinetics izidakamizwa ezimweni emitholampilo ekhethekile

Izidakamizwa "Velaksin" imfundo liyadingeka ukufunda kubantu abanegciwane isifo sokusha kwesibindi unezinye izici kinetic. igazi lokuhlushwa izidakamizwa kwanda kulezi iziguli, futhi ulinganisele yayo excretion, kunalokho, encishisiwe.

Ngo esingamahlalakhona kwezinso ezinzima, ukwehluleka kwezinso uphinde ungamele imvume Imininingwane EFA futhi venlafaxine kuyehla nokuqedwa isigamu-nokuphila isikhathi yinde.

Kufanele kuqashelwe ukuthi le ngobulili nobudala isiguli ayithinti le pharmacokinetics zomuthi enixoxa ngalo.

izinkomba ngoba

Kungani sidinga ithuluzi ezifana "Velaksin"? Ukusetshenziswa kwalesi izidakamizwa kuboniswe ukucindezeleka Lokudabuka ehlukahlukene (yokwelapha kanye prophylaxis).

Uvala ukuqokwa

Kungaphansi kwaziphi hhayi izimo ungasebenzisa izidakamizwa "Velaksin"? Izibuyekezo iziguli kanye odokotela bathi lokhu izidakamizwa is contraindicated ukuthola:

• ngenkathi ethola mao inhibitor ;
• e ezinzima izinso iziyaluyalu;
• ngesikhathi sokukhulelwa esolwa noma ezimisiweyo;
• in iziyaluyalu ezinzima kwesibindi;
• ngesikhathi ibele;
• entsheni futhi ebuntwaneni, okungukuthi, kuze yobudala;
• ngozwelo eliphezulu emuthini.

Ngaphezu kwalokho, lokhu izidakamizwa kufanele ngokucophelela ezithathwe angina engazinzile, isilethikusebenza (kuhlanganise esanda bafudukela), umfutho wegazi ophakeme, Ukudlikizela umlando, tachycardia, ukuncipha emzibeni, waqinisa intraocular, engela-Ukuvalwa ukufiphala nezici ezithile ukuze opha lwamafinyila kanye isikhumba, uthi eshintshashintshayo.

Izidakamizwa "Velaksin" (amaphilisi): yokusetshenziswa

Antidepressant "Velaksin" kufanele kuphela ezithathwe ngesikhathi sokudla. I Kunconywa sokuqala umthamo zomuthi 75 mg, ahlukaniswe 2 ngemithamo ahlukaniswe (ngamanye amazwi, 37.5 mg kabili ngelanga), nsuku zonke.

Uma ngemva kwamasonto ambalwa okwelashwa, isimo lesiguli akubi ngcono, umthamo wansuku zonke luyanda 150 mg ngosuku, ngemithamo ezimbili ohlukeneko (isib 75 mg kabili ngelanga).

Uma isiguli kudinga umthamo ephakeme i antidepressant (isib disorder ezinkulu futhi bacindezeleke, noma ezinye izimo ezidinga ukwelashwa umile), khona-ke uchwepheshe ungakwazi uqoke 150 mg izidakamizwa ngo-2 amahora, bese kancane kancane ukwandisa umthamo ngo-75 mg (ngemva kwezinsuku 2-3) ukufeza umphumela oyifunayo.

Ngokusho imiyalelo, umthamo esiphezulu "Velaksina" kuyinto 375 mg ngosuku. Ngemva kokufinyelela nomphumela ofiselekayo, kungashiwo kancane kancane sehliselwe ubuncani.

zokuvimbela Ukushiyeka nokwelulekwa yesondlo

ukunakekelwa sisekele izimali kungathatha kusuka ezinyangeni eziyisithupha. Kulokhu, imithi kuthathwe ngemithamo omncane.

Ngo omnene esingamahlalakhona kwezinso ukulungiswa kokudla nokufakwa lwemithi liyadingeka. Ngo isifo esifanayo umthamo ngokulinganisela Kunconywa aphansi by 25-50%. Kufanele kuphawulwe ukuthi venlafaxine akufanele lisetshenziswe ezinzima esingamahlalakhona kwezinso, njengoba engekho ulwazi ukuphepha yokwelapha enjalo kuze kube manje, cha.

Abantu abaku- hemodialysis, kumele zithole 50% umthamo evamile yansuku zonke zomuthi ngemva kuseshini kuphelile.

Ukuze omnene hepatic esingamahlalakhona ukulungiswa kokudla nokufakwa lwemithi futhi kungadingeki. Lapho lesi sifo umthamo ngokulinganisela kufanele yehliswe ngama-50%. Ngokuphathelene ukwehluleka ezinzima hepatic, kulesi simo ukusetshenziswa venlafaxine akuvunyelwe.

Ngo abadala, lesi sidakamizwa "Velaksin" kumele kusetshenziswe ngokuqapha okukhulu. Lokhu kungenxa kungenzeka yini ukuthi kwephulwe nezinso. Iziguli kumele linqume umthamo ephansi ngempumelelo. Kulokhu, isiguli kufanele kube ngaphansi kweso lwezokwelapha njalo.

Khansela antidepressant

Lapho beqeda ethola izidakamizwa kufanele kubhekwe ukunciphisa umthamo kancane kancane (ngaphakathi ngesonto). It is abulunge ngezimo zesiguli, ukuze unciphise ingozi ukusabela ezingezinhle elihlobene ne ukuqedwa zomuthi.

Isikhathi esidingekayo ukuze ukumisa okuphelele imithi, kuncike umthamo, ubude ukwelashwa futhi kumuntu nomuntu.

side effects

Yimiphi imiphumela engadingeki izidakamizwa kungabangela "Velaksin"? Nobufakazi bathi ukuthuthukiswa walabo noma ezinye izigameko ezingezinhle ezavela kulandela ukusetshenziswa kwaleli thuluzi kuncike umthamo wathola.

Ukusabela esivamile wabonisa imvelo ezimbi zihlanganisa lezi ezilandelayo:

• umfutho wegazi ophakeme, kwehle esesuthi, amaphupho normal, ukuqunjelwa, ukuqwasha, isicanucanu, siwasebenzise kwesikhumba, ukundindizela, ukuhlanza, imisipha amajaqamba, nomlomo owomile;
• ukuhhema, i-hepatitis, ukuncipha emzibeni, tachycardia, hyponatremia, ukunganakwa, hypotension postural, isiyezi, ukuphendula ukwenama, excitability kwemizwa, yawning, paresthesia, syndrome neuroleptic, stupor, syndrome serotonergic;
• anda imisipha ithoni, ukuquleka, dysuria, photosensitivity, nokugcinwa urinary, anorgasmia;
• ukopha isikhumba, ejaculation normal, menorrhagia, kwehle libido, ukujuluka;
• thrombocytopenia, yokuhlala thuthuva, erythema multiforme, mydriasis, Stevens - Johnson, ukuphazamiseka visual, ukunambitheka kahle, prolongation ezophayo isikhathi, ubuthakathaka, ukuqubuka kwesikhumba, ukukhathala, ukusabela anaphylactic.

Kufanele kuphawulwe ukuthi emva ukudamba ngokushesha imoto kubhekwe noma ukunciphisa umthamo yayo zingenzeka ezifana side ukusabela njengoba kwemizwa ukucasuka, ukukhathala, uhudo, ukozela, ukungahlaliseki, ikhanda elibuhlungu, paraesthesias, isicanucanu, hypomania, ukuhlanza, ukujuluka, sokuzincisha ukudla, ukuqwasha, ezomile umlomo, ukukhathazeka, isiyezi kanye disorientation. Ngokuvamile, lezi zimpawu simnene futhi uhambe ngaphandle iyiphi indlela yokwelapha.

izincomo

Kungakhathaliseki ukuthengisa non-kadokotela anti-depressants? Uhlu lezi imithi akuyona omkhulu kakhulu ( "Prozac", "Paxil", "Despres", "Azafen", "Persian", "amitriptyline"), futhi lesi sidakamizwa "Velaksin" akufakwanga ke. Thenga ke Pharmacy, unga kuphela kadokotela kadokotela.

Ngaphambi kokuthatha lesi imithi kokubuyekezwa, ikakhulukazi iziguli ezinokuphazamiseka bacindezeleke, kufanele kubhekwe awokuthi imizamo yokuzibulala. Kule ndaba, ekuqaleni ukwelashwa Kunconywa ukuba isetshenziswe umthamo ubuncane nangaphansi eduze kweso lwezokwelapha.

Abantu ne kwemizwelo ngesikhatsi ukwelashwa nge antidepressant angagcina isimo ukwenama noma hypomanic.

Iziguli kufanele qiniseka sixwayisa ngokusondela isidingo ngokushesha ubone udokotela uma izakhi urticaria, ukuqubuka noma ukusabela kabi komzimba.

Ezinye iziguli enqubeni ekutholeni venlafaxine waphawula ukwanda umthamo ancike wegazi.

ezigulini esezikhulile kufanele waxwayisa ngokuhlehla kungenzeka yini ukuthi kwephulwe umqondo ukuzimelela kanye nesiyezi ukuthuthukiswa.

Phakathi ekwelapheni izimali kufanele agweme ukuthatha iziphuzo ezidakayo.

Antidepressant "Velaksin": kobufakazi nesineke, analogue umkhiqizo

Okushiwo ngabantu ngalokhu izidakamizwa isiguli? Iningi labathengi liye labika inani elikhulu side effects ezenzeka ngenkathi kokuthatha lesi imithi. Isikhathi esining impela lokhu izidakamizwa kubangela ukusabela ezingezinhle ezifana ukozela, ubuthakathaka, ukuqwasha, ukuquleka, ukucabanga okungavamile, ukucindezeleka futhi ukudideka. Ngaphezu kwalokho, ezinye iziguli zithi miphumela okusalayo ngemuva kokuphothulwa ukwelashwa. Futhi, abasebenzisi eziningi akhononde ukubonakala izimpawu zokuqaleka kanye nokulutheka.

Yini esikhundleni antidepressant ezifana "Velaksin"? Analogs yalesi izidakamizwa akufanele ezitholakala yonke drugstores. Njengomthetho, ochwepheshe Lezi zihlanganisa lokhu okulandelayo: "Venlafaxine Sandoz", "Efevelon", "Alvent", "Nyuvelong", "Velafaks", "Dapfiks", "Voksemel", "Venlaksor", "Vensuert", "venlafaxine".