Wena usho kanjani ukuthi, 'HCV RNA itholiwe "? Ukuhlaziya HCV RNA

Utheleleke nge-hepatitis C can ngamunye. Abantu abaningi banombono sifo iminyaka futhi ngeke zazi ngisho nokuthi baye sethulwa ngo indlela ukuthi ngesinye kuholele kona kuletha imiphumela emibi. Abantu abanjalo ngenkuthalo ukuthelela abanye, futhi ngesilinganiso Kuvamisile ngokuqhubekayo okwandisa. Ukuze wehlise lezi zibalo, umuntu kufanele wenze kube umthetho ukuba ibhekane ukuhlaziywa yezikhathi sokusha kwesibindi kohlobo C, ikakhulukazi uma isengozini.

lwati lolufinyetiwe isifo

Hepatitis C virus (HCV) RNA-molecule yakhiwa ethwele ukwaziswa kwezakhi zofuzo namaprotheni ekhethekile lapho uxhumana umzimba womuntu. Ezithathelwana ngocansi ikakhulukazi ngokusebenzisa igazi. Kwezinye izimo, kungenzeka ukudluliswa mpo (t. E. Kusukela kumama kuya enganeni).

Engena phakathi umzimba, ke luhlala kumaseli ahlukahlukene igazi (ama-neutrophil monocytes, ama-lymphocyte) futhi isibindi (hepatocytes).

ukutheleleka inkohliso kuyinto engekho izimpawu esigabeni oyingozi. It ngokushesha iba asymptomatic chronic kancane obonisa emiphumeleni yayo ebulalayo.

imiphumela

Kusukela ekuqaleni Ukungena emzimbeni HCV RNA phambi izimpawu zokuqala kungathatha iminyaka eminingi, kokunye kuze kuphele iminyaka 15-20 noma ngaphezulu. Ukuvela izikhalazo ejwayelekile yamafomu eziseqophelweni sokusha kwesibindi kohlobo C, isibindi isivele kakhulu abathintekayo. Iningi lalaba bantu lihlale iziguli uxilongwe elandelayo izifo zesibindi:

• isifo sokusha;
• necrosis;
• izinhlumba ingozi;
• Oncology.

Ngaphambi ukuthuthukiswa yezinkinga isiguli angase abone indisposition okuncane, ngokuvamile akusho unamathisele ukubaluleka.

Ukuze afeze ukuhlaziya

Ukuhlaziya HCV RNA ukhonjiswa abantu bethambekele ekubeni ukutheleleka. Ngo iqembu elinjalo yilezi:

• abayimilutha;
• abantu ngokobulili;
• bonke abenza izenzo socansi olungavikelekile, ikakhulukazi nomlingani entsha;
• abalandeli tattoo, ukubhoboza, ubuhle salon (abalungisa izinwele);
• abantu abaye zabhekana izinqubo kuhlinzwa (kuhlanganise nokubeletha, isifo amazinyo);
• Wazalelwa phambi 1990, omama izingane (yokuthi ngesikhathi lesi sifo ingakamiswa ezikhonjwe, ngakho ukumpontshelwa laba besifazane itheleleke ngegciwane);
• Izingane nomama;
• amalungu omndeni kanye nabo kwezocansi we onegciwane;
• Iziguli ezingamahlalakhona isibindi isifo bemvelo engaziwa.

Loluhlu ngempela ebanzi, abambalwa kangaka ngubani bakwazi ukusho ngokuqiniseka ukuthi ingozi yakhe ukutheleleka zero.

ukuhlolwa ikhaya

Abaningi bangathanda ukuthi zihlolelwe ukuzimisela HCV RNA, kodwa hhayi ukuya kudokotela ngenxa yamahloni, yokungabi nesikhathi esanele, ukungathandi ezibhedlela nokunye. N.

Ingabe ukusiza ukuxazulula inkinga uphethwe elula usebenzisa Assay ekhethekile okusheshayo (ELISA). Kulokhu, indlela qualitative inquma kuphela yokuthi ukuba khona amasosha igciwane.

Isebenza isimiso uvivinye sokukhulelwa, kodwa njengoba igazi ukuhlolwa impahla edingekayo:

1. Qedela nge isiqeshana plastic (qapha ukuze iyohlolwa) kuyinto Lancet ekhethekile ihlaba umunwe ngaleso touch of a inkinobho.
2. Nge ingxenye igazi pipette ibekwa egunjini elikhethekile, futhi emva kwemizuzu 10-15 ukuhlola impendulo.
3. Amabha amabili zibonisa yalokho omuhle, munye - ongemuhle. Nokho, ukubukeka Esikhunjeni Esiphaphathekile of endaweni yesibili ezonini ukuhlola kubonisa khona isifo, lokuhlushwa masosha omzimba egazini liphansi kakhulu.

Uma lesi sifo ukhonjwe, kubalulekile ukuya udokotela ukuhlola okunzulu.

Izimiso eziyisisekelo ukuthola HCV RNA

Ngalezi Imiphumela kubalulekile ukuba siphendukele zezifo ezithathelwanayo namakhambi Hepatology, ngubani uzoqoka kokuxilongwa ezengeziwe.

Into esemqoka ukuba afeze Uhlaziyo luqhubeka - ukukhomba lapho genotype zihlanganisa kokutholakala ukushisa kwesibindi, ukucacisa senani egazini. Kusukela idatha etholwe kuzoncika okunye ukwelashwa, kusukela zonke izinhlobo ihluke nomunye futhi banganika tiphakamiso letehlukile izidakamizwa. Ngaphezu kwalokho, angenziwa bayakwazi ngobuciko simaskwe.

izinhlobo zocwaningo

Ngo sitholakele HCV usebenzise eyodwa yezindlela ezilandelayo:

1. PCR. Kulokhu sikhuluma izinhlayiya eziyisisekelo zofuzo we lwegciwane.
2. ukuhlaziywa quantitative ka HCV RNA (r-DNK, TMA). azihlole Kwenziwa emva isiqinisekiso khona pathogen emzimbeni. Ibizwa nangokuthi wegciwane. It ikuvumela ukuba ukuhlonza inombolo abamele pathogenic e 1 ml igazi. Kusukela lezi yizinkomba incike isikhathi sokwelashwa degree of infectiousness isiguli. R-DNK wenza ukuhlolwa uhla phezu 500 ME, futhi TMA at 5-10 ME. Bobabili izindlela abhekwa elula ezishibhile.
3. Genotyping. It kwenziwa zokugcina futhi ivumela ukuba ucacise lapho zilwane zihlanganisa ekuboneni lesi sifo.

Ukuhlolwa Imiphumela

Uma ukuhlaziya HCV RNA wawumuhle ngu-PCR futhi ELISA, uphethwe kuqinisekisiwe. Nokho, umphumela omubi akukuniki lokuqiniseka ukungabi ukutheleleka. Ngeshwa, kuyenzeka kaningi ngoba inqubo kungasetshenziswa reactants nge okuhlonishwayo ezahlukene.

Abantu abaningi bayazibuza ukuthi kusho, "HCV RNA itholiwe". Lobu bufakazi kungase kubonise ngempela ukungabi khona kwezifo noma emakamu yayo ongaphakeme. Ngokwesibonelo, i-PCR 200 ME / ML akhiphe imiphumela eyiphutha uma inombolo nesineke kwamakhophi viral kancane. Lokhu kungenzeka uma igciwane yamuva noma ngesikhathi ukwelashwa.

Ngokuvamile isiguli ayidingi ukuba ulidle ulwazi olunje, kusukela ngala maphuzu kufanele kucatshangelwe ngu udokotela ukuba khona.

Ukuthola HCV RNA ocwaningweni ambalwa ku-400 000 ME nokuningi uthi igciwane alikho kuphela igazi, kodwa futhi ngenkuthalo okusakazwa, ngaleyo ndlela bathelela abanye na. Uma Inkomba iseduze 800 000, kuba eyabonisa esigabeni oyingozi futhi esebenzayo amaseli isifo sesibindi.

Nakuba kukhona umbono uchwepheshe washintsha. Ezinye zazo baphikisa ngokuthi ubuhlobo ijubane ukuqhubeka kwesifo kanye inani lamakhophi encwadi engeyesibili igciwane khona.

Iziguli ezinjalo kufanele baqaphele ikakhulukazi ukuxhumana nabathandekayo babo.

nophenyo ezengeziwe

Ngemva sokunquma HCV RNA nezinye izifundo angabelwa ukuba isiguli, ehlanganisa:

• ukuthola ukusha kwesibindi kohlobo B,
• ukuhlaziywa jikelele egazi noma omchamo;
• biochemistry;
• Ultrasound esiswini;
• MRI noma ama-CT scan kwesibindi (kuboniswe).

Emva kokuthola yonke imininingwane edingekayo udokotela ehlola ngokucophelela imiphumela, isimo sezempilo lesiguli, bese ukhetha umuntu uhlelo ukwelashwa kuye.

Lapho ukuthola esifike umonakalo hepatic, ngokuvamile engekho.

izindlela zokwelapha futhi isikhathi

Isikhathi ukwelashwa incike genotype. Namuhla siyazi 11 zezintaka okuyinto 6 nkinga ivame kakhulu. ERussia, ezivame kakhulu 1, 2 hlobo 3rd.

Eminyakeni embalwa edlule hepatitis C wayephakathi kweqembu izifo ezingelapheki. Ukwelashwa olwenziwa ikakhulu interferon, kungenzeka kakhulu ngcono ngezimo zesiguli, kodwa abahlulekayo ukumphilisa ke ngokuphelele.

Breakthrough ekwelapheni isifo ube izidakamizwa "sofosbuvir," esavela kuyi Pharmacy ngaphansi ezahlukene egameni lendawo yokuhweba noma "Sovaldi". Kuze kube manje, kukhona eziningana izindlela eziphumelelayo analogue:

• "Viropak";
• "Gratitsiano";
• "Geptsinat";
• "Gopetavir".

Ngokuvamile, basuke kahle ikubekezelele iziguli, kodwa kwezinye izimo kuyagcinwa:

• ikhanda;
• isicanucanu;
• ukuqwasha;
• ukulahlekelwa esesuthi;
• Ukudlikizela;
• migraine;
• nokucindezeleka;
• umuzwa ukoma emlonyeni;
• ubuhlungu besifuba;
• nezinwele.

I ethile kuphela zale ndlela yokwelapha - (. Okuyisilinganiso sabangu-10 000-12000 p iphakethe ngalinye) eyingozi kakhulu, Okungukuthi, kuncike nomuthi akhethiwe ingahluka liye phezulu noma phansi.

reinvestigation

Ngemva ukwelashwa, okuthatha amasonto 12 kuya 24, isiguli bayonikezwa ukuhlaziya liphindwe khona RNA viral egazini.

Kulokhu, kufanele kusetshenziswe indlela nge embundwini ubuncane ukuzwela, kusukela ngemva kokungenwa HCV izidakamizwa lokuhlushwa kungenzeka azinakwa. Kulokhu ukwelashwa kufanele baqhubeka.

A yi negative ukungabi-hepatitis C virus RNA lapho lwegciwane kutholwa. Ukutadisha okunjalo kwakuzodingeka ukuchitha isikhathi xaxa (ngezikhawu iDemo), ukuqinisekisa ukuthi ukwelashwa okuphumelelayo.

zokuvimbela

Wonke umuntu obelokhu ukwelashwa okude nezindiza ukusha kwesibindi kohlobo C, kuyafaneleka ukukhumbula ukuthi lomzimba wakhe asisho ukukhiqiza amasosha omzimba, ngakho bathelelane kungenzeka.

Lesi sifo kulula ukuze kuvinjelwe kuka ukuze ikhambi. Vikela ngokugcwele ngokwakho kusuka noma yini engalifaka engozini akusebenzi, kodwa ukuze ke Akumele ucele ukuthi kusho, "HCV RNA itholiwe", izinyathelo ezilandelayo kufanele libukwe:

• ungasebenzisi inhlanzeko yomuntu siqu kwabanye abantu izinto (izinsingo zokushefa ezilahlwayo, sikelo, lokuluhlaza amazinyo);
• Gwema ucansi olungavikelekile;
• vakashela udokotela wamazinyo, nokucwala (ubuhle, izindawo zokudweba imifanekiso, njll ...) kuphela idumela elihle;
• ukuvala wonke umonakalo usimende noma ngebhandeshi isikhumba;
• ngangokunokwenzeka ukuze zigweme ukuthintana nomuntu onegciwane.

ukuba nombono ongafani ngeke

I ngaphambili lesi sifo itholiwe, ephumelela kakhulu ukwelashwa kuyoba. Ngokuvamile, ngokungabi bikho yangaphakathi isitho hepatitis C ingelapheka ngokuphelele futhi ngaphandle kwemiphumela.

Uma iyekwa ingelashwa sokusha kwesibindi kohlobo C, uyobe ngokushesha noma kamuva kuholele sibe sesomile noma nomdlavuza wesibindi. Lokhu kungenzeka nangemva kweminyaka 30-40 emva igciwane.

Ngokoma kwesibindi, eyabonakala bedle hepatitis C kuyinto isifo esingalapheki. Ngo zisaqala kungenzeka ukubambezela ukugeleza esimweni egijima kuphela ongasindisa abantu isibindi ukufakelwa.

Lapho ufunda umphumela omuhle ukusha kwesibindi kohlobo C, musa ngokushesha ukwethuka. Okokuqala, kufanele uhlole isimo isibindi sakho bese uqale ukuthi ilwe nezifo comorbidities. Ukwelapha lide futhi kuyabiza, kodwa inikeza lesi nesineke ithuba ngesikhathi impilo ende futhi enhle.