UProfesa Skulachev: ngeso lehla. Eye lehla "Vizomitin" (lehla Skulachev), inani Umhlahlandlela

Isikhathi akusho yima, zonke izinhlobo zokuphila begazi Emhlabeni angaphansi izinguquko ukuguga. Okuphambili izinqubo ukuguga ukuthola ukubukeka Ukunganeliseki umzimba siqu nabanye, okuvela motion ngesikhathi ukuphefumula okusheshayo, dyspnea, walunguza ukuma kanye nokunyakaza ishintshela kokungavinjelwe. Ngaphezu kwalokho, umbono liwohloka.

Kukhona umbono, ngenhlanhla, kuvamile ukuthi inqubo yokuguga akuyona into ayeke, bese wehlisa ijubane cishe akunakwenzeka. UProfesa Skulachev, ngeso lehla okuyizinto ngempela nethonya isimangaliso, ithobela nezinye umbono.

Yiqiniso, ukuguga - kuyinqubo engokwemvelo, kodwa ngasizathu simbe akunakuba sokwehlisa ijubane? Aging aliyona ngaphandle isizathu. Ngo kwesiyingi ososayensi ehilelekile inqubo yokuguga komzimba womuntu, kukhona umbono onamandla ukuthi i-DNA yethu uchungechunge eqoshiwe isimiso esikhethekile ukuthi unesibopho inqubo yokuguga emzimbeni. Lapho ufika ebudaleni obuthile kuphela, kukhona ukusebenza uhlelo okwagcina kuholela ngenakugwemeka - ukufa.

Yini kuyingozi ngoba amehlo ukuguga

Ukwephula izinqubo okuqonda sibonwa ingenye izimpawu zokuguga. Cha, yebo, ungakwazi ukuhlangana nabantu nge isimo omkhulu wezempilo, okuyinto kwanele aphikisayo asebenzayo futhi egcwele olusebenza zonke izinhlobo zezifo ezingapheli zokuguga, kodwa uma umuntu ngokuzumayo ulahlekelwe umbono, noma uzophiwa ziwohloka kakhulu, ngisho "iqhawe" onjalo abasoze ukukhubazeka.

Abaningi kakhulu izifo iso ngokuhamba kwesikhathi kancane kakhulu. Njengoba bekhula, indlala lacrimal isebenza kancane, futhi lokhu kuhilelani ukwehla ekukhiqizeni kanye nekhwalithi izinyembezi. Kuba lubonakale sifikile engu-40 ubudala, kodwa kungenzeka futhi emva 30.

Thanda, yini lena? Kungokwemvelo ukuba ngeminyaka kuba ohlabayo zokuvikela amehlo plyonochku zenzeka microtrauma corneal umonakalo, Izifo ukuvuvukala, eyestrain ngokushesha. Eqhubeka microchanges zinjalo isisekelo sokuthuthukiswa izifo ezisongela njenge cataract, waqinisa intraocular ukuthuthukiswa ukufiphala ungase uqale izinguquko esiwohlozayo retina futhi izinzwa optic kusuka ukulahleka okuqhubekayo umbono. Kodwa ungesabi ukuthi lezi zifo kungenzeka, futhi bonke ngokushesha. ukuthuthukiswa wabo kancane futhi kancane kancane.

Lokhu kuye kwaphoqa yokuthi lo profesa wanquma ukwenza Skulachev iso amaconsi. Izibuyekezo zaphetha kubo omuhle kakhulu. A esikhulu kakhulu, uma kungekhona omkhulu, inani leziguli amehlo ithuba futhi nge look ocacile uneso umhlaba ngaphandle ukuhlinzwa. Futhi sibonga ukuthi kusungulwe UProfesa Skulachev iso amaconsi, intengo okuyinto engcono kakhulu kunaleyo yeningi.

Antioxidants ezifana mitochondrial

Esikhathini eMoscow State University. University kusukela 2005, uye waqala wocwaningo phezu kwemithi yakhelwe uyephuza ukusebenza ohlelweni bese wehlisa ijubane inqubo yokuguga. Ngaphansi kokuqondisa V P. Skulacheva, Academician we-Russian Academy of Sciences, ezinto owaqamba iminyaka engaphezu kwamashumi amane waziphatha ucwaningo izinqubo ezenzeka mitochondria, yasungulwa uhlobo olusha ezisebenzayo - Antioxidants uhlobo mitochondrial.

Ngesifundo ngemva kokusungulwa yokuqala yale amakhemikhali uhlobo, ososayensi batholé ukuthi Antioxidants mitochondrial behlisa, futhi kwezinye izimo kuhlehlisiwe izinqubo izifo amehlo ezilwaneni ekuhlolweni. omningi ku kokusungulwa kwemithi emisha esekelwe Antioxidants mitochondrial osekwenziwe eminyakeni embalwa kamuva, kanye noSolwazi Skulachev iso amaconsi yethulwe ngaphansi kwegama "Vizomitin".

Ake sibheke esinye izimpawu zokuqala iso ukuguga - ukungasebenzi ezihlobene nokukhula of indlala lacrimal. Kwenzekani ngeminyaka? Njengoba bekhula kukhona ukwehla ngezici ambalwa kanye qualitative we uketshezi lacrimal consequently ukuthuthukiswa sifo of "amehlo omile". It is olwaboniswa Umuzwa wokuqala wokukhululeka kabi emehlweni, umuzwa wokuthanda zesihlabathi noma umzimba ezincane angaphandle, futhi ukuqhubeka kancane kancane isifo bangezwa kwaba nemiphumela emibi nakakhulu.

Qaphela ukuthi kwasesitsheni ngwengwezi ezikhona emakethe ezithaka imithi ngamanani amakhulu. Futhi enkulu kanye nenani izidakamizwa okuhloswe ngazo ekwelapheni ukubonakaliswa lingaze phakathi "izinyembezi", kodwa cishe bonke of them (noma iningi) kuyinto analogue zokwenziwa of womuntu izinyembezi uketshezi. kusimo lawo eliyinhloko ukuthi isiguli yokusebenzisa le mithi kusukela ezikhathini 10 kuya 20-25 ngosuku, kusukela ukusetshenziswa nje okuhloswe ngaso ekubuyiseleni evamile okuqukethwe izinyembezi oketshezini iso.

ukuhlolwa Laboratory futhi emtholampilo

I iconsi zakamuva "Vizomitin" kuhluke ngokuyinhloko kusukela Umgomo we operation izidakamizwa ezifanayo ezisetshenziselwa ukwelapha izinyembezi. Ziyakwazi kakhulu imbangela nezifo, okuye kwathuthukisa ukusebenza indlala lacrimal kanye ephumula izinguquko wakhe esiwohlozayo. Ngaphezu kwalokho, amaconsi spray nomphumela ofanayo njengoba amaconsi izinyembezi yokufakelwa cataract based.

Lokhu isimo - akuyona nje isitatimende theory, kodwa eqinisweni empeleni aqine. UProfesa Skulachev wamehlo kakhulu kucwaningwe ezilwaneni zokwelapha zomuthi labetibambile ezikhungweni eziningi iso: eMnyangweni Ophthalmology (Russian State Medical University) futhi ngesikhathi Research Institute Eye Izifo Helmholtz.

Imiphumela etholwe kuqhutshwa lezi zifundo, zokwelapha, imiphumela kuyakhuthaza impela. UProfesa Skulachev, iso amaconsi, okuyinto imakethwa ngaphansi kwegama "Vizomitin", kusho ukuthi kukhona kuphumelela kangcono kunokuthi izidakamizwa ezifanayo ezisetshenziselwa ukwelapha kanye nokuqedwa izibonakaliso syndrome ka "izinyembezi". Ngaphezu kwalokho, kufanele kuphawulwe ukuthi imiphumela emibi ngesikhatsi ukwelashwa nalezi amathonsi ezigulini babonakala.

Ngokusekelwe imiphumela yalolu cwaningo, umuthi bhalisiwe e eMnyango Wezempilo Nokuthuthukiswa Komphakathi ngo-December 2011 njengendlela yokuthola keratoprotektornogo ngokuthi "Vizomitin", noma ngeso lehla Skulachev. Lapho ukuthenga imithi namuhla? Kusukela ngehlobo lika-2012, wabonakala wezwe okudayisa inethiwekhi Pharmacy.

Yiqiniso, njenganoma iyiphi enye umuthi omusha ngempahla asebenzayo ezazaziwa "Vizomitin" eyakhululwa kuphela kadokotela. Ngingaba ukuthenga ngaphandle ngeso lehla Skulachev? Lapho ukuthenga kubo, uma hhayi okuthile okuphekwa ngayo? Aziphendukeli namaqhinga, futhi uxhumane ophthalmologist yakho bayahlanganyela. Iholide kadokotela Akubalulekile ubheke amaphutha - ikakhulukazi inquma injongo yayo abahlosiwe, okuyinto yena, kusho nethonya elihle isicelo.

A ukutholakala eyingqayizivele ngempela eyenziwe UProfesa Skulachev. Eye lehla, okuyinto Izibuyekezo kuphela ukuhlangabezana ezinhle ngempela nethonya eliyisimangaliso. Ukuze ekusetshenzisweni kwazo futhi izifundo zokwelapha kumele kube opticians hhayi kuphela e-Russia kodwa futhi emhlabeni wonke. Lesi sidakamizwa isihloko izingqungquthela ahlukene kanye nemihlangano yokufundisa ukuletha ulwazi zonke ophthalmologist.

Ake kwethu ongahlala ngokuningiliziwe "Vizomitin" ukulungiselela. Yokusetshenziswa anganika ulwazi oluningi ezithakazelisayo.

Incazelo ukulungiselela

Lokhu kusho ukuthi kuyinto kakhulu okusobala, ezinemibala mhlawumbe ngandlela-thile noma kancane liquid opalescent. Plastohinonildetsiltrifenilfosfoniya izidakamizwa esebenzayo bromide, okuyinto 1 ml ukulungiswa iqukethe 0,155 micrograms. Njengoba excipients esetshenziswa benzalkonium chloride, hypromellose, i-sodium chloride nabanye. Lesi sidakamizwa kungokwalabo ejenti iqembu keratoprotektornyh pharmacotherapeutic, kanye neqembu Antioxidants.

Idatha pharmacodynamics

Plastohinonildetsiltrifenilfosfoniya bromide kwakwakhe kuyinto esuselwe plastoquinone okuyinto ngokusebenzisa kangaka okuthiwa linker uchungechunge elihlobene ne triphenylphosphine asalile. Njengoba uDkt Skulachev wathi ngeso amaconsi (ngentengo yabo ngenxa cheapness eyisihlobo zamagama lokhu kwakwakhe akuyona okusezingeni eliphezulu) e nanomolar lokuhlala uyakwazi bembonisa umsebenzi omkhulu kakhulu antioxidant nge high emnandi nomthelela slezoobrazovaniya izinqubo ukwandisa ukuzinza ngokomzimba ezakhiwe ifilimu izinyembezi futhi inethonya izinqubo epitealizatsii.

idatha pharmacokinetic

Kuze kube manje, kufanele kusho ukuthi inani lezifundo pharmacokinetic ezingazange iqhutshwe abantu. Mayelana pre-emitholampilo izifundo isilwane, ukusatshalaliswa asebenzayo izidakamizwa amaconsi e umzimba kwaphawuleka izinsuku 2 emva ekuphathweni wetemlomo nobe parenteral. Ukuba khona bromide plastohinonildetsiltrifenilfosfoniya obhalisiwe lamanani aphezulu e izicubu kwezinso nezicubu isibindi, inhliziyo emva 1 ihora ngemva kokuphathwa. It kwaphawuleka ukuthi imfuyo owabeka ngokushesha kakhulu nokwahlukana usebenzisa enzyme futhi wafakazela uyakwazi covalent Abathandana amaprotheni.

Izinkomba kanye contraindications

Drops Skulachev "Vizomitin" esinqunyiweyo syndrome ka "izinyembezi", izinguquko ezihlobene nokukhula kwe-ndlala lacrimal, ikhompyutha syndrome. Ngokusekelwe yokuthi ekucwaningeni kwesayensi okuphathelene nemiphumela zomuthi kukhona lusaqhubeka, ibuye Kunconywa cataract, ukufiphala kwamehlo kanye nokwelashwa eyinkimbinkimbi yisiphi isifo zamehlo.

Njengoba Skulachev uVladimir sabonisa, iso amaconsi kuthiwa contraindicated uma hypersensitivity kuya izidakamizwa, kanye nezingane ezineminyaka engaphansi kwengu-18.

Isicelo ekhulelwe kanti ngesikhathi ibele

Kuze kube manje, izimpumputhe, izilingo elawulwa zomuthi kwabesifazane abakhulelwe, futhi yayingawuthinti iqhutshwe lactating omama olwenziwa ngokugcwele. Ngenxa lesi simo, it is hhayi Kunconywa ukusetshenziswa kwezidakamizwa ngesikhathi sokukhulelwa. Uma kukhona ngaphakathi dire dingo for ukuqokwa esikhathini lactation, ukuncelisa kufanele inqanyulwe.

Indlela isicelo futhi umthamo

Umuthi kumele safaka 1-2 amathonsi ku sac conjunctival of iso lesiguli kathathu ngosuku. Kuye kobukhulu izimpawu nokugasela ngamandla isikhathi Yiqiniso zokwelapha lesi sifo lingasethwa ngamunye ekwelapheni ophthalmologist.

side effects kanye ukweqisa izidakamizwa

Ngokwe ucwaningo, kanye nokuhlolwa emitholampilo laboratory zomuthi, imiphumela emibi sezihlonziwe, kodwa kungase kube ibonakalisa komzimba. Idatha ukweqisa izidakamizwa uhlelo ngezihloko ezihlukene izidakamizwa itholakale.

ekusebenzisaneni izidakamizwa

Idatha ye-izidakamizwa ekuxhumaneni nezinye izidakamizwa babe amaqembu. Uma kukhona isidingo isicelo kanyekanye "Vizomitina" nezinye amathonsi iso, iso instillation igebe phakathi kufanele kube okungenani imizuzu engu-5.

Izixwayiso

Ngo zokwelapha ngemiphumela izidakamizwa eyatholakala, ukuthi "Vizomitin" abangela yesikhathi esifushane yokuhlala thuthuva, kulandele ukunciphisa yayo. Uma emva nokuphathwa izidakamizwa siyenzeka ukuphazamiseka visual, kufanele uyeke imoto noma ukulawula izindlela, kanye ukuqaliswa imisebenzi ezidinga ukunakwa, kuze babuyele ngokugcwele acuity ezibukwayo.

ukukhululwa Ifomu

Eye lehla ne isithako okuqukethwe okusebenzayo ka 0,155 UG / ml akhiqizwa amabhodlela olukhethekile polyethylene 5 ml ivolumu bavimbe - droppers futhi isikulufa cap. Umuthi ikhishwe kuphela kadokotela. Hlala iconsi iso kuyadingeka ezingeni lokushisa kusuka 2 kuya ku-8 ⁰ C.

Kuphi ukuthenga izidakamizwa

Thenga Drops "Vizomitin" namuhla abazinhliziyo intengo akuyona omkhulu, uma le ndaba ukuze umphumela olulindelekile, kungenzeka cishe kuwo wonke ikhemisi Russia. Izindleko isilinganiso Russian Federation amaconsi kuyinto ruble mayelana 500. Umthelela izidakamizwa nje cwe. Inani elikhulu labantu bakwazi ukusula futhi nombono ocacile ngokusebenzisa lokhu kusho. Njengoba kuveziwe uProfesa Skulachev, iso amaconsi, intengo elitholakala kuwo wonke umuntu kuyowuthonya ngempumelelo zokwelapha kuyinto kulabo abaphethwe izifo iso.

Akungabazeki ukuthi ngemva kwesikhathi esithile, amanyuvesi ucwaningo iziqu isifundo full-scale iso lehla "Vizomitin" bese nge awokuthi kuyoba amathuba amasha ukusetshenziswa Antioxidants mitochondrial hhayi kuphela umkhuba emtholampilo zamehlo, kodwa futhi kwamanye amagatsha emithi.

Izibuyekezo sokulungiselela

kobufakazi eziningi nabantu asebeke babasebenzisa ngeso lehla "Vizomitin" esekelwe kungani leso senzo sabo. Iziguli uyajabula ukuthi ukulungiswa akudingi instillation njalo, futhi ukusetshenziswa isikhathi eside, futhi imvamisa yokusetshenziswa kwawo zingancishiswa kanye ngosuku. Ngokusho abathengi, izinkinga iso ngempela ingaxazululwa. Angabe esaba othi awube, ngaphansi ukhathele, ukuvuvukala senzeka. Yini imiphumela emibi, iziguli ebesenza.