Ukuhlaziywa kwe-ACCP ku-arthritis ye-rheumatoid: evamile, ukucacisa

Izibalo zezokwelapha zikhombisa ukwanda nokuqhubeka kwenani lezifo ohlelweni lwe-musculoskeletal. Ngokuqhubekayo, iziguli ezigugile zikhalaza ngobuhlungu emajoyini abo. Abantu abasha nabo abazange baphambane nalesi sifo, izingane zihlupheka ngakho. Izifo zamalunga zibalulekile ukuqaphela ngezigaba zokuqala ukuvimbela ukuqhubekela phambili kwazo nezinye izinkinga. Isifo esivame kakhulu phakathi kwezifo zesimiso somuntu wesifo yisifo se-rheumatoid arthritis, esibonakala inkambo eyinkimbinkimbi futhi ayikho imithi encane eyinkimbinkimbi. Ngakho-ke, wonke umuntu obhekene nalesi sifo unesibopho sokukwazi ngokuhlaziywa kwe-ACCP ku-arthritis ye-rheumatoid. Isimo salo sizophiwa kule ngqungquthela.

Kuyini ukuhlolwa kwe-ATSCP?

I-RA, noma i-arthritis ye-rhumum, iyisifo esiyinkimbinkimbi sezingxenyana ezithinta kokubili izingane nabantu abadala. Lesi sifo sibonakala ngokuvuvukala kwebhubhisi ye-synovial, ukubhujiswa kwezicubu ze-cartilaginous ze-joint kanye ne-deformation yayo. Imiphumela yokuthi i-pathology ayitholakalanga esigabeni sokuqala futhi ukwelashwa ngokushesha akuzange kuqalwe kungaba yingozi kakhulu. Ukuguqulwa nokubhujiswa kombuthano kuhlanganisa ukulahlekelwa okuphelele noma okuncane kwezimoto, okuyinto ezimweni eziningi kuyindlela yokukhubazeka.

Iyini injongo yokuhlaziywa kwe-ACCP ku-arthritis ye-rheumatoid? Ukujwayelekile kwezinkomba kubaluleke kakhulu.

Kuyini?

Isigaba esibalulekile ukuhlolisisa i-arthritis ye-rheumatoid ngesikhathi esifanele, okuzovumela ukunikeza ukwelashwa okuphumelelayo nokulungile kumguli ozoyeka inqubo yokuvuvukala futhi abuyisele umsebenzi wamalungu. Kule ndlela, kusetshenziswe izindlela ezimbili ezivumela umuntu ukuba anqume ukuhlushwa kwama-antibodies ku-peptide ye-citrulline cyclic (ACPC) ne-rheumatoid factor (RF).

Ukuze uhlolisise i-pathology ekuqaleni, odokotela beluleka ukuhlaziywa kwe-ATSTs, ngoba le ndlela inezinkomba ezinembile futhi ikuvumela ukuba unqume lesi sifo kungakhathaliseki ukuthi isigaba. Isivivinyo se-RF siqondile, futhi ukunemba kwemiphumela yaso kuncike kakhulu esikhathini sokuthuthukiswa kwempilo.

I-arthritis ye-rheumatoid ibonakala kahle esikhathini sokuqala ngosizo lwe-ATSTS test. Futhi, ngenxa yakhe, inani lama-antibodies nama-marker ajikeleza egazini ngesikhathi sokuqhubeka kwesifo kutholakala egazini. Lokhu kuhlolwa kunquma inani lama-antibodies ehlobene negazi ne-peptide ye-citrulline cyclic. Le peptide iyisici esibalulekile se-metabolism. I-Citrulin yenziwa ngesikhathi sokuphikisana kwamakhemikhali ngosizo lwama-angina, okuyi-amino acid ehlukile.

Yilokho i-ACPI enesifo se-rheumatoid arthritis. Umkhuba uzonikezwa ngezansi.

Ukunakwa! Kumele kuthiwa i-citrulline ayibambi iqhaza ekuqaliseni amaprotheni futhi idonswa esikhathini esithile esivela emzimbeni.

Lapho amalunga ehlushwa yi-arthritis, umzimba uthola izinguquko eziningi. Ngesikhathi esifanayo, isakhiwo seprotheyini i-amino acid chain, esithinta ukusebenza kwezicubu zomzimba we-joint, ishumeke ku-citrulline. I-peptide, equkethe i-citrulline, ibonakala ukuthi isimiso somzimba sokuzivikela sisuke singaphandle futhi sikhiqiza imishanguzo yokuqeda lesi songo.

Yiziphi izinzuzo lapho ukuhlaziywa kwe-ATSTSP kunesifo samathambo? Ukujwayelekile kwakhe kufanele kwaziwe kuwo wonke umuntu.

Izinzuzo ze-A / CCP

Ukuhlolwa kwe-ACPC kusiza ukunquma kuphela izinhlobo ezahlukene ze-arthritis, kuhlanganise nesifo samathambo, kodwa akufanele neze ukuxilongwa kwezinye izifo. Le ndlela yokuhlola i-serum yegazi ingenye yezinto ezithakazelisayo kunazo zonke futhi ngesikhathi esifanayo enembile, ngoba ayitholi kuphela isifo esasencane, kodwa futhi nesigaba sesifo kanye nesimo sayo. Uhlolo lubekwe ekuxilongweni komonakalo ohlangene we-rheumatic kanye ne-RA ekuqaleni kokuthuthukiswa kwawo. Ucwaningo lukuvumela ukuba wenze uhlelo oluphelele kakhulu lokwelapha, olwenzelwe ukuqeda ubuhlungu nokuqeda ukuvuvukala, ngokushesha ukuqeda isifo esifana nesifo samathambo.

I-ACPC inezinzuzo eziningi ngaphezu kwe-RF: ithuba eliphakeme lokuthola ama-antibodies ku-ATSPP izinyanga ezimbalwa ngaphambi kokuthuthukiswa kwe-articular non-cecile syndrome noma i-rthumic arthritis ngendlela eyinkimbinkimbi ye-arthritis; Ukukwazi ukuthola i-RA emazingeni okuqala ka-70%; Ukukwazi ukuthola uhlobo lwesigaba sesi sifo; Ukutholakala kwe-RA esigabeni esithuthukayo ku-79% wamacala; Okucacile nokunemba kokuhlaziywa ngu-98%.

Futhi konke lokhu kungabonisa ukuhlaziywa kwe-ACCP ku-arthritis ye-rheumatoid. Siye sabheka ukuthi kuyini.

Indlela ye-ATSTSP ingabizwa ngokuthi i-high-precision, lapho odokotela baqala ukuyiqoka khona ngokuvamile kubagulayo abanezibonakaliso zokuthuthukisa i-arthritis. Imiphumela yokuhlolwa inganquma uhlobo lwe-arthritis, kanye nokubikezela inkambo yayo, okukuvumela ukuba unike isiguli ilungelo lokwelapha.

Izici zenqubo

Iyini inqubo yokulungiselela yokuhlaziywa? Ngemuva kokuba isiguli sinikezwe ukuhlaziywa kwe-ATSPP, kumele ilandele imithetho eminingi. Ngaphambi kokuhlolwa, awukwazi ukudla (amahora angu-8). Noma yikuphi uketshezi, okufaka itiye, ijusi nekhofi, ngeke kusetshenziswe kungakapheli amahora angu-24. Le mithetho iyasebenza ekubhemeni, ngoba obhemayo kuyodingeka akhiphe ugwayi amahora amabili, aze ahlaziye i-ACCP ku-arthritis ye-rheumatoid. Ukumangalelwa kulokhu kuzoba okunembile kakhulu. Ukuziqhenya kwalesi sifo kubambe iqhaza esiswini esingenalutho.

Ukuphumelela ukuhlolwa: i-algorithm

Isivivinyo senziwa ngokuthatha igazi kusuka emthanjeni. Khona-ke, i-serum isuswa kuso, esetshenziselwa ukuhlolwa ku-ATSP. I-Serum itholakala ku-centrifuge ekhethekile. Ngokuya ngokuphuthumayo kokuhlaziywa kanye nokuqashwa kwelabhorethri, imiphumela ingatholakala engakapheli isonto noma ngokushesha ngosuku locingo.

Kubalulekile! I-serum ingafakwa iqhwa kanye kuphela, bese ngokuphequlula ngokuphindaphindiwe, imiphumela ngeke ibe yalungile.

I-ACPC ihlaziywa kanjani isifo samathambo? Kuyini, sesiyazi kakade.

Inqubo yokucwaninga: i-serum ifakwa emgodini wokuhlola kanye ne-translucent nge-laser. Le ndlela ibizwa nge-cytofluometry. Ngokusabalalisa i-laser beam in liquid futhi uhlamvu lwayo, umuntu angakwazi ukwahlulela ukungabikho noma ukuba khona ATSP emzimbeni.

Izindleko

Ukuhlaziywa kuphephile ngokuphelele futhi kungenabuhlungu kwesiguli, kodwa kubiza kakhulu. Izindleko zokuhlolwa zihluka kusuka ku-ruble ayizinkulungwane eziyisikhombisa kuya kwamakhulu ayisikhombisa namakhulu ayisikhombisa, kuye ngokuthi ukuphuthuma kanye namanani we-laboratory aqhuba ukuhlolwa. Lokhu kuhlaziywa akuthunyelwanga kuzo zonke iziguli, ngoba lokhu udinga ukuphenya izimpawu zesifo nezikhalazo zesiguli.

Okulandelayo, sizocabangela indlela ukuchazwa kwemiphumela yokuhlaziywa kwe-ATSCP ku-rheumatoid arthritis kwenziwa ngayo.

I-Norm

Ngokusho kwemiphumela yokuhlolwa, udokotela ufunda ngokuba khona noma ukungabikho kwe-RA, isigaba esilandelayo sokuthuthukiswa kwesifo nokuqina kenkambo yayo. Kumele kuqashelwe ukuthi lokhu kuhlolwa kwemithi kungomunye wabambalwa lapho okujwayelekile kuvame khona kancane phakathi kwabantu abaneminyaka ehlukene.

Ngemuva kokuthola igazi, lingagcinwa okungaphezu kwesonto emazingeni okushisa ukusuka ku-+8 degrees.

Khona-ke, ukuhlaziywa kwe-ACPC ku-arthritis ye-rheumatoid isenziwa. -200 degrees ukushisa okungcono kokuqandisa isampula segazi, emva kwalokho kungagcinwa isikhathi esingenamkhawulo uma kunesidingo.

Umkhuba wokuhlaziywa kwamadoda, abesifazane kanye nezingane ezineminyaka ehlukene kungachazwa ngo-3-3.1 U / ml futhi kwezinye izimo ezingasodwa zingashintsha kancane: zisencane emntwaneni onesisindo se-bone esingenakuqalwa - 2,7-2,7 ED / ml; I-ACCP ku-RA yabesifazane abakhulelwe - 3.8-4 U / ml; Kubantu asebekhulile, ukwanda kancane kancane ku-2 U / ml kuvunyelwe.

Ukuhlaziywa kuqhathaniswa kanjani?

Ukucabangela imiphumela yokuhlaziywa, ochwepheshe ubeka ukwelashwa okuyinkimbinkimbi, ukusebenza okuzoboniswa kamuva ngokuhlolwa okuphindaphindiwe. Ukufaneleka kokwelashwa kufanele kwahlulelwe ngesisekelo sokunciphisa inani le-antibody kule serum. Ihlukanisa i-ATSTSP phambi kwe-arthritis ye-rheumatoid kanje: 0-20 - inkomba ayibi; 20,0-39,9 40-59.9 - enhle; Amayunithi angaphezu kwezingu-60 - aqondile, ahlonishwa kakhulu.

Kubalulekile! Kungakhathaliseki ukuthi u-20 U / ml ubhekwa njengendlela evamile yokuhlaziywa, ochwepheshe abaningi bayaqiniseka ukuthi kungenzeka ukukhipha i-RA kuphela uma kwenzeka imingcele ye-ATSP isilingo, okungukuthi, ngokungabikho okuphelele kwama-antibodies egazini.

Isiphetho

Kubalulekile ukukhumbula isiguli ngasinye ukuthi ukuhlaziywa kwe-ATSCP kungamaphesenti angama-95 athembekile futhi uma umphumela wokuhlolwa ungalungile, kodwa kukhona zonke izibonakaliso zesifo samathambo, kufanele udinga ukuhlolwa okungeziwe usebenzisa ezinye izindlela zokuxilonga ezikhethwe udokotela oya khona.

Sihlolisise ukuhlaziywa kwe-ACCP ku-arthritis ye-rheumatoid. Kwabesifazane, emadodeni nakwabantwana, ama-indices avamile ahlukile.