"Sumatriptan": yokusetshenziswa, ukubuyekezwa. Izidakamizwa analogue "Sumatriptan"

Asho izidakamizwa "Sumatriptan"? Yokusetshenziswa zomuthi, wesenzo kwemithi, kanye nefomu sokuqanjwa izokwethulwa kancane okunye. Futhi, lesi sihloko sizokutshela ngalokho le contra-izinkomba kanye nemiphumela engemihle yalesi izidakamizwa has, yini izindlela zayo kwesicelo kanye umthamo, uma kwadingeka iyiphi analogue nokunye.

Ukwakheka imithi futhi Ukwakheka yayo

Okwamanje, kungenziwa amaphilisi kuphela ezitholakala Pharmacy acinene fafaza "Sumatriptan". Yokusetshenziswa kwaleli thuluzi inikeza ukwaziswa okuphelele ukubunjwa izidakamizwa. Ujwayelene ke uzokwazi ukuba manje.

A amaphilisi ifilimu camera aqukethe ketshezi asebenzayo ezifana sumatriptan succinate. Ngokuphathelene izakhi elisizayo, lezi zihlanganisa lezi ezilandelayo: i-calcium hydrogen phosphate dihydrate, microcrystalline cellulose, giproloza (Klutsel noma LF hydroxypropylcellulose), i-magnesium stearate, mannitol (noma mannitol), i-sodium croscarmellose (noma primelloza).

Esebenzayo isithako acinene fafaza "Sumatriptan" ikhonza sumatriptan. Ngokuqondene izingxenye elisizayo, bona kungashintshwa ngokuvumelana ukuma ukukhululwa nomuthi. Kufanele kuqashelwe ukuthi spray isetshenziswa ukwelapha kude bungavami kuka ezibhebheni. Nokho, banayo abathengi zabo. Njengomthetho, lawa iziguli abangekho ukhululekile ukuthatha imithi ngomlomo.

Izimfanelo kwemithi zomuthi

Yiziphi izinto ezinganembile "Sumatriptan" amaphilisi, okuyinto libuyekeza sibheka okunye?

Wathi ukulungiselela kuyinto protivomigrenoznoe kusho. Kuyinto agonist ethize futhi ukukhetha ama-receptor 5-HT1-serotonin, okuyinto isebenza igazi izitsha ubuchopho. Kufanele kuqashelwe ukuthi izidakamizwa akunamthelela nezinye subtypes ka-receptor 5-HT-serotonin.

Ngemva ngokuthatha izidakamizwa kudala vasoconstriction okuqondene carotid lwemithambo embhedeni. Ngakho, nomuthi "sumatriptan" (amaphilisi) usinikeza igazi intracranial nezicubu extracranial. Kufanele kuqashelwe ukuthi vasodilatation meningeal, nokuvuvukala yabo futhi izimbangela migraine kubantu.

Asikwazi ukusho ukuthi emva ukwamukelwa kwaleli thuluzi akunamthelela abalulekile (negative) ku-cerebral ukugeleza kwegazi. Tablets kuphela zivimbela yokwamukela umsebenzi afferent zesivikelo sesifuba (eziyimpumelelo yabo) ka emsipheni trigeminal, okuyinto Itholakala laseDura. Lokhu kwenzeka ngenxa Ukwehla sezinzwa neuropeptide ukukhululwa.

Kufanele ukuthi lesi sidakamizwa "Sumatriptan" futhi "Sumatriptan Teva" aluqede ngokuphelele photophobia nesicanucanu, okuyinto ehlobene ukuhlaselwa migraine.

Ukuphumelela lomuthi

Kanjani ngokushesha kuza umphumela omuhle emva Ukwamukelwa "Sumatriptan" izidakamizwa? Nobufakazi lokhu nomuthi aqukethe ulwazi ukuthi izidakamizwa iqala ukwenza imizuzu kuphela emva 30. Ngakho isiguli kufanele bathathe umthamo mg 100. Phela, ngo 50-70% eziguli ngokushesha iqedwe ukuhlaselwa migraine emva ukusetshenziswa 25-100 mg zomuthi. Emini ngesikhathi 1/3 iziguli ngiwela ogibeni lwezidakamizwa, okuyinto kudinga ukusetshenziswa okuphindiwe izidakamizwa.

Pharmacokinetics

izidakamizwa "Sumatriptan" Kuyoze esikuthola? Impendulo yalo mbuzo liyatholakala nasemiBhalweni yokusetshenziswa kwezimali. Ngemva kokuthola lo izidakamizwa ngaphakathi, cishe ngokushesha ugxile ipheshana wokugaya ukudla. Ngemva kwemizuzu engaba ngu-45 lokuhlushwa izidakamizwa e- serum igazi ifinyelela mayelana 70%.

Ngenxa ukumuncwa akuphelele futhi lokuqala pass umzimba, i-bioavailability ngokuphelele izidakamizwa uma iqondiswa ngokwesilinganiso 14%. Ngokuqondene sesibopho ukuthobisa i-plasma amaprotheni, uphansi kakhulu (mayelana 15-21%). Isikhathi isigamu-ukuphila imayelana 2-amahora. Ukulungiselela etholakala ogxile ngokusebenzisa nezinso.

Absorbability zomuthi ezimweni ezithile zokwelapha

Ngokwe-ubuciko, ukuhlaselwa migraine musa kakhulu kuthinte absorbability we asebenzayo ejenti sumatriptan (by ukungenisa noma intranasal abaphathi).

Uma isiguli kuyaphazamiseka kokusebenza kwesibindi, bese ngemva kokusebenzisa imithi angase ukuzwa izinga lenyuke isithako esisebenzayo-plasma. Lokhu kwenzeka ngenxa ukunciphisa imvume lokuqala pass.

Izinkomba ukusetshenziswa kwemithi

Kwezinye izimo, prescribers "Sumatriptan"? Yokusetshenziswa zomuthi uthi kufanele kuthathwe kuphela ukubonakaliswa migraine (ngaphandle aura noma wakhe).

Izimo ukusetshenziswa

Uma kukhona ngeziphambeko ke akuvunyelwe nhlobo ukuthatha imithi "Sumatriptan" analogs lokhu izidakamizwa? Ngifuna ukugcizelela ukuthi kulesi sici nase imiyalelo kukhona semali ulwazi. Yingakho ngaphambi kokuthatha izidakamizwa nalo, uqinisekise ukuthi ufunda.

Ngakho yiziphi contra-izinkomba uye wasibonisa izidakamizwa? Cabanga uhlu njengamanje:

• anda nozwela isiguli tincenye ekwakhiweni;
• ezigulini esezikhulile (engaphezu kwengu-65);
• basilar, noma oftalmoplegicheskaya ifomu hemiplegic migraine;
• reception ngesikhathi esisodwa nomuthi nge ukuthaka imithi aqukethe ergotamine nemikhiqizo yalo ehlukahlukene, kanye mao inhibitor (banqatshelwe nokwamukela izindlela ngaphambi kwezinsuku eziyi-14 ngemuva kokuhoxiswa kokuhlelwa wathi izidakamizwa);
• isifo senhliziyo, futhi kusolwa ke;
• yokweva eshumini nambili neminyaka yobudala zezingane (iminyaka engu-18);
• angina, kuhlanganise Prinzmetal angina ;
• bekhulelwe nangenkathi bencelisa,
• isilethikusebenza, kuhlanganise egeleza emlandweni;
• nomfutho wegazi ophezulu (uhlobo engalawuliwe);
• nomfutho wegazi ophezulu (uhlobo elawulwa);
• occlusive neuropathy Umthambo isifo;
• isithuthwane, kubandakanya noma iyiphi izimo zokucabanga okubangelwa isifo elihlobene ne ongaphakeme embundwini sokuwa;
• kwezinso noma hepatic ukwehluleka;
• unhlangothi noma isimo lezivakashi ka-cerebral ukugeleza kwegazi, kuhlanganise ukugeleza umlando.

Njengoba kushiwo ngenhla, lesi sidakamizwa "Sumatriptan" akumele zisetshenziswe ngesikhathi sokukhulelwa. Kodwa uma ingozi embungwini ingaphansi inzuzo unina, namanje elibekelwe abesifazane e omama isimo nabancelisayo. Nokho, ukwenza lokhu kuphela uchwepheshe abanolwazi (isidakamizwa esithathwayo ngokuqinile ngaphansi kweso layo). By endleleni, it is hhayi Kunconywa ukuba ondle ingane yakho ibele ngosuku ngemuva kokuthola amaphilisi wathi.

Izidakamizwa "Sumatriptan": yokusetshenziswa

Lesi sidakamizwa esithathwayo ngomlomo, kungakhathaliseki ukudla. Isikali kulokhu kufanele alingane mg 50 (uma kudingeka - 100 mg).

Uma unquma ukusebenzisa acinene nomuthi "Sumatriptan" (spray), umthamo salo 20 mg e ikhala ngalinye. ekuphathweni okuphindiwe kwe- izidakamizwa ovunyelwe ngaphambili kuka emva 2 amahora.

Umkhawulo umthamo nsuku zonke ekuphathweni bomlomo abulona mg 300. Lapho usebenzisa i-intranasal ekwakhiweni, kuba elilingana ezimbili esenikwe mg 20.

Izici imithi

Manje ngoba sewuyazi ukuthi kanjani ukunqoba migraine. "Sumatriptan" (amaphilisi kanye spray) ubhekana kahle umsebenzi. Nokho, kufanele kuphawulwe ukuthi nomuthi ayenzelwanga i prophylaxis of wathi ukuphambuka.

Ukusebenzisa izidakamizwa kungenzeka kuphela esimweni lapho uphethwe ungaqiniseki. Ngaphambi ukuqokwa izidakamizwa "Sumatriptan" iziguli ezine atypical hhayi ngaphambili ukuthi nginesifo migraine, udokotela kufanele qiniseka siqambe nezinye izimo zezinzwa enobungozi. Kufanele kukhunjulwe ukuthi iziguli ezine-ukuxilongwa emva Ukwamukelwa amaphilisi wathi angagcina iziyaluyalu cerebrovascular.

Ukuba khona kwezinso ku isimiso sokujikeleza kwegazi (ezingabantu abaneminyaka engama-40 nabesifazane postmenopausal) kudinga Nokuhlola kokuqala ukuze ngakususi kwezinso izitsha inhliziyo negazi.

Okwamanje kukhona ulwazi mayelana nesenzakalo ukwephulwa kokuxhumana, ubuthakathaka kanye hyperreflexia ngemuva kokuthatha izidakamizwa, "Sumatriptan" nezinye izidakamizwa kusukela iqembu abakhethayo inhibitor.

Ngaphambi naphakathi ukwelashwa nge izidakamizwa ethulwa sidinga ukudla njalo eyanele, kanye ukunamathela ukudla okuqinile. Ngakho, isiguli kufanele ukuqeda ukudla yakho Ukudla aqukethe tyramine izidakamizwa (ushokoledi, ezisawolintshi, ukhokho, isilimo esidliwayo esinamagatsha anamanzi, amantongomane, ushizi, nobhontshisi, utamatisi). Ngaphezu kwalokho, kubalulekile ukuba ayiyeke le ukusetshenziswa uphuzo oludakayo, kuhlanganise amawayini abomvu, elikhazimulayo futhi omile, champagne, ubhiya.

Ukuzivocavoca nokugcina yokuphila enempilo ngokuvamile (ukuhamba, ukubhukuda, Ukushushuluza), kanye nokuba khona noma yimuphi umdlalo neqhaza ukuvela imizwelo eyakhayo, okuyinto kuvimbela ukuthuthukiswa yesiguli wobuntu ukuhlaselwa migraine.

Imiyalelo ukusetshenziswa isifutho acinene

egameni lendawo yokuhweba noma isifutho ne esebenzayo izidakamizwa sumatriptan kuzwakala "Imigran". Lesi sidakamizwa has izingxenye ezilandelayo:

• ukunqanda iminwe;
• ithiphu;
• blue inkinobho.

Kufanele kuqashelwe ukuthi inkinobho eluhlaza okwesibhakabhaka icushiwe ngokushesha okukhulu futhi kanye kuphela. Kule ndaba kutuswa ukuba ucindezele kuso kuze ichopho singenelwe ukudlula acinene. Kungenjalo, umthamo umnyuziki kuyophela ngeze.

Ukusebenzisa spray acinene, isiguli kufanele uthathe isikhundla ukhululekile, zilale phansi, emi noma ukuhlala. By endleleni, emva acinene ingaphakathi lesiguli Kunconywa ukuba zihlanzwe kanye swabs ukotini.

Ukususa iphakethe ibhamuza nokususa izidakamizwa ukusetshenziswa acinene, umuthi kufanele ifakwe eyodwa ikhala. Njengoba for nye ndima acinene, kumelwe sicindezelwe umunwe kuya septum acinene. Kulokhu, isiguli kumele uphefumula ngomlomo.

Faka ichopho singene ikhala acinene ekwakhiweni kufanele kube 1 isentimitha. Inhloko isiguli kufanele ugcine ngqo, akufanele ulahle emuva emuva. Ngemva kwalokho, isiguli kufanele ukuvala umlomo wakhe kokwenza nomoya onokuthula kancane ngokusebenzisa ikhala nge umzamo kanyekanye uchofoze inkinobho eluhlaza okwesibhakabhaka nge isithupha sakho. Kulokhu, umuntu kungase kubonakale ukuthi inkinobho wenziwe phakathi nesikhathi esifushane. Kodwa lokhu akulona icala. Phakathi umjovo we izidakamizwa phakathi komgodi acinene isiguli kufanele uzwe eyethile ngokucindezela umsindo. Lokhu kusho ukuthi inkinobho uye wasebenza ngokuphumelelayo.

Ngemva le nqubo, isiguli liyadingeka umlomo wakhe futhi uphefumule kancane kulo. Shona kumelwe siqhubeke ngqo. Ngokulandelayo, isiguli kufanele wenze umoya onokuthula ngokusebenzisa ingaphakathi acinene, futhi ke exhale - ngomlomo (i-10-20 imizuzwana). Kunconywa ukuba uphefumule kakhulu.

Uma inqubo usuphothuliwe umjovo izidakamizwa, umuntu uzwa khona umswakamo ekhaleni, futhi Akunambitheki. Lezi emizweni akuzona ingozi empilweni futhi ngokushesha sidlule angesabi. Ngemva kwesicelo eyodwa dispenser kungenziwa kulahliwe.

Kuxwayisa uma usebenzisa

Izidakamizwa "Sumatriptan Teva", ukubuyekezwa zazo akhayo ngokwezinga elikhulu, kufanele kuthathwe ngokucophelela okukhulu kubashayeli bezimoto, kanye nalabo abenza imisebenzi enobungozi ezidinga enanini eliphakeme ukuphendula nokunakwa.

side effects

Can avuse imiphumela engemihle imithi "Sumatriptan"? Amalungiselelo lolu hlobo kungaba neqhaza ekuthuthukiseni yenombolo kahle esikhulu imihlola ezimbi. Ake sixoxe ngazo ngokuningiliziwe:

• Isimiso somuntu sokujikeleza kwegazi. On the yesimiso e isiguli umfutho ophansi wegazi lungase lubonwe, isilethikusebenza, okusezingeni eliphezulu okwesikhashana komfutho wegazi (ngokuvamile ngokushesha ngemva kokungenisa), tachycardia, bradycardia, tachycardia, futhi kwezinye izimo, arrhythmia, zibe kwemithambo yegazi i-coronary, lezivakashi ECG izinguquko Raynaud syndrome.
• isimiso sezinzwa futhi izinzwa. Ngemva ngokuthatha izidakamizwa umuntu bangase bakhathale, isiyezi, ubuthakathaka futhi ukozela. Kwezinye izimo, umuthi kubangela diplopia, ukuquleka, okuvela kuyo kulokolokoza izimpukane phambi kwamehlo akhe, nystagmus, kwehle acuity ezibukwayo, scotoma futhi ngokwengxenye ukulahlekelwa lezivakashi mbono.
• Ipheshana wokugaya ukudla. Kusukela agayeke isiguli ngokuvamile kubonakala ukuhlanza, dysphagia, isicanucanu futhi ngikhishwe okwandisa (ezincane) umsebenzi enzyme isibindi, ukungakhululeki besisu futhi nesifo ischemic.
• Yokungezwani komzimba. Emva kokuthatha umuthi, ezinye iziguli kubika ukubukeka pruritus, amawala, urticaria futhi erythema. Futhi siyazithanda ngempela nezinyoni anaphylaxis, umuzwa wokuthanda ukushisa, ukuluma nobuhlungu ekhanda, ukusinda, ingcindezi, siwasebenzise, futhi myalgia. Intranasal nokuphathwa izidakamizwa kungavuka ngendlela ukusabela wendawo wamaphaphu ukucasuka lezivakashi noma ukuncinza emphinjeni kanye ingaphakathi acinene futhi acinene ukopha.

Ukuxhumana nezinye izidakamizwa

kanjani neminye imithi mayelana nokusebenza kahle umthelela kanye nobukhulu bale "Sumatriptan" izidakamizwa? Imiyalelo, amazwana kusukela ochwepheshe ngale ndaba aqukethe ulwazi okulandelayo. With ukusetshenziswa ngesikhathi esisodwa izidakamizwa kanye nomuthi "Ergotamine" futhi kusho ergotaminsoderzhaschimi nesineke kungenzeka vasospasm eside. Kule ndaba, lo kweminyaka emkhatsini imithamo le mithi kufanele kube okungenani amahora angu-24.

Ngokwe ucwaningo, kukhona ukuxhumana phakathi izidakamizwa "sumatriptan" futhi mao inhibitor. Ngakho izinga umzimba kuyehla lokuqala, futhi okuhlushwa yayo iyakhula.

Ngekusetjentiswa ngesikhathi esisodwa wathi elwa ne-migraine, futhi ephethwe abakhethayo serotonin reuptake inhibitor, isiguli singase ukuthuthukisa ubuthakathaka, hyperreflexia ziphazamiseke nokudidiyela ukunyakaza.

Overdose izidakamizwa (izimpawu, ukwelashwa)

Kwenzekani uma ungenawo athobele umthamo Kunconywa ngudokotela wakho? Lapho ukusetshenziswa okweqile ukulungiswa "sumatriptan" iziguli zingase ukwandisa ngenhla ohlangothini ukusabela. Kule ndaba, isimo sabo kudinga observation ekhethekile amahora 10.

Uma kudingeka, uhlelo nesineke ukweqisa izidakamizwa usizwa ngesimo ukwelashwa lingaze.

Izidakamizwa "Sumatriptan": analogue futhi intengo izidakamizwa

Zuza ithuluzi ngasiphi ekhemisi. Kufanele kuqashelwe ukuthi intengo "Sumatriptan" zomuthi, uma kuqhathaniswa nezinye, iphansana. Ngakho, ifilimu camera amaphilisi angaphezu kuka-50 wena kuyodingeka bakhokhe ruble Russian 170-200 kuphela. Ngokuqondene acinene kusho ukuthi intengo yayo imayelana okufanayo.

kungakhathaliseki nozakwabo ube izidakamizwa "Sumatriptan"? "Amigrenin" - umuthi uvame atholwe ukuqeda ukuhlaselwa migraine uma ngenhla kusho engekho ekhemisi. Ngaphandle-ke, analogue nomuthi "sumatriptan" lomcebo okusebenzayo okulandelayo izidakamizwa: "Sumarin" "Imigran", "Sumitran", "Migrepam", "Sumatriptan-Teva", "sumatriptan succinate", "sumatriptan Pfizer", "sumatriptan Adifarm "" Sumamigren "," Trimigren "nokunye.

Futhi, njengoba yokuvula amakhala efanayo acinene, abanye ochwepheshe batusa besebenzisa spray "Imigran".

izimo Isitoreji eshalofini yokuphila

izidakamizwa Kwethulwa kufanele agcinwe kuphela ezomile futhi avikelwe elangeni indawo. Amazinga egumbini akufanele kube degrees ezingaphezu kwezingu-25. Impilo eshalofini medical izindawo kuba iminyaka engu-3. Emva kwalesi sikhathi, umuthi akumele zisetshenziswe.