"Relpaks": yokusetshenziswa, ukubuyekezwa. izidakamizwa analogue

Bekhanda, nakuba ayengafiki ezisongela ukuphila ukuhlupheka kwabantu, kodwa ngesikhathi esifanayo iyehlisa izinga lempilo. Kuyo yonke le minyaka, imboni eyenza imithi isebenza ukwakha imikhiqizo ezazingeke zigcine ukuqeda izimpawu okubuhlungu lesi sifo, kodwa futhi ukuthonya izinqubo ezibangela le migraine. Phela, ukumisa ubuhlungu kungaba amaphilisi ezinhlungu eqinile. Kodwa ezinye izimpawu migraine ezinjengesicanucanu, ukuzwela ekukhanyeni nokungabekezelelani imisindo, akulula ukuqeda. I kwezidakamizwa migraine "Relpaks 'ngayo ngokuqondene nalokhu, ochwepheshe bathi omunye ephumelela kunazo. Kuyini lokhu izidakamizwa? Indlela ukuthatha kuso nalokho nozakwabo kwakhe lapho? Konke lokhu ungafunda on.

incazelo ekwakhiweni

The main asebenzayo izidakamizwa "Relpaks" ukulungiselela - ngesimo eletriptan hydrobromide kuqukethwe izibhebhe mg 20. Kukhona umthamo 40 mg. Nezinsizasenzo ezisetshenziswa embonini eyenza imithi i-lactose monohydrate, magnesium stearate, sodium croscarmellose futhi MCC. Lezi zinto zehlela musa kuthinte ikhono zomuthi kuya ukugaya, futhi akuphazamisi umzimba iyonke. Tablets migraine "Relpaks" camera ulwelwesi igobolondo orange, equkethe ama-titanium dioxide, colorants, monohydrate lactose, hypromellose futhi triacetin.

kwakhiwa ithebhulethi ngamunye emzuliswaneni biconvex ukuma. Kolunye uhlangothi kule mpi ke ulotshwe «Rep 20» noma «Rep 40 '(kuye ngokuthi lemali eziqukethwe ithebhulethi isithako esisebenzayo) kanye« Pfizer »- kwenye. Kokunye ibhamuza esifanelana 2, 3, 4, 6 noma 10 amaphilisi, okuyinto yena, phama amakhadibhodi amabhokisi 1, 2, 3, 4, 5, 6 noma 10 izingcezu.

Pharmacokinetics futhi pharmacodynamics

Medicine "Relpaks" ngokushesha futhi kahle amuncwa ngemva kokuphathwa yomlomo, ikakhulukazi lihambisana ukudla okunamafutha. Absorption eletriptan ezomhlaba mayelana 81%, kanye nalokho okuthiwa bioavailability - 50%. Okuqukethwe esiphezulu we ketshezi asebenzayo oketshezini olungenambala lwegazi isivele ngemuva kwamahora eyodwa nengxenye ngokuthatha izidakamizwa.

The main asebenzayo izidakamizwa "Relpaks" ukulungiselela has a ukusebenza kuhle ngokuqondene plasma amaprotheni (85%). umzimba Primary eletriptan kwenzeka kumaseli isibindi. kwakhiwa Ngakho metabolite amabili afundwa, elilodwa (ezakhiwe N-namachibi) asinawo umsebenzi. Eyesibili (kwakheka N-demethylation) has kakhulu ezifanayo kodwa ngesikhathi esifanayo njengoba kokuqala, kodwa lokuhlushwa yayo plasma kuyinto% 10-20 kuphela lokuhlushwa eletriptan. Ngenxa metabolite asebenzayo akunamthelela appreciable zokwelapha.

Tablets migraine "Relpaks" izimpendulo wezazi okuyinto lingama omuhle, ngempumelelo kungakhathaliseki ubulili isiguli. Excretion we metabolites izidakamizwa kwenziwa ngokwezinga elikhulu ngokusebenzisa izinso (cishe 90%), kanye ngokusebenzisa emathunjini.

Ucwaningo luye waqinisekisa yokuntuleka umphumela habituation ukuze isakhi esiyinhloko esebenzayo zomuthi, ngakho namuhla azikho imikhawulo isikhathi yokwelapha zobuhlungu migraine ngokusebenzisa izidakamizwa "Relpaks".

Ngokulinganiswa pharmacodynamic izidakamizwa "Relpaks" isicelo Umsebenzisi ukhuluma iqiniso lokuthi izidakamizwa zalo eziyinhloko asebenzayo okuqondene iqembu abakhethayo serotonin semithambo kanye receptor neuronal, uzabalaza nemiphumela ngezinye izinhlobo kubo. Ngakho selectivity kubonakala ukuthi kukhona okukhulu ngezinga ngokuhlobene receptor elise imithambo carotid. Protivomengrinoznuyu umsebenzi eletriptan inquma hhayi kuphela ikhono layo ukuvaleka imithambo yegazi kubekwe phakathi Nogebhezi lwawo, kodwa futhi zibe nethonya elihle ubunjalo ukuvuvukala neurogenic. Kulokhu, ketshezi abaphuma njalo seliphindeke izikhathi cishe akunamthelela la mangqamuzana we femoral kanye nemithambo yegazi yenhliziyo.

ubufakazi

Izidakamizwa "Relpaks" yokusetshenziswa yanconywa ezimbili izinhlobo migraine:

1. Nge aura lapho ukungezwa ku ezinzima izimpawu ubuhlungu ezifana ezibukwayo, ethintekayo, motor, olfactory neziyaluyalu sokuzwa.
2. Ngaphandle aura, lapho ngaphezu ikhanda isiguli ukhathazekile isicanucanu, ukuhlanza, ukuzwela ekukhanyeni futhi umsindo.

Uma kukhona nezinye izinhlobo zesifo ukusetshenziswa kwezidakamizwa akugcini nje kuye kwaba nomphumela omuhle, kodwa futhi kungadala yezinkinga eziningana. Ngakho-ke, ngaphambi kokusebenzisa lo muthi ukuqeda ikhanda, migraine, kudingeka libheke onguchwepheshe futhi ibhekane ukucwaningwa okuningiliziwe. Lokhu kuzosiza hhayi kuphela ukuba linqume ukwelashwa okufanele, kodwa futhi ukuqeda ingozi ngokushesha impilo isiguli.

Izimo

Cabanga uhlu Izimo ukusetshenziswa "Relpaks" izidakamizwa. Tablets, njengoba kushiwo ngenhla, aqukethe eletriptan olukwazi imiphumela letindzala ku umzimba namathonya izinqubo eziningi. Kwezinye izimo, ukusebenzisa umkhiqizo ingamukeleki kuye noma engathandeki:

• ebukhoneni ezwela ephakeme nesineke kuwo wonke izinto eziyingxenye izidakamizwa;
• in iziyaluyalu kwesibindi nezinso, njengoba umzimba futhi kukhuthaza isithako esebenzayo main kwenzeka kuzo;
• nge nomfutho wegazi ophezulu engalawuliwe;
• nezifo elele noma esanda ngembobo kwenhliziyo, kuhlanganise isifo senhliziyo, angina, yenhliziyo Umthambo isifo;
• ebukhoneni inklyuzionnyh neuropathy isifo semithambo;
• lapho idluliswe noma ekhona okwamanje ka lezivakashi kuhlasela ischemic, kanye nanoma yikuphi ukwephula kwegazi cerebral palsy.

Izidakamizwa "Relpaks" sebekubeke hhayi Kunconywa abantu kabani yobudala engaphansi kuka-18 ubudala. Ngaphezu kwalokho, lo izidakamizwa ayikwazi ukusetshenziswa ngoba esiqoshiwe izinhlungu ezihambisana izinhlungu zekhanda ezifana izinhlobo migraine njengoba basilar, amehlo kanye hemiplegic.

Sebenzisa phakathi nokukhulelwa kanye lactation

Ukusebenzisa izidakamizwa "Relpaks" ngesikhathi sokukhulelwa iye insufficiently wafunda. Nokho, izifundo laboratory ezilwaneni zibonisa umphumela eletriptan phezu embungwini. Okokuqala, inani elincane zezakhi zofuzo soguquko lwegciwane singalawuleka (ngokuvumelana nesimiso of polyploidy) kubonakele ku-embryo. Okwesibili, ukuzalwa ulithola eside kwaba kakhulu ngaphansana izilwane ayitholanga ngesikhathi sokukhulelwa eletriptan. Yingakho izazi kubekwa umthetho yakhe eqondiswa, okuyinto ukuthi inzuzo elindelekile ukuba unina bulingana Ngokuzayo kungenzeka nezingozi ezingenzeka embungwini. Kufanele kuqashelwe ukuthi eletriptan, ingxenye izidakamizwa ezitholakala ubisi womuntu, ngisho emva kwezinsuku emva reception. Ngakho-ke, ukusetshenziswa imithi by nabancelisayo kungenzeka kuphela uma ukwehluleka uncelisa okungenani ngosuku.

emibi ehambisana nokusetshenziswa kwezidakamizwa "Relpaks"

Ukuthwaleka "Relpaks" izidakamizwa Izibuyekezo Ochwepheshe ukunikeza ulwazi mayelana kobukhulu ababuthakathaka yemiphumela emibi, okuyinto wedwa esikhathini esifushane yesikhathi. Akukona yini umthamo (20 mg noma 40) wathola yisiguli ezibalulekile. Izimpawu ezivame kakhulu nayo lapho ngokuthatha izidakamizwa yilezi:

• ukuvuvukala ingaphakathi acinene futhi pharynx (pharyngitis, kanye rhinitis);
• thuthuva nemizwa efana ukuluma, "washington";
• ukozela;
• isiyezi noma ikhanda;
• myasthenia gravis noma hypoesthesia;
• hypertonicity ka kwezintambo zesivikelo sesifuba imisipha;
• ubuhlungu noma uzizwe liqinile ngemuva nasesifubeni;
• arrhythmias inhliziyo, e tachycardia esithile;
• iziyaluyalu dyspeptic ezifana ubuhlungu noma ukungaphatheki esiswini, nomlomo owomile kanye nesicanucanu;
• anda ukujuluka;
• ukufikelwa ukushisa noma Ukugodola nobuso.

Ikhumbula Ukwakheka kwamakhemikhali "Relpaks", ochwepheshe musa ukubeka eceleni ukuthuthukiswa komzimba nezinto izingxenye izidakamizwa, okungase luboniswe ukubukeka ukuqubuka, ukulunywa noma ububomvu. Ngaphezu kwalokho, ezimweni ezingajwayelekile, iziguli kungenzeka ukhathazekile ezinjengokungcoliswa:

• sokuzincisha;
• lymphadenopathy;
• ukudideka, nesasasa noma ukucindezeleka, ukuqwasha kanye lability ngokomzwelo;
• photophobia, ubuhlungu inhlamvu yeso, conjunctivitis, kungancipha noma lenyuke lacrimation;
• ukunambitha ukungasebenzi;
• enkeneneza ezindlebeni, noma soreness;
• umfutho wegazi ophakeme;
• ukuhlaselwa kwakhe isifuba somoya;
• ukushintsha e izwi ithoni;
• nokuvuvukala ngalo ingaphakathi ngomlomo;
• ukuqunjelwa noma isifo sohudo;
• sokuqaqamba kwamalunga noma arthrosis;
• myalgia noma myopathy;
• polyuria noma ukuchama kaningi;
• iziyaluyalu kokuya esikhathini;
• nesifo ischemic.

Ikhumbula oshiwo ngenhla side effects, ukusetshenziswa indlela migraine "Relpaks" Kunconywa ukuba afeze ngaphansi kokuqondisa ochwepheshe, futhi kuphela emva izifundo adingekayo ukuze izifo ekhona oyokwenziwa, okungase izinkinga nokwelashwa.

ukuxhumana

Cabanga nokuxhumana nabathile izidakamizwa antimigraine ejenti "Relpaks". Imithi Umhlahlandlela equkethe ulwazi olubanzi mayelana ukuhambisana yayo nezinye izidakamizwa akufanele kuthathwe kanye imithi edingekayo elandelayo amaqembu:

• inhibitor isozyme, okuhlanganisa "erythromycin", "ketoconazole" "Clarithromycin" futhi "Itraconazole";
• protease inhibitors, kuhlanganise "nelfinavir" futhi "Indinavir".

Ochwepheshe uqaphele iqiniso lokuthi reception kanyekanye "Relpaks" izidakamizwa imithi "Propanolol" futhi "Verapamil" kungaba kuphela avuse nokwanda okuphawulekayo blood pressure, kodwa futhi kuthuthukise ingozi yezinye engemihle. igazi Ukwandiswa ingcindezi kungalindeleka endabeni ukusetshenziswa ahlangene izidakamizwa caffeine izidakamizwa. Yingakho ochwepheshe batusa ukuthi isikhawu nsuku zonke phakathi nedili izidakamizwa ezifana "Relpaks" (analogue futhi angena ngaphansi kwalo definition) nezidakamizwa ergotaminopodobnyh.

Emtholampilo, it is wafakazela ukuthi izindlela migraine okukhulunywa ngazo kulesi sihloko akasabeli nge izinto ezihlobene beta-blocker, estrogensoderjath hormone noma zokuvimbela inzalo ngomlomo, kodwa futhi ukuba tricyclic antidepressant.

ukweqisa izidakamizwa

Uma weqa i-Kunconywa udokotela inani izidakamizwa "Relpaks" imfundo manual uxwayisa ukweqisa izidakamizwa, okungase kubangele ukwanda ziphikelele komfutho wegazi nezinye izifo yisimiso senhliziyo nemithambo yegazi. Lapho zivela nokwelashwa lingaze Kunconywa uma kunesidingo lavage esiswini.

nokushintsha kokudla nokufakwa

Izidakamizwa "Relpaks" ochwepheshe batusa ukuthatha ekuqaleni ukuhlaselwa migraine. Uma ikhanda nezinye izifo conjugate kukuhlupha isiguli amahora ambalwa, njengoba izidakamizwa azigcina ekulenzeni libe namandla. Kufanele kuqashelwe ukuthi yokwamukela izidakamizwa njenge-ejenti yokuvimbela migraine kuyinto inexpedient, njengoba kubonakaliswa ukuthi kuleli cala ayinayo umphumela oyifunayo. Ngesikhathi esifanayo lapho esondela aura (iziguli, yesikhathi eside migraine abanalesi sifo ukuhlonza kulesi simo) ngokuthatha izidakamizwa hhayi kuphela kunciphisa ubuhlungu elandela aura, kodwa futhi aqede izimpawu ezifana isicanucanu, ukozela kanye photosensitivity. Lokhu kwenzeka hhayi kanye, kodwa kuphela lapho kuqala wezakhiwo. Ngakho-ke, migraine abanale nkinga akufanele ukusheshe aphuze iphilisi ngaso sonke isikhathi izifo.

Umthamo kokuqala kwezidakamizwa iziguli iminyaka 18-65 ubudala kuyinto 40 mg. Ngemva ngempumuzo ubuhlungu migraine ingaqhutshezwa. Kulokhu, lo mhlahlandlela incoma ngokuthatha izidakamizwa futhi nganoma umthamo ofanayo, kodwa amahora hhayi ngokushesha kunezinsuku 2 emva reception kuqala. Uma kwenzeka ukwehluleka izidakamizwa lapho ikhanda zingancishiswa ngesikhathi 2 amahora ngemva ekuphathweni izidakamizwa, kabusha ukungenisa is hhayi Kunconywa umthamo. I Ochwepheshe aveze ukuthi ukuhlasela elilandelayo migraine e isiguli esifanayo kungenziwa iboshiwe kokuqala umthamo "Relpaks" izidakamizwa. Umthengi Izibuyekezo kulesi senzakalo futhi aqukethe ulwazi efanayo.

Umthamo esiphezulu nomuthi wathola ngaphakathi olulodwa akufanele idlule 160 mg. Ukuphuza ithebhulethi kufanele kube lonke, ngaphandle ukuhlafuna, ukuphuza uketshezi oluningi.

Izixwayiso

Ukusetshenziswa "ukulungiselela Relpaks 'kungenzeka kuphela emva isiqinisekiso sitholakele" migraine ". Lokhu kungenxa yokuthi uma ubuhlungu bekhanda atypical, ezingasetshenziswa futhi kubangelwe unhlangothi, isifo sokuvuvukala kwemithambo ukudabuka nezinye izifo ezingathi sína, ukuqashwa kwakhe babekwazi kubangele yezinkinga ezihlukahlukene. Ngaphezu kwalokho, kuba engathandeki ukusebenzisa lolu izidakamizwa ukuthi uyoqeda ubuhlungu obukhulu migraine kwezinhlansi izifo zenhliziyo nemithambo yegazi kanye iziyaluyalu izinso futhi isibindi, njengoba lokhu kungabangela nomfutho wegazi ophakeme ezingeni esibucayi. Kuyefana nasendleleni iziguli bani ingozi yokuba nesifo senhliziyo kuphezulu. Yingakho ngaphambi enquma izidakamizwa "Relpaks" isiguli kufanele ahlolwe ngokugcwele. Iziguli ngesikhathi ukusetshenziswa eminyakeni engaphezu kwengu-65 zomuthi kufanele kube ngaphansi kokuqondisa ochwepheshe, njengoba kuyintando zivame kakhulu waphawula ukwanda wegazi.

Isexwayiso! Ngokuphathelene yokwamukela lesi sidakamizwa "Relpaks" imfundo manual liqukethe izinkomba ezifana side effects njengoba isiyezi futhi ukozela, ngakho kufanele uqaphele ikakhulukazi uma ushayela izimoto kanye ekuphatheni kobuchwepheshe obuyinkimbinkimbi.

Analogs "Relpaks" intengo izidakamizwa

Iningi izidakamizwa ekhiqizwa ngokuzimisela yizinkampani ezithaka imithi eNtshonalanga, kukhona nozakwabo yasekhaya. Singakhuluma mayelana nangokumelene Pfizer - umkhiqizi "Relpaks" izidakamizwa. Nokho, njengoba yabhaliswa muva nje, kuze kube manje akukho izidakamizwa eyayizoba ezifanayo kodwa ngesikhathi esifanayo njengoba izidakamizwa "Relpaks". Analogs main isithako eletriptan eyaziwa, okuyindawo lingahunyushwa baphetha ukuthi ukulungiswa uhlukile. izindleko zalo eRussia ruble 380 kuya 1200. Intengo ethize incike isibalo izibhebhe iphakethe futhi yini umthamo wabo.

Ngu indlela umthelela izitsha ubuchopho amaphilisi "Relpaks" kukhona nozakwabo eziningana, okuyinto hhayi kuphela musa ihluke okuningi kuye ngezindleko, kodwa kaningi ibiza kakhulu. Ngokwesibonelo, ikhambi i-migraine "Zomig" angathengwa ngentengo azungeze 400 ruble ngamaphilisi amathathu. Izidakamizwa "Imigran" futhi "Sumatriptan" futhi efana "Relpaksom" ine umphumela futhi intengo. Okuwukuphela izidakamizwa, okwabangela inhlekelele kancane kakhulu kunalokho "Relpaks" ithebhulethi - a "Kofetamin". intengo zabo ingeqi ruble 75 iphakethe ngalinye.

Izibuyekezo sokulungiselela

Ngakho, ukuze umbuzo obaluleke kunayo. Yini abacabanga mayelana nomkhiqizo zokwelapha "Relpaks" Abathengi futhi odokotela babo? Yiziphi izinzuzo nezingozi baye lokhu izidakamizwa? Into yokuqala bathi mayelana 80% wabaphenduli - iyona kahle eliphezulu amaphilisi "Relpaks" ngisho ne ezinzima migraine kuhlasela. Impendulo ezigulini, ngemva kokuthatha iphilisi elilodwa nje ubuhlungu amuke emva kwemizuzu 30-40. Mayelana 8% abathengi okwaxoxwa wabonisa ukuthi ngemuva kokusebenzisa i umthamo kokuqala 40 mg avele izimpawu ezifana eliqhaqhazelayo we izitho zomzimba ukunsonsotha ubuso nezandla. Nokho, lezi zenzakalo ezivele zenzeke ezingemnandi zenzeka amahora amabili ngaphandle esinye isinyathelo.

Ngaphansi kuka 1% ezigulini wabelwe izidakamizwa "Relpaks", ukwamukela lokuqala akuyona wazizwa nhlobo emiphumeleni yayo. Okukodwa kubo lapho kabusha kufanelekile zomuthi kuye kwadingeka nomphumela walo, kanti abanye baphoqeleka ukuba bathole indawo yakhe.

Ochwepheshe uqaphele phakathi izinzuzo ukulungiselela emiphumeleni yayo imnene ku imithambo yegazi ekhanda. Noma kunjalo, phawula ukuthi ukubonakala ngisho ezincane kakhulu side effects isiguli kufanele ukulala nje. Lokhu kuyoba okwanele zonke izenzakalo ezingajabulisi zokuya esikhathini esidlule. Ochwepheshe uqaphele lokhu okulandelayo: ngokungafani emithini efanayo, ezingesiyo ingxenye eletriptan izidakamizwa "Relpaks" lula kakhulu ibekezelelwe migraine abantu.