Glycosides senhliziyo. Kuyini lokhu?

glycosides senhliziyo zifana ngezindlela isakhiwo sazo sekhemikhali kuya Bile acid, cortisone, amavithamini, ama-hormone, cholesterol. Lezi izinto kukhona metabolites yemvelo ukuthi silondoloze ukusebenza evamile inhliziyo.

glycosides senhliziyo yakhiwa glucone (ushukela) kanye aglycone. It aglycone iyona sokunquma zomuthi emsebenzini kwemithi. Ukungena ukuphendula nezinye izinto asebenzayo kuqinisekisa unsaturated emihlanu membered indandatho isakhiwo sabo.

glycosides senhliziyo kwezicubu kanye nezinhlaka zabiwa Ukuboshelwa. Qondisa izenzo zabo - myocardium, lapho igcina% 10 kuphela ekwakhiweni, i ezengeziwe 50% ilungiswe imisipha striated lapho zibangele noma iyiphi ukusebenza.

Kuze kuphele isikhathi isinyathelo of glycosides inhliziyo zihlukaniswe zibe:

- eside - digitoxin,

- maphakathi - digoxin

- iDemo - strofantin, Korglikon.

glycosides senhliziyo: mshini wezenzo

Esimweni esejwayelekile e cardiomyocytes equkethwe izikhathi 30 potassium kakhudlwana futhi izikhathi 20 sodium encane. Lapho esephumule, ebusweni elingaphandle we ulwelwesi cell is kahle icala, kanye yangaphakathi - kunalokho, alivumi. Lapho excitation imbangela ulwelwesi depolarization: sodium ne-calcium faka cell. Kule nqubo, i-potassium angeke sadlulela ngale ulwelwesi cell. Njengoba masinyane njengoba they uphume iseli, inqubo repolarization iqala. Lokhu mzuzu kwenzeka nje ngaphambi imisipha. Ngakho, inani calcium ngemvume inikeza amaseli nokuncipha. Potassium ion ezisele cell, kukhona abaphikisi yenqubo.

glycosides senhliziyo khawuleza kokuqala repolarization futhi ahlinzeke isivuno esiphezulu potassium cardiomyocytes. Ngemva ukunciphisa okudingekayo ukuze ababuyisele ekupheleleni ibhalansi ion ngaphakathi nangaphandle cell (i-potassium ne-sodium ukubuya isivuno). Le nqubo luncike amandla reserve amaseli, ayengumlamuleli waso ATP-ase-enzyme. indawo yayo asebenzayo - sulfhydryl iqembu. glycosides senhliziyo ukuvimba indawo esebenzayo, ukunciphisa umsebenzi. Konke lokhu kuholela yokuthi sodium ion ahlale esitokisini, futhi lokhu ngesivinini ukuqala depolarization esilandelayo. Uma okuqukethwe potassium ion uzokwehla kakhulu, ukuhlanganiswa kwezici creatine phosphate sinqamukile, okuholela ukuncipha osikweni ukusikwa imisipha inhliziyo.

glycosides senhliziyo: Izimo

Izimo Ingabe Ohulumeni Banalo Lonke ukusetshenziswa yabo yilezi: atrioventricular block II degree, itheku bradycardia, komzimba nezinto lezi izidakamizwa, ukudakwa kwabo.

Ukuze Izimo isihlobo yilezi ezilandelayo: bradyarrhythmia ciliary, AV-block mina degree, ogulayo itheku syndrome, isifo senhliziyo, itheku bradycardia, umfutho ophakeme wegazi, inhliziyo, hypercalcemia, hypokalemia, kwezinso noma yamaphaphu esingamahlalakhona umlando.

Kuyinto okungalungile ukusebenzisa glycosides inhliziyo ngaphansi kwale mibandela elandelayo: amyloidosis inhliziyo, diastolic inhliziyo ivolumu sindisa nge esingamahlalakhona yomthambo i-aorta, thyrotoxicosis, acute isilethikusebenza, zenhliziyo, pericarditis constrictive, congestive inhliziyo ukwehluleka ngenkathi sigcina okusezingeni eliphezulu okukhipha inhliziyo, anaemia nokunye.

Ngqo ngokwabo Izimo ngenxa ukungabi nezinkinga systolic, echaza le nokungasebenzi we glycosides inhliziyo. Futhi, isibonelo, phakathi ukuthuthukiswa acute isilethikusebenza, ukusetshenziswa kungaba avuse ukuthuthukiswa arrhythmias, okunikeza Izibikezelo esibi ukuphila okwengeziwe isiguli.

Ngaphambi isicelo ka glycosides inhliziyo kufanele uthintane nge onguchwepheshe. Lokhu kuzosiza ukuvimbela ukuthuthukiswa sengozini yokuthola izifo.