"Prepidil" (i-gel): incazelo, imiyalelo yokusetshenziswa nokubuyekezwa. Gel for ukulethwa ukuthutha

Kungani usebenzise umuthi onjalo ngokuthi "Prepidil" (gel)? Ukubuyekeza mayelana nokusebenza komuthi, kanye nobufakazi baleli thuluzi kuzochazwa okuncane kakhulu. Siphinde sinikeze ulwazi mayelana nendlela yokusebenzisa lesi sidakamizwa, ukuthi kubiza kangakanani nokuthi yisiphi isimiso saso senqubo.

Incazelo, ukupakisha nokubunjwa

Uhlobo luni lwephakheji lwenza umuthi "Prepidil"? I-gel intracervical iyaqhubeka ukudayiswa ema-syringes alahlwayo aphethwe nge-catheter. Zibekwe emgodini wezintambo zokupakisha kanye namabhokisi emabhodoni ngokulandelana.

Ukulungiswa kwe-preludil "(i-gel) okuguquguqukayo kanye ne-viscous iqukethe isithako esisebenzayo esinjenge-dinoprostone. Njengezinto ezisizayo, i-colloidal i-silicon dioxide ne-triacetylglycerol iyongezwa kuso.

Indlela yokusebenza

Uyini umuthi "Prepidil"? I-gel ngesikhathi sokuzalwa ivuselela ukuvuthwa komlomo wesibeletho. Imithwalo yayo esebenzayo i-fatty acid engasetshenzisiwe, ehlanganiswa ngaphansi kwezimo zomzimba.

Isimiso esithile salesi sidakamizwa ngesikhathi sokusetshenziswa kwayo kwe-intracervical asikafundiwe. Kodwa-ke, ochwepheshe bakholelwa ukuthi i-dinoprostone iyakwazi ukwandisa ukunikezwa kwegazi emgodini wesibeletho, ngaleyo ndlela ivuselele ukuvuthwa kwayo (ukunciphisa, ukuhogela nokuvuleka). Izenzo ezinjalo zihambisana ngokujwayelekile nokushintsha okwenziwe ngokujwayelekile, okuholela ekunciphiseni ukumelana komlomo nangokwanda kwe-myometrium, kanye nokwethulwa.

Kumele futhi kuqaphele ukuthi isici esisebenzayo se-ejenti esicatshangelwayo singabuye sibe nomthelela oshukumisayo kumfutho wegciwane lokugaya. Ezimweni ezingavamile, lokhu kuvuselela isinxephezelo noma ukuhlanza kumfazi ohamba phambili.

Ngezilinganiso eziphakeme, i-dinoprostone iyakwazi ukunciphisa ukucindezelwa kwegazi (ngenxa yethonya emithanjeni ebushelelezi emithanjeni yegazi nama-capillaries), futhi nokwandisa izinga lokushisa komzimba. Kodwa-ke, kufanele kuqashelwe ukuthi yonke le miphumela ayitholakali lapho izidakamizwa zisebenza ngendlela efanele, okungukuthi, kumanani okunconywa okwenziwe ukuvuthwa komlomo wesibeletho.

AmaKinetics

Yimiphi imingcele yekinetic yomuthi "Prepidil"? Ijel, intengo yalo ekhonjisiwe ngezansi, emva kokujova kwe-intracervical ka-500 μg ifinyelela ukuhlushwa okuphezulu egazini ngemva kwemizuzu engu-35-45. Emva kwalokho, okuqukethwe okusebenzayo kwezinto ezibonakalayo okuncipha kunciphisa ngokushesha ezingeni lokuqala (kungakhathaliseki ukuthi umsebenzi wesivumelwano unesivumelwano).

I-Dinoprostone nge-albumin yabantu ibopha ku-73%. Kulesi simo, ingxenye esebenzayo yesidakamizwa isakazwa phezu kwazo zonke izicubu kanye nezikhukhula eziphilayo zomzimba wokubeletha.

Ngokwezinga elikhulu, i-dinoprostone ihlanganiswe emaphashini, kanye nezinso nesibindi. Emcinini kanye negazi lomuntu, okungenani ama-metabolite angu-9 e-prostaglandin E 2 atholakala.

Iningi lomuthi osebenzayo "Prepidil" unxuswe yizinso, futhi ngamanani amancane - ngendwangu.

Izinkomba

Iyini ukusetshenziswa komuthi "Prepidil"? Ijelisi lisiza ukugqugquzela ukuvuthwa komlomo wesibeletho. Isetshenziswa kuphela lapho kukhona khona izinkomba zomsebenzi.

Ukungafani

I-gel yokuvuselela ukubeletha ayisetshenziselwa izimo lapho izinqamulelo ze-uterine ezinde ziphikisana khona. Zihlanganisa:

• Ukukhulelwa okuningi;
• Akukho ukufakwa kwekhanda le-fetal;
• Kusukela ku-6 ukukhulelwa kwesikhathi esigcwele;
• Ukuzalwa okudabukisayo noma okunzima (kubandakanya emlandweni);
• Ukungenelela okuhlinzekwayo esigabeni sesibindi noma se-cearean (kufaka phakathi emlandweni);
• Ukubamba isifuba somama kanye nenhloko ye-fetus;
• Ukucindezeleka kwesisu (esandulele);
• Isimo lapho ukungenelela okuhlinzekwa khona kungcono;
• Ukuhlukumeza ngesigqi sezinhliziyo zenhliziyo;
• Ukukhipha isisu kusukela emzimbeni wesisu ngesikhathi sokukhulelwa (okuvela emvelaphi engaziwa);
• Izifo zegciwane lesandulela ngculaza (ukuhlukana okuphansi);
• Isethulo esingavamile le-fetus ;
• Hyperersensitive kuya izithako zejel.

Ngokuqapha, i-ejenti embuzweni isetshenziselwa ukucindezeleka komzimba, izifo zenhliziyo, ukwephulwa kwesibindi sokusebenza, ukuphefumula kwesifo somzimba, ukukhubazeka kwesibindi, isisu sokuvuvukala, isifo sofuba se-ophthalmic noma i-glaucoma.

Isidakamizwa "Prepidil" (gel): imfundo

Njengomthamo wokuqala, sebenzisa konke okuqukethwe kwesirinji, usebenzisa i-catheter enamathiselwe kulokhu. Ijojowe emgodini wesibeletho somlomo wesibeletho, esitholakala ngaphansi kwesigaba se-pharynx yangaphakathi.

Uma i-gel isilayiwe, owesifazane olele embhedeni kufanele alale amahora angu-¼ ngemuva kwakhe. Lokhu kuyadingeka ukuze unciphise ukuvuza kwesidakamizwa.

Uma ukugqugquzelwa emkhakheni wokuqala wezokwelapha akuzange kwenzeke, imithi iphindzwa futhi (emva kokuphela kwamahora angu-6). Umthamo wokuphathwa ngokuphindaphindiwe komuthi uhlala ufana.

Isidingo sokwengeziwe ukusetshenziswa kwe-gel sinqunywa ngokusekelwe esimweni sempilo.

Isilinganiso esiphezulu nsuku zonke yomuthi owubuzwa ngu-1.5 mg.

Indlela yokusebenza

Kufanele ngisebenzise kanjani i-gel ukukhuthaza ukubeletha? Imfundo iqukethe izinyathelo ezilandelayo ngezinyathelo:

• Susa isiraphu oyinyumba nomcathisi kusuka kuphakheji.
• Susa i-cap kusukela endle ye-syringe.
• Faka i-cap ibe yindilinga (ngakolunye uhlangothi) ukuyisebenzisa njengepiston.
• Beka i-catheter (ngokuqinile) engxenyeni yesirinji ukuze kube khona i-lye.
• Faka okuqukethwe kwe-syringe.

Ukuphendula okubi

Imiphi imiphumela emibi ingabe umuthi "Prepidil" ubangelwa? I-gel engxenyeni ye-parturient iyakwazi ukucasula izithiyo ze-titanic zesisu (ukwandisa ithoni yayo, imvamisa kanye nobude bezinqamuzana), kanye nesicashu, ukuphuka kwesibeletho, ukuhlanza, ubuhlungu bokubuyela emuva, isifo sohudo, umkhuhlane, ukusabela kwamagciwane kanye nomzwelo wokushisa esiswini.

E-fetus, lesi sidakamizwa singabangela ukuthuthukiswa kokucindezeleka kwesifo, kanye nokuguqula isilinganiso senhliziyo, ukunciphisa ukuhlolwa komntwana osanda kuzalwa esikalini se-Apgar kuya kumaphuzu angu-7. Phakathi kwezinye izinto, ukusetshenziswa kwalo muthi akuvamile, kodwa kusengabangela ukubeletha.

Isidakamizwa "Prepidil" (i-gel): ukubuyekezwa kanye nentengo

Izindleko zalesi thuluzi ziphakeme kakhulu. I-syringe eyodwa ne-gel ingathengwa ama-ruble angu-580-650. Kumele kuqashelwe ukuthi lesi sidakamizwa sidingeka kuphela esibhedlela.

Odokotela bathi ukuthi ukusebenzisa "u-Prepidil" kufanele uqale uhlole ukulandelwa kwekhanda lomfazi kanye nobukhulu bekhanda le-fetal. Uma bengavumelani, abasebenzisi imithi.

Ngokusho kweziguli, izidakamizwa ezicatshangelwayo zingabangela inani elikhulu lemiphumela emibi, kuhlanganise nezingane ezisongela ukuphila. Ngakho-ke, iningi labo lenqaba ukusebenzisa leli gel, ikakhulukazi ngemva kokufinyelela eminyakeni engu-35 ubudala.