Lipid-ukwehlisa izidakamizwa "Rosuvastatin": yokusetshenziswa

Medicine "Rosuvastatin" imfundo manual uchaza izidakamizwa njengoba hypolipidemic ka-statin. Ukusebenza kwalesi abakhethayo izindlela kuyinto okusithiyayo ukuncintisana HMG-CoA reductase. Ukusetshenziswa wokulungiselela "Rosuvastatin" (yokusetshenziswa ke kuqinisekisa) izikhathi eziningana anda LDL catabolism, likhuphuke ka hepatic LDL receptor kanye nenani VLDL encishisiwe. Ngokuqondene izakhiwo pharmacokinetic imithi lipid-ukwehlisa, buphawuleka nomphumela oqabulayo reception yayo waphawula izinsuku eziyisikhombisa ngemuva kokuqala ukwelashwa, ukufinyelela yi yayo best emasontweni amane.

Thatha iphilisi "Rosuvastatin" umkhiqizi incoma ukuthi abantu abaphethwe ifomu okuxubile hypercholesterolemia (uhlobo IIb) hypercholesterolaemia noma IIa (kuhlanganise heterozygous) njengenhlangano adjunct yokudla.

Ngakho nekusebenta eliphakeme hypolipidemic izidakamizwa esebenzayo esimweni lapho ezinye izinqubo zokwelapha (ukuvivinya umzimba, nokwehlisa isisindo somzimba) akuvezi ukuzuzwa yalokho efanele zokwelapha. Ngaphezu kwalokho, ukusebenzisa abakhethayo ejenti "Rosuvastatin" imfundo manual uncoma njengenhlangano izidakamizwa asizayo ngo yokwelapha homozygous uhlobo hypercholesterolemia umndeni.

Nikeza lezi amaphilisi akuvunyelwe nhlobo ku Endabeni yesiguli izifo ezinzima isibindi, myopathy noma ukuphazamiseka kwempilo uboniswe izinso. Phakathi nenkathi yokukhulelwa, futhi akufanele bathathe izidakamizwa lipid-ukwehlisa "Rosuvastatin." Umuthi is contraindicated esikhathini lactation. Ngaphezu kwalokho, it is hhayi Kunconywa ukuthatha lezi amaphilisi kanyekanye cyclosporine noma hypersensitivity kuya izingxenye zawo. Abantu abangazange sebethole engu-nesishiyagalombili, futhi akudingekile ukuba amise ejenti abakhethayo "Rosuvastatin." Yokusetshenziswa kungukuthi belulekwa ulithathe kunjalo utshwala esungulwe kwezinso ukwehluleka noma isibindi izifo.

Ngokunakekela okukhulu ukusebenzisa izidakamizwa lipid-ukwehlisa kufanele kube abantu abaphethwe electrolyte, endocrine kanye umzimba iziyaluyalu, i-hypothyroidism noma hypotension. Ngo sepsis, isithuthwane engalawuliwe, proteinuria, ukuhlukumezeka okukhulu kanye nokungenelela kuhlinzwa kufanele ziyeka izidakamizwa, "Rosuvastatin." Ngaphezu kwalokho, Izimo isihlobo lezinceku izifo kwemisipha kanye nobudala amadala kweminyaka engamashumi ayisithupha nanhlanu.

Ekuphetheni, kufanele ishiwo kungenzeka ukusabela ezingezinhle, okuvela kuyo okungase senziwa yokwamukela kusho "Rosuvastatin." Ngokwesibonelo, iziguli eziningi esekhala besisu ubuhlungu, ukuqunjelwa, isiyezi kanye nesicanucanu. Ngaphezu kwalokho, kukhona ingozi kancane myopathy, proteinuria, asthenia , futhi myalgia.