"Imovan": yokusetshenziswa. Izibuyekezo mayelana analogue izidakamizwa nokuthengisa imithetho Pharmacy

Nomuthi "imovan" imfundo manual ikhomba njengendlela aid ubuthongo, ebhekisela tsiklopirrolonov iqembu. Ukulungiswa possesses anxiolytic, okuyiluthayo, imisipha relaxant, sine izakhiwo anticonvulsant.

pharmacodynamics

A zokwelapha izidakamizwa umphumela "imovan" (umsebenzisi kufakazelwa) ephathelene ethize agonist nomthelela receptor omega (eyayaziwa ngokuthi benzodiazepine receptor uhlobo wabo wokuqala nowesibili). Imithi kunganciphisa isikhathi ukulala futhi ukunciphisa izinga lokuhlasela kwesifo awakenings ekuseni imini nobusuku, futhi ukwandisa isikhathi futhi ngcono ikhwalithi ubuthongo. idatha PSG ukubonisa ukuthi lesi sidakamizwa "imovan" e iziguli ukuqwasha, ukulala kunciphisa Isigaba sokuqala futhi bandisa wesibili, izitolo yesithathu neyesine (ubuthongo obukhulu) kanye isinyathelo nakuba (REM) isigaba. Ucwaningo olwenziwa kokubhalisa polysomnograms ukuhoxiswa akalushongo iyiphi enkulu Rebound ukuqwasha ngemuva kokuthatha imithi izinsuku ezingamashumi amabili nesishiyagalombili. Okunye ukuhlola kwabonisa ukuthi uma usebenzisa izidakamizwa ngoba nesikhombisa amasonto ukunyamalala umphumela okuyiluthayo is hhayi waphawula.

Pharmacokinetics

amaphilisi Sleeping "imovan" matasa ngokushesha, kungakhathaliseki ukuthi ukudla. Ngo-plasma ngemva kokuphathwa ngemlomo ngaloko lokusandza kwenteka 3,75 kanye 7.5 angu kwezimali ngaphakathi eyodwa nengxenye emahoreni amabili ifinyelele okuhlushwa eliphakeme labantu abangu-30 no-60 ng / ml, ngokulandelana. Njengoba Amaprotheni egazi plasma futhi isibopho unsaturated ibuthakathaka (cishe 45%). Ezingeni amaprotheni ngenxa ingozi ekuxhumaneni nezinye izidakamizwa sincane kakhulu. izidakamizwa "imovan" zanda ngokushesha ngempela kusukela kwegazi. Umhlahlandlela ibika ukuthi lokuhlushwa yayo nobisi lwebele zifana ebonwe plasma. Ingxenye-ukuphila zomuthi ku yayinjalo ngesikhathi ukuthatha Kunconywa ngemithamo ezomhlaba kwamahora amahlanu. Umuthi livela ogxile ngesimo metabolites e umchamo (80%) kanye indle (16%).

izinkomba ngoba

Nomuthi "imovan" imfundo kubonisa ukusetshenziswa ekwelapheni nesimo, lezivakashi, ukuqwasha okuphikelelayo kwabadala. Ikakhulu, isetshenziswa nobunzima e ngilale ubusuku awakenings ekuseni.

Khipha ifomu kanye nokwakheka

Umuthi itholakala ngendlela ezimhlophe amaphilisi ifilimu-camera nge umugqa okusaqanda ngakolunye uhlangothi. Omunye iyunithi izindlela luyinto ingxenye esebenzayo ehlanganisa - zopiclone - 7.5 angu mass. Tablets "imovan" zihlanganisa sodium carboxymethylstarch, ama-titanium dioxide, i-calcium hydrogenphosphate dihydrate, magnesium stearate, monohydrate lactose, ukolo isitashi, hypromellose.

Indlela I-eyamukelayo kanye nesikhathi sokwelashwa

Wabonisa nomuthi ngomlomo ngokushesha ukulala ngaphambi ebusuku. Uma kungenzeka, ukwelashwa kumele ibe mifisha futhi akufanele idlule amasonto amane, kuhlanganise inkathi umthamo encishisiwe. Ukuthatha izidakamizwa isikhathi eside ukwedlula zibekwe emiThetjhwaneni, kumele bavunyelwe kuphela emva ukuhlolwa uchwepheshe isiguli. kudingeka Njalo ukuqala ukwelashwa nge umthamo ephansi ngempumelelo, okwandisa ke uma kunesidingo, kodwa awukwazi idlule umthamo esiphezulu. Lapho ukuqwasha lezivakashi (isib, kubangelwa ushintsho endaweni ngesikhathi hambo) Inkambo yokwelashwa ingeqi kwezinsuku ezimbili kuya kwezinhlanu. Lapho isimo ukuqwasha, kuba kwamasonto amabili kuya kwamathathu. Endabeni ukuqwasha okuphikelelayo kudinga ukwelashwa eside, isikhathi esabekwa udokotela.

umthamo ezinconyiwe

I umthamo wansuku zonke abangaphansi kweminyaka engu-65 ubudala - 7.5 angu. ezigulini esezikhulile (engaphezu kwengu-65), futhi labo abanale nkinga yokungadli kahle kwesibindi noma ukucindezeleka zokuphefumula of kobukhulu ngokulinganisela, ebekiwe engayitholi nsuku zonke 3,75 angu. Thatha imithi yakho ngendlela mass ezingaphezu kuka 7.5 angu ngelanga kuvunyelwe kuphela ezimweni ezimbi kakhulu. Ukwelashwa kweziguli ukwehluleka kwezinso, naphezu kweqiniso lokuthi e Kulokhu akalushongo Ukubuthelela izidakamizwa futhi metabolites yayo, kubalulekile ukuqala umthamo zonke izinsuku we 3,75 angu.

side effects

Mayelana "imovan" ukulungiselela Izibuyekezo etholakala kakhulu omuhle, ngokuvamile asibekezeleleki kahle. Kodwa cishe zonke iziguli ukuthi ngemuva kokuthatha izidakamizwa emlonyeni uhlala a aftertaste okumunyu. Abanye abantu bakhuluma ngokuthuthukisa ukuvela ikhanda, isiyezi ku ngemuva ukusetshenziswa elele amaphilisi. Phakathi nemiphumela engase negative Kumelwe kuphawulwe futhi hypotonia kwemisipha, ukozela asalile lapho evuka, diplopia, asthenia, ukulahlekelwa libido. Kukhona ingozi iziyaluyalu wokugaya ukudla: isicanucanu, dyspepsia, nomlomo owomile. Ngezinye izikhathi kukhona esikhumbeni ukusabela ezifana nokuqubuka, izinhlungu eziba kanye ukulunywa, ezimweni ezingajwayelekile - ukusabela anaphylactic, angioedema ukushaqeka. Kwezinye iziguli emva ukuphuza amaphilisi elele avele ukusangana, ukucindezeleka, amaphupho amabi, izinkinga nekubambisana ukunyakaza, ulaka, ukucasuka, isimo sokucindezeleka, uhamba ephusheni, ukuziphatha okungalungile (kungenzeka lihambisana ukulahlekelwa amandla okukhumbula). Ngisho nalapho kusetshenziswa zokwelapha ngemithamo amaphilisi "imovan" (ngesandla uxwayisa ngalokhu) angagcina kwencika ngokwengqondo nangokomzimba.

ukuhoxiswa

Abanye abantu emva ukumisa yokwelapha imithi eba zokulutheka syndrome. Izimpawu zayo zingase zishintshe, ngokuvamile avele ifomu yokukhathazeka, ukudideka, Abuya ukuqwasha, tachycardia, ukucasuka, liqhaqhazela, ikhanda elibuhlungu, delirium, kukhuphuke ukujuluka, ebusuku ephupha kabi, tachycardia, ukuyaluza, ukusangana. Ezimweni ezingavamile kakhulu ukuquleka kwenzeka.

Izimo

Abantu ne hypersensitivity kuya izithako kusho "imovan" kufanele uhlukane nale ukusetshenziswa kwalo. Futhi, amaphilisi elele kungukuthi inikezwa iziguli gravis e ezinzima isibindi ukwehluleka ngefomu okukhulu (nge ingozi encephalopathy), ezinzima zokuphelelwa umoya syndrome, ukwehluleka ezinzima zokuphefumula, ubuthongo. Contraindicated izidakamizwa engakayihlanganisi iminyaka engu-iminyaka eyishumi nesishiyagalombili. Abantu abanegciwane le-umlando zezidakamizwa, utshwala, ukuluthwa izidakamizwa eziyingozi, izidakamizwa kusetshenziswe ngokuqapha, njengoba kulokhu, kukhona kwengozi sokuncika okwandisa noma ukuhlukumeza.

Sebenzisa phakathi nokukhulelwa kanye lactation

Thatha elele amaphilisi "imovan" kwabesifazane abakhulelwe kanye lactating is hhayi Kunconywa. Lapho izidakamizwa iqondiswa ngesikhathi senyanga yesithathu usana angagcina imiphumela emibi ezifana hypotension, ukucindezeleka zokuphefumula, hypothermia. Abesifazane uhlela noma ukukhulelwa esolwa kufanele ayeke ukuthatha izidakamizwa.

ukweqisa izidakamizwa

Ngokuvamile ukweqisa izidakamizwa izimpawu kubonakala ka CNS ukucindezeleka ngezindlela ezingafani kusuka somnolence elula ikhoma (kuncike umthamo). Ezimweni omnene, kukhona abantu bengasinaki, ukozela, ukudideka, e esibi kakhulu - ukucobeka, ukucindezeleka zokuphefumula, ataxia, hypotonia, equlekile. Kuyinto kakhulu ezingavamile block atrioventricular. ukweqisa izidakamizwa esisongela ukuphila akulona, uma yokwamukela amaphilisi elele aluhlanganiswa yokwamukela nezinye izidakamizwa lapho sicindezeleke isimiso sezinzwa emaphakathi, noma utshwala. Futhi kungenzeka izimpawu ukweqisa izidakamizwa zaba zimbi uma isimo jikelele isiguli siye saba buthaka noma comorbidities. Ezimweni ezinjalo, kungaba ngisho nasekufeni (ezingavamile). Ngaphambi izidakamizwa ngemithamo ngokweqile kuboniswe ukwelashwa lingaze futhi basekelane, kodwa esibhedlela. Ukunakwa enkulu kumele zikhokhelwe imisebenzi senhliziyo zokuphefumula. Izinyathelo ezifana carbon isebenze abese egeza esiswini kukhona newusizo kuphela uma kwenziwe ngokushesha emva ukusetshenziswa nomuthi "imovan".

analogs

Banikwa imithi ejwayelekile okuyiluthayo ezifana "Somnol", "Thorson", "Relakson", "Piklodorm" nabanye. Njengomthetho, ishibhile kuka original, kodwa ngesikhathi esifanayo mancane ngempumelelo.

Izixwayiso

Njengoba kushiwo ngaphambili, ukuthatha sedatives, kuhlanganise "imovan" izidakamizwa, kungabangela ukuthuthukiswa sokuncika ngokwengqondo nangokomzimba. Ubungozi kwandisa ukwelashwa eside futhi ukuphuza amaphilisi elele ngemithamo ephakeme, kanye nokusebenzisa kabi uphuzo oludakayo, izinto psychotropic, kanye khona nokukhathazeka. Uma ukubukeka kwencika ngokomzimba evele phela ukwelashwa kungase ukuthuthukisa a syndrome zokulutheka okwakubekelwa kuchaziwe ngenhla. Ukuze ugweme lokhu, kubalulekile ukunciphisa umthamo izidakamizwa kancane kancane. Vimbela ingozi ezifana side effects njengoba ukulahlekelwa amandla okukhumbula anterograde, kuyasiza ukugcina izimiso ezimbili: Kufanele baphuze iphilisi nje ngaphambi sokulala (ukugwema semali isikhathi phakathi ukusetshenziswa kwezidakamizwa kanye ekulaleni) futhi ubuthongo okungenani amahora ayisithupha (hhayi ukuphazamisa ubuthongo ngaphambili kuka amahora ayisithupha emva ngilale). Imithi aluboniswa ekwelapheni ukucindezeleka futhi kungase kufihle ngisho izimpawu zawo.

izidakamizwa ekuhlanganyeleni

ukuphathwa ngesikhathi esisodwa elele amaphilisi "imovan" futhi ngokweqile kungaholela anda ukupholisa. Ngaphezu kwalokho, awukwazi ukuthatha imithi kanye ukwelashwa izidakamizwa, wokucindezela isimiso sezinzwa esiyinhloko: barbiturates, antidepressant nge sine-zinhlungu, antipsychotics, ama-ejenti antitussive, imithi ebulala izinzwa, analgesics kwezidakamizwa, izidakamizwa antiepileptic nesenzo emaphakathi. Endabeni ukusetshenziswa ahlangene nomphumela nokudangala ku isimiso sezinzwa esiyinhloko kungase ukugqanyiswa. Futhi, ungaphuzi "imovan" amaphilisi kanye nezidakamizwa equkethe trimipramine, ngoba emakamu plasma wale mithandazo nomphumela waso kuzoncishiswa. Joint reception buprenorphine soporific kwandisa ingozi yokucindezeleka zokuphefumula (umphumela ungase ube ngisho ukubulala).

Lapho ukuthenga "imovan"

Umuthi okuthengiswa drugstores kakhulu. amaphilisi Sleeping etholakalayo ku kadokotela. Abanye abantu abafuna ukuthenga imithi ngaphandle kadokotela, zisebenzisa amasevisi Pharmacy inthanethi. Nokho, kufanele sikhumbule ukuthi uma wenza engozini ukuthenga izinga abampofu, umgunyathi noma izimpahla yisikhathi.