I-Zoledronic acid: isenzo semithi kanye nezifanekiso

Kuyaziwa ukuthi ama-bisphosphonates anempahla yokuvimbela ukuthuthukiswa kwe-bone metastasis nokuvimbela ukulahlekelwa kwamathambo. Esinye sezidakamizwa ezingcono kakhulu kuleli qembu i-zoledronic acid. Kukhona nobufakazi bokuthi lesi sidakamizwa sinamandla okuvimbela i-antigenogenis, ukuhlasela kwe-tumor, ukunamathela kwamangqamuzana amathumba emathanjeni amathambo, kwenza ukuba i-apoptosis, kanye ne-synergism ne-chemotherapy ibonwe.

Ukwakhiwa kwebhodlela eli-1

I-Zoledronic acid monohydrate - 4.26 mg, izithako - i-citrate ye-sodium, i-D-mannitol.

I-Pharmacology

I-inhibitor ye-bone resorption. I-Zoledronic acid ingokwesigaba esisha sama-bisphosphonates esiklasi esiphakeme. Inomthelela wokukhetha emathanjeni amathambo. Iyanciphisa umsebenzi wama-osteoclasts, ngaphandle kokuba nomthelela omubi ekwakheni kanye nezinye izimfanelo zamathambo esithambo. Umphumela wama-bisphosphonates ethanjeni usekelwe ekufaneni okuphezulu emathisini amathanga amancane, kodwa indlela eqondile ye-molecule ehlinzeka umsebenzi ongenakwenzeka we-osteoclasts ayizange ifundwe kuze kube yilolu suku. Ibuye ibe nomthelela oqondile wokuphikisa, ohlinzeka ngempumelelo emathinasisini yethambo.

I-in vitro, itholakale ukuthi i-zoledronic acid, ekwenzeni i-apoptosis nokucindezela ukwanda kwamaseli, inomphumela wokuphikisa ngokuqondile kwi-myeloma, kanye namaseli omdlavuza webele, ngenkathi kunciphisa ingozi ye-metastasis. Futhi i-zoledronic acid inendawo yokunciphisa ukuxilongwa kwe-calcium ku-serum ene-hypercalcemia, ebangelwa yisisu.

Izinkomba zokusetshenziswa

• I-osteolytic foci ku-multiple foci ye-myeloma.
• I-osteoblastic, i-osteolytic, ixube le-metastases yamathambo amakhulu.
• I-Hypercalcemia, ebangelwa ukwakheka okungalungile.

Ukungafani

• Ukukhulelwa nokuncelisa.
• Ukungasebenzi kahle kwe-Renal.
• Izingane kanye nentsha (ukuphepha kokusetshenziswa kungasungulwa).
• Hypersensitivity kuya kwe-bisphosphonates ne-zoledronic acid.
• Ngokuqapha: umsebenzi ongasebenzi ngokweqile, isifo se-asthma esibuhlungu, ukungakwazi kahle kwe-hepatic.

Imiphumela emibi

I-anemia, i-thrombocytopenia, ikhanda, isizungu, i-conjunctivitis, i-nausea, i-anorexia, ukuhlanza, isifo sohudo, ubuhlungu besifo, i-arthralgia, i-hypophosphatemia, i-hypocalcemia, umkhuhlane, isifo sofuba, i-asthenia, inzuzo yesisindo. Kulezi ziguli ezine-zoledronic acid, i-osteonecrosis yomhlathi ikhonjwa ngezinye izikhathi (ngokuvamile emva kokungenelela kwamazinyo).

Indlela yokusebenza

Ukuthinta futhi kuqhube imizuzu engu-15, kodwa hhayi ngaphansi. Ku-metastase ye- myeloma eminingi , umthamo we-4 mg kanye ngenyanga unconywa. Njengoba i-hypercalcemia, ebangelwa isisu esinonya, umthamo u-4 mg kanye.

Imiyalo ekhethekile

Emva kokuba isidakamizwa sisungulwe, kubalulekile ukulawula ukuhlushwa kwe-magnesium, i-phosphorus, i-creatinine ne-calcium e -serum yegazi. Uma kunokwenzeka, izinqubo zamazinyo kufanele zigwenywe.

I-Zoledronic acid. Ama-analogues

Amalungiselelo "Actonel", "Aneldronat", "Aredia lyophilizate", "Bonviva", "Bonnronat", "Bonefos", "Klobir", "Xidifon", "Lindron", "Ostalon", "Ostealen", "Ostererepair" "I-Pamidronate", "Pomegara", "Risendros", "Strogos", "Tevanan", "Forosa", "Fosamax", i- "Fosfoteh", "i-Rizarteva."

I-Zoledronic acid. Intengo:

Ngokuvamile, amasayithi ahambisa imithi ngaphakathi kwemingcele yomthetho abonisa amanani wezimpahla zawo. Kodwa, ngokumangalisayo, intengo ye-zoledronic acid ivame ukuboniswa cishe. Kodwa izindleko zayo ezilinganiselwa cishe yizinkulungwane ezingu-14 ze-ruble ibhodlela ngalinye. Kuthengiswa kuma-pharmacy kuphela emtholampilo.

Ulwazi olunikezwe ngenhla luhloselwe ukujwayela abasebenzi bezokwelapha. Lesi sihloko se-zoledronic acid asithathi indawo yokubonisana nodokotela oqeqeshiwe, futhi ngeke isiqinisekise ukuthi umuthi usebenza kahle.