"Dopamine" - kunjani lokho? "Dopamine": imfundo, isicelo, intengo

Umuthi 'Dopamine "libukeka powder crystalline umbala omhlophe nge iphunga ngokulambisa lizwakale ka hydrochloric acid. Leli fomu-ke has ngesimo hydrochloride. "Dopamine" - into oncibilikayo emanzini futhi utshwala. It kuthintwa alkalis, ezintweni ezihlukahlukene oxidizing nensimbi nosawoti. Izinkomba kanye contraindications ukusetshenziswa kwezidakamizwa "Dopamine", ukulaya ku ukusetshenziswa kwalo ezibekwe ezincwadini zethu.

Kusho ekhishwe njengoba isixazululo ukumnika ukugxilisa ingqondo.

izici kwemithi

"Dopamine" - into, a neurotransmitter. On the izakhiwo umzimba Dopamine kuyinto eyandulela adrenaline futhi noradrenaline. Umuthi sithinta receptor ohambelana, futhi lokuhlala eliphezulu sithuthukisa umsebenzi α- futhi β-adrenoceptors. umsebenzi "Dopamine" kuhloswe:

• nekusita neuropathy ukumelana semithambo;
• anda systolic blood pressure;
• ukukhuthazwa kwenhliziyo;
• anda okukhipha inhliziyo;
• ushintsho ingane kwenhliziyo;
• abalulekile umoya-mpilo umncane.

"Dopamine" sijulisa ukugeleza kwegazi izitsha ubuchopho, inhliziyo, izinso kanye namathumbu. Ukwandiswa glomerular filtration isilinganiso kanye sodium excretion yi izinso.

"Dopamine" - umuthi okusheshayo-esebenza. Ngemva 5-10 imizuzu emva i / ukusebenza v ukumnika uphela. Ingxenye-ukuphila - cishe amabili imizuzu. Isigamu efana baxhumana iprotheni e oketshezini olungenambala lwegazi. Umuthi sihamba ngokushesha umzimba inqubo e izinso, isibindi kanye plasma yegazi ngenxa ithonya mao futhi catechol-O-methyltransferase esimweni metabolites alisebenzi futhi limatasa ezivezwa izinso. Ikota ukusetshenziswa umthamo is kuguquka norepinephrine ku adrenergic emsipheni amahlumela. Ngenxa nokuqedwa asebenzayo akuyona Ukubuthelela izidakamizwa emzimbeni womuntu, ngisho emva kwesikhathi eside i-reception.

"Dopamine": isicelo

Izimpawu ze-eyamukelayo:

• izinhlobo ezahlukene ukushaqeka, njengemoto esibuhlungu, cardiogenic, nasezinkingeni ezilandela ngemva kokuhlinzwa, hypovolemic, endotoxin.
• semithambo olunamandla futhi senhliziyo.
• Okuphansi okukhipha inhliziyo.

"Dopamine" nge ukushaqeka cardiogenic abanezidingo ezikhethekile, it kwandisa esivimba amanzi contractile umsebenzi.

Umuthi iqondiswa ngemithambo yegazi. 125 noma 400 ml isixazululo ezinhlanu amaphesenti sodium chloride noma isixazululo glucose esidingekile ngalesi 25 noma 200 mg ngokulandelana. Ngakho, 1 ml ikhambi etholwe 200 noma 500 izidakamizwa .mu.g. Uma isiguli singenakukwazi esizosingathwa lemiqulu emikhulu uketshezi zingenziwa isixazululo kanzulu ngokwengeziwe ukuze 1 ml 800 micrograms kwaba "Dopamine". Ukuze wenze lokhu, thatha 200 mg ngayinye 250 ml isixazululo. Izinga isethulo ifinyelela 1-4 UG / kg ngeminithi isisindo ngokwesilinganiso umzimba 70 kg (2 kuya ku-11 amathonsi 0.05% isixazululo noma 1.5 kuya 6 amathonsi 0.08% isixazululo). Oqabulayo Isikali - kusuka 5 kuya ku-9 mg / kg 1 iminithi. Isikali "Dopamine" 10-15 .mu.g / kg ngomzuzu kuwusizo vasodilation futhi hypotension. Izinga ekuphathweni zingandiswa 18 .mu.g / kg ngomzuzu. I ukumnika senzeka ngaphandle kokuphazamiseka futhi uhlanganisa inkathi esukela izinsuku 2-3 amahora 1-4 noma ngaphezulu. Umthamo ngelanga esingeqile 800 mg. Ngokwethulwa "Dopamine" Kunenkolelo zokuqapha ECG. Ukunqunywa umthamo kanye izinga yokuphathwa okuvumelana ingcindezi lwemithambo, kwenhliziyo, okukhipha inhliziyo, kwenhliziyo diuresis. Uma hypotension asivelanga, futhi kwehle umchamo okukhipha, umthamo kumele kungancipha.

Izimo

Umuthi is contraindicated uma kwenzeka izinkinga ezifana:

• arrhythmia;
• pheochromocytoma;
• hypertrophy Prostatic;
• Ukuvalwa glaucoma.

side effects

Ukwethulwa ketshezi ngemithamo ezinkulu, ezingeni lelisetulu "Dopamine" kungabangela side effects, kuhlanganise:

• eliqhaqhazelayo;
• tachycardia;
• vasospasm;
• arrhythmia;
• kokunikezwa kwe-isigqi zokuphefumula;
• anginal futhi ikhanda;
• lengqondo ukuyaluza ;
• kwezinye izimpawu, ukubona isenzo Adrenomimeticalkie.

Njengoba nokuqedwa "Dopamine" iyasebenza, izimpawu ngenhla zinyamalale uma wehlise umthamo noma umise nokuphathwa izidakamizwa. Uma sinqamukile isigqi, kubalulekile ukusebenzisa izidakamizwa antiarrhythmic, kuhlanganise "Verapamil", "lidocaine" nabanye. isixazululo Extravasation "Dopamine" kungaholela necrosis ijwabu ongama adipose futhi kwesikhumba.

Izixwayiso

"Dopamine" ngesikhathi sokukhulelwa nalokuvalelwa kuphela uma ukwelashwa okutlhogekako kumama kanye nomphumela oqabulayo njengoba ingaphezulu kuka ingozi embungwini.

isixazululo Fresh kufanele ibe ukuthungwa esobala futhi bengenalo luhlaza nezingahlobene nendaba.

ukwelashwa kanye kanye nezinye izidakamizwa

Umuthi lingathathwa ngokulinganisa ne glycosides zenhliziyo isisu (isib furosemide nezinye). ukushaqeka Hypovolemic kudinga ukwethulwa "Dopamine" kanye lonke igazi, oketshezini olungenambala olusegazini noma plasma esikhundleni.

Ungathathi "Dopamine" ngesikhathi esifanayo ne "cyclopropane", mao inhibitor namanxusa ngoba izinzwa ne-halo ( "Halothane" kanye nabanye).

Nosimende ukuxubana ekwakhiweni engamukeleki nezixazululo ane-alikhali nezinye izidakamizwa.

"Dopamine" - umuthi isetshenziswa kuphela kadokotela. intengo kwakho kuncike umthamo kanye nenani ampoules iphasela, ezisukela 80 ruble 300 iphakethe ngasinye (5-10 ampoules).