"Choludexan": yokusetshenziswa, nozakwabo yangempela

Kungani ngidinga imithi "Choludexan" ukwenzani? Yokusetshenziswa zomuthi izokwethulwa ukubuyekeza kwethu. Futhi, kusuka mathiriyeli lo sihloko uzofunda mayelana kwindlela sisuke sicabanga iyatholakala kusho ukuthi elinye lamalungu ayo, okuyinto ke has Izimo, uma kuye kwadingeka yini imiphumela emibi nokunye.

Khipha ifomu zomuthi, kwikhava yawo nokwenza

Uma unquma ukuthenga iphilisi "Choludexan", ngakho-ke angeke aphumelele. Ngemva izidakamizwa ikhishwe kuphela ngesimo amaphilisi. Ziyakwazi amaseli contoured, nakho ibekwe ebhokisini amakhadibhodi. iphakethe ngasinye siqukethe amaphilisi 20.

"Choludexan" imithi iqukethe isici asebenzayo ezifana ursodeoxycholic acid (e inani 300 mg).

Izimfanelo kwemithi zomuthi

Uyini izidakamizwa "Choludexan"? Iziyalezo yokusetshenziswa Lithi eyisidalwa esinenkululeko hepatoprotective. It uyakwazi ukunikeza cholelitolitic, immunomodulatory, hypolipidemic, imiphumela choleretic futhi ane-ukwehlisa.

Nge kuqhathaniswa okusezingeni eliphezulu izakhiwo polar, le micelles esebenzayo isithako capsule ifomu elixutshwe (akunabo ubuthi) anobuthi (apolar) Bile acid. Leli qiniso kunciphisa amathuba reflyuksezofagity futhi biliary Reflux kolwelwesi, lapho ezilimele cell ulwelwesi.

Kufanele kuphawulwe ukuthi ursodeoxycholic acid uyakwazi ukwakha molecule double ukuthi kamuva lithathwa Ulwelwesi lwamangqamuzana egazi (isib cholangiocytes, hepatocytes namaseli EPITHELIAL emathunjini), usimamise ngibenze abuthonywa imithelela micelles cytotoxic.

Ngu wehlise lokuhlushwa Bile acid zinobuthi amaseli isibindi futhi zikhuthaza cholepoiesis ecebile ngokubhekisela Bicarbonate, esebenzayo nomuthi isici kudambisa cholestasis intrahepatic.

Asinakusho ukuthi izidakamizwa "Choludexan" uyakwazi ukunciphisa saturation Bile ne-cholesterol. Lo mphumela ngenxa nokucindezela ukumuncwa isithako esisebenzayo emathunjini, kanye nokuncipha uketshezi e Bile zamagama kanye ukucindezelwa esibindini.

Ngemva ngokuthatha izidakamizwa ngaphakathi ke ngesivinini noqhekeko cholesterol Bile, kanjalo ukwakha nalo zinhlayiya (liquid). Kufanele kuphawulwe ukuthi umuthi ukwazi ukunciphisa Inkomba lithogenic of Bile.

Ngemva ukwelashwa, imithi "Choludexan" nesineke Ukuqedwa cholesterol calculi. Futhi kusho akunqandi kumiswa amatshe entsha.

Pharmacokinetics zomuthi

Lapho ukumuncwa lesi sidakamizwa "Choludexan"? Iziyalezo ukusetshenziswa amaphilisi liqukethe ulwazi mayelana yokuthi isithako yabo okusebenzayo ugxile esincane (90%) kanye ileum (10%).

Ubuningi esiphezulu ingxenye esebenzayo egazini (at 50 mg) yafinyelelwa ngemuva kwamahora mayelana 1.2-3.

izidakamizwa Active lingena isithiyo esinomhlapho. Anakho amaprotheni eliphezulu kakhulu ngibopha (kufika ku 97-99%).

Imithi akheka esibindini. Kuboniswa ukulungiselela kanye Bile.

Izinkomba ukusetshenziswa kwemithi

Kwezinye izimo, imithi kuboniswa ukusetshenziswa "Choludexan" okuyinto Izibuyekezo izokwethulwa kancane okwengeziwe? Ngokusho imiyalelo, umuthi kuboniswa ngenxa ngeziphambeko ezilandelayo:

• Reflux esophagitis, kuhlanganise biliary;
• sclerosing cholangitis (primary);
• cholelithiasis (inkimbinkimbi ngohlobo);
• dyskinesia biliary ;
• ukusha kwesibindi kohlobo ezingamahlalakhona esebenzayo;
• atresia biliary (intrahepatic), kanye Bile imbobo atresia azalwa naso;
• enobuthi isibindi ukulimala, kuhlanganise emva imithi;
• cystic fibrosis;
• Alcoholic isifo sesibindi;
• steatohepatitis nonalcoholic;
• isifo sokusha biliary (okuyinhloko).

Izimo ukusetshenziswa kwezidakamizwa

Ngaphansi akukho pathologies kunoma isiphi isimo akumele sithathe lesi sidakamizwa "Choludexan"? Imiyalelo, amazwana kusukela ochwepheshe bathi kule izidakamizwa has inqwaba Izimo:

• ubudala zezingane (iminyaka efinyelela kwemithathu);
• amatshe atholakala enyongweni rentgenpolozhitelnye (calcium okusezingeni eliphezulu);
• empyema kwesinye nenyongo ;
• ukungasebenzi kwe-gallbladder;
• gastro-biliary fistula;
• hepatic noma esingamahlalakhona kwezinso (uhlamvu uzwakalise);
• cholecystitis acute;
• izifo ezithathelwanayo (abukhali kakhulu), Bile Amapayipi, amathumbu nenyongo-esinyeni;
• isimiso biliary;
• cholangitis acute;
• isifo sokusha (ikakhulukazi decompensation isinyathelo);
• hypersensitivity emuthini.

Ohlakaniphile wamukelekile imithi

Ngaphansi kwaziphi izimo kufanele libekwe imithi "Choludexan" ngokucophelela okukhulu? Uphenyo odokotela bathi isithako yayo asebenzayo ayinakho yobudala. Nokho, kakhulu ngokuqapha amaphilisi inikezwe izingane ezineminyaka engu-3.5-4, ngenxa kungenzeka nobunzima yabo ukugwinya.

Nomuthi "Choludexan": yokusetshenziswa

Udaba phambi kwethu kuphela ngaphakathi imithi nge ukudla.

Nge nalokhu kwenqaba njengoba Reflux kolwelwesi, kuhlanganise biliary, umuthi ezinqunyiwe kanye nsuku zonke ngesikhathi sokulala. Inkambo yokwelashwa kungaba isukela izinsuku 10-16 izinyanga 6 (uma kunesidingo, kuze kube iminyaka engu-2). Uma isiguli presents nge ngokukhukhumala kwentamo isifo sesibindi, umthamo senyuselwa 3 amaphilisi ngosuku.

Ngo pathologies hepatic okungamahlalakhona, cholelithiasis nomuthi ezithathwe njalo isikhathi eside (izinyanga noma ngisho neminyaka) e inani kusuka amaphilisi 2 kuya 5 nsuku zonke. Ubude besikhathi eyamukelayo kusho nokonakala amatshe izinyanga 3.

Nokuvinjelwa yokuphindela cholelithiasis (ikakhulukazi ngemva cholecystectomy) izidakamizwa letimisiwe capsule kabili ngosuku izinyanga eziningana.

Lapho ukulimala kwesibindi (anobuthi, uphuzo oludakayo kanye nemithi), kanye biliary atresia nomuthi okumele zithathwe volume of 3-5 amaphilisi ngosuku izinyanga eziyisithupha noma ngaphezulu. I umthamo ofanayo futhi lilondolozwe eyinhloko isifo sokusha biliary, steatohepatitis nonalcoholic, sclerosing eyinhloko cholangitis.

side effects

Yiziphi imiphumela emibi izidakamizwa "Choludexan"? Yokusetshenziswa, ukubuyekezwa nomuthi ukusho ukuthi emva elisetshenziswa iziguli zingase zibhekane iqolo, uhudo, exacerbation psoriasis, isicanucanu, ukuqunjelwa, ukuhlanza, ukwanda transaminases isibindi (lezivakashi), Alopecia namatshe calcining (Bile).

Lapho ukubonakaliswa lezi ngeziphambeko kufanele ngokushesha ayeke ukuthatha izidakamizwa kanye nodokotela.

Ukuxhumana nezinye izidakamizwa

Antacids eziqukethe inhlaka ion exchange kanye ne-aluminium, uyakwazi ukwehlisa ukumuncwa zomuthi. izidakamizwa lipid-ukwehlisa ukwandisa saturation Bile ne cholesterol, okungaba kamuva ukunciphisa ikhono zomuthi ukuncibilikisa amatshe atholakala enyongweni.

Asinakusho esiyicabangelayo izindlela sithuthukisa umphumela zokwelapha izidakamizwa hypoglycemic kwezokuphatha ngomlomo.

Isikhathi esesibelethweni kanye lactation

Abesifazane yokuzala ngesikhathi isicelo zomuthi Kunconywa ukuba asebenzise zokuvimbela inzalo non-hormone.

Ursodeoxycholic acid ngesikhathi sokukhulelwa kungenzeka kuphela uma inzuzo elindelekile kowesifazane kude okungaba yingozi ingane.

Okwamanje, ulwazi mayelana nokunikezela ursodeoxycholic acid kungekho ubisi lwebele. Uma udinga lokumamukela wanikezwa ngesikhathi lactation, kubalulekile ukuba sicabangele inkinga ehushule ibele umntanakho.

iziyalo ezikhethekile ngokuqondene ukusetshenziswa kwezidakamizwa

Lapho ethola izidakamizwa ukuncibilikisa amatshe kule mibandela elandelayo kufanele kuqashelwe: calculi kufanele kube roentgen (cholesteric). usayizi itshe kumele singeqi 1.5-2 cm. Ngakho gallbladder kumelwe asebenze kahle futhi concrements egcwele ayibi ngaphezu kuka ½ okuyingxenye. Ngaphezu kwalokho kubalulekile ukuthi permeability we Bile ezivamile futhi imbobo fibrosis igciniwe.

Lapho ukwelashwa eside (wenyanga eyodwa) njalo emavikini 4, isiguli kufanele sigcwaliswe ukuhlaziywa kwamakhemikhali kwegazi. Lokhu kuyadingeka ukuze sithole umsebenzi transaminases isibindi.

Ukuqapha ukusebenza yokwelapha kutuswa ukuba afeze zonke izinyanga ezingu-6. Ukuze wenze lokhu, sebenzisa ama-X-ray kanye ultrasound.

Ngemva kokuphela amatshe isiguli kufanele uthathe isidakamizwa for ezinye izinyanga 3.

Uma ngemva kwezinyanga eziyisithupha ngemuva kokuqala ukwelashwa yokuchitheka olungaphelele amatshe akwenzekanga, akunakwenzeka ukuthi imishanguzo okwengeziwe zizosebenza.

Izidakamizwa "Choludexan": nozakwabo kanye nezindleko

Okwamanje, imithi "Choludexan" angathengwa at ekhemisi for 550-600 ruble Russian (20 amaphilisi). Uma sicabanga ukuthi izidakamizwa kumele kuthathwe isikhathi eside, kulula ukuqonda ukuthi imithi iya eqolo. Ngeshwa, esikhundleni izidakamizwa ne analogue eshibhile ungatholi. Lokhu kungenxa yokuthi ezinye gepatoprotektory abe izindleko kuqhathaniswa eliphezulu.

Kodwa kuthiwani uma akakwazanga ukuthenga imithi "Choludexan"? Analogs yalesi izidakamizwa zingatholakala kunoma iyiphi ekhemisi. Phakathi kwabo kukhona izindlela ezilandelayo: "Ursodeks", "Ursoprim", "Livodeksa", "kwesikhombi Rompharm", "Urdoksa", "kwesikhombi On", "Ursosan", "Ursol", "Ursodez", "Ekskhol", " ursofalk "," Ursol "nokunye.

Uphenyo nomuthi

Okushiwo ngabantu mayelana izidakamizwa "Choludexan"? Izibuyekezo lokhu nomuthi bathi lokhu ingenye gepatoprotektorov engcono. Iziguli ukusho ukuthi emva ngokuthatha izimpawu izidakamizwa zesifo sihamba ngokushesha kakhulu, futhi umphumela waba ukuthi umuntu uzizwa ngcono kakhulu.

Nge isifo sokusha kwesibindi izidakamizwa esikhathini esifushane usizo eside yokuthuthukisa izinga lempilo isiguli futhi unikeza ithemba lokuthola eside elindelwe.

Ochwepheshe bathi emva ngokuthatha izidakamizwa (ekupheleni ngesonto lokuqala ukwelashwa) ezigulini zinyamalale ngokuphelele izimpawu ezifana isilungulela, isicanucanu futhi ngikhishwe ubuhlungu epigastric. Izibuyekezo zabantu abaye babhekana isenzo sisuke sicabanga imithi ngokwakho, ziqinisekisa ukwaziswa okunjalo. Nokho, odokotela musa batusa yokwelapha okuphelele ngokushesha ngemva kwamaphaphu nesineke. Phela, ukuhlanganisa imiphumela, kubalulekile ukuthatha izidakamizwa ezinyangeni ezimbalwa.