Umuthi 'Sulpiride ": ukubuyekezwa, izinkomba, analogs

Sengqondo of kobukhulu obuhlukahlukene ephelezelwa isintu kuze kube phakade. Emakhulwini eminyaka amaningi kukholakala ukuthi emimoya uSathane umuntu ogulayo, futhi ngenxa yalokho "ikhambi" le nkinga kuye kwafaneleka. Ngaphambi ukudalwa neuroleptic imithi impumuzo zengqondo ekhiqizwa ukwelashwa herbal ithuthukiswe ngesisekelo Belladonna, henbane, opiates. Kwenziwe njengoba ukwelashwa nge-calcium (ngomjovo) kanye ngibhapathiza esigulini ngesimiso izidakamizwa ingalali.

I chlorpromazine sokuqala ngqa antipsychotic kungenziwa ngokuthi, okwakubekelwa ngenkuthalo esetshenziselwa ukwelapha iziguli ezinezinkinga zempilo yengqondo kusukela ngo-1953. Okwamanje, uhlu imithi antipsychotic, antipsychotics kwelulwe kakhulu. Omunye izidakamizwa esetshenziswa kabanzi leli qembu "Sulpiride". Nobufakazi bamchaza njengomuntu antipsychotic atypical kakhulu.

pharmacodynamics zomuthi

Neuroleptic umphumela "sulpiride" antidofaminergicheskim elihlobene ne-action, m. E. Ngo isimiso sezinzwa esiyinhloko izidakamizwa amabhlogo ikakhulu receptor dopaminergic. Dopamine kuyingxenye ebalulekile ye "umvuzo uhlelo" zobuchopho - kuvusa ukuzwa ubumnandi, wanelise kuka yena, kuthinta izinqubo zemfundo futhi ugqozi. Ngo okusezingeni eliphezulu ngemithamo ngokwanele, akhiqizwa inqubo yimuphi umuzwa omuhle (ku umbono subjective lomuntu) - yokwamukela ukudla okumnandi, ucansi, akukho mnandi komzimba emizweni. Uma ucabangela ubuningi yokwanda kokungabi Dopamine e isimiso sezinzwa esiyinhloko kuyathuthuka induduzo ngokwengqondo, kanye ukwehla - ukuthuthukisa izimpawu zokucindezeleka.

Isenzo "sulpiride" umthamo esingeqile 600 mg (isamba nsuku zonke imithi) kuyinto imvelo antipsychotic. Uma imithamo esingaphansi 600 mg - ivuselela zigcwele yonk 'indawo futhi imiphumela antidepressant. Nokho serotonicheskie, histamine, adrenergic izidakamizwa ezenza has awakuthinti.

Imithi - analogue

I nomuthi "Sulpiride" - neuroleptic atypical, okuqondene iqembu benzamides ukufaka endaweni - linenani ngokwanele enkulu imithi ukuthi zifana ukubunjwa futhi ine umphumela. Kunemithi ehambelana ikhodi ATC 4th ezingeni. Lawa "Betamax", "tiaprid", "Eglonil". Ngaphandle kwalezi, okuvulekile zabathengi isidingo "Prosulpin", "Eglek" "elizolisayo '" Vero Sulpiride "," Sulpiride Belupo. " Uphenyo zonke imithi abathengi ungaba kokubili isiqondiso emihle nemibi. Konke kuncike kobukhulu isimo lesiguli zempilo, ukuzwela lakhe isithako esebenzayo main - sulpiride, futhi umthamo zomuthi babelwe ukuthola udokotela.

Izinkomba ukuze bathole imishanguzo engabasiza

Sam neuroleptic "Sulpiride", analogs ayo sphere sasivumela ezibanzi ithonya angabelwa ukuthola izifo ngokwanele sina. Yiphathe khona bayasangana emabangeni acute, futhi uma ezingamahlalakhona. Sulpiridsoderzhaschih walungisiswa ukusetshenziswa antipsychotics phakathi esiteji okukhulu ekuthuthukiseni delirium (isifo sengqondo imvelo, ephelezelwa ukuphazamiseka ukwazi ezisukela isiyezi ngisho ikhoma). Kaningi isidakamizwa ezinqunyiwe kwempilo Neurotic nokucindezeleka, kungakhathaliseki imvelaphi yabo.

Lapho inzululwane Lokudabuka ezahlukene incoma ukuthatha "Sulpiride" imfundo manual. Izibuyekezo iziguli futhi abezokwelapha zinezikhathi kahle nomuthi ekwelapheni neuritis vestibular, lapho uhlobo ukwehluleka vertebrobasilar-basilar ngabezindaba otitis kanye ezibuhlungu cranial, nge nesifo i-Meniere sika (umthamo uketshezi zandiswe kwangaphakathi indlebe ingaphakathi, okuyinto ubeka ingcindezi amaseli ubophezelekile ukunakekela yakhoibrium umzimba kanye nesimo sobudlelwane yayo emkhathini).

Ngenxa "Sulpiride" ingxenye yokwelapha esibanzi ingasetshenziswa emisebenzini ezakhelwe peptic isilonda isifo futhi sicasuke wamathumbu syndrome.

Ubani okufanele uyeke ukuthatha imithi antipsychotic ngesisekelo sulpiride?

Neuroleptics "Sulpiride" izidakamizwa analogue isithako esebenzayo main has a uhlu ezithile Izimo. Musa niwayise abantu hypersensitivity kuya sulpiridu nokuhlupheka hyperprolactinemia (kakhulu aphakeme amazinga prolactin i-hormone egazini). Ngakho, lokhu izidakamizwa alinikeziwe ngemihlume prolactin ancike (umdlavuza webele, prolactinoma pituitary indlala , njll).

Ngaphezu kwalokho, "Sulpiride" (izinkomba ezichazwe ngenhla) eyenqabela nokuyala pheochromocytoma (hormonally asebenzayo chromaffin cell izimila), sengqondo ukwenama kanye ahlukahlukene iziyaluyalu affective nge kokuziphatha ubudlova isithuthwane. Ungayisebenzisi le sulpiridsoderzhaschih imithi ngaphansi kwesimo acute utshwala ukudakwa, ushevu lapho ehlangana namaphilisi kadokotela okuyiluthayo futhi analgesics kwezidakamizwa.

Akubonisi ukusetshenziswa neuroleptic "Sulpiride" abantu abaneminyaka engu-engaphansi kwengu-18 futhi abantu besifazane phakathi lactation.

Okungenzeka imiphumela engemihle

ukusabela ezingezinhle ukuze neuroleptic yena kanye analogue "sulpiride" kobufakazi nesineke bezempilo agcwele njengoba ngokwanele sina, kakhulu eziya ziba zimbi isimo iziguli. Kukhona kungenzeka hyperprolactinemia ezihlukahlukene amafomu (gynecomastia, dysmenorrhea, frigidity, potency encishisiwe, galactorrhea, ukwanda isisindo emzimbeni).

Ngaphezu kwalokho ukubonakaliswa kungenzeka yalesi sifo extrapyramidal, okuyinto livezwa iziyaluyalu sokugembula we nangohlobo lwezinto indaba yokuzikhethela ezivezwa imisipha yohlaka, ukushintsha ezicutshini ithoni. Nokho, ukukhubazeka akulona uphawu okufakazela iqiniso extrapyramidal syndrome.

Njengoba uhlangothi ukusabela "Sulpiride" analogs neuroleptic, kungenzeka liqhaqhazela, akathisia (ukungakwazi ngiphumule), dyskinesia, ukuqwasha, ukozela, ukukhathazeka excitability okusezingeni eliphezulu, ukucasuka. Engaveza izimpawu of neuroleptic syndrome abulalayo, libhekene kwezinso autonomic, ukuphaphatheka isikhumba, komzimba okukhulu.

Imiphumela engemihle evela pheshana emathunjini kungaba lokujabulela ukoma emlonyeni, ukuthuthukiswa isilungulela, isicanucanu ukubukeka, retching, ukuqunjelwa. kusebenze olungenzeka transaminases hepatic futhi ane-alikhali phosphatase.

uhlelo lokusebenza senhliziyo "sulpiride" Ungaphendula ukwanda blood pressure (akuvamile - ukwehla komfutho wegazi, isiyezi), kwenhliziyo, kukhuphuke qt-isikhawu. Kakhulu akuvamile, kodwa ungezwa ukuthi phezu "Sulpiride" Ukusabela izidakamizwa kusukela odokotela ukhombise ukuthuthukiswa torsadedepointes uhlobo arrhythmia.

ukubonakaliswa Allergic ezifana ukuqubuka kwesikhumba, ukukhishwa pruritus, izilonda eczematous. Ngezinye izikhathi ungase uzwe mayelana nokwephula ka acuity ezibukwayo.

Umthamo futhi isicelo wesifunda Imodi

Ngokusho imiyalelo yokusebenzisa le nomuthi, iziguli ngokuvamile omdala kuye isifo umthamo onqunyiwe 100-300 mg ngelanga (ihlukaniswe 2-3 ngemithamo). isixazululo Oral yaphathwa Isikali ezahlukene: 100-800 mg ngelanga kwezokuphatha esicutshini (ngaphambi kokusebenzisa ngempela Shake). Umkhawulo ibekezelelwe umthamo omdala kuyinto 1.6 g

Uma kuba kunesidingo sokujuba "sulpiride" ukuba izingane ezingaphansi kweminyaka engu-18 ubudala, umthamo kufanele ibalwe kucatshangelwa isisindo ngesisekelo 5 mg amakhilogramu esisindo ngayinye.

Uma isiguli sine-isimo sengqondo esigabeni oyingozi noma ezingamahlalakhona, ukwelashwa ngokuvamile iqala nge abaphathi esicutshini (400-800 mg nsuku zonke). Ezimweni eziningi, isikhathi sokwelashwa okungenani 2 amaviki. Njengoba nje impilo isiguli, ngomjovo esicutshini idluliselwe yokwamukela "sulpiride" ngaphakathi iphilisi. Neuroleptic "Sulpiride" Izibuyekezo nesineke ukuchaza njengenhlangano umuthi. Isikhathi inkambo yokwelapha kungaba azimisele futhi washintsha kuphela udokotela ukuba khona.

Ukweqiwa ngokweqile

Noma yimuphi izimpawu ezicacile ezibonisa ukuthi kwakuyokwenziwa iqiniso adlula ubukhulu ngemithamo kuvunyelwe ngenhla, akukho. Ngokuvamile kulezi zimo, akukho kakhudlwana blood pressure, angaboni kahle. Mhlawumbe ukuthuthukiswa ukupholisa (ukucindezelwa ukwazi cuphuluza izidakamizwa, opholile umphumela, kuyilapho ngemithamo ephakeme - okuyiluthayo). Ezimweni eziningi, imiphumela zomuthi "Sulpiride" kobufakazi nesineke ukhombise ukubonakala isicanucanu, nomlomo owomile, ukujuluka yanda, ukuhlanza. Ezimweni ezingavamile nezimpawu extrapyramidal, gynecomastia singenzeka iziguli besilisa (webele ukukhulisa). Kakhulu akukavami kutsi bakhulume ka parkinsonism evelele, equlekile.

Njengoba yokuvimbela abakhethayo ngoba "sulpiride" okungaxhunyiwe ku-intanethi, impatho lingaze Kunconywa, kuncike ngezimo zesiguli. Kwezinye izimo, sebenzisa holinoblokatory isinyathelo emaphakathi.

On lokho ukuba banake?

Kasibili yonke imikhiqizo iqembu antipsychotic (kuhlanganise sulpiridsoderzhatsie "Betamax", "Vero Sulpiride", "Prosulpin", "Sulperid Belupo", "Eglonil", "Sulpiride") libuyekeza Ochwepheshe kanye neziqondiso vala ngemuva uphuzo utshwala. Ezigulini ezine-isithuthwane Kunconywa ukuze baqhube izifundo emitholampilo electrophysiological ziye sulpiride kwehlisa embundwini for umsebenzi kokuquleka. Uma izidakamizwa isetshenziswa concomitantly nezidakamizwa ukuthi kwandisa ingozi yokungenwa ventricular arrhythmias, iziguli enjalo idinga ukuqapha njalo electrocardiogram. Ukwandiswa qt-isikhawu kuncike umthamo.

Uma ngesikhatsi ukwelashwa, "sulpiride" babe nezimpawu of komzimba (a yokuthi ukhomba ukuthuthukiswa neuroleptic syndrome abulalayo), ngokusebenzisa izidakamizwa kufanele ayisekho.

ukumisa ezesabisa yokwelapha "sulpiride" kungaba avuse nokuqaleka. Maltitol elikhona izidakamizwa kwenza kube nzima ukusebenzisa abantu abaphethwe fructose ukungabekezelelani.

Phakathi naso sonke isikhathi ukwelashwa kufanele uqaphele izimoto kanye nokusentshenziswa kwe ukuphathwa imisebenzi ezidinga ngokushesha Ukusabela lengqondo emakamu eliphezulu.

Sulpiridsoderzhaschie imithi nokukhulelwa

Abesifazane ngesikhathi sokukhulelwa "Izibuyekezo Sulpiride 'kwesokunxele ohlangothini omuhle kakhulu. Ubuningi umthamo ovumelekile kwabesifazane abakhulelwe 200 mg ngelanga akazange avuse imiphumela teratogenic (kuka ukuthuthukiswa embryonic). Imithamo elikhulu zomuthi kwabesifazane abakhulelwe Alukho ulwazi olutholakalayo. Futhi, akukho idatha umthelela ongaba izidakamizwa-antipsychotics ku kobuchopho womntwana.

Ngokuvamile, izisebenzi zezempilo uncamela ukungasebenzisi "Sulpiride" ekwelapheni abesifazane abakhulelwe, ngaphandle ezimweni lapho kuba nemiphumela emihle ngoba abesifazane ubusa ngaphezu engaba ingozi embungwini. Ezimweni ezinjalo, "Sulpiride" imfundo (izibuyekezo abezimo eziphuthumayo waqinisekisa) incoma yaphathwa ngemithamo ephansi okunokwenzeka futhi uma kungenzeka ukunciphisa isikhathi sokwelashwa.

Ezinganeni ezizalwa omama ukuthatha ngesikhathi sokukhulelwa sulpiridsoderzhaschie imithi ngezikhathi waphawula izimpawu emathunjini (ukuvuvukala, nokunye. N.) Ephathelene atropinopodobnye ithonya neuroleptics. Ngezinye izikhathi ungase ukuzwa extrapyramidal syndrome. Phakathi ibele wamukelekile "sulpiride" contraindicated.

Mbiko iziguli "sulpiride"

Kwenqwaba iziguli emuthini "Sulpiride" Izibuyekezo eshiya isiqondiso esihle. Neuroleptic ngokwanele ngempumelelo futhi ithethelele izici wamemezela. Abantu ukuthatha "Sulpiride" noma analogue yayo ngoba izimpawu sengqondo ngesikhathi isilonda esiswini noma isilonda duodenal, kubika ukwehla ukushuba ubuhlungu besisu nokwenziwa ngcono isimo jikelele.

amavolumu elincane nomuthi (mg 50 300 ngosuku) bavame elibekelwe seziguli ezithola at ngezikhalo isiyezi njalo ezivukayo ngenxa yezizathu ezihlukahlukene. Kwenqwaba salezi ziguli waneliswa imiphumela yokwelapha.

Ukweqiwa ezinkulu "sulpiride" (angaphezu kuka-600 mg ngelanga), ngokubona abasebenzi bezokwelapha ukuhlinzeka umphumela antipsychotic ngempumelelo iziguli. Ukweqiwa esingaphansi 600 mg, futhi ngokubona kodokotela neziguli, kwenziwe ukuthi kuqabula futhi umphumela antidepressant.

Kukhona iqembu iziguli owashiya "sulpiride" ngendlela engafanele. Ingabe abantu ukuthuthukisa isicanucanu, injabulo, isiyezi. izimpawu Negative banyamalala emva ukuqedwa we "sulpiride".