Anti-TPO - ukuhlolwa ngozwela sitholakele thyroiditis sokuhlasela kwamasosha omzimba

Kanye yezifo esimiso senhliziyo nemithambo yegazi iqhubeka ukukhula endocrine iziyaluyalu - sikashukela kanye yegilo izilonda ezihlukahlukene.

Phakathi yokugcina unendima hypothyroidism ekhethekile, kusukela zaqala ukuba ebuntwaneni kubangela ukuntuleka okukhulu yentuthuko ezingokwengqondo ingane. Ngokuvamile, lezi zincwadi ezibizwa ngokuthi thyroiditis sokuhlasela kwamasosha omzimba noma i-Hashimoto sika. Kulesi isifo singenzeka kunoma izinhlobo ezintathu emtholampilo. Lokhu hypertrophic, okuthi compensatory Hyperplasia we yegilo indlala, atrophic, ukuthuthukisa nesigaba lesi sifo yesibili futhi esibonakala ngokuqina esikhundleni evamile zezinzwa ukwakheka kwezicubu, futhi Alopecia lapho lesion ihlanganisa share umzimba owodwa kuphela.

ukubaluleka ukuhlaziywa

Ngokuvamile, ubufakazi okuwukuphela kwako okunembile mayelana isifo iyona ukuthola igazi anti-TPO, isb amasosha omzimba ngokumelene yegilo peroxidase - enzyme eyinhloko kumiswa triiodothyronine kanti thyroxine.

Ngenxa yomsebenzi wabo iphazamisekile iodination ka thyroglobulin, amaprotheni yegilo kwesakhiwo ukuthi amabhlogo okwengeziwe zamagama izigaba hormone ayo. Njengoba lena ukuhlolwa ebucayi kakhulu sitholakele goiter Hashimoto sika, ngaleso sikhathi udokotela okucatshangwa ukuthi banalo sifo inikezwa kwegazi hormone. Anti-TPO endabeni yalokho omuhle izokwenyuka, bese uphethwe kubonakaliswa ngokuphelele. Kuphela kuleli cala, lo dokotela uzoba nelungelo ukuncoma ukuphathwa ezifanele futhi unikeze Izibikezelo esihle isiguli. Okwakubaluleke ngokukhethekile yilona test kwabesifazane abakhulelwe, t. Ukuze., Uma zingavela anti-TPO, likhuluma ngokuphela ingozi engathi sína yokuba nesifo kwangemva kokubeletha thyroiditis kanye nethonya elilimazayo yesifo embungwini. Izinga la masosha omzimba ngokuvamile 0-5,6 IU ngemililitha ka serum ngalinye, futhi ukwehla kungabonakala nasemkhakheni abantu abayimiqemane ngaphansi kweminyaka eyi-50. Kodwa omuhle (anti-TPO ngenhla evamile) uvivinyo lungase lube kwezinye izifo indlala yegilo, ngakho uphethwe lezi pathologies kufanele kwenziwe ngempela eziyinkimbinkimbi, kanye lihlaziya T3, T4 futhi TSH.

ucwaningo eziyinkimbinkimbi

isifo Hashimoto sika kwenzeka uma ukwehluleka kwesimiso somzimba sokuzivikela, okungukuthi, uma impendulo ngokweqile noma ukunciphisa umsebenzi T-suppressor. Ngakho-ke (kanye anti-TPO) egazini iziguli atholakala kwezinye amasosha omzimba: isakhiwo njengoba yegilo (thyroglobulin microsomal ingxenyenamba) kanye nezinye izitho ngokuphelele. Lokhu kwenza kube uhlanganise nezinye, hhayi endocrine, pathologies Lokudabuka sokuhlasela kwamasosha omzimba. Ngaphezu ekuhlolwa anti-TPO futhi hormone, kudingekile ithuluzi isiqinisekiso goiter Hashimoto. Ngakho, phakathi kokuxilongwa ultrasound indlala yegilo ingase ibonise heterogeneity yokulandelana kwayo ngokohlu, hypoechogenicity ezinye izigaba, khona calcification futhi ukuqina capsule. Izibikezelo Okuningi ezinzima iba lokhu ikakhulukazi ezimweni lapho isitho kuyoba ISIZINDA njengoba mayelana-5% izimo ozlokachestvlyayutsya.