"Zanidip": yokusetshenziswa, iziguli zangempela futhi odokotela nozakwabo. "Zanidip-Rekordati": Umhlahlandlela, ukubuyekezwa, analogs

Ngokwezibalo, mayelana 26% wabantu abadala emhlabeni uhlushwa umfutho wegazi ophakeme njalo. Ngokuvamile lesi sifo lihlotshaniswa yofuzo. Nokho, zikhona nezinye izizathu ivela khona. Lezi zihlanganisa ukukhuluphala, ukubhema, engayitholi ngokweqile usawoti, ukungabi izakhi trace kanye amavithamini emzimbeni, ukusetshenziswa kabi kotshwala, ukucindezeleka, umsebenzi ongaphakeme ngokomzimba, kanye nabanye.

Kufanele kuphawulwe ukuthi ukuthuthukiswa nomfutho wegazi ophezulu incike yobudala lomuntu. Omdala nguye, nengozi isuke inkulu kwesimo sokugembula ezinjalo. Lapho ngineminyaka engu-iminyaka engu-40, lesi sifo cishe njalo umphumela izilonda sclerotic semithambo.

ulwazi olujwayelekile

Ngokuvamile, odokotela ukubeka iziguli zabo uphethwe "umfutho wegazi ophakeme kubalulekile". Kuyini lokhu? Kuyinto isifo esingelapheki futhi ifomu nomfutho wegazi ophezulu. uphawu yakhe eyinhloko emitholampilo izenzo kokuphakama eziphikelelayo futhi isikhathi eside wegazi.

Kushintsha Izimo isifo enjalo ingase ibe khona ehlukile. Noma kunjalo, ngokuyinhloko ezihlobene imithambo yegazi kanye inhliziyo.

Ukuze kwenziwe ngcono isimo lesiguli, odokotela batusa lokhu izidakamizwa ngokuthi "Zanidip". Izibuyekezo iziguli ku ukuphumelela izidakamizwa kuzoxoxwa ngakho mathiriyeli lo sihloko. Futhi lapho uzothola ulwazi mayelana nendlela ukuthola wathi imithi, uma kwadingeka iyiphi analogue nama-side effects.

Incazelo, ukwakheka, ukuma emaphaketheni

I nomuthi "Zanidip" imfundo lilondolozwe isixha amakhadibhodi kukhishelwa ngesimo amaphilisi ukukhanyisa amafomu ophuzi eyisiyingi biconvex uphawu omunye izinhlangothi. Ziyakwazi ifilimu-camera futhi ube tint aphuzi phezu break.

Isithako asebenzayo yalesi izidakamizwa izenzo lercanidipine hydrochloride. Futhi, kuhlanganisa futhi izingxenye elisizayo, okuyinto zivezwa povidone K30, monohydrate lactose, sodium carboxymethyl isitashi, microcrystalline cellulose kanye magnesium stearate.

Ngokuphathelene ifilimu-enamathela ekwakhiweni ke yakhiwa izinto ezifana Opadry Yellow, talc, hypromellose, ama-titanium dioxide, yensimbi oxide udayi ophuzi kanye macrogol 6000.

Thenga "Zanidip" amaphilisi e ibhamuza amaphakethe kungenzeka, ukuthi ezibekwe amabhokisi iphepha.

izici kwemithi izidakamizwa

Bewazi yini ukuthi umuthi "Zanidip"? Imiyalelo isicelo ibonisa ukuthi kuba-calcium channel blocker kancane. isithako zayo asebenzayo inhlanganisela racemic we stereoisomers dextro-futhi levorotatory. Kufanele kuqashelwe ukuthi i-esuselwe 1.4-dihydropyridine.

Lokhu nomuthi ngokukhetha ekuvimbeni samanje calcium ion ku amaseli inhliziyo, amaseli semithambo kanye muscle bushelelezi.

Umgomo we umphumela okuqhubekayo antihypertensive zomuthi kungenxa oqondile relaxant nomthelela semithambo bushelelezi imisipha amaseli.

Ngokusho imiyalelo, futhi ngemva kokwamukela nomphumela oqabulayo we nomuthi kufinyelelwa ngemuva kwamahora 5-7. Isikhathi sokusebenza yayo inakekelwa usuku lonke.

Ngenxa selectivity eliphezulu zomuthi kuya semithambo bushelelezi imisipha amaseli, awusebenzi ibe nomphumela ongemuhle inotropic.

Ngakho-ke yini umuthi "Zanidip-Rekordati"? Umhlahlandlela Lithi kuyinto metabolically ikhambi kokungathathi hlangothi ongenalo ithonya kakhulu kokuqukethwe apolipoproteins futhi lipoproteins egazini serum, kanye ayishintshi iphrofayili amanoni abantu nomfutho wegazi ophezulu.

I kinetics zomuthi

Lapho ugxile izidakamizwa "Zanidip"? Yokusetshenziswa uzokwazisa kithi ukuthi ngemuva kokuthola izibhebhe (10 noma 20 mg) ngaphakathi lercanidipine ugxile cishe ngokuphelele pheshana emathunjini. Ngemva kwamahora angu-1.5-3 emakamu esiphezulu izidakamizwa e-plasma ifinyelela ukubaluleka 3.3 ng / ml noma 7,66 ng / ml ngokulandelana.

Ukusatshalaliswa izidakamizwa izicubu kanye izitho senzeka ngempela ngokushesha. Ukuxhumana-plasma amaprotheni idlula 98%. amaphilisi umthamo okuphindaphindayo wayenemfuyo sabo siyenzeka.

Umzimba izidakamizwa Kwenziwa ngesikhathi kudlula lokuqala ngokusebenzisa isibindi. Lokhu kwenzeka ngo-biotransformation CYP3A4. Lokhu kudala eziningi metabolites abangenalo umsebenzi kwemithi.

imithi ezibonisiwe "Zanidip", ukubuyekezwa zazo ethulwa kancane ngokusebenzisa amathumbu nezinso. Kunezigaba ezimbili ekubekweni ukususwa lercanidipine: ekuseni kabani nkathi amahora 2-5 kanye yokugcina - amahora 8-10.

Umuthi ingashintshiwe is cishe hhayi zitholiwe indle kanye nomchamo.

Abantu nge isibindi noma kwezinso amaprotheni isifo okuqukethwe plasma is kakhulu ziyancipha. Kule ndaba, lo ingxenyenamba khulula we ketshezi esebenzayo ye nomuthi kungenzeka kakhulu lenyuka.

Izinkomba ukuze bathole imishanguzo engabasiza

Lokhu kwakwenziwa ngayiphi injongo kungenziwa imithi inikezwa "Zanidip"? Izibuyekezo lodokotela libike ukuthi lo ejenti ngempumelelo ubukisa ngokwaso nomfutho wegazi ophezulu kubalulekile futhi okuncane zaba namandla kakhulu.

Izimo ukuba ngamukele izibhebhe

Ngokusho imiyalelo, lesi sidakamizwa "Zanidip" akufanele athathwe ngaphansi kwale mibandela elandelayo:

• umsebenzi isibindi ezinzima;
• ezingamahlalakhona senhliziyo nemvelo (ikakhulukazi decompensation isinyathelo);
• kahle umsebenzi kwezinso;
• angina engazinzile ;
• lihambisana inhibitor eqinile isoenzyme CYP3A4 (isibonelo, "ketoconazole", "erythromycins", "itraconazole") kanye ne "cyclosporin" kanye ubhamubhamu juice;
• ngesikhathi sokukhulelwa;
• ukuvimbela yegazi zivela i-ventricle engakwesobunxele wenhliziyo;
• zokungezwani ne-lactose, ukusweleka lactase futhi malabsorption syndrome galactose / glucose;
• ngesikhathi ibele;
• muva ngo isilethikusebenza (ngesikhathi esikhathini esingangenyanga);
• Abesifazane yokuzala abangabhalisile usebenzisa izindlela eziqinile zokuvimbela inzalo;
• kweminyaka engu-(nephephe ungazange sezisunguliwe);
• hypersensitivity kuya lercanidipine nezinye nemikhiqizo dihydropyridine noma iyiphi izingxenye umuthi.

imithi ethatha Ohlakaniphile

I nomuthi "Zanidip-Rekordati" ngokuqapha Kunconywa ukuthatha abantu kahle isibindi umsebenzi (ngokulinganisela nobumnene), ezingamahlalakhona inhliziyo nedostatochnostyusindromom itheku, kwesokunxele ukwehluleka ventricular futhi yenhliziyo Umthambo isifo, kanye reception kanyekanye "Digoxin" beta-blocker.

Tablets "Zanidip": yokusetshenziswa

Uma kucatshangelwa inani elikhulu izigameko ezingezinhle ezavela izidakamizwa kubhekwe kumele iqondiswa ngabasebenzi abanolwazi. Ngokuvamile, izidakamizwa esebenzayo Kunconywa ukuba bangenise imali 10 mg kanye ngelanga.

Amaphilisi kufanele kwenziwe ekuseni, ngokuba ¼ ihora ngaphambi kokudla kwasekuseni.

Kuye umphumela oqabulayo umthamo zomuthi olucutshungulwayo kungenziwa kabili, isb ukuba mg angu-20. Ukwandisa esenikwe nomuthi kumele kwenzeke kancane kancane. Uma kudingeka, ukwanda inani nomuthi eyenziwa ngemva kwamasonto amabili ngemva Ukuqalwa yokwelapha.

kufanele Ngithatha kanjani "Zanidip-Rekordati"? Musa ukuhlafuna ezibhebheni. Ivamise kugwinywe futhi wageza phansi imali eyanele ketshezi.

Kwasebekhulile Ayikho ukulungiswa Isikali liyadingeka. Kodwa lapho ukuthatha imithi ngenxa yesimo sabo kudinga ukuqapha njalo.

Ephambi kwezinduna ukwehluleka hepatic noma kwezinso noma okusesilinganisweni kobukhulu Isikali ukulungiswa ayidingekile. Ezinsukwini zokuqala ezimbalwa izidakamizwa yaphathwa isamba 10 mg, bese ngokuqapha okwandisa umthamo kuya ku-20 mg ngosuku.

Uma inciphise umfutho wegazi ophakeme kakhulu uzwakalise, umthamo ocacisiwe encishisiwe.

side effects

Can baxabane engadingeki "Zanidip-Rekordati"? Izibuyekezo Umthengi wazise ukuthi ukuthathwa lokhu kusho ukuthi ngokuvamile babonakala engemihle. Yini kahle hle, sicabanga njengamanje:

• izivikeli mzimba: Hypersensitivity.
• Isimiso senhliziyo nemithambo yegazi: tachycardia, angina, palpitations, yokufikelwa, siwasebenzise ukuze isikhumba ebusweni, ubuhlungu besifuba, imakwe ukunciphisa umfutho wabo wegazi, isifo senhliziyo.
• isimiso sezinzwa: somnolence, ikhanda, isiyezi.
• ipheshana wokugaya ukudla: ukuhlanza, dyspepsia, isicanucanu, ukwanda esethola e enzyme isibindi, uhudo nobuhlungu besisu.
• Ukuqubuka kwesikhumba.
• uhlelo zemisipha: myalgia.
• Urinary: polyuria.
• Okunye: neuropathy edema, ukukhathala, Hyperplasia gingival, ukukhathala.

Izimpawu ukweqisa izidakamizwa

Buhle buni obungaba izolandela, uma uthatha ngemithamo ephakeme zomuthi "Zanidip"? Umhlahlandlela libala izimpawu ezilandelayo ukweqisa izidakamizwa: isilethikusebenza, tachycardia reflex, vasodilation neuropathy nge ukwehla okuphawulekayo wegazi, ukwanda isikhathi kanye nokuvama ukuhlaselwa angina.

Ukuqeda uthi ezifana ukwelashwa lingaze.

izidakamizwa ekuhlanganyeleni

Kungenzeka yini ukuba zihlangana kanjani nezinye izidakamizwa imithi "Zanidip"? Yokusetshenziswa ibonisa ukuthi ithuluzi asivunyelwe ukuhlanganisa enjalo inhibitor CYP3A4 (cytochrome P450 kwesibindi), ngokuthi "Itraconazole" "ketoconazole" futhi "erythromycin". Lokhu kungenxa yokuthi zonke lezi imithi ukwandisa lokuhlushwa lercanidipine egazini, kanye phambili kuya inciphise umfutho wegazi ophakeme.

Kanyekanye reception yokubika kusho ukuthini "cyclosporin" is contraindicated, njengoba kungase kuholele ukwanda okuqukethwe kokubili izinto egazini lesiguli.

Lercanidipine akuvunyelwe ukuba asetshenziswe kanye ubhamubhamu juice. Le nhlanganisela kungaholela potentiation we inciphise umfutho wegazi ophakeme ka lercanidipine futhi okusithiyayo lokugayeka kokudla.

Kufanele baqaphelisise lapho ethola "Zanidipa" nge izidakamizwa ezifana "Astemizole", "Terfenadine" futhi "quinidine", futhi antiarrhythmics ekilasini lesithathu (isb, "Amiodarone").

Ingxube nomuthi kubhekwe nezidakamizwa anticonvulsant ( "phenytoin," Carbamazepine ") futhi" rifamycins "kungase kube nomthelela nokuncipha amazinga igazi lercanidipine, okuholela ukwehla we inciphise umfutho wegazi ophakeme ka lercanidipine.

Lapho inhlanganisela izidakamizwa nge "Digoxin" Kufanele kubhekwe izimpawu zokudakwa.

ukwelashwa kanye kanye ne nomuthi "midazolam" lapho usukhulile kungase kwandise absorbability ka lercanidipine futhi sinciphise ukumuncwa yayo ingamaphesenti.

Ochwepheshe bathi "metoprolol" uyakwazi ukunciphisa bioavailability of lercanidipine 50%. Kulokhu, lo bioavailability of "Metoprolol" uhlala ingashintshiwe. Lo kusukela ukwehla hepatic ukugeleza kwegazi okubangelwa beta-blocker.

Ukulungiselela "Cimetidine" ngezilinganiso 800 mg ngosuku musa kuholele izinguquko eziphawulekayo emakamu igazi lercanidipine. Kodwa reception yayo kudinga ukuqapha okukhethekile, kusukela ebulilini kungase kwandise bioavailability of lercanidipine futhi ngenxa yalokho ukwandisa umphumela wawo antihypertensive.

Nge inhlanganisela "Zanidipa" nge "Simvastatin" izidakamizwa kuqala ukuze uyiswe ekuseni, kanti eyesibili - kusihlwa.

I nomuthi "fluoxetine" akunamthelela le kinetics ka lercanidipine.

reception Kanyekanye "Zanidipa" nge "warfarin" akazange kuthinte pharmacokinetics lakamuva.

Kulaba izimali kungenziwa kuhlangene isisu, beta-blocker futhi ACE inhibitor.

Kufanele futhi wazi ukuthi i-ethanol sithuthukisa antihypertensive umphumela lekarnidipina.

izincomo ezithile

Izidakamizwa "Zanidip", analogue zazo ezibalwe ngezansi, kufanele kube ngokucophelela okukhulu kubantu abanegciwane kahle izinso umsebenzi futhi yenhliziyo Umthambo isifo, njengoba kulokhu, kukhona ingozi enkulu imvamisa anda ukuhlaselwa angina.

Ngaphambi kokuthola izidakamizwa kufanele njalo ihlawulelwa senhliziyo bemvelo ezingamahlalakhona.

ngokuqapha elithile kufanele libukwe ekuqaleni ukwelashwa, ikakhulukazi in iziguli degree nokulinganisela sibi esingamahlalakhona hepatic.

Phakathi ukwelashwa, kuyinto efiselekayo ngokucophelela ukufeza umsebenzi odinga ukunakekelwa okukhethekile, kufaka phakathi ukuphathwa komgwaqo. Lokhu kungenxa yokuthi ekuqaleni yokwelapha kanye ngemithamo ngokweqile kukhona ingozi okuvela ubuhlungu bekhanda, ukozela nesiyezi.

izimo isitoreji, impilo eshalofini ekulungisweni nokudayiswa

Ngingalutholaphi ukuthenga amaphilisi "Zanidip-Rekordati"? Analogs izimali yena imithi edayiswa iyiphi ikhemisi. Noma kunjalo, angathengwa kuphela kadokotela kadokotela.

Gcina le imithi kude efiselekayo izingane ezincane lapho izinga lokushisa ingeqi degrees 30.

Impilo eshalofini zomuthi olucutshungulwayo sekuyiminyaka emithathu. Emva kwalesi sikhathi, imithi ukuthatha akuvunyelwe.

izidakamizwa analogue

Ingabe uyazi ukuthi yini ungakwazi ukushintsha amaphilisi "Zanidip"? Analogue kwaleli thuluzi kunzima ngempela ukuthola. Ochwepheshe ukubika ukuthi izakhiwo kanye umsebenzi amalungiselelo anjalo efanayo ifa ngokuthi "Lerkamen" futhi "Lercanidipine". Ngemva kokuzindla ngalezi imithi kufanele kuphela ngemiyalo yezokwelapha.

Izidakamizwa "Zanidip": Izibuyekezo iziguli kanye nezifundiswa

Kuyinto ejenti ngempumelelo kakhulu antihypertensive. Ukuthi lokhu umbono olwabiwa odokotela abaningi. Sivumelana nabo, cishe kanye nazo zonke iziguli ukuthatha amaphilisi "Zanidip". Zithi ngemuva kokuthatha imithi ngokuphawulekayo isimo yabo iba ngcono. Izimpawu nomfutho wegazi ophezulu ebalulekile kobukhulu okuncane noma okusesilinganisweni ushiye cishe ngokushesha.

I ethile kuphela lokhu imithi ukuthi ukuthatha ngokuvamile kakhulu kubangela imiphumela emibi, ikakhulukazi ingxenye ipheshana wokugaya ukudla bese uhlelo senhliziyo nemithambo yegazi.

Kufanele kuqashelwe ukuthi abantu abaningi akhononde inani lentengo lomuthi liphezulu kakhulu. Lesi sidakamizwa ungaphakathi inani amaphilisi 28 zingathengwa for ruble 450-500. Kufanele kuqashelwe ukuthi analogue of nomuthi wathi ngesimo "Lerkamena" futhi "lercanidipine" ayizange eshibhile. Bona angathengwa ngentengo efanayo.

Ochwepheshe bathi izindleko "Zanidip" izidakamizwa antihypertensive ihambisana ngokugcwele izinga layo. Ibonisa cishe wonke nakho kwakhe isikhathi eside isicelo.