Umuthi 'Proksium ": yokusetshenziswa, nozakwabo yangempela

Indlela yokusebenzisa lesi sidakamizwa "Proksium"? Yokusetshenziswa zomuthi kuchazwa izinto sihloko. Kuyo uzothola ulwazi mayelana kwindlela wathi nomuthi senziwa, uma kuye kwadingeka iyiphi analogue lapho oda wamiswa nokunye.

Ubujamo, emabhokisini Ukwakheka izidakamizwa

Ngayiphi ifomu ukuthi likhiqizwa buyisidakamizwa ngokuthi "Proksium"? Yokusetshenziswa busikisela ukuthi leli izidakamizwa iyatholakala njengoba amaphilisi mhlophe amakhadibhodi amaphakethe, kanye lyophilizate nge ampoule of kuphela (10 ml).

Ifomu yokuqala izidakamizwa ngokwalo yakhiwa pantoprazole (40 mg), kanye izinto ezengeziwe. Mayelana umfuma lyophilizate ke inawo futhi 40 mg isithako esisebenzayo + sodium hydroxide.

Pharmacodynamics nomuthi

Iziphi izici has umuthi "Proksium"? Yokusetshenziswa ibonisa ukuthi lokhu anti-isilonda kanye antisecretory ejenti.

Ngemva ngokuthatha izidakamizwa ngaphakathi amabhlogo ke ukukhiqizwa kwe hydrochloric acid. Lokhu kwenzeka ngenxa ezivimbela isenzo se-proton ukusebenzisa, okungukuthi kumaseli parenteral isisu.

I asebenzayo izidakamizwa izidakamizwa uyakwazi ukunciphisa basal pentagastrin-inkanuko yobulili-enzyme, ukudla kanye insulin, uketshezi esiswini. Ngaphezu kwalokho, izidakamizwa kuvimbela msebenzi obalulekile amagciwane Helicobacter pylori. Njengoba yaziwa, ne ukukhiqizwa kabusha yayo asebenzayo attribute ukwakheka izilonda futhi erosions e nolwelwesi lwamafinyila izindonga esiswini.

Ngaphezu okungenhla, bebheka bonke izidakamizwa kwandisa kusebenta namanye amanxusa imithi elwa nawo.

Pharmacokinetics zomuthi

Yini izidakamizwa anezakhi pharmacokinetic "Proksium"? Yokusetshenziswa uzokwazisa iziguli mayelana lokuthi emva komthamo wokuqala umphumela izidakamizwa okhula ngokushesha okukhulu futhi luthatha izinsuku.

Okuqukethwe esiphezulu izidakamizwa e oketshezini olungenambala lwegazi waphawula amahora amane ngemva kokwamukela umthamo esezingeni 40 mg. I degree of coupling nge amaprotheni kuyinto 98%. Isikhathi isigamu-ukuphila zomuthi ifinyelela amahora amabili.

Etholakale izidakamizwa ngokusebenzisa izinso namathumbu.

Pantoprazole amuncwa umzimba emathunjini amancane. I bioavailability we ketshezi cishe 75%.

Umzimba izidakamizwa isithako esibindini. Uma lokhu kwenzeka i-conjugation ukuphendula, dealkylation kanye namachibi nge iqhaza ngqo ka-enzyme ezifana cytochrome P450.

Kufanele futhi wazi ukuthi izidakamizwa kubhekwe kweqa kalula umgoqo gazi ebuchosheni. Ngaphezu kwalokho, ukuthi ivelele nge ubisi lukamama.

Ngo abadala, emakamu plasma bese bioavailability zomuthi lingaphezulu kakhulu kunezinye iziguli abasebasha.

Phambi ngokoma kwesibindi izidakamizwa kungenziwa ngokukhishwa ayisi-9.

Lapho iqondiswa?

Manje uyazi ukuthi lesi sidakamizwa "Proksium". Yokusetshenziswa, ukubuyekezwa mayelana izidakamizwa kusikisela ukuthi izinkomba zayo ukusetshenziswa zihlanganisa lezi zifo ezilandelayo:

• izilonda esiswini kanye 12 isilonda duodenal (kuhlanganise izinkathi exacerbation);
• ekwelapheni amabhaktheriya Helicobacter pylori (ukwamukela ingxenye kuphela yokwelapha eziyinkimbinkimbi);
• Reflux esophagitis futhi Zollinger-Ellison syndrome;
• umkhiqizo wawanda of juice esiswini;
• sibi Reflux esophagitis.

Awukwazi ukusebenzisa

iyiphi Izimo has a izidakamizwa ngokuthi "Proksium" (amaphilisi)? Yokusetshenziswa uzokwazisa iziguli ukuthi leli fomu zomuthi noma kunjalo akufanele enqunywe wumgomo, uma:

• ukuhluleka hepatic, ezinzima;
• ukhulelwe;
• komdlavuza e izinhlaka pheshana emathunjini;
• ibele;
• umzimba wakho uxabana imithi izingxenye;
• izingane ezingaphansi kweminyaka engu-14.

Mayelana isixazululo in vials, it is hhayi Kunconywa for iziguli komzimba nezinto "Pantoprazole". Ngaphezu kwalokho, lolu hlobo imithi noma kunjalo ayikwazi ngokuhlanganiswa "ATV".

Tablets "Proksium": yokusetshenziswa

Analogs zomuthi anti-isilonda izokwethulwa ekupheleni isihloko. Kule ngxenye, sizokutshela ngalokhu izidakamizwa kumele kuthathwe ngaphansi izifo ezithize.

Ngo kuqokwa izidakamizwa "Proksium" odokotela abaningi abakhetha ifomu tablet. Uma isiguli nobunzima nge nokugwinya, isixazululo bese wagunyaza.

Umthamo zomuthi, kanye ukuthola imodi kufanele kunqunywe udokotela wakho kuphela.

Ngakho indlela ukuthatha izidakamizwa "Proksium 40"? Ukufundiswa (ithebhulethi akhangiswe kusho ukuthi konke Pharmacy) uthi umthamo Kunconywa zomuthi 40 mg ngosuku. Umuthi ezithathwe ngesikhathi noma ngemuva kokudla, amanzi amaningi.

Lapho kuhlolwa isilonda esiswini noma ukuguguleka umthamo wansuku zonke anda ku-80 mg.

Ukuze ekwelapheni 12 imithi isilonda duodenal iphuzwe izinsuku ezingu 15-30. Kepha Reflux esophagitis, futhi izilonda esiswini, ukwelapha izifo ezinjalo kufanele kube hhayi ningi than 2 izinyanga.

Ukuqeda Helicobacter pylori amagciwane nesineke 1 ithebhulethi kabili ngosuku. Isikhathi salesi kwelashwa 2 amaviki.

Iziguli nokwehluleka ukusebenza kwezinso, kanye nabantu abadala umthamo nsuku zonke is hhayi iqondiswa ezingaphezu kuka-40 mg.

Lapho yokwehluleka kwesibindi ukusebenza futhi ezinzima isibindi sibe sesomile imithi ovunyelwe ukuthatha 1 ithebhulethi Njalo ngemva kosuku olulodwa.

Isixazululo "Proksium": yokusetshenziswa

I ampoules ukulungiselela enjalo ezinqunyiwe ekuphathweni temlomo kungenakwenzeka.

Into the isitsha eliqukethe lyophilisate is batheleka 10 ml isixazululo ngokomzimba. Abanye ochwepheshe batusa umuthi onjalo kuyinto okwengeziwe exutshwe 100 ml 5% isixazululo glucose.

ukumnika intravenous kumele kutsatse emaminithi okungenani amabili (mhlawumbe mayelana ¼ ihora).

Isixazululo izidakamizwa kumele kusetshenziswe ngokushesha ngemva uxhumano kuzo zonke izingxenye. Uma lokhu kungadingeki, umuthi ke kumele ibekwe ekamelweni ukupholisa futhi zisebenza kungakapheli amahora angu-12.

Isikhathi yokwelapha nomuthi ngakho efanayo ifomu tablet. Isikhathi esiphezulu yokwelashwa - izinyanga 2.

Ngo uphethwe ezifana Reflux esophagitis, umuthi iqondiswa i inani ibhodlela elilodwa zonke izinsuku.

Ukuze ekwelapheni ukopha okwenzeka endaweni isilonda 12 duodenal isilonda kanye isisu umdlavuza kanye nokuvinjelwa uyahluleka uma elwa nokuphuza, umuthi isetshenziswa ne 80 ml ngemithambo yegazi (bolus).

Isingeniso yalesi izidakamizwa eboniswe infusomats usebenzisa 8 mg ngehora.

Lapho Zollinger-Ellison syndrome ne hypersecretion nomuthi enqunyiwe 80 mg. udokotela angase ukwandisa umthamo kuze kufinyelele 160 mg uma kunesidingo. Kulokhu-ke, kuyadingeka ukuba wahlukanise 2 imithamo.

Ukuze ngokushesha ukunciphisa asidi of juice esiswini, ngokuvamile besebenzisa 80 mg zomuthi kabili ngosuku.

amacala ukweqisa izidakamizwa

Yiziphi izimpawu zenzeka lapho ngemithamo ephakeme "Proksium" izidakamizwa (40 mg)? Manual ithi okwamanje izimo ezinjalo azikho imilayezo.

Lapho iqondiswa imithi ngemithambo yegazi (esiphezulu 240 mg) kwamukeleka kahle impela. Uma usebenzisa imali enkulu izidakamizwa, kubalulekile ukusebenzisa nokugcinwa ngokukhishwa kobuthi egazini yokwelapha.

Ochwepheshe basikisela ukuthi ukweqisa izidakamizwa "Proksium" amaphilisi kungase kwandise amandla futhi imvamisa okuba nemiphumela engemihle. Kulokhu, uyeka ukuphuza amaphilisi.

ukusabela ezingezinhle

Buhle buni obungaba engadingeki kungenzeka seziguli ezithola "Proksium 40" izidakamizwa? Ukufundiswa uthi ukusetshenziswa kwaleli thuluzi Imvama:

• ukuqunjelwa, ubuhlungu esiswini, uhudo kanye ukubuyisa;
• cephalgia.

Ngezinye izikhathi, iziguli may:

• ukulunywa futhi ukuqubuka;
• ukuhlanza;
• arthralgia;
• kome nolwelwesi lwamafinyila;
• anda esesuthi;
• nokubhamuka;
• Angioedema;
• ubuthakathaka futhi ukozela;
• isiyezi.

Futhi, amacala kwezinso elandelayo abikwe:

• ukucindezeleka, myalgia, Lyell syndrome, amawala, Stevens-Johnson syndrome;
• umsebenzi kunyuke enzyme isibindi, jaundice, hepatocytes ezilimele, imfiva, nephritis;
• ukuzwela ekukhanyeni, thrombocytopenia, leukopenia;
• thrombophlebitis (ezihlobene isixazululo kwenzeka ngesikhathi indawo umjovo);
• liqhaqhazela, uvalo wehlise ukuzwa futhi umbono;
• induna, Alopecia, hyperglycaemia.

izidakamizwa ekuhlanganyeleni

Yikuphi izakhiwo zomuthi esigulini ukwazi ngaphambi ukuthatha imithi "Proksium"? lokhu kusho umyalelo kubonisa izici ezilandelayo:

• imithi Okubukwe kungenziwa ngokuhlanganiswa "Diclofenac" caffeine "glibenclamide" Ethanol "phenytoin", "metoprolol", "diazepam" "nifedipine", "carbamazepine" "theophylline", "digoxin" futhi abameleli umuthi hormone "naproxen" futhi "digoxin".
• Kuyinto engathandeki ukuthatha ithuluzi ne "ATV".
• anticoagulants ezinjalo coumarin ngokuthi "phenprocoumon" futhi "Warfarin" lihambisana "Proksiumom" kungaholela ukwehla PB.
• Ayikho emtholampilo abalulekile izidakamizwa ukusebenzisana "metronidazole", "amoxicillin" futhi "clarithromycin" aye atholakala.
• Pantoprazole kunciphisa absorbability izidakamizwa, le bioavailability zazo ibuthinta ngokuqondile inani pH we juice esiswini (isibonelo, "Posaconazole", "ketoconazole" "Itraconazole" "Atazanavir", "Erlotinib").
• Inhlanganisela ne nomuthi kubhekwe "MTX" ngokuvamile kuholela ekwandeni in the ubuthi yokugcina.

izincomo ezithile

Yikuphi izici izidakamizwa kufanele wazise udokotela ngaphambi oyinikeza isiguli sakho imithi efana "Proksium" (amaphilisi)? Regulations olubekwe ngasekupheleni kwaleli nomuthi, ukufunda okudingekayo. Wawuthi lokhu izidakamizwa kungavunyelwe ukuthatha abantu dyspepsia sezinzwa.

Lapho ethola izidakamizwa izinyanga ezingaphezu kwezintathu, isiguli singase ukuthuthukisa hypomagnesemia. Izimpawu zalokhu isifo yilezi: amajaqamba, ukukhathala, tetany, delirium, isiyezi kanye ventricular arrhythmia. Esimeni izimpawu ezifana imithi kufanele kumele amiswe futhi ngokushesha uxhumane nodokotela wakho.

Ngaphambi ukwelashwa futhi emva Ukuvalwa yayo gastroendoscope ngempela eyenziwa ukunquma isimo emathunjini. Kumele kukhunjulwe ukuthi pantoprazole kungaba lula impela imaski izimpawu umdlavuza.

Umthamo esiphezulu ngelanga asebekhulile futhi iziguli ezinokuphazamiseka ku ezinso 40 mg. Ezigulini ezine-isifo sokusha lemali nsuku zonke imithi okumele kuyehla ngesigamu.

Ukwelashwa sikhuluma ngokuhoxiswa izindlela, ezimweni ezingajwayelekile, kuholele ukuthuthukiswa campylobacteriosis futhi salmonellosis.

Proton futha inhibitor kwandisa ingozi yokungenwa ithambo waphuka kwasebekhulile cishe ngo-30% (-long term ukwelashwa).

Analogs futhi omqondofana izidakamizwa

Manje uyazi ukuthi nokuthi ukuthatha izidakamizwa "Proksium". ukusetshenziswa le ndlela imfundo kwachazwa ngokuningiliziwe ngenhla.

Uma nganoma isiphi isizathu zomuthi engenzi ivumelane wena, kungaba kuthathelwe indawo nozakwabo ezivamile enjalo, njengoba "Barolo", "Emanera", "Geerdin", "esomeprazole", "Diaprazol", "Ortanol", "Nexium", " rabeprazole, "" Veloz "," Sanpraz "," lansoprazole "," Ezolong "," Gasek "," Ultop "," Deksilant "" Pariet "," Zulbeks "," omeprazole "," Omelik "," Ozol " "Losek", "Omez", "esingumGreki", "Omealoks".

Futhi, lesi sidakamizwa "Proksium" kusho kukhona izidakamizwa-omqondofana "Kontrolok", "Pantazi", "Panzol", "Panum", "Nolpaza", "Penta", "Pantex", "Pultset", "Ultera".

Uphenyo nomuthi

Cishe zonke izibuyekezo imithi ezibhekwa omuhle. Iziguli zithi izidakamizwa "Proksium" ikhuthaza ukuphulukiswa okusheshayo erosions kanye nezilonda, kanye ukuvimbela ukuthuthukiswa kokushelela.

Kepha-side effects, iziguli ngokuvamile wabonakaliswa ibandakanya ukucanuzela kwenhliziyo kanye nezinkinga isihlalo.