Umuthi 'Leykostim ": yokusetshenziswa, nozakwabo yangempela

Uyini izidakamizwa "Leykostim"? Imiyalelo, ifomu ukukhululwa, izinkomba kanye contraindications kule izidakamizwa uzobe kuchaziwe ngezansi. Siphinde ukukutshela ngalokho analogs ziyatholakala leli thuluzi likhona ngezithako zawo, njalo njalo.

Ubujamo, emabhokisini ingxenye izidakamizwa

Yini ifomu owenza izidakamizwa "Leykostim"? Yokusetshenziswa ibika ukuthi nomuthi asebenzayo ekhiqizwa njengoba isixazululo kwezokuphatha ongama noma emthanjeni.

Uphiko esebenzayo ye-ejenti kuyinto filgrastim. Kuyinto isakhi sokuzakhela granulocyte koloni-inkanuko isici. 1 ml ikhambi izidakamizwa ingaqukatha 300 mg (izigidi ezingu-30. IU), 600 mg (izigidi ezingu-60. IU) noma 150 micrograms (izigidi ezingu-15. I.U.) filgrastim.

Ngokuqondene excipients ke ukusebenzisa kwakhe mannitol, sodium acetate trihydrate, dextran, acetic acid, polysorbate, namanzi umjovo.

Ngo isixazululo emaphaketheni okuthengiswa "Leykostim"? Yokusetshenziswa ezishumekwe ebhokisini amakhadibhodi kanye eyodwa noma ezinhlanu izitsha eziyisikhombisa izidakamizwa.

I izakhiwo zomuthi

Uyini lo mshini wezenzo zomuthi e "Leykostim"? Yokusetshenziswa, odokotela Izibuyekezo bathi umuthi-immunomodulator. Kuyinto ukuhlanzwa kakhulu amaprotheni-non-glycosylated ukuthi unomthelela zokulawula on ukuthuthukisa kanye ukunyakaza (kusukela umnkantsha lingene egazini) neutrophil sokusebenza.

Ngemva ukwethulwa izidakamizwa kakhulu kwandisa isibalo neutrophil egazini kancane kuphela - monocytes. Lokhu kwenzeka phakathi namahora angu-24.

Ukwanda igazi neutrophil kuyinto umthamo nasekuthengeni. Generation of amaprotheni eziphila abakhuthele, isb filgrastim, okuyinto normalizes ekwandeni futhi kwamangqamuzana lamaseli eyalo zakulezi amabhaktheriya Escherichia coli. Phela, lo yokugcina, ngenxa amakhono ubunjiniyela yesimanje zofuzo, kwahambisana ngu isakhi sofuzo granulocyte koloni inkanuko isici womuntu.

Ngokusho isimiso sakhe yemiphumela emzimbeni izidakamizwa kufana granulocyte koloni-inkanuko isici, okuyinto odabuka yemvelo. Umehluko kuphela amaqiniso ukuthi "Leykostim" (isixazululo) is hhayi glycosylated, futhi N-esibulalayo acid acid amasalela methionine.

Izici zomuthi

Iziphi izici has umuthi "Leykostim"? Iziyalezo yokusetshenziswa uthi kufanele lisetshenziswe sitholakele neutropenia e abantu ibhekane ngamakhemikhali. Futhi, lolu izidakamizwa iphumelela kakhulu neutropenia ezingamahlalakhona. Lokhu kungenxa yokuthi uyakwazi ukubuyisela isibalo kahle neutrophil emzimbeni womuntu.

Ukusebenzisa ekwakhiweni nokuvimbela, isiguli kakhulu ukunciphisa izinga lokuhlasela kwesifo neutropenia, kanye ukunciphisa yinkimbinkimbi ukugeleza futhi inkathi isikhathi lesi sifo. ukuchayeka okunjalo kuvimbela yezinkinga ezithathelwanayo, encishisiwe obuphelele nesineke kokuhlala esibhedlela, ivumela nokwelashwa ngamakhemikhali ngaphandle kokuhamba imigomo sezisunguliwe isikimu jikelele ukwelashwa.

Njengoba umzimba womuntu izenzo "Leykostim"? Yokusetshenziswa kubonisa ukuthi ukusetshenziswa kwezidakamizwa kunomthelela isiqondiso neuropathy egazi hematopoiesis ngaphambi, okwakubekelwa eqoqwe yinoma cytapheresis (isb, ihlukanisa igazi ku ingxenye yeselula nokukhishwa abakhethayo) yaphinde yaphathwa isiguli emva inkambo umthamo ephezulu ngamakhemikhali.

Ngakwelinye ihlangothi, amaseli injected (stem) kokuba umsebenzi hematopoietic, encishisiwe namasosha omzimba futhi hematopoietic, kanye kuncishiswe ingozi nobukhali yezinkinga ezithathelwanayo futhi oluhambisana.

imithi nokuphepha

Kuphephile izidakamizwa womuntu "Leykostim"? Manual ithi izidakamizwa ingasetshenziswa kokubili ngabantwana nangabantu abadala. Kuyathokozisa iphephile kubo bonke abantu abathola imiphumela emibi yokwelashwa ngamakhemikhali cytotoxic.

Iziguli isixazululo immunodeficiency virus Isicelo inikeza ezingeni elikhulu neutrophil futhi ukunika ithuba ukulandela yonke imithamo Kunconywa zokwelashwa ngama-antiretroviral noma myelosuppressive.

Uma usebenzisa lokhu umkhiqizo ukufanisana HIV uyalandelwa.

Pharmacokinetics

Yini izidakamizwa pharmacokinetic has "Leykostim"? Ukufundiswa ubonisa ukuthi lokuhlushwa isithako esebenzayo lokhu ejenti kuyinto encike ngqo kwi umthamo iqondiswa.

Ngemva kokuphathwa ongama, inani elikhulu izidakamizwa egazini waphawula ngemva cishe 8-15 amahora.

Ingxenye-ukuphila "Leykostima" impahla esebenzayo amahora amathathu kuya kwamane. Filgrastim akheka ukuze peptides. Mayelana 1% ingxenye esebenzayo livela ezingaguquliwe umchamo.

Filgrastim ekuqongeleleni emzimbeni womuntu ingekho ngisho nangemva ukusetshenziswa isikhathi eside zomuthi (lapho ukwelashwa idlula ngenyanga). Ngale nkathi isigamu-nokuphila yayo uyefana.

izinkomba

"Leykostim" Umuthi ezinqunyiwe ngezinhloso ezilandelayo:

• ukwehlisa ubude neutropenia ukugeleza izinyathelo 2-4, futhi ukunciphisa izinga lokuhlasela kwesifo neutropenia febrile kubantu ngemihlume nemieloproliferativnymi emva nokwelashwa ngamakhemikhali kanye ejenti cytostatic;
• ukunciphisa izenzo nezinkinga ezingase ziphakame uma neutropenia, kanye ukwehlisa Yiqiniso isikhathi izifo kubantu umdlavuza ngamakhemikhali myeloablative nge umnkantsha transplantation isidingo;
• iseli izindawo esandulele hematopoiesis egazini neuropathy ngenjongo uhlukanisa futhi zitshala kubo emva nokwelashwa ngamakhemikhali myelosuppressive;
• ukwelapha neutropenia kubantu nge-HIV (kuhlanganise nelase-Usuqhubekile) ukuze kuncishiswe ingozi izifo ezithathelwanayo Lokudabuka webhaktheriya;
• ukwelapha neutropenia ezingamahlalakhona;
• iseli izindawo hematopoiesis ngaphambi, egazini neuropathy abanikele enempilo ukuba utshalwe zihlukanise zigule.

Izimo

Yiziphi Izimo izidakamizwa has "Leykostim"? Izibuyekezo ochwepheshe kubika enqabelo ezilandelayo:

• anda ukuzwela ngazinye isiguli ezisebenzayo kanye nezinye lichaza ekwakheni zomuthi;
• neutropenia azalwa naso, ezinzima ogeleza iziyaluyalu cytogenetic (Kostmann syndrome);
• isikhathi ezisanda kubelethwa (ikakhulukazi ngenyanga yokuqala yokuphila).

Izidakamizwa "Leykostim": imfundo kanye nesicelo

imithi Okubukwe ingasatshenziswa ngezindlela ezimbili:

• ngemithambo yegazi;
• phansi kwesikhumba.

Isikali futhi indlela isimiso sokuqondisa 'Leykostima "Kufanele sizimisele ngochwepheshe, kuye ngokuthi isimo sokucindezeleka, izici ngabanye isiguli kanye sifo. Nokho, kufanele kuphawulwe ukuthi kwezokwelapha kutuswa ekuphathweni ongama zomuthi.

Ukuze emthanjeni nomuthi asebenzayo kuhoxiswe kusukela isitsha yi isipetu, bese-ke ingezwe ku-umfuma 5% dextrose. Isixazululo kwaphumela iqondiswa isiguli for isigamu sehora.

Indlela yokufaka isicelo "Leykostim"? Imiyalelo (analogue lomutsi kuzoxoxwa ngezansi) uthi izidakamizwa kumele kusetshenziswe akukho ngaphambi kosuku ngemuva kokuphela imiphumela emibi yokwelashwa ngamakhemikhali.

Isixazululo izidakamizwa saphathwa kuye isisindo lesiguli. Umthamo amabanga of 5-12 mg ngayinye isisindo 1 kg. Imijovo kuyenziwa usuku ngalunye ngokuhlola itekisi imvamisa kanye ngosuku.

Ukwelashwa kubhekwa izidakamizwa kumele kwenziwe nje isibalo neutrophil egazini ungayifinyeleli amazinga evamile. Ngokuvamile, isikhathi kwelashwa amasonto amabili.

Phakathi abaphathi ongoti ukuze kutholwe njalo isibalo leukocyte egazini. Uma inombolo mkhulu kunezinhliziyo 50,000 / microliter, umuthi amankeyane.

Phakathi ukwelashwa, isiguli singase ukuthuthukisa thrombocytopenia. Endabeni e assays waphinda platelet count value kugcinwa ngezansi 100,000 / microliter ke uhlola yokukhansela yesikhashana zomuthi noma ukunciphisa umthamo yayo.

side effects

Ngokwezibalo, lesi sidakamizwa "Leykostim" ayivamile ukubangela ukusabela ezingezinhle. Nokho, kungaba namanje neqhaza ukuvela imiphumela efana:

• dysuria;
• ubuhlungu emathanjeni noma imisipha;
• Alopecia;
• hepatomegaly, splenomegaly;
• hypotension (lezivakashi);
• amazinga anda uric acid kanye phosphatase ane-alikhali;
• ubuthakathaka, ikhanda kanye ukukhathala;
• ziyabagulisa ekuqaleni ukwelashwa, okuvame kwenzeka ngemva kokuphathwa emthanjeni zomuthi.

Kufanele kuphawulwe ukuthi uma umjovo ayilungile ungase uphazamise ukuqaleka nesineke ngesikhathi indawo umjovo.

izidakamizwa ekuhlanganyeleni

Ngaphambi kokusebenzisa lo izidakamizwa, kumele ukuthola indlela basebenzisane neminye imithi "Leykostim". Imiyalelo (INN we imithi kuzwakala "filgrastim") iqukethe ulwazi oluphelele ngokusebenzisa:

• Nomuthi "5-FU" kuqinisa neutropenia.
• Ngenxa yokukhula amaseli myeloid ezikhathalela kakhulu ejenti cytotoxic, ukuqoka kukhona "Leykostim" kufanele kube usuku ngaphambi noma ngemva ukusetshenziswa kwalezi izidakamizwa.
• Okubukwe nomuthi aluhambisani ne-sodium chloride.
• Uma usebenzisa ikhambi isiqondiso sikakhokho amaseli elandelayo nokwelashwa ngamakhemikhali kufanele kubhekwe ukuthi kahle kunciphisa lapho duty ukugqugquzela isicelo "carmustine" "Melphalan" futhi "carboplatin".

izincomo ezithile

It is hhayi Kunconywa yokunika "Leykostim" nabantu kahle isibindi umsebenzi nezinso, njengoba filgrastim ukuphepha nokusebenza ngempumelelo kulezi iziguli engakaze wafunda.

Iziguli kwamathambo nezinye isifo ithambo, abasebenzisa izidakamizwa ngokuqhubekayo izinyanga eziyisithupha, kufanele ukuqhuba kokulawulwa kwamathambo.

Ukuphumelela izidakamizwa abantu esincane myeloid sikakhokho amaseli engakaze wafunda. Nokho, ochwepheshe bathi iziguli ezifana degree of ukwanda kwenani neutrophil kungaba aphansi.

Ngempumelelo nokuphepha "Leykostima" kubantu abanegciwane ezingamahlalakhona wegazi myeloid futhi myelodysplastic syndrome ungazange sezisunguliwe. Kule ndaba, yezifo ezifana ayiboniswa.

Monotherapy abaqondanga izidakamizwa kuvimbela sokuntuleka kwegazi kanye thrombocytopenia, okuyinto zibangelwa nokwelashwa ngamakhemikhali myelosuppressive. It liyadingeka ukuze anqume inani zegazi kanye hematocrit. ngokuqapha Kumele lapho usebenzisa ingosi eyodwa-ingxenye noma inhlanganisela zemithi chemotherapeutic, zaziwa ikhono lazo kubangele thrombocytopenia ezinzima.

Ngaphambi kokuqala ukwelashwa, "Leykostimom" kudingekile ukwenza analysis eningiliziwe igazi nge ethile platelet ne leukocyte ibala, futhi hlola karyotype futhi umnkantsha isithombe.

Ngesikhathi ukwelashwa liyadingeka ukuqapha njalo umchamo kanye nobukhulu ubende.

Izidakamizwa "Leykostim": analogs futhi intengo

Analogue izidakamizwa zibhekwa izidakamizwa ezilandelayo: "Filergim", "Grasalva", "Granogen", "Neupogen," "leucite", "Neypomaks", "Mielastra", "Neyrostim".

Ngokuqondene intengo, bese uthi "Leykostima" kuphezulu kakhulu. Thenga le izidakamizwa Pharmacy eMoscow nakwamanye amadolobha Russian kungaba ruble 2500-4500. Intengo yale imithi incike ngobukhulu futhi nenombolo of ampoules iphakethe ngalinye.

imithi Izibuyekezo

Ngeshwa, ukubuyekezwa iziguli abathatha lesi izidakamizwa, kuncane kakhulu. Ngokwe-lokuthi kukhona, imithi avame engabelwe izivikeli mzimba, kanye neutropenia eyindilinga ezinganeni. Umthelela izidakamizwa yezifo ezibucayi ezifana sifushane.

Kufanele kuphawulwe ukuthi zikhona kobufakazi isiguli ukusetshenziswa emitholampilo ye "Leykostima" ezinganeni nakubantu abadala nge neutropenia elihlobene ne umdlavuza ngamakhemikhali. Ukulungiselela eyabelwe izingane ngezilinganiso 5 mg / kg ngosuku, aziyeka ngokubekezela kunalokho kahle.

Ezinye iziguli abanesifiso sokwazi ukuthi nhloboni isixazululo kungcono: "Leykostim" noma "Neupogen". Ngenxa zokwelapha ukuthi Kwakuseshwa ukuhlonza tolerability nokusebenza ngempumelelo kwala magciwane, iziphetho ezilandelayo kwafinyelelwa: isikhathi okuvalwa ngaso ukulungiswa neutropenia ngemva kokusebenzisa imithi okukhulunywa akuzona okhetheke khulu. Ngaphezu kwalokho, banayo ncamashi izinkomba efanayo ngempumelelo futhi tolerability.