Ucwaningo luveza: "Tylenol" kususa ubuhlungu nje kuphela, kodwa futhi kwi imizwelo eyakhayo

Abacwaningi e-Ohio State University lwathola ukuthi ingxenye eyinhloko amaphilisi ezinhlungu eziningi acetaminophen (paracetamol) has eyodwa ngaphezulu ezazingaziwa side effect. Phakathi kwezinye izinto, lokhu izidakamizwa "Ubumpofu bubulala" imizwelo eyakhayo.

experiment Inqubekela

82 abahlanganyeli cwaningo bahlukaniswa amaqembu amabili. Abamele omunye wabo wathola umthamo zonke izinsuku we-1000 mg-paracetamol, kanye nezinye placebo. Umuthi is angena igazi Ngemva kokuba kudlule cishe ihora. Futhi lokho kusho sekuyisikhathi esigabeni ukuhlola kwesibili. Manje, sokuzithandela ngasinye kwakumelwe ubone izithombe ezibangela imizwa ehlukene (kusuka emnandi kakhulu ezimbi kakhulu), bese ukuchaza imizwa yabo. Kwabe sekuvela ukuthi, umuntu ovamile ubuhlungu yokunciphisa abathuntubezwe bezibona ngokomzwelo wabahlanganyeli kusukela iqembu lokuqala. Ngokuvamile, babika imizwa elikhanyayo kancane nje uma eqhathaniswa naso abahlanganyeli wathatha i-placebo. Labo kini abaye eduze kulandela ucwaningo, bazi ukuthi ukuhlanganisa ayikwazi ulinganiswa causation. Yize kunjalo, uma bati nezinye ukuhlola okwenziwa inqola i kule ndawo, bese uthola konke okuhilelekile.

Isakhi esiyinhloko e eziningi ubuhlungu relievers

Paracetamol iyona isici esiyinhloko e amaphilisi ezinhlungu ithengiswe ngaphandle kadokotela. Ngokwesibonelo, lesi sidakamizwa "Tylenol" lisetshenziswa e-United States has amashumi eminyaka ayisikhombisa. Zonke imiphumela emibi izidakamizwa esebenzayo isikhathi eside wafunda. Ucwaningo lwamanje wakwazi wengeze esinye isici esidinga uhlu umxhwele. Uma ukholwa ukuthi i-Association of umthengi nemithi, esekelwe-paracetamol ekhiqizwa angaphezu kuka-600 ezahlukene izidakamizwa. Lokhu kuvumela izibalo zokuhlukanisa wathi ingxenye komunye ezivamile chemical compounds eziqukethwe amaphilisi.

Ulwazi Iziguli

Abakhiqizi Ungashintshanisa ulwazi isembozo "Tylenol", "Panadol" noma "ibuprofen". Lezi mshini - "izinzwa" futhi "ukuqeda imizwa" - Kuyathokozisa kweqiniso. Kuphela neze umthengi efuna ukuyibuyisa ngokuyithenga futhi iphakethe, eyayinekheli isitatimende elishaqisayo. Lolu lwazi kufanele ishiywe ngaphandle ukunakwa zabantu ukuzithiba medicate. A ikhanda kancane - ngokushesha kuziwa iphilisi wokutakula ukonga. Yiqiniso, zikhona izikhathi lapho ungeke ume ubuhlungu, kodwa kukhona abanye lapho kwakunokwenzeka ngempela ukwenza ngaphandle izidakamizwa. Njengoba kwaba sobala ukuthi "ingozi" ukuphathwa ubuhlungu okungenzeka nemiphumela engemihle kakhulu kunalokho esingase kwakucatshangwa, umuntu ngamunye kufanele basondele udaba ngokungaziniki ubuhlungu sina.

izifundo langaphambilini

izifundo Ngasekuqaleni okuhloswe ngaso ukuhlola amathuba acetaminophen, kwembulwe izikhathi ezithakazelisayo. Ososayensi kungenzeka wayazi ukuthi lokhu izidakamizwa kungathinta hhayi kuphela ngokomzimba kodwa ubuhlungu obungokomzwelo. Futhi lokhu kusho ukuthi ingasetshenziswa njengendlela eyodwa ingxenye yokwelapha eyinkimbinkimbi zengqondo. Nokho, ulwazi olusha olubonisa ukuvaleka bohlu imizwelo eyakhayo, kufanele wazise kodokotela neziguli. Ukusetshenziswa "Tylenol" nezinye analogue analgesic ekhiqizwa ngesisekelo paracetamol, kungaholela kwaba nemiphumela emibi nakakhulu.

Ubungozi ephethwe yisifo senhliziyo

Okubalulekile, ukusetshenziswa kwezidakamizwa izinzwa (isib aspirin ne-ibuprofen) ephathelene congestive senhliziyo ingozi. Abantu ukuthatha igazi thinners, ngokushesha khawuleza bathi, "Ngani, ngoba i-aspirin iyisithako ngesisekelo umuthi wokuvimbela amahlule?" Nokho, abantu abaningi ukhohlwe ukuthi kuleli cala, isiguli uthola ithebhulethi ayimbijana isithako esisebenzayo, incommensurable ne ukuthi ngokuvamile kuthathwe okudambisa ubuhlungu. Ukweqiwa okweqile nsukuzonke kuholela akuzuzisi imiphumela, futhi abantu ubuhlungu esikhundleni ephulukisa inhliziyo yakho. Ingasaphathwa ukuthi ama-aspirin buqeda odongeni esiswini, ngakho kule ukwenziwa kwemithi, igazi thinners, isithako esebenzayo kulekelelwa magnesium igobolondo.

Ukubukeza zokwelapha

Ososayensi base sibuyekezwe 754 zokwelapha, lapho kwatholakala ukuhlanganisa ocacile phakathi edonsa analgesics futhi kwengozi yokufa kwabantu bengabulawa senhliziyo kubantu. Ngokwe abalobi ukubuyekeza, ukusetshenziswa eside izidakamizwa, ngesisekelo aqukethe acetaminophen, okubangela izinkulungwane yinhliziyo emhlabeni wonke. Painkillers kuvuse okungazelelwe ukuboshwa inhliziyo. Idatha zathathwa yenkathi ephakathi 1999 - 2003 iminyaka, imiphumela yocwaningo olwanyatheliswa kuyi-Lancet. Futhi kulolu cwaningo it okukhulunywa eziyihlazo izidakamizwa "Vioxx" kabani nomkhiqizi sekuqalile emikhulu ukukhuthazwa izindlela kwezemithi emakethe ngasekupheleni kwekhulu lama-20.

inhlolovo okutholakele

A meta-ukuhlaziywa novivinyo olwenziwa futhi izifundo elibukelayo luye lwabonisa ukuthi coxibs (ama-NSAID) ahlanganiswa nesihlalo kwengozi yokuthola izifo eziphathelene nenhliziyo yezinkinga ezihlobene nomsebenzi elingenhla pheshana emathunjini. Ososayensi baxwayisa ngokuthi ukusetshenziswa eside ebulilini umuthi wezinhlungu iqukethe ngengozi engaba khona impilo yabantu. Ngenxa yalesi sizathu, uma izidakamizwa "Vioxx" inqanyuliwe e-United States.

Ukuqedwa yokuthonywa imizwelo engakhi

Cabanga ngomphumela ubuhlungu imithi ukunciphisa bezibona izimo ezingezinhle. Njengoba ungase ucabange, isithako esebenzayo abavumelekile ukwabelana imizwelo ku okuhle nokubi. It buthuntubeze bezibona ngokomzwelo jikelele, futhi, kanye "ukubulawa" omubi futhi imizwelo eyakhayo. Lokhu kusho ukuthi umphumela analgesic ku anhlobonhlobo imizwa nokuziphatha. Ngokwesibonelo, ukuzwela encishisiwe ubudlelwane obuholela abantu ibe ngaphansi ezinqala, ngokuvamile baba nomuzwa sengqondo ngingafaneleki futhi banemizwa engqubuzanayo kubantu ngabanye.