Okwelapha Nokuhlinza sawo esiningi. androstenedione isigqugquzeli

Androstenedione libhekisela wobulili i-hormone wesilisa. Lokhu androgen kuyinto testosterone eyandulela. In amadoda, ogama ukukhiqiza senzeka ikakhulukazi testes. Ngo abesifazane, 60% androstenedione kuwumphumela izinguquko neuropathy, 40% ikhiqizwa nezindlala adrenal futhi ezikhiqiza amaqanda. Ngesikhathi bubuhle ubulili ngesilinganiso kwetinhlavu kanye uketshezi kwale hormone ingaphezu kwe-testosterone, futhi kakhulu isikhathi eside uzwakalise extraadrenal ukuguqulwa testosterone.

androstenedione ezingeni kunqunywa isakhiwo DHEA-S futhi DHEA. Lokhu kuyadingeka ngezinhloso zokuxilonga kanye nokuhlola nomphumela oqabulayo e izimo hyperandrogenic.

androstenedione esiphakeme ukuhlaziya igazi sici kweziguli adrenal cortex Hyperplasia imvelo azalwa nako. Ngaphezu kwalokho, lapho izinga Kutholwe syndrome Cushing, Hyperplasia noma neoplasm stroma wamasende e esibelethweni, kanye ethunjini ACTH uketshezi.

androstenedione aphakeme ukubonwa in iziguli hirsutism futhi ezikhiqiza amaqanda polycystic.

Zokwelapha, lokuhlala serum le-hormone kabanzi ukuqapha ukusebenza kwe ezelaphayo nokusetshenziswa glucocorticoids e azalwa naso Hyperplasia adrenal, njengoba kubhekwa isilinganiso esinembile kakhulu kunamanye androgens.

Ayikho anda androstenedione, futhi aba amaSheshi, ukunciphisa okuqukethwe kwayo kubonisa khona isikela-cell anemia. Pathology eba ngaphansi kwesimo esingamahlalakhona wesibeletho kanye adrenal.

Androstenedione. Lapho ihlolwe?

Izinkomba isifundo yilezi:

- ukwelashwa ukuqapha kanye ukuxilongwa izimo hyperandrogenic;

- iziyaluyalu zokuzala on isizinda hormone ukwehluleka;

- ukwelashwa nge glucocorticoids.

Ngokukhethekile ikhokhelwa androstenedione abantu abathintekayo sawo esiningi okhokhelwayo. Kukholakala ukuthi amalungiselelo ama-hormone, futhi ekuqukethe ukukhuthaza ukukhula kwemisipha. Nokho, lokhu akusho ngaso sonke isikhathi kunjalo.

Androstenedione kuyinto hormone eyinhloko nezindlala adrenal futhi kungenziwa iguqulwe noma testosterone noma i-estrogen. Esimweni sokuqala it is zishukunyiswa ethize enzyme ukuguqulwa. Kufanele kuqashelwe ukuthi uchungechunge kugucuka androstenedione steroid ukuze testosterone eduze kuka DHEA. Lokhu kuholela enkulu amandla ayo ukuze aguqule. Ngakho, ukuguqukela nomphumela we androstenedione ukuze testosterone isizinda bedle omunye enzyme bangaya dihydrotestosterone. Lokhu, sekusilethela ekuthuthukiseni nemiphumela eziningi ezingajabulisi esibhekana nazo. Dihydrotestosterone kuvusa futhi balding ikhanda, futhi kweNdikimba wendlala yabesilisa, kanye ngokweqile izinwele ukukhula emzimbeni nasebusweni. Ngaphezu kwalokho, izakhiwo Anabolic ayinayo, Nokho akunamthelela yemisipha. Ngakho, lapho androstenedione yanda, kukhona kungenzeka okwandayo lokuhlala dihydrotestosterone.

Ngaphezu miphumela, kunesinye inkinga - gynecomastia. Kuvusa ukukhula webele ukuguqulwa kwe-testosterone ukuze estradiol (aromatization).

Naphezu kwalezi ziqinisekiso abakhangisi ongadalwa androstenedione umphumela enhle kwemisipha ukukhula uma wamukelwe kahle, ama-hormone "zokukhwabanisa" ngokuvamile kukhona inqubo ezingalindelekile futhi kunzima. Futhi ucabangele iqiniso lokuthi ukwanda emazingeni testosterone usebenzisa izidakamizwa hormone, yebo, kuthinta uhlelo elawula ukukhiqizwa ubulili steroid.

Namuhla, androstenedione futhi umphumela wawo womuntu bawuqonda. Ngaphezu kwalokho, lapho ithola lawo noma amanye amalungiselelo hormone kufanele acabangele izici umzimba ngamunye. Ngokwesibonelo, ngo-ukwanda abathile lokuhlushwa Kusizuzisa androstenedione ku kwemisipha ukukhula, kuyilapho abanye zinkinga ezinkulu.