Nalidixic acid: Isicelo Ekwelapheni

Kuyaziwa ukuthi amagciwane kuyizinto Amagciwane njalo iningi Izifo ukuvuvukala kanye nezifo. Ukuze ukuhlukana emzimbeni wabo, usebenzisa imithi elwa namagciwane ezahlukene. Kunamaqembu amaningi izidakamizwa, abazidumbu zabo isinyathelo sibhekiswe amagciwane. Omunye zindlela kuyinto nalidixic acid. Kuyinto isithako esebenzayo kwezidakamizwa eziningi elwa namagciwane. Esinye isibonelo - iphilisi "nevigramon". Lesi sidakamizwa kungokwalabo quinolones, iqembu kwemithi - antiinfectives. Ngaphambi kokuba uqale ukwelashwa, kumele iphumelele ekuhlolweni ukuhlonza lwegciwane kanye nokuvivinya ukuzwela aso nomuthi.

Nalidixic acid - kuyini?

Ngokuqinisekile wonke umuntu ujwayelene amalungiselelo equkethe nalidixic acid. Le nto isivele usetshenziswe iminyaka kwezokwelapha njengenhlangano ejenti anti-microbial anti-yisinanakazana. Nalidixic acid, njengoba kuphawulwe ngenhla, libhekisela eqenjini quinolones. imithombo Medical ukuhlobanisa la izinto nge izidakamizwa elwa namagciwane. Nalidixic acid kuyinto imithi zokwenziwa ukuthi kudalwa elabhorethri. Kuyinto powder ukukhanya yellow, okungakwazi chaza emanzini. Isicelo eyinhloko acid - umuthi. Uyilunga kwezinye antibiotic.

Isenzo nalidixic acid

Ukuze ukwazi ngaphansi kwaziphi izimo isicelo nalidixic acid, kubalulekile ukufunda lo mshini wezenzo zawo. Imiphumela esemqoka zomuthi - kuyinto nokucindezela ukukhula kwamagciwane nokubhujiswa kwabo. indlela yayo isinyathelo sokuqeda DNA zamagama by nezilwanyana ezincane polymerization. nalidixic acid izidakamizwa isinyathelo ngokukhetha ku Gram (-) amagciwane. Ziyakwazi ngempumelelo yokulwa izilokazane ezincane bohlobo lwe-Proteus, Escherichia coli. Ngakho-ke, abacindezela Izifo ukuvuvukala, okuyinto zibangelwa la magciwane.

Isenzo zomuthi incike lokuhlushwa yayo emzimbeni. Ngemithamo emincane, ke kunomphumela bacteriostatic, ie-ke kuvimbela DNA ukufanisana. lokuhlala ezinkulu izidakamizwa ezithinta on the zamagama protein ne-RNA. Ngakho-ke, ukusetshenziswa eside noma ukuphathwa amaphilisi ngemithamo ezinkulu okuholela isinyathelo amagciwane. Kufanele kukhunjulwe ukuthi Gram (+) amagciwane futhi anaerobes kukhona kungayinaki nalidixic acid. Ngakho-ke, ngaphambi oyinikeza ke, kumelwe enze ukuhlolwa bacteriological of izinto eziphilayo azithathe (umchamo, igazi) futhi bachitha antibiotikogrammy.

Izinkomba ngokusetshenziswa nalidixic acid

Kunezindlela ezihlukahlukene Izifo ukuvuvukala lapho isicelo nalidixic acid. Imiyalelo e iphakheji umkhiqizo, ngokunembile amaphuzu kuyo wathunyelwa ketshezi asebenzayo ukutheleleka. Noma kunjalo, kufanele sikhumbule ukuthi lezi zifo kungukuthi njalo zibangelwa Gram (-) flora. Ngakho-ke, uma ukwehluleka izidakamizwa kufanele kuthathelwe indawo nomunye izidakamizwa ezinsukwini ezingu-3. Acute ukuvuvukala kwezinso - spectrum eyinhloko izifo lapho wabelwa nalidixic acid. Ukusetshenziswa imikhiqizo equkethe lokhu izidakamizwa, kuvamile hhayi kuphela e Nephrology, kodwa nakwezinye imikhakha wezokwelapha. I izinkomba main - kuyinto:

1. Cystitis. Ukuvuvukala kwesinye uvame kubangelwa Escherichia coli futhi Proteus, Nokho prescribers quinolone kokuba kusebenta phezulu bamelane alawa magciwane.
2. Pyelonephritis. Ukuvuvukala izinso tubules kakhulu iyaphendula kahle ekwelashweni ne izidakamizwa nalidixic acid, ikakhulukazi esigabeni oyingozi.
3. Ukuxilongwa pheshana urinary nezifo. Kulokhu, imithi enqunyiwe manipulations urological kanye nokusebenza.
4. abezindaba otitis olunamandla.
5. Cholecystitis.
6. Okuvuthayo ezinkulu nezincane isifo emathunjini (enterocolitis).
7. Urethritis futhi prostatitis.

Futhi, nalidixic acid ingasatshenziswa nezinye izifo zibangelwa igremu (-) nezilwanyana ezincane.

Yimiphi imithi aqukethe nalidixic acid?

Kunemithi eminingi equkethe nalidixic acid. Bonke babe isenzo esifanayo futhi izinkomba ukusetshenziswa. Kwezinye izimo, umthamo ezahlukene ketshezi esebenzayo eyinhloko. Amagama ahlukile namanani yalezi mithi kuncike kuzwe ukwakhiwa kanye nenkampani ekhiqiza imithi. Omele elidume kunawo wonke izidakamizwa "nevigramon". Lesi sidakamizwa inezinto eziningi analogue. Phakathi kwalezi izidakamizwa, "bangamaNigro", "Nalid", "Tsistidin", "Vintomilon", "Urogram" nabanye. Zonke lezi izidakamizwa nomphumela ofanayo emzimbeni.

Nalidixic acid: yokusetshenziswa we nomuthi

Amalungiselelo equkethe nalidixic acid, okumele zithathwe izilinganiso 500 mg 3-4 izikhathi ngosuku. Ezimweni eziningi, leli nani isithako esisebenzayo eziqukethwe iphilisi elilodwa noma capsule. Ngo inflammations ezinzima kungathatha 1000 mg kane ngosuku. Ezinganeni, umthamo kufanele ibalwe (60 mg esisindo / kg).

Izimo futhi side effects

Njengo-antimicrobial kakhulu, nalidixic acid is contraindicated kwabesifazane senyanga yokuqala sokukhulelwa futhi ibele. Futhi, le mithi ayikwazi ukusetshenziswa izingane kuze iminyaka 2. Phakathi kwezinye Izimo isehlane kwezinso futhi esingamahlalakhona hepatic.

imiphumela emibi zihlanganisa emathunjini umsebenzi ukwephulwa (ukuqumba, isicanucanu, ukuhlanza), isiyezi, nokungezwani komzimba. Okumele kuqashelwe kumele kusetshenziswe nalidixic acid abantu abaphethwe pathologies zezinzwa (Parkinson, isifo sokuwa, unhlangothi).