"Metadoksil": libuyekeza yotshwala, yokusetshenziswa, ukwakheka kanye nencazelo

Kanjani ngempumelelo liziphatha izidakamizwa "Metadoksil"? Izibuyekezo yotshwala, intengo kulo mkhiqizo futhi izinkomba zayo zichaziwe ngezansi. Futhi kulesi sihloko, uzofunda indlela kwesicelo zomuthi, imiphumela engemihle kanye contraindications.

Incazelo, ifomu, ukwakheka

Izidakamizwa "Metadoksil" (yotshwala Izibuyekezo ngakho uyoboniswa ngezansi) itholakale ukudayiselwa e amafomu alandelayo:

• Biconvex, round amaphilisi emhlophe Valium ngakolunye uhlangothi kanti eziqoshwe igama lomkhiqizo - ngakolunye. isithako wayo esebenzayo L-ezimbili pyridoxine pyrrolidone carboxylate nanhlanu noma kangaka okuthiwa metadoksin. Futhi kufakwe leli thuluzi kukhona MCC kanye magnesium stearate.
• Isixazululo ukusula lomjovo tint kungekho nto enemibala emihle noma aphuzi. ingxenye yayo esemqoka nayo metadoksin. Ngaphandle-ke, lichaza ekwakheni izidakamizwa kuhlanganisa sodium edetate, amanzi d / kanye sodium metabisulfite futhi methyl parahydroxybenzoate.

umphumela we izidakamizwa

"Metodoksil" - ikhambi utshwala. Kuba yisikhathi futhi lapho yokubonisa ngokukhishwa kobuthi egazini futhi izakhiwo hepatoprotective.

umphumela Hepatoprotective zomuthi ngenxa ulwelwesi yayo eliletha ukuthula umphumela. Ngaphezu kwalokho, lokhu izidakamizwa uyakwazi ukunciphisa isilinganiso khulula unsaturated igcwaliswe fatty acid. Ngenxa yalokho ukumelana lenyuka emiphumeleni hepatocyte peroxidation kwamafutha ezivukayo ngaphansi kwethonya ejenti anobuthi.

Nokwehlisa izakhiwo zomuthi ngenxa ukusebenza enzyme isibindi zinengxenye okuyinto e umzimba ethanol (ikakhulukazi utshwala dehydrogenase futhi acetaldehyde dehydrogenase), kakhulu ngesivinini inqubo kususwe umzimba futhi, ngenxa yalokho, ngoba kunciphisa umphumela anobuthi.

Izici izidakamizwa

Kuyini izidakamizwa emangalisayo "Metadoksil"? Ukufundiswa izilinganiso zithi imfuyo yayo asebenzayo evimbela kumiswa izakhi ezifana collagen futhi fibronectin, iphinde ivimbele ekuqongeleleni triglyceride, okuyinto kakhulu kubamba ukuthuthukiswa isifo sokusha.

Kufanele kuqashelwe ukuthi leli thuluzi ukwazi ukunciphisa isikhathi wokukhululeka kwezimpawu zokuqaleka, ukunciphisa izimpawu ukuphathwa kwabathintwayo nangokwengqondo Hangover.

Asinakusho ukuthi metadoksin oyenza isebenze Gaba-ergic futhi cholinergic neurotransmitter ithiya motor excitation, kuthuthukisa nenkumbulo esifushane futhi ukucabanga. Ngaphezu kwalokho, into okwazi ezikhandla imiphumela nonspecific anxiolytic futhi antidepressant, kanye ukunciphisa ukuqalekela utshwala.

kinetics

Emva kokuthatha umuthi ngaphakathi it is ngokushesha ugxile kusukela amathumbu. Metadoksin has a bioavailability okusezingeni eliphezulu (cishe 60-85%). Its sesibopho ukuthobisa plasma amaprotheni 50%.

Le ngxenye is akheka esibindini ukwakha amagama ahlobene asebenzayo - pyrrolidone carboxylate futhi pyridine.

Isigamu-ukuphila izidakamizwa by abaphathi parenteral noma ukungenisa imizuzu 45-57 of. Cishe 40-50% zomuthi ivela umchamo emini futhi mayelana 35-50% - endleni yabantu abanaleli kungakapheli amahora 95.

ubufakazi

Kungaphansi kwaziphi izimo izidakamizwa ephumelela kunazo iziphatha "Metadoksil"? Izibuyekezo yotshwala zithi lokhu remedy kuhle kakhulu:

• ukuluthwa utshwala;
• ekwelapheni isifo sesibindi, kuhlanganise omsakazo utshwala;
• utshwala ukuhoxiswa syndrome ;
• utshwala ukudakwa, kuhlanganise oyingozi.

Izimo

imithi Okubukwe is contraindicated ku:

• ibele;
• sokukhulelwa;
• sensitivity high izakhi zomuthi.

Ngokunakekela kulesi sikhungo kufanele lisetshenziswe Parkinson, ikakhulukazi uma isiguli isivele isebenzisa levodopa. Lokhu kungenxa yokuthi metadoksin ukwazi ukunciphisa ukusebenza lakamuva.

Izidakamizwa "Metadoksil": yokusetshenziswa

Izibuyekezo ukubika ukuthi ukusetshenziswa kwezimali kufanele kube kuphela emva kokubonisana onguchwepheshe.

Lapho utshwala ukudakwa, sibi nakakhulu, izidakamizwa esebenzayo iqondiswa intramuscularly ngesikhathi umthamo 300-600 mg noma ngemithambo yegazi - 300-900 mg.

Lapho iqondiswa ngemithambo yegazi, umthamo izidakamizwa kuboniswe ngaphambili buhlanjululwe in 5% isixazululo dextrose noma nge 500 ml i-sodium chloride. Ngesimo esinjalo ukulungiswa yethulwa dropwise, phezu 1.4 amahora.

Njengengxenye ukwelashwa kuhlangene izifo kwesibindi, nokuluthwa utshwala ezingamahlalakhona ithuluzi 500 mg iqondiswa kabili ngosuku imizuzu 25-35 ngaphambi kokudla. Lokhu umthamo kungenziwa lenyuke 500 mg kathathu ngosuku.

Inkambo yokwelapha nale izidakamizwa kumele kutsatse okungenani izinsuku ezingu-90.

Lapho bakwazi syndrome (utshwala) le nomuthi iqondiswa ngemithambo yegazi by ukumnika at umthamo 900 mg kanye ngelanga izinsuku 3-7 (kuye ngokuthi isiguli).

side effects

Isiphi isinyathelo negative ingumuthi "Metadoksil"? Izibuyekezo yotshwala libike ukuthi umongo yokusebenzisa lokhu kusho bavame ukuqala komzimba.

Kufanele kuphawulwe ukuthi abantu bronchospasm kungenzeka somoya bronchial (kaningi uma usebenzisa ikhambi).

ulwazi oluthile

Ikhambi for "Metadoksil" umjovo iqukethe ingxenye ezifana sodium metabisulfite. Lokhu kwaziswa kungabangela ukuhlaselwa kwakhe isifuba somoya e ngabanye singangena komzimba, kanye okhulisa yabo.

Izidakamizwa "Metadoksil": Izibuyekezo yotshwala

Ngeshwa, izibuyekezo "Metadoksil" ukulungiselela, akukho kakhulu. Nokho, lezo ezishiye abantu othambekele ukuba umlutha wotshwala, singaphetha kahle ukuthi izidakamizwa inomphumela omuhle ekwelapheni utshwala.

Kepha ukuphumelela ukwelashwa kwezimpawu zokuqaleka, ngempendulo isiguli ngokuphawulekayo etshiyeneyo. Abanye baphikisa ngokuthi uma umuthi isimo esinjalo kusisiza kahle, kanti abanye - hhayi baye baqaphela yimuphi umphumela.

Futhi wathola eziningi nemibiko engemihle mayelana intengo leli thuluzi. Njengomthetho, kuba ruble 1250-1450.