"Meloksikam-Prana": imiyalelo yokusetshenziswa, impendulo

Kulesi sihloko sizokhuluma ngomuthi "Meloksikam-Prana". Imiyalo yokusetshenziswa, ukubuyekezwa nezincomo zabasebenzi bezokwelapha - into ezosithakazelisa kuqala. Ngaphezu kwalokho, sizobe sichaze imininingwane, izinkomba, nemiphumela emibi yomuthi. Futhi cabanga ngokubunjwa kanye nezakhiwo zemithi.

Ulwazi jikelele

Ukubhekisela eqenjini elikhulu lokulungiswa kwemithi engeyona-steroidal yokulwa "Meloksikam-Prana". Imiyalo yokusetshenziswa (amaphilisi) aqukethe izincomo zokugcina kahle komkhiqizo. Ngakho-ke, lesi sidakamizwa kufanele sigcinwe endaweni eyomile, emnyama, imingcele yokushisa ephakathi kuka-0 kuya ku-25 ° C. Ngaphansi kwezimo ezinjalo, izidakamizwa zizofaneleka ukusetshenziswa iminyaka emithathu.

Amathebulethi womuthi ayatholakala ku-7.5 noma ku-15 mg. Zingafakwa emaphaketheni amathebulethi angu-10 noma embizeni ye-polymer (kusuka ezingxenyeni ezingu-50 kuya ku-100). Ama-blisters noma izimbiza zigcwele emabhokisini amakhadibhodi kanye nemiyalelo.

"I-Meloksikam-Prana" ikhishwa kuma-pharmacy ngaphandle kwemithi.

Ukwakhiwa

"I-Meloksikam-Prana" (imfundo yokusetshenziswa iqinisekisa lokhu) inomsebenzi wayo osebenzayo obizwa ngokuthi i-meloxicam. Kuye ngendlela yokukhululwa, inani laso kuthebhulethi lingaba ngu-15 mg no-7.5 mg.

Ngaphezu kwalokho, ukulungiselela kuqukethe izithako ezisizayo ezilandelayo:

• I-Microcrystalline cellulose;
• I-colloidal silicon dioxide ;
• I-magnesium stearate;
• Isitashi sommbila;
• I-Lactose monohydrate;
• I-croscarmellose ye-sodium.

I-Pharmacology

"I-Meloksikam-Prana (lo myalelo uqukethe lolu lwazi) unemiphumela efana ne-analgesic, antipyretic kanye ne-anti-inflammatory. Ukusebenza kwalesi sidakamizwa kunikezwa ngokuvimbela umsebenzi we-COX-2 (i-cyclooxygenase), ehilelekile ku-biosynthesis ye-prostaglandins endaweni lapho ukuvuvukala kwaqala khona. Isidakamizwa esincane kakhulu sithinta i-COX-1, ehilelekile ekuqaliseni i-prostaglandins, evikela i-mucosa yegciwane lesisu futhi ehileleke ekulawuleni ukunikezwa kwegazi ezinso.

"I-Meloksikam-Prana" ixhunywe ngokuphelele yi-tract digestive. Ngaphezu kwalokho, ukudla akungathinti le nqubo okungenani.

Isidakamizwa sinqwabelene ngokwanele emzimbeni futhi siqala ukusebenza ngenkuthalo phakathi nezinsuku ezingu-3-5. Izinga le-meloxicam e-plasma alishintshi ngisho nangemva kokuthatha lesi sidakamizwa iminyaka engaphezu kwengu-1.

Isidakamizwa sisungulwe ngokuphelele ngesibindi, okuholela ekubunjweni kwe-metabolites engasebenzi. Okuyinhloko yi-carboxymelloxicam (60%). "I-Meloksikam-Prana" idutshulwe emzimbeni nge-urine nemifino. Eziguli ezikhulile, isikhathi esithathwe ukuhoxisa lesi sidakamizwa senyukile.

Izinkomba

Ngabe iziphi izimo odokotela abangakhetha ngayo uMeloksikam-Prana? Izimpawu zokusetshenziswa, ezihlanganiswe umenzi, ziyizifo ezilandelayo:

• I-arthritis rheumatoid;
• Isifo sikaBechterew (i-ankylosing spondylitis);
• I-osteoarthritis.

Kodwa-ke, lesi sidakamizwa sinqunywe kuphela ngenxa yokwelashwa kwesifo, njengoba kunciphisa ubuhlungu nokuvuvukala, kodwa akuqedi izimbangela zesifo futhi akuvimbeli ukuqhubeka kwazo.

"Meloksikam-Prana": imiyalelo yokusetshenziswa

Amathebulethi omuthi atholakalayo emithini emibili - 15 mg wezinto ezisebenzayo kanye no-7.5 mg, ngakho udokotela, onquma imithi, uzoqondiswa uhlobo lokukhululwa.

Iziguli eziphethwe isifo samathambo e-rheumatoid ziyanconywa ukuthatha amaphilisi angu-15 mg. Uma lesi sidakamizwa sinomthelela omkhulu wokwelashwa, isilinganiso ngokuvamile sinconywa ukuba sinciphise sibe ngu-7.5 mg.

Abantu abane-osteoarthritis banikwa ithebhulethi ene-7.5 mg yezinto ezisebenzayo. Futhi uma kungabikho umphumela odingekayo, umthamo ukwandiswa ube ngu-15 mg.

Labo abagulayo nge-anondlosing spondylitis, enqunywe ama-15 mg ngosuku.

Kuzo zonke izimo ezingenhla, "Meloksikam-Prana" kuthathwa i-tablet eyodwa ngosuku ngokudla. Ukwandisa umthamo ngaphandle kokubonisana akuvunyelwe ngokuphelele.

Kulezi ziguli ezitholakala ukuthi zinezinkinga zokuhlukumezeka komzimba kanye nemiphumela emibi kungenzeka, umthamo wansuku zonke wesidakamizwa awufanele udlule i-7.5 mg.

Izici zohlelo lokusebenza

Kubalulekile ukugcina izinyathelo lapho kunqunywe nokusebenzisa lesi sidakamizwa "Meloksikam-Prana". Imiyalelo yokusetshenziswa okugqamile iziguli ezitholakale zinezilonda ze-duodenal noma izilonda zesisu futhi ezathola ukwelashwa kwe-anticoagulant. Lokhu kungenxa yokuthi ezigulini ezinjalo ingozi yokuthuthukisa izilonda ezilonda izilonda zamathambo ezinyuka, ngakho-ke, uMeloksikam-Prana kufanele uthathwe ngokucophelela.

Futhi, lesi sidakamizwa sinqunywe ngokucophelela ngeziguli ezigugile, iziguli ezinesifo esingenasifo senhliziyo, isibindi se-forhosis, i-hypovolemia.

Akunconywa ukuthi abantu bathathe imithi ukuthi bahlanganyele emsebenzini ohlobene nezingozi ezihlukahlukene futhi kudinga ukunakwa okukhudlwana, njengoba izidakamizwa zingabangela ukuzondeka, ikhanda nokulala.

Imiphumela emibi

Unemiphumela emibi ye "Meloksikam-Prana".

Ngokuphathelene nepheshana lomzimba, ngokuvamile (amacala angu-1%) kukhona:

• I-Dyspepsia;
• Ukuvota;
• I-nausea;
• Ukuqokwa;
• Ubuhlungu besisu ;
• Isifo sohudo;
• Flatulence.

Ngokuvamile (kusuka ku-0.01 kuya ku-0.1% wamacala):

• Ukuhlushwa;
• Hyperbilirubinemia;
• I-Esophagitis;
• I-GIT yokuphuza;
• Isilonda se-Gastroduodenal;
• Stomatitis.

Ngokuvamile kakhulu (ku-0.01% wamacala):

• I-colitis;
• I-Gastritis;
• Ukuguqulwa komkhondo wamathumbu;
• I-hepatitis.

Emsebenzini we-cardiovascular system, lezi zinguquko ezilandelayo zingenzeka:

• I-edema ye-Peripheral (ngokuvamile);
• I-Tachycardia (engavamile);
• Isimo samathambo "(okungajwayelekile);
• Umfutho wegazi ophezulu.

Engxenyeni yokuphefumula ezimweni ezingavamile, ukuphefumula kwesifo sofuba kungabonwa.

Imiphumela emibi ehlotshaniswa nesistimu yenzwa yomphakathi:

• Usizi (ngokuvamile);
• Izikhwama (ngokuvamile);
• I-Tinnitus (engavamile);
• Ukulala (okungavamile);
• I-Vertego (engavamile);
• Ukudideka (okungavamile kakhulu);
• Ukudideka (okungavamile kakhulu);
• Ukufaneleka komzwelo (kakhulu okungajwayelekile).

Izinguquko ezilandelayo zingase zenzeke ohlelweni lwe-urinary:

• Ukuhlushwa okuphezulu kwe-serum urea kanye ne-hypercreatininaemia (okungavamile);
• Ukuhluleka kwezinso (okungajwayelekile);

Imiphumela emibi ye-Dermatological:

• Ukukhwabanisa isikhumba;
• Ukubamba;
• I-Urticaria (engavamile);
• Izimpondo ezinzima (kakhulu kakhulu);
• Ukwanda kwe-photosensitivity (kakhulu okungavamile);
• I-necrolysis ye-Epidermal (kakhulu engavamile).

Ukusabela okuvela ohlelweni lwe-hematopoietic kungaba kanje:

• I-anemia (kaningi);
• I-Thrombocytopenia (engavamile);
• I-Leukopenia (engavamile).

Isidakamizwa singabangela ukusabela kokugula. Uma izibonakaliso zokuqala zenzeka, kubalulekile ukuthatha izidakamizwa ze-antihistamine, uyeke ukuthatha imithi bese uthintana nodokotela.

Ukungafani

Ukulungiselela "Meloksikam-Prana" (imiyalelo yokusetshenziswa iqukethe imiyalelo ecacile kule ndaba) ayinikezwa kumacala alandelayo:

• Hypersensitivity;
• Ukuhlanganisa okuphelele noma okuyingxenye ye- polyposis yama-nasal ephindaphindiwe , i- asthma ye-bronchial, ukungabekezelelani ku-acetylsalicylic acid;
• Isifo sesilonda se-Peptic se-duodenum nesisu (isigaba sokukhuphula);
• Ukwehluleka okukhulu kwesinselo;
• Ukusuka okuhlukahlukene;
• Isifo sesifo sofuba;
• Izifo ezihlukahlukene zesifo nesibindi (ukuqhubeka);
• Ukwehluleka kwenhliziyo okukhulu;
• Ukwehlukana kwe-Lactose noma ukuntuleka;
• I-asthma ye-Bronchial.

Futhi, le mithi ayinqatshelwe ukubeka izingane ezinganeni ezingu-12, abesifazane abakhulelwe nabalahlayo.

Ukusebenzisana nezinye izidakamizwa

Kungenzeka ukuthi uqaphele lezi zici ezilandelayo uma uxhumana neminye imithi yomuthi "i-Meloxicam-Prana" (imfundo yokusetshenziswa ithatha ukunakwa okukhethekile kulokhu):

• Isicelo kanye namanye ama-NSAID angandisa ingozi yokuvula ukuphuma kwamathumbu kanye nokubonakala okungavamile kwezilonda zesilonda;
• Ukusetshenziswa kwesidakamizwa esinama-antihypertensive kungaholela ekunciphiseni ukuphumelela kwalokhu okulandelayo;
• Ngenkathi ukuphathwa okuhambisanayo nezidakamizwa ezine-lithium kungandisa uketshezi oluyingozi lensimbi nokuthuthukiswa kwe-lithium cumulation (ngokuvamile kuvunyelwe ukuba kuqaphe ukuxilongwa kwe-lithium egazini kulo lonke ukwelashwa);
• Ukuchaza ngesikhathi esifanayo ne-methotrexate kungaholela engozini yokwanda kwe-leukopenia ne-anemia, ngakho-ke kunconywa ukuthi ukuhlolwa kwegazi jikelele kwenziwe njalo;
• Ukusebenza ngesikhathi esisodwa nge-cyclosporine kanye ne-diuretics kuholela ekutheni kwenzeke ukwehluleka kwenqunu;
• Ngenkathi yokwamukela ngesikhathi esisodwa "i-Meloxicam-Prana" enezidakamizwa zokubeletha ngaphakathi kwe-intrauterine, ukuphumelela kwalezi zinsuku kunciphisa;
• Ukusetshenziswa ngesikhathi esisodwa ngezidakamizwa ze-thrombolytic kanye nama-anticoagulants (i-warfarin, i-heparin) yandisa kakhulu ingozi yegazi elihlukile, ngakho-ke kuyadingeka ngenkathi yokwelapha ukuqapha izinga lokugaya igazi esigulini;
• Uma isetshenziswe ngesikhathi esifanayo ne-colestyramine, inani le-meloxicam elikhiqizwa ngokusebenzisa i-tract emathunjini.

Overdose

Sihlolisise imiyalelo yokusetshenziswa kwesidakamizwa esithi "Meloksikam-Prana", okusiza kuyo, sathola ukuthi akufanele kuthathwe yini-nayo yaboniswa. Manje ake sibhale izibonakaliso zokudlula ngokweqile:

• I-nausea;
• Ukungazi kahle;
• I-GIT yokuphuza;
• Ubuhlungu ku-epigastrium;
• Ukwehla okunamandla noma ukungakwazi kahle kwe-hepatic;
• I-Asystole;
• Ukuboshwa ngokuphefumula.

Uma noma yikuphi kwezimpawu ezingenhla kwenzeka, kuyadingeka ukuba uhlanza ngokushesha isisu bese uthatha amalahle acushiwe. Uma kunesidingo, ukwelashwa kwesifo kwenziwa. Ayikho i-antidote ekhethiwe ngokukhethekile.

«Meloksikam-Prana: Ukuphazamiseka

Amathebulethi anemibiko eminingi enhle evela kuziguli. Ngakho-ke, ukusebenza kahle kwezidakamizwa kuphawulwe futhi kujabulise ngokujabulisayo ijubane lesenzo. Okubalulekile ukutholakala kwezidakamizwa kumaketanga ekhemisi. Naphezu kokuchichima nokuhluka kwemiphumela emibi, akuvamile.

Noma kunjalo, kunezibuyekezo eziningi ezingalungile mayelana nomuthi. Ngokuyinhloko, zihlobene nokuphazanyiswa komsebenzi nokukhushulwa kwezifo ezihlukahlukene zesigcawu somzimba. Kodwa kunezinkinga ezifanayo ikakhulukazi ezigulini ngisho nangaphambi kokuthatha ikhambi.

Ngakho-ke, "iMeloksikam-Prana", ukubuyekezwa okuyiwona kuphela okubaluleke kakhulu, kubonakala sengathi kuyisidakamizwa esithembekile futhi esisebenzayo, okwamanje, engavunyelwe abantu abanezifo ezihlukahlukene zamathumbu, ikakhulukazi eziyingozi.

Kubalulekile ukunaka iqiniso lokuthi umuthi uhanjiswa ngaphandle kwemithi, kodwa lokhu akusho ukuthi awudingi ukufuna iseluleko sezokwelapha ngaphambi kokuyisebenzisa. Futhi, akufanelekile ukufaka esikhundleni sesidakamizwa esinqunyiwe nge-Meloxicam, okungaba isifaniselo sayo eshibhile. Yiba nempilo!