Kuyini isifo Addison sika?

isifo Addison kwenzeka lapho ukungasebenzi cortex adrenal. Lesi sifo sitholakale umuntu kokubili amadoda nabesifazane, ikakhulukazi maphakathi (ezineminyaka engu-30 kuya ku-40). Lesi isifo ezingavamile, ebhaliswe eyodwa umuntu ngamunye 100 ayizinkulungwane. Population. Addison Biermer isifo angagcina ngenxa izinqubo sokuhlasela kwamasosha omzimba, izifo ezithathelwanayo (ugcunsula, isifo sofuba kanye adrenals typhoid), futhi amyloidosis kanye izimila ebulalayo. Ngo-70% eziguli, lesi sifo kwenzeka ngenxa ukwehluleka kwesimiso somzimba sokuzivikela (amasosha omzimba sebeqala ukuthatha omzimba imizimba angaphandle, ehlasela futhi ekubhubhiseni). Nge lapho kubhujiswa lesi adrenal cortex amaseli incipha zamagama gluco futhi mineralocorticoids (cortisol, 11-deoxycorticosterone, aldosterone). Ososayensi baye babonisa ukuthi glucocorticoids alawule izinqubo ezihlukahlukene kwamakhemikhali emzimbeni (ulawula umfutho wegazi, insulini lokuhlushwa ehilelekile ukulawulwa amaprotheni zamagama, lipids kanye carbohydrate).

Gipokortitsizm sivame ukuba khona iziguli ziphathwe amahomoni we- cortex adrenal. Ezimweni eziningi, etiology lesi sifo namanje ayikaziwa. esingamahlalakhona adrenal oluthathwa zibe zamabanga aphansi naphezulu. ukuhluleka Primary eba kokunqotshwa izicubu adrenal, kanye yesibili - ngenxa ukushukuma enganele hormone adrenocorticotropic.

Addison sika Isifo

izimpawu zokwelashwa Isifo esibangelwa ukuntula in an amaminerali umzimba glucocorticoids. Izici sici kakhulu kukhona ubuthakathaka, hypotension, emathunjini enezinkinga (nesicanucanu, ukungakuthandi ukudla, ukuhlanza, ukuqunjelwa, uhudo okuvame indawo). Ezinye iziguli hypochlorhydria.

isifo Addison sika kuhambisana ukucasuka anda noma isimo sokucindezeleka, ngiphathwa ikhanda njalo nokuqwasha. -X-ray yesifuba sikhombisa ukwehla ngobukhulu inhliziyo. I electrocardiogram ilandisa izimpawu hyperkalemia (okusezingeni eliphezulu potassium lokuhlushwa egazini). Ibala lesikhumba akubonisi ngobucayi isifo Nokho, ukwanda noma kwehla ke ekwelapheni ubufakazi mayelana nokusebenza kahle isenzo zokwelapha.

isifo Addison sika libhekene umsuka izimpawu yesibili kancane ezinzima. Kakhulu akuvamile sifo kubonakala ngaphandle lesikhumba (ngakho isihloko "Addison elimhlophe"). Imbangela enkulu yalesi sifo sofuba adrenals. In the ukungabikho ukwelashwa okufanele isifo Addison sika inkimbinkimbi. izimpawu Clinical kuthiwa ngamawalaYize isicanucanu, ukuhlanza, uhudo, umfutho wegazi lehla kakhulu, okwandisa lokuhlushwa potassium igazi. Esikhathini igazi neuropathy of nitrogen asalile kwandisa amaseli abomvu egazi, i-hemoglobin. Ngakho-ke, uma ngesikhathi esibucayi addisonicheskogo nesineke alinikezi usizo ngesikhathi esifanele, uyafa nge izimpawu kwezinso kanye nezifo zenhliziyo.

Into ebaluleke kakhulu imingcele laboratory uphethwe okuqukethwe 17-OCS e-plasma-17 KS emchamweni, kanye ukwehla kwamazinga igazi glucose. luhlolo morphological igazi kubonisa lymphocytosis, eosinophilia futhi ESR imisiwe.

isifo Addison sika umahluko kusuka lezi zifo ezilandelayo: zethusi sikashukela, pellagra, ubuthi arsenite futhi Bismut Argentum. Lesi sifo ngokuvamile has a Yiqiniso ezingamahlalakhona NEKUKHULUMA gqwa. Addison Biermer isifo ngobucayi kunqunywa ngobucayi izimpawu ezinkulu zesifo, kanye ngenani izidakamizwa edingekayo ukuze sivale lapho sisilela esingamahlalakhona adrenal.