Izilonda "Cefotaxime": imiyalo yokusetshenziswa, izinkomba, intengo. Ukubuyekeza mayelana nomuthi

Akuyona imfihlo kunoma ubani ukuthi ama-antibiotic we-semisynthetic anemisebenzi eminingi. Imithi enjalo isetshenziselwa ukuphatha izifo ezihlukahlukene zokuvuvukala nezifo ezithathelwanayo. Kodwa ngaphambi kokuqoka leyo mithi, udokotela kufanele ancoma isiguli ukuba ahlolwe ngokwezokwelapha. Lena yindlela ewukuphela yokuqonda ukuthi imiphi imithi elwa namagciwane ezozibonakalise ngokuphumelelayo ekwelapheni kwesifo esithile.

Ukwelapha uhlelo lwe-genitourinary, kanye nomzila wokuphefumula, izijovo ze- "Cefotaxime" zisetshenziselwa ukusebenza. Izici zalesi sidakamizwa, ukuphikisana kwawo, isilinganiso kanye nendlela yokuphatha, sizocabangela ngezansi.

Ukwakhiwa, incazelo, ifomu kanye nokupakishwa kwemithi

Iziphi izithako eziqukethe umuthi we "Cefotaxime"? Izilonda (izingane umthamo walesi sidakamizwa isethwe ngabanye) zifaka izinto ezisebenzayo, njenge-cefotaxime (usawoti sodium).

Ukuzilungiselela ngokwawo kungumquba omhlophe noma ophuzi, osetshenziselwa ukulungisa isisombululo somjovo we-intravenous or intramuscular.

Imithi ingathengwa ngezikhumba zeglasi, ihlanganiswe ngamaphakheji ekhadibhodi.

Izakhiwo zomzimba

Uyazi ukuthi umuthi "Cefotaxime" uwuphi? Imiyalo yokusetshenziswa (imijovo yezingane - ukuhlolwa akuyona into elula, kodwa kuthiwani uma kudingekile?) Kuthiwa imithi encane inqunywe ngokuqapha okukhethekile, ngoba i-antibiotiki engezansi. Imithi yayo esebenzayo ihlukaniswa njenge-cephalosporins yesizukulwane sesithathu.

Isetshenziswe ngezikhathi zomzimba. Isebenza ngokumelene ne-flam-positive, kanye nama-microorganisms agugu-negative, abonisa ukumelana okukhulu nesenzo se-aminoglycosides, i-sulfonamides ne-penicillin.

Isimiso senqubo yokulwa namagciwane yalesi sidakamizwa sisekelwe emandleni ayo okuvimbela umsebenzi we-transpeptidase. Lokhu kungenxa yokuvimba kwe-peptidoglycan.

Izici zengqondo zesidakamizwa

I-Cefotaxime ixube kanjani? I-abstract (imijovo - lena yindlela kuphela yomuthi) ikhombisa ukuthi emva kokujova kwe-intramuscular ukuhlushwa okuphakeme kakhulu kwezidakamizwa egazini kubonakala emva kwemizuzu engama-35. Cishe 27-40% yezinto ezisebenzayo zibopha amaprotheni e-plasma.

Umphumela we-bactericidal wesidakamizwa uhlala amahora angu-12. Isidakamizwa sitholakala e-gallbladder, i-myocardium, amathambo nama-soft tissues.

Umuntu akanakusiza ukusho ukuthi isakhi esisebenzayo salesi sidakamizwa sikwazi ukungena ngaphakathi kwe-placenta futhi sitholakale emzimbeni we-pleural, peritoneal, synovial, cerebrospinal kanye ne-pericardial fluids.

Cishe amaphesenti angama-90 omuthi adutshiwe emcinini.

Ngomjovo we-intramuscular, i-half-life yomuthi ingama-60-90 amaminithi, futhi ngenxa yokujova okufakwe ngaphakathi, ihora elilodwa. Isithako esisebenzayo senziwa nge-bile. Ukwenyuka kwezidakamizwa akugcini.

Izinkomba zokusetshenziswa

Ngisiphi izifo okufanele ngisebenzise i-antibiotic "Cefotaxime"? Imiyalo yokusetshenziswa (imijovo, intengo echazwe ngezansi, kufanele inqunywe udokotela kuphela) ithi le mithi iboniswa phambi kwezifo ezithathelwanayo.

Ngokuvamile kuvame ukusetshenziswa kulezi zifo ezilandelayo zesistimu yokuphefumula:

• I-pneumonia;
• I-Pleurisy;
• Ama-abscesses;
• I-brronchitis.

Futhi, ithuluzi liyasebenza uma:

• I-meningitis yebhaktheriya;
• Endocarditis;
• Izinkinga zokuthutha;
• I-Septicemia;
• Izifo zamathambo namathambo athambile;
• Isifo samaLyme;
• Izifo ze-urinary tract, umphimbo, indlebe, impumulo, izinso;
• Izifo zamalungu namathambo;
• Izifo zesisu;
• Izifo ezenzeke ngokumelene nesizinda se-immunodeficiency.

Kumele futhi kuqaphele ukuthi izijovo ze-Cefotaxime zivame ukushiwo ngenhloso yokuvimbela izifo ezenzeke ngemuva kokungenelela kokuhlinzwa (kufaka phakathi ukuhlukumezeka, izithandani-gynecological, ematheni emathunjini, njll).

Ukungafani nokusetshenziswa kwesidakamizwa

Mayelana nendlela yokuhlunga umjovo we "Cefotaxime", sizokutshela kancane kancane. Kumele kuqashelwe ukuthi le remedy ayinaso uhlu olude kakhulu lwezingqinamba. Ngokweziqondiso, le mithi ayinqunyiwe uma:

• Ukuphuza;
• Ukukhulelwa;
• I-hypersensitivity ngayinye kumuntu osebenzayo;
• I-enterocolitis (kufaka phakathi emlandweni).

Ngingafaka yini isisombululo se-Cefotaxime? Ukushaya izingane (impendulo ngokusebenza komuthi kuzokwethula ekugcineni kwalesi sihloko) kuvunyelwe ukuba kwenziwe kuphela emva kokuba isiguli sifinyelele eminyakeni yobudala engama-2.5 (ngomsakazo / / m).

Ngokunakekelwa okukhethekile, imithi inqunyelwe izinsana ezisanda kuzalwa ngesikhathi sokuncelisa (njengoba lo muthi udonswa ngemali encane nobisi lomama), kanye nokuhluleka kwezinso ezingapheli kanye neNNC (kufaka phakathi emlandweni).

Ku-pathology yezinhlelo ze-renal ne-hepatic, isiguli siyadingeka ukuba sithole ukuhlolwa okwengeziwe kwezokwelapha ukuze sithole isiphetho ngokungabikho kokuphikisana nokwelashwa kwama-antibiotic.

Isidakamizwa "Cefotaxime": imiyalelo yokusetshenziswa (imijovo)

Indlela yokuhlunga kahle i-powder? Ukuze uphendule lo mbuzo, ake sibuyele emfundisweni enamathiselwe. Ichaza izindlela eziningiliziwe zokulungisa izixazululo zomjovo.

Ngakho-ke, ukwenzela umjovo (injection) we- injection (i-injection) yesidakamizwa u-1 g we-powder uhlanza u-4 ml wamanzi ngomjovo (oyinyumba). Imithi ekulungele isetshenziswa kancane kancane imizuzu engu-4-7.

Ukuze ukumnika okungenayo, 1-2 g we-powder ihlanjululwe 50 noma 100 ml we-solvent. Njengoba isetshenziswa isisombululo se-0.9% se-sodium chloride noma isisombululo se-glucose esingu-5% (dextrose). Ubude bomjovo onjalo ngumaminithi angu-55-65.

Ukuphathwa kwezidakamizwa zesidakamizwa, i-1 g ye-powder ichitheka 4 ml we-solvent. Njengoba isetshenziselwa amanzi okujola noma isisombululo se-1% se-lidocaine.

Ngakho-ke, izidakamizwa ezibuzwayo zingasetshenziswa ngendlela efanelekile noma i-jet, futhi iphinde ibe ne-intramuscularly.

Imithi ivame ukuqondiswa iziguli ezikhulile, kanye nezintsha ezingaphezu kweminyaka engu-12 ubudala nesisindo somzimba esingaphezu kuka-50 kg. Lapho kudingeka ngokuphuthumayo, isetshenziselwa ukuphatha izingane ezincane.

Isilinganiso somkhiqizo wokwelapha

Manje uyazi ukuthi ungenzenjani ngamagciwane e-Cefotaxime. Kodwa yimuphi umthamo wabo? Kuxhomeke ekubonisweni nasebunzima besifo.

Ukutheleleka kwegciwane le-urogenital, kanye nokutheleleka okungahambi kahle, isidakamizwa senziwa nge-intravenously noma nge-intramuscularly 1 g njalo ngamahora angu-9-12.

Ukutheleleka kokucindezela okulinganisela - 1-2 g njalo amahora angu-12.

Njengoba i-gonorrhea enzima engaqondakali, imithi inqunywe nge-intramuscularly kumthamo we-1 g (kanye).

Ngezifo ezinzima (isibonelo, nge-meningitis), lesi sidakamizwa sisetshenziswa ngaphakathi, 2 g njalo ngamahora angu-6-9. I-dose esiphezulu ngosuku liyi-12 g. Isikhathi sokwelapha sisethwe ngabanye.

Ukuvimbela ukuthuthukiswa kwezifo ezithathelwanayo ngaphambi kokuhlinzwa, isiguli ngesikhathi se-anesthesia sokuqala isilawulwe "i-Cefotaxime" kumthamo we-1 g. Uma kudingeka, umjovo uphindwa emva kwamahora angu-6-12.

Esigabeni sokudla ngesikhathi sokudla lapho kusetshenzwa izigqoko ezitholakala emgqeni wesidakamizwa, umuthi ulawulwa nge-intravenously nge-1 g. Ngaphezu kwalokho emahoreni angu-6-12, umjovo owengeziwe ngesilinganiso esifanayo.

Ukufundiswa kwezingane

Uma kunesidingo, ama-"Cefotaxime" ezinsana ezisanda kuzalwa, kanye nezinsana ezingakapheli iviki elilodwa ubudala, zinikezwa nge-intravenously ngesamba sama-50 mg ngegesi lesisindo somzimba njalo emahoreni angu-12. Uma uneminyaka engama-1-4 amaviki, umuthi unikezwa ngesilinganiso esifanayo, kodwa njalo ngamahora angu-9.

Izingane ezineminyaka engaphezu kuka-2.5 enesisindo somzimba wemithi engaphansi kuka-50 kg inqunywe nge-intramuscularly noma nge-intravenously ngesamba esingu-50-180 mg ngesisindo somzimba ngamunye (ku-4 noma 6 injection).

Ezifo ezithathelwanayo ezikhulayo, kuhlanganise ne-meningitis, ukulinganisa kwansuku zonke kwezidakamizwa kwanda ku- 100-200 mg ngekg. Kulesi simo, amajojo alawulwa nge-intramuscularly noma nge-intravenously ngesamba izikhathi ezingu-4-6 ngosuku. Isilinganiso esiphezulu semithi ngosuku nguku-12 g.

Izenzakalo ezimbi

Ngokuphathelene nesimo sokusetshenziswa kwezidakamizwa "i-Cefotaxime" ezigulini zingathuthukisa ukusabela okunjalo kwendawo njenge:

• Ukukhathazeka ngejozi lomjovo;
• I-Phlebitis, ithuthuka nge-infusion emangalisa.

Imiphumela elandelayo engathandeki nayo ingabonakala:

• I-jaundice yama-cholestatic, i-colitis engama-pseudomembranous;
• I-hepatitis, i-nausea, i-hypoprothrombinemia;
• Ukwandisa i-ALT, i-AST, i-anemia ye-hemolytic;
• I-diarrhea syndrome, ukwehla kwenani lamaplatelet;
• Ukuvota, i-neutropenia.

Ezimweni ezingavamile, izimpendulo ze-allergenic zingenzeka (inani elandayo lama-eosinophil, i-edema ka-Quincke nokukhwabanisa isikhumba), kanye nephritis yangaphakathi ne-candidiasis.

Lapho ubona ezinye imiphumela emibi, usizo lodokotela nokuhoxiswa okuzimele komuthi kuyadingeka.

Inani namanye ama-antibiotic

Izindleko zezidakamizwa ezibuzwayo zixhomeke emkhawulweni wenethiwekhi nesifunda sokuthengisa. Ngokwesilinganiso, ama-ampoule-vials (izingcezu ezingu-5 nge-1 g) angathengwa ama-ruble angu-160-170.

Uma kunesidingo, le mithi ingashintshwa ngezindlela ezifanayo ezifana noClaforan, uCefabol noCefosin.

Kodwa-ke, kufanele kuqashelwe ngokushesha ukuthi le mithi ingasetshenziswa kuphela emva kokubonisana nodokotela.

Ukubuyekeza mayelana ne-agent ye-antibiotic

Ekusebenzeni kwezingane, le mithi ivame ukushiwo njenge-agent ye-antimicrobial. Njengomthetho, kwenziwa kulezo zimo lapho amanye ama-antibiotic engaboni umphumela omuhle wezokwelapha.

Ukuphawula komthengi mayelana nokufakwa kwe "Cefotaxime" kunomqondo omuhle kakhulu. Imibiko yeziguli iqinisekisa ukusebenza kwayo okuphezulu kwe-antimicrobial. Kodwa-ke, umuntu angathola futhi izimpendulo ezinjalo, ezikhuluma ngokuqondile kwenani elikhulu lokuphendula okungalungile okwenziwe ngemuva kokwelashwa (ukubhubhisa, i-dysbiosis, i-colic nabanye).