Isizukulwane yakamuva ama-NSAID: ukubuyekezwa, uhlu amanani

Kuningi izinguquko sokugembula ezenzeka emzimbeni, ephelezelwa ubuhlungu. Ukuze ulwe izimpawu ezinjalo athuthukile ama-NSAID noma non-steroidal anti-inflammatory ejenti. Basuke anesthetized kahle, ukunciphisa ukuvuvukala, ukunciphisa ukuvuvukala. Nokho, imithi eminingi neminye imiphumela emibi. Lokhu kukhawulela kungenzeka ngokusebenzisa kwawo kahle kwezinye iziguli. kwemithi Modern isungule isizukulwane yakamuva ama-NSAID. izidakamizwa ezinjalo kakhulu mancane amathuba okuthi baxabane ezingemnandi, kodwa ahlale imithi eminye esebenza ngempumelelo ngokumelene ubuhlungu.

umthelela isimiso

Lokho kungenxa umphumela ama-NSAID emzimbeni? Ngokuthatha isinyathelo kuqala kwi cyclooxygenase. Cox has isoforms ezimbili. Ngamunye wabo lucwaningo imisebenzi yayo. enzyme okunjalo (Cox) ebangela ukusabela chemical okuphumela arachidonic acid ludlulele prostaglandins, thromboxanes futhi leukotrienes.

Cox-1 obangela ukukhiqizwa prostaglandins. Zivikela esiswini kusukela imiphumela engasi mihle sinomthelela ukusebenza zegazi, futhi umthelela ushintsho kwezinso ukugeleza kwegazi.

Cox-2 ngokuvamile engekho futhi kuyinto ethize enzyme ukuvuvukala kwemiqondo ngokusebenzisa cytotoxins, kanye nezinye balamuli.

Lezo of ama-NSAID njengoba okusithiyayo of Cox-1, athwala sebuningini ohlangothini-nemiphumela.

ezintsha

Akusiyo imfihlo ukuthi amalungiselelo isizukulwane sokuqala ama-NSAID babe nomthelela omubi le mucosa esiswini. Ngakho-ke, ososayensi baye umgomo - ukunciphisa imiphumela engathandeki. ifomu elisha ukukhululwa yasungulwa. Ngo ukwakhiwa okunjalo isithako esebenzayo kuyinto emvilophini ekhethekile. I capsule senziwa zezinto zokusebenza ezinjalo ukuthi musa chaza imvelo azibukhali esiswini. Baqala igoqe kuphela uma hit esiswini. Kungenzeka ukunciphisa umphumela kuyacasula phezu mucosa esiswini. Nokho, indlela yokulimala ezingemnandi emathunjini ipheshana izindonga is namanje walondoloza.

Lokhu kwashukumisela bamakhemikhali kwemiqondo ekhuthaza entsha ngokuphelele. imithi Langaphambilini zingabantu indlela bahluke yesenzo. isizukulwane esisha ama-NSAID elinesimo umphumela abakhethayo ku Cox-2, kanye okusithiyayo zokukhiqiza prostaglandin. Lokhu kukuvumela ukuba ufinyelele yonke imiphumela kudingekile - analgesic, antipyretic, anti-inflammatory. Kulokhu, isizukulwane yakamuva ama-NSAID ukuze sinciphise umthelela ku igazi coagulation, umsebenzi platelet mucosa esiswini.

umphumela anti-inflammatory ngenxa permeability engezansi izindonga imithambo yegazi, kanye ukwehla odala ezihlukahlukene ukuba balamuli ukuvuvukala. Ngenxa yalesi ukuchayeka lincishisiwe ukucasuka Izinzwa zobuhlungu. Umthelela on izikhungo ezithile thermoregulatory ebuchosheni, ukuvumela isizukulwane yakamuva ama-NSAID muhle kakhulu ukwehlisa izinga lokushisa jikelele.

izinkomba

Njengoba baziwa imithelela ama-NSAID. Umthelela izidakamizwa ezinjalo ukuze kuvinjelwe noma ukunciphisa ukuvuvukala. Le mithi ukunikela umphumela omuhle antipyretic. Imiphumela yawo emzimbeni ingafaniswa umphumela analgesics kwezidakamizwa. Ngaphezu kwalokho, ukuhlinzeka isidambisa-zinhlungu, imiphumela ethile eqeda ukuvuvukala. Ama-NSAID ephumelelisa isikali ububanzi esimweni emitholampilo ekuphileni kwansuku zonke. Namuhla-ke ingenye izidakamizwa zemithi ethandwa kakhulu.

Umthelela omuhle Kuyaqapheleka ku lezi zinto ezilandelayo:

1. Izifo uhlelo zemisipha. Ngezinye Ukwenyela ahlukahlukene, nemivimbo, idatha imithi sokuqaqamba kwamalunga zimane Irreplaceable. Ama-NSAID elisetshenziswa osteochondrosis, arthropathy ukuvuvukala, Arthritis. Umuthi kunemiphumela eqeda ukuvuvukala e ukugobeka komhlandla, akwazi ukugcina herniated.
2. sebuhlungwini obunzima. Amalungiselelo esetshenziswa ngempela ngempumelelo colic biliary, ukusebenza kwayo nezifo zabesifazane izifo. Bona ukuqeda ubuhlungu bekhanda, ngisho migraines, izinso ukungakhululeki. Ama-NSAID asetshenziswa ngempumelelo iziguli esikhathini postoperative.
3. lokushisa okuphezulu. umphumela antipyretic evumela ukusetshenziswa kwezidakamizwa e izifo imvelo olungafani kokubili abadala kanye nezingane. Le mithi aphumelela ngisho imfiva.
4. Thrombus kumiswa. Ama-NSAID yizidakamizwa antiplatelet. Lokhu kubenza bakwazi zisebenza ischemia. Ziyakwazi isilinganiso zokuvimbela ekuhlaselweni senhliziyo kanye nesifo sohlangothi.

ngezigaba

Mayelana 25 edlule, wayeklanyelwe amaqembu 8 kuphela ama-NSAID. Namuhla lelo nani liye landa 15. Nokho, leli nani ngqo ngisho ngokuthi odokotela kungukuthi kuthathwe. Ukuvela emakethe, ngokushesha won bebaningi abantu ama-NSAID. Amalungiselelo owaketulwa analgesics opioid. Ngenxa yokuthi, ngokungafani esidlule, akazange avuse ukucindezeleka zokuphefumula.

Ukwahlukaniswa ama-NSAID kuhilela division ngamaqembu amabili:

1. izidakamizwa Okudala (isizukulwane sokuqala). Lesi sigaba sihlanganisa izidakamizwa, "Tsitramon", "ukuphuza ama-aspirin", "ibuprofen", "naproxen", "Nurofen", "Voltaren", "Diklak", "diclofenac", "indomethacin", "Movimed", "Phenylbutazone" .
2. Ama-NSAID okusha (isizukulwane sesibili). Kule minyaka 15-20 iminyaka, kwemithi isungule imikhiqizo emihle kakhulu, njengokuthi "Movalis", "Nimesil", "Nise", "Celebrex" "Arcoxia."

Nokho, lokhu akulona nje ngezigaba ama-NSAID. izidakamizwa isizukulwane esisha zihlukaniswe non-acid nemikhiqizo kanye acid. Ekuqaleni, cabanga isigaba yokugcina:

1. Salicylates. Leli qembu iqukethe imithi NSAID, "aspirin", "diflunisal," "Lizinmonoatsetilsalitsilat".
2. Pyrazolidine. Abamele kulesi sigaba sama-mithi "Phenylbutazone", "azapropazone", "oxyphenbutazone."
3. Oxicams. Lesi yisizukulwane esisha ezintsha iningi ama-NSAID. Uhlu izidakamizwa: "piroxicam" "Meloxicam", "Lornoxicam", "tenoxicam". Imithi akuzona ezishibhile, kodwa umphumela zabo emzimbeni ihlala isikhathi eside kakhulu kunezinye izinto ama-NSAID.
4. Phenylacetic acid nemikhiqizo. iqembu okunjalo ama-NSAID kuhlanganisa izindlela "diclofenac", "tolmetin," "Indomethacin", "Etodolac", "Sulindac," "Atseklofenak".
5. Ukwakhiwa anthranilic acid. Omele eyinhloko yomuthi "Mefenaminat".
6. Esebenzisa propionic acid. Lesi sigaba iqukethe ama-NSAID eziningi ezinhle. Uhlu izidakamizwa: "ibuprofen" "ketoprofen" "benoxaprofen", "fenbufen," "fenoprofen," "tiaprofenic acid", "naproxen", "Flurbiprofen", "pirprofen," "nabumetone".
7. Isonicotinic acid nemikhiqizo. imithi Main "Amizon".
8. pyrazolone izidakamizwa. Ukuze lesi sigaba kungokwalabo izindlela owaziwa, "Analgin".

Ngu-non-acid ahlobene zihlanganisa sulfonamides. Leli qembu kuhlanganisa izidakamizwa, "Rofecoxib" "Celecoxib", "Nimesulide".

side effects

isizukulwane esisha ama-NSAID engenhla, ezahlukene umthelela ngempumelelo emzimbeni. Noma kunjalo, musa kuthinte ukusebenza pheshana emathunjini. Uhlukanisa mithi elinye futhi iphuzu omuhle: isizukulwane esisha ama-NSAID akudingeki nethonya elilimaza kakhulu izicubu uqwanga.

Nokho, ngisho i zindlela ngempumelelo uyakwazi ingqondo eziningana imiphumela engathandeki. Kumele bazi, ikakhulukazi uma izidakamizwa isetshenziswa isikhathi eside.

The main side effects kungabandakanya:

• isiyezi;
• ukozela;
• ikhanda;
• ukukhathala;
• palpitations inhliziyo;
• okwandisa ingcindezi;
• a kufushane kancane umoya;
• isifuba esomile lapho;
• iziyaluyalu wokugaya ukudla;
• amaprotheni ku umchamo;
• enzyme isibindi ephakeme;
• ukuqubuka kwesikhumba (iphuzu);
• Ukugcinwa kwamanzi emigodini;
• yokungezwani komzimba.

Kulokhu, umonakalo mucosa esiswini ningagcini e ukwamukelwa ama-NSAID entsha. Izidakamizwa musa abangele exacerbation izilonda ukopha.

Izincomo zokusetshenziswa

The best izidakamizwa eqeda ukuvuvukala babe phenylacetic acid, salicylates, pirazolidony, oxicams, alkanones, izidakamizwa propionic acid sulfonamide.

Kusukela ubuhlungu bamalunga ukuqeda ngempumelelo izidakamizwa "Indomethacin", "diclofenac", "Ketoprofen", "Flurbiprofen". Lona NSAID best osteochondrosis. Imithi ngenhla ngaphandle "ketoprofen" ukulungiselela ifa liphinyiselwe umphumela anti-inflammatory. kusho "piroxicam" bawela kulesi sigaba.

analgesics abaphumelelayo "Ketorolac" izidakamizwa "Ketoprofen", "Indomethacin" "Diclofenac".

Umholi uphakathi kwesizukulwane yakamuva ama-NSAID kwaba lesi sidakamizwa "Movalis". Leli thuluzi kuvunyelwe ukusebenzisa isikhathi eside. izidakamizwa eqeda ukuvuvukala kukhona analogs ngempumelelo izidakamizwa "Movasin", "Mirloks", "Lem", "Artrozan", "Melox", "Melbek", "Mesipol" futhi "Amelotex".

Izidakamizwa "Movalis"

Lesi sidakamizwa iyatholakala njengoba amaphilisi, suppositories futhi isixazululo rectal kwezokuphatha esicutshini. Agent libhekisela nemikhiqizo enolovoy acid. Libhekene kakhulu izidakamizwa analgesic kanye izakhiwo antipyretic. Kwatholakala ukuthi izinqubo cishe zonke ukuvuvukala umuthi kuletha nomphumela ozuzisayo.

Izinkomba wokusetshenziswa kwezidakamizwa kukhona osteoarthritis, ankylosing spondylitis, i-rheumatoid arthritis.

Nokho, qaphela ukuthi kukhona contraindications amanxusa ukuthola:

• hypersensitivity kunoma ingxenye imithi;
• isifo ulcerous esigabeni acute;
• ukungakhuli ezinzima kwezinso;
• isilonda ukopha;
• ukuhluleka ezinzima hepatic;
• sokukhulelwa, ukuncelisa;
• isifo senhliziyo ezinzima.

Musa thatha izingane izidakamizwa iminyaka engu-12.

iziguli Adult ngubani uxilongwe osteoarthritis, Kunconywa nsuku zonke 7.5 mg. Uma kudingeka, lokhu umthamo kungase kukhule izikhathi 2.

Ngo-rheumatoid arthritis kanye ankylosing spondylitis kuyinsakavukela nsuku zonke 15 mg.

ukunakekelwa Extreme kufanele athathe izidakamizwa iziguli abanemizimba ukuvela amathuba okuba nemiphumela engemihle. Abantu abaye babonisa esingamahlalakhona kwezinso futhi abaku- hemodialysis, besamukela ezingaphezu kuka 7.5 mg emini.

Lokho okwakudingeka ukuze kukhokhwe izidakamizwa "Movalis" amaphilisi-7.5 mg, № 20 kuyinto ruble 502.

Umthengi umbono mayelana imithi

Izibuyekezo zabantu abaningi abaphinde babophezeleke ngaphansi sebuhlungwini obunzima, abonisa ukuthi lesi sidakamizwa "Movalis" - ithuluzi best for kwesikhathi eside. It is kahle ikubekezelele iziguli. Ngaphezu kwalokho, ukuba khona kwayo okwakuzothatha isikhathi eside emzimbeni kwenza kube nokwenzeka ukuba umthamo owodwa we-imithi. Isici esibaluleke kakhulu, ngokusho iningi abathengi, ukuvikela uqwanga, ngoba izidakamizwa ayinakho nomthelela omubi kubo. Kubalulekile kakhulu ezigulini eziye wasebenzisa izindlela e osteochondrosis, arthrosis.

Ngaphezu kwalokho, umuthi omuhle silondoloza kusukela izinhlungu ezihlukahlukene - amazinyo, ikhanda. Ukukhokhela ukunakekelwa okukhethekile ukuze iziguli i uhlu umxhwele okuba nemiphumela engemihle. Nakuba kokuthola ukwelashwa NSAID naphezu kwesixwayiso umkhiqizi, ayiyona inkimbinkimbi nemiphumela ebuhlungu.

Izidakamizwa "Celecoxib"

Isenzo kwaleli thuluzi is okuhloswe ngakho ukuqeda isimo nesineke osteochondrosis futhi arthrosis. Umuthi ngokuphelele aqede ubuhlungu, ngempumelelo aqede ukuvuvukala. nemiphumela emibi isimiso sokugaya ukudla bungene aye atholakala.

Izinkomba ukusetshenziswa ezinikezwe kumanuwali yilezi:

• arthritis psoriatic ;
• osteoarthritis;
• rheumatoid arthritis;
• ankylosing spondylitis.

Lokhu ekwakhiweni enezinto eziningi Izimo. Ngaphezu kwalokho, izidakamizwa akuhloselwe izingane ezingaphansi kweminyaka engu-18. ngokuqapha elithile kufanele libukwe abantu abanale senhliziyo okwatholakala indlela yokwandisa ezifweni ukuba nokugcinwa uketshezi.

Izindleko zomuthi iyahlukahluka kuye ngokuthi iphakethe, endaweni ruble 500-800.

umbono umthengi

Izibuyekezo Abaningana impela ephikisanayo mayelana lo muthi. Ezinye iziguli ngenxa lesi sakhiwo ebelizowina ubuhlungu bamalunga. Ezinye iziguli ukuthi isidakamizwa awazange asize. Ngakho, le ndlela akuyona ngempumelelo njalo.

Ngaphezu kwalokho, akufanele uthathe isidakamizwa ngokwabo. Kwamanye amazwe aseYurophu lo muthi akuvunyelwe ngoba umphumela cardiotoxicity, okuyinto kwanele inhliziyo kubathinta.

Izidakamizwa "Nimesulide"

Lokhu imithi akukhona nje kuphela ukuthi umphumela anti-inflammatory futhi antipain. Kusho anezakhi antioxidant ukuthi zivimbela izidakamizwa izinto ezibhubhisa uqwanga futhi collagen ethandele.

Zifakwe ikhambi:

• sokuqaqamba kwamalunga;
• sokuqaqamba kwamalunga;
• osteoarthritis;
• myalgia;
• arthralgia;
• bursitis;
• umkhuhlane;
• ubuhlungu syndromes ahlukahlukene.

Kulokhu, umphumela analgesic zomuthi inikeza fast kakhulu. Ngokuvamile, isiguli uthola inkululeko phakathi nemizuzu engu-20 ngemva ukungenisa. Yingakho leli thuluzi siyasebenza kakhulu ngoba acute paroxysmal ubuhlungu.

Cishe njalo, umuthi kahle ikubekezelele iziguli. Kodwa ngezinye izikhathi, ungase uzizwe imiphumela emibi njengokuba nesiyezi, ukozela, ikhanda elibuhlungu, isicanucanu, isilungulela, hematuria, oliguria, urticaria.

Ithuluzi ayivunyelwe ukwamukela abesifazane abakhulelwe kanye nezingane iminyaka engu-12. Kudingeka ukunakekela okukhethekile kufanele uthathe isidakamizwa "Nimesulide" abantu eziye zabona umfutho wegazi ophakeme, kahle izinso umsebenzi, umbono noma inhliziyo.

Inani izidakamizwa ngokwesilinganiso 76,9 ruble.

What do abathengi?

Izibuyekezo sokulungiselela cishe njalo omuhle. Njengoba umuthi kahle aqede ubuhlungu futhi kunciphisa imfiva, izimpi ezinkulu ukuvuvukala.

Iziguli eziningi ukubika ukuthi izimpawu impumuzo kwenzeka ngokushesha ngokwanele, kanti isikhathi isinyathelo salo cishe amahora ayisishiyagalombili.

ithuluzi elihle kakhulu aqede ngokuphelele ngezinyo, kuyashaqisa, ubuhlungu arthritic. Umuthi ungakwazi akhulule kabi kubangelwa emsipheni ukubhajwa.

Izidakamizwa "Ksefokam"

Lesi sidakamizwa likhona oxicams iqembu. Leli qembu NSAID esihluke anda isigamu-nokuphila, okuholela isikhathi eside izidakamizwa ukuchayeka. It kakhulu ziyancipha imvamisa ekutholeni nomuthi. Ngenxa yalokho, ingozi nemiphumela engathandeki yalawo maphilisi kuyehla.

Izidakamizwa "Ksefokam" kukhona ikhono eliphakeme ukuletha ubuhlungu. Imiphumela yako analgesic emandleni ukubonakaliswa okufanayo nalokho morphine. Nokho, ngokungafani yokugcina, ithuluzi ayiluthi futhi akuphazamisi isimiso sezinzwa esiyinhloko.

Phakathi ukuhlolwa, ke kwaphawuleka ukuthi izidakamizwa aqede ubuhlungu amahora 12.

Lokho okwakudingeka ukuze kukhokhwe izidakamizwa e ifomu tablet (8 mg) № ukupakisha 10 ruble 205.

Izidakamizwa "Rofecoxib"

Umuthi has analgesic eqeda ukuvuvukala, antipyretic nomphumela anti-edematous. Inikezwe izindlela eziphumelelayo ukuze izifo elandelayo:

• periarthritis ezingamahlalakhona;
• rheumatoid arthritis;
• tendonitis;
• bursitis;
• ukulimala umsipha ka nemisipha, imisipha.

Kwanele ukuqeda ngempumelelo lesi sidakamizwa "Rofecoxib" izimpawu ezinhlobonhlobo buhlungu kubangelwa neuralgia, osteochondrosis, epulpiti. Kusho kahle aqede sokuqaqanjelwa yiqolo, umfutho amazinyo, syndrome radicular.

Umuthi akufanele kube kuncike ukwamukelwa iziguli somoya, ngemuva kokushaywa yisifo senhliziyo, unhlangothi. Akubalulekile ukuyisebenzisa, futhi abantu abanezifo oncological, umfutho ophezulu wegazi kanye isifo sokuqina kwemithambo yegazi. Umuthi akuvunyelwe izingane ezingaphansi kweminyaka engu-12. Ngaphezu kwalokho, ngaphambi kokusebenzisa kungcono ngokucophelela imiphumela engemihle.

Izidakamizwa "Parecoxib"

Lena indlela enhle kakhulu ngawo ukunciphisa impendulo ukuvuvukala kanye nekufaka ligalelo nokwehlisa nozwela zobuhlungu. Umuthi odingeka for iziguli othola ukuhlinzwa.

It iqeda ubuhlungu syndromes of ngokulinganisela umfutho ezinzima. Iphathwe ngemva hip Imininingwane nedolo esikhundleni, hysterectomy, yenhliziyo ukuhlinzwa Umthambo dlula, elisetshenziswa umkhuba yamazinyo.

Isikali ukulungiswa kwenzelwe nje ngabanye. It kuncike isimo emitholampilo inkomba. Izingane ezingaphansi kweminyaka engu-18 imithi akuhloselwe.

Izidakamizwa "Arcoxia"

Umuthi has elinye igama - "Etorikoksib". Izindlela libhekene okusezingeni eliphezulu antiinflammatory, izakhiwo analgesic. Ukulungiswa ikhuthaza okusithiyayo we ngiyibona ubuhlungu.

Iziguli eziphathwa ukugula of the system zemisipha ngosizo leli thuluzi ukuqeda ekuseni ukuqina. Ukuthi aye athuthuka ukuhamba ngokuhlanganyela, kunciphisa ukushuba ukuvuvukala, kahle gidi ubuhlungu. Ngemva kokuthola lezi nomphumela oqabulayo kwenzeka kungakapheli imizuzu engamashumi amabili nane. I asebenzayo izidakamizwa izidakamizwa is kahle amuncwa egazini. Ukulungiswa libhekene bioavailability okusezingeni eliphezulu. Kulolu hlu 100%.

Umthamo zomuthi kungenziwa kunqunyiwe ngudokotela. Ngokwejwayelekile zokhahlamba kusuka mg 60 ukuze mg 120 izinsuku.

Umuthi ayenzelwanga ukusetshenziswa abesifazane abakhulelwe nezingane kuze kube iminyaka engu-16.

isiphetho

kwemithi Modern akuyona emi namanje. Ukuthuthukiswa amasha, ama-NSAID ephumelela kakhudlwana. Uhlu ngaphandle isizukulwane esisha izidakamizwa, ngenhla, ikuvumela ukuthi ukhethe ithuluzi best for yimuphi pathologies. Nokho, qaphela ukuthi le mithi abakwazi ukwelapha lesi sifo. Sinenkosi nomphumela eqeda ukuvuvukala kanye analgesic kuphela.